Birgit Claus Henn | Profiles RNS

Birgit Claus Henn, MPH, ScD

Assistant Professor

Boston University School of Public Health

Dept of Environmental Health

SD, Harvard School of Public Health
MPH, University of California, Berkeley School of Public Health

Birgit Claus Henn’s research focuses on exposure to environmental toxicants and their impact on child development. She has examined associations between metals, pesticides, and other chemical exposures and neurodevelopment in multiple pediatric cohorts worldwide, spanning critical periods of development from prenatal exposure through late childhood. Dr. Claus Henn is the PI of an NIEHS Career Development Award to utilize novel statistical approaches for analyzing chemical mixtures data in order to understand neurodevelopmental effects of multiple metals. Other research interests include exposure to chemicals in consumer products, effects of toxicants on birth outcomes, and the development and use of novel biomarkers. Dr. Claus Henn also serves as the director of the PhD program in Environmental Health.

BU Sponsored Research
NIH RePORTER Sponsored Research

METAL MIXTURES, CHILDREN'S COGNITION, AND SENSITIVE DEVELOPMENTAL WINDOWS
03/03/2015 - 12/31/2018 (PI)
NIH/National Institute of Environmental Health Sciences
5R00ES022986-05

MANGANESE EXPOSURE WINDOWS AND NEUROLOGIC FUNCTION IN ADOLESCENCE
09/30/2016 - 08/31/2018 (PI)
Icahn School of Medicine at Mount Sinai NIH NIEHS
5R01ES019222-07

NOVEL BIOMARKER TO IDENTIFY CRITICAL WINDOWS OF SUSCEPTIBILITY TO METAL MIXTURE
09/01/2016 - 08/31/2018 (PI)
Icahn School of Medicine at Mount Sinai NIH NIEHS
5R01ES026033-02

Yr	Title	Project-Sub Proj	Pubs
2017	Metal mixtures, children's cognition, and sensitive developmental windows	5R00ES022986-05	8
2016	Metal mixtures, children's cognition, and sensitive developmental windows	5R00ES022986-04	8
2015	Metal mixtures, children's cognition, and sensitive developmental windows	4R00ES022986-03	8
2014	Metal mixtures, children's cognition, and sensitive developmental windows	5K99ES022986-02	2
2013	Metal mixtures, children's cognition, and sensitive developmental windows	1K99ES022986-01	2

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Butler L, Gennings C, Peli M, Borgese L, Placidi D, Zimmerman N, Hsu HL, Coull BA, Wright RO, Smith DR, Lucchini RG, Claus Henn B. Assessing the contributions of metals in environmental media to exposure biomarkers in a region of ferroalloy industry. J Expo Sci Environ Epidemiol. 2018 Oct 18. PMID: 30337680; DOI: 10.1038/s41370-018-0081-6;.
Liu SH, Bobb JF, Claus Henn B, Gennings C, Schnaas L, Tellez-Rojo M, Bellinger D, Arora M, Wright RO, Coull BA. Bayesian varying coefficient kernel machine regression to assess neurodevelopmental trajectories associated with exposure to complex mixtures. Stat Med. 2018 Dec 30; 37(30):4680-4694. PMID: 30277584.
Horton MK, Hsu L, Claus Henn B, Margolis A, Austin C, Svensson K, Schnaas L, Gennings C, Hu H, Wright R, Rojo MMT, Arora M. Dentine biomarkers of prenatal and early childhood exposure to manganese, zinc and lead and childhood behavior. Environ Int. 2018 Dec; 121(Pt 1):148-158. PMID: 30205321; DOI: 10.1016/j.envint.2018.08.045;.
Bobb JF, Claus Henn B, Valeri L, Coull BA. Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression. Environ Health. 2018 08 20; 17(1):67. PMID: 30126431; DOI: 10.1186/s12940-018-0413-y;.
Sun R, Wang Z, Claus Henn B, Su L, Lu Q, Lin X, Wright RO, Bellinger DC, Kile M, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. Identification of novel loci associated with infant cognitive ability. Mol Psychiatry. 2018 Aug 17. PMID: 30120420.
Liu SH, Bobb JF, Lee KH, Gennings C, Claus Henn B, Bellinger D, Austin C, Schnaas L, Tellez-Rojo MM, Hu H, Wright RO, Arora M, Coull BA. Lagged kernel machine regression for identifying time windows of susceptibility to exposures of complex mixtures. Biostatistics. 2018 Jul 01; 19(3):325-341. PMID: 28968676; DOI: 10.1093/biostatistics/kxx036;.
Liu SH, Bobb JF, Claus Henn B, Schnaas L, Tellez-Rojo MM, Gennings C, Arora M, Wright RO, Coull BA, Wand MP. Modeling the health effects of time-varying complex environmental mixtures: Mean field variational Bayes for lagged kernel machine regression. Environmetrics. 2018; e2504.
Preston EV, Webster TF, Oken E, Claus Henn B, McClean MD, Rifas-Shiman SL, Pearce EN, Braverman LE, Calafat AM, Ye X, Sagiv SK. Maternal Plasma per- and Polyfluoroalkyl Substance Concentrations in Early Pregnancy and Maternal and Neonatal Thyroid Function in a Prospective Birth Cohort: Project Viva (USA). Environ Health Perspect. 2018 02 27; 126(2):027013.View Related Profiles.
Claus Henn, Birgit
Pearce, Elizabeth
Braverman, Lewis
McClean, Michael
Sagiv, Sharon
Webster, Thomas
PMID: 29488882; DOI: 10.1289/EHP2534;.
Claus Henn B, Austin C, Coull BA, Schnaas L, Gennings C, Horton MK, Hernández-Ávila M, Hu H, Téllez-Rojo MM, Wright RO, Arora M. Uncovering neurodevelopmental windows of susceptibility to manganese exposure using dentine microspatial analyses. Environ Res. 2018 02; 161:588-598. PMID: 29247915; DOI: 10.1016/j.envres.2017.12.003;.
Claus Henn B, Ogneva-Himmelberger Y, Denehy A, Randall M, Cordon N, Basu B, Caccavale B, Covino S, Hanumantha R, Longo K, Maiorano A, Pillsbury S, Rigutto G, Shields K, Sarkis M, Downs TJ. Integrated Assessment of Shallow-Aquifer Vulnerability to Multiple Contaminants and Drinking-Water Exposure Pathways in Holliston, Massachusetts. Water. 2017; 10(1):23.

