Birgit Claus Henn | Profiles RNS

Birgit G. Claus Henn, MPH, ScD

Associate Professor

Boston University School of Public Health

Dept of Environmental Health

SD, Harvard School of Public Health
MPH, University of California, Berkeley School of Public Health

Birgit Claus Henn’s research focuses on exposure to environmental toxicants and their impact on child development. She has examined associations between metals, pesticides, and other chemical exposures and neurodevelopment in multiple pediatric cohorts worldwide, spanning critical periods of development from prenatal exposure through late childhood. Dr. Claus Henn is the PI of an NIEHS Career Development Award to utilize novel statistical approaches for analyzing chemical