Showing 10 of 30 results. Show More

Bauer JA, Claus Henn B, Austin C, Zoni S, Fedrighi C, Cagna G, Placidi D, White RF, Yang Q, Coull BA, Smith D, Lucchini RG, Wright RO, Arora M. Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility. Environ Int. 2017 Nov; 108:299-308.View Related Profiles.
Claus Henn, Birgit
Yang, Qiong
White, Roberta
PMID: 28941415; DOI: 10.1016/j.envint.2017.08.013;.
Chiu YM, Claus Henn B, Hsu HL, Pendo MP, Coull BA, Austin C, Cagna G, Fedrighi C, Placidi D, Smith DR, Wright RO, Lucchini RG, Arora M. Sex differences in sensitivity to prenatal and early childhood manganese exposure on neuromotor function in adolescents. Environ Res. 2017 Nov; 159:458-465. PMID: 28858760; DOI: 10.1016/j.envres.2017.08.035;.
Wang Z, Claus Henn B, Wang C, Wei Y, Su L, Sun R, Chen H, Wagner PJ, Lu Q, Lin X, Wright R, Bellinger D, Kile M, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environ Health. 2017 Jul 28; 16(1):81. PMID: 28754176; DOI: 10.1186/s12940-017-0288-3;.
Muñoz-Rocha TV, Tamayo Y Ortiz M, Romero M, Pantic I, Schnaas L, Bellinger D, Claus-Henn B, Wright R, Wright RO, Téllez-Rojo MM. Prenatal co-exposure to manganese and depression and 24-months neurodevelopment. Neurotoxicology. 2018 Jan; 64:134-141. PMID: 28728787; DOI: 10.1016/j.neuro.2017.07.007;.
Claus Henn B, Bellinger DC, Hopkins MR, Coull BA, Ettinger AS, Jim R, Hatley E, Christiani DC, Wright RO. Maternal and Cord Blood Manganese Concentrations and Early Childhood Neurodevelopment among Residents near a Mining-Impacted Superfund Site. Environ Health Perspect. 2017 06 28; 125(6):067020. PMID: 28665786; DOI: 10.1289/EHP925;.
Valeri L, Mazumdar MM, Bobb JF, Claus Henn B, Rodrigues E, Sharif OIA, Kile ML, Quamruzzaman Q, Afroz S, Golam M, Amarasiriwardena C, Bellinger DC, Christiani DC, Coull BA, Wright RO. The Joint Effect of Prenatal Exposure to Metal Mixtures on Neurodevelopmental Outcomes at 20-40 Months of Age: Evidence from Rural Bangladesh. Environ Health Perspect. 2017 06 26; 125(6):067015. PMID: 28669934.
Harley KG, Berger K, Rauch S, Kogut K, Claus Henn B, Calafat AM, Huen K, Eskenazi B, Holland N. Association of prenatal urinary phthalate metabolite concentrations and childhood BMI and obesity. Pediatr Res. 2017 Sep; 82(3):405-415. PMID: 28426647; DOI: 10.1038/pr.2017.112;.
Preston EV, McClean MD, Claus Henn B, Stapleton HM, Braverman LE, Pearce EN, Makey CM, Webster TF. Associations between urinary diphenyl phosphate and thyroid function. Environ Int. 2017 Apr; 101:158-164.View Related Profiles.
Claus Henn, Birgit
Pearce, Elizabeth
Braverman, Lewis
McClean, Michael
Webster, Thomas
PMID: 28162782; DOI: 10.1016/j.envint.2017.01.020;.
Claus Henn B, Ettinger AS, Hopkins MR, Jim R, Amarasiriwardena C, Christiani DC, Coull BA, Bellinger DC, Wright RO. Prenatal Arsenic Exposure and Birth Outcomes among a Population Residing near a Mining-Related Superfund Site. Environ Health Perspect. 2016 Aug; 124(8):1308-15. PMID: 26859631; PMCID: PMC4977047; DOI: 10.1289/ehp.1510070;.
Sanders AP, Claus Henn B, Wright RO. Perinatal and Childhood Exposure to Cadmium, Manganese, and Metal Mixtures and Effects on Cognition and Behavior: A Review of Recent Literature. Curr Environ Health Rep. 2015 Sep; 2(3):284-94. PMID: 26231505; PMCID: PMC4531257; DOI: 10.1007/s40572-015-0058-8;.
von Stackelberg K, Guzy E, Chu T, Claus Henn B. Exposure to Mixtures of Metals and Neurodevelopmental Outcomes: A Multidisciplinary Review Using an Adverse Outcome Pathway Framework. Risk Anal. 2015 Jun; 35(6):971-1016. PMID: 26096925; DOI: 10.1111/risa.12425;.
Bobb JF, Valeri L, Claus Henn B, Christiani DC, Wright RO, Mazumdar M, Godleski JJ, Coull BA. Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Biostatistics. 2015 Jul; 16(3):493-508. PMID: 25532525; DOI: 10.1093/biostatistics/kxu058;.
Claus Henn B, Coull BA, Wright RO. Chemical mixtures and children's health. Curr Opin Pediatr. 2014 Apr; 26(2):223-9. PMID: 24535499; PMCID: PMC4043217; DOI: 10.1097/MOP.0000000000000067;.
Roels HA, Bowler RM, Kim Y, Claus Henn B, Mergler D, Hoet P, Gocheva VV, Bellinger DC, Wright RO, Harris MG, Chang Y, Bouchard MF, Riojas-Rodriguez H, Menezes-Filho JA, Téllez-Rojo MM. Manganese exposure and cognitive deficits: a growing concern for manganese neurotoxicity. Neurotoxicology. 2012 Aug; 33(4):872-80. PMID: 22498092; DOI: 10.1016/j.neuro.2012.03.009;.
Claus Henn B, Kim J, Wessling-Resnick M, Téllez-Rojo MM, Jayawardene I, Ettinger AS, Hernández-Avila M, Schwartz J, Christiani DC, Hu H, Wright RO. Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models. Environ Health. 2011; 10:97. PMID: 22074419; DOI: 10.1186/1476-069X-10-97;.
Claus Henn B, Schnaas L, Ettinger AS, Schwartz J, Lamadrid-Figueroa H, Hernández-Avila M, Amarasiriwardena C, Hu H, Bellinger DC, Wright RO, Téllez-Rojo MM. Associations of early childhood manganese and lead coexposure with neurodevelopment. Environ Health Perspect. 2012 Jan; 120(1):126-31. PMID: 21885384; PMCID: PMC3261931; DOI: 10.1289/ehp.1003300;.
Claus Henn B, Ettinger AS, Schwartz J, Téllez-Rojo MM, Lamadrid-Figueroa H, Hernández-Avila M, Schnaas L, Amarasiriwardena C, Bellinger DC, Hu H, Wright RO. Early postnatal blood manganese levels and children's neurodevelopment. Epidemiology. 2010 Jul; 21(4):433-9. PMID: 20549838; PMCID: PMC3127440.
Claus Henn B, McMaster S, Padilla S. Measuring cholinesterase activity in human saliva. J Toxicol Environ Health A. 2006 Oct; 69(19):1805-18. PMID: 16905510.
Bradman A, Whitaker D, Quirós L, Castorina R, Claus Henn B, Nishioka M, Morgan J, Barr DB, Harnly M, Brisbin JA, Sheldon LS, McKone TE, Eskenazi B. Pesticides and their metabolites in the homes and urine of farmworker children living in the Salinas Valley, CA. J Expo Sci Environ Epidemiol. 2007 Jul; 17(4):331-49. PMID: 16736054.
Bradman A, Barr DB, Claus Henn BG, Drumheller T, Curry C, Eskenazi B. Measurement of pesticides and other toxicants in amniotic fluid as a potential biomarker of prenatal exposure: a validation study. Environ Health Perspect. 2003 Nov; 111(14):1779-82. PMID: 14594631; PMCID: PMC1241723.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 30 publications over 10 distinct years, with a maximum of 9 publications in 2017 and 2018

Bar chart showing 30 publications over 10 distinct years, with a maximum of 9 publications in 2017 and 2018

Year	Publications
2003	1
2006	2
2010	1
2011	2
2012	1
2014	2
2015	2
2016	1
2017	9
2018	9

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Pumping for answers: Holliston mothers push for answers on drinking water

The Milford Daily News 2/28/2018

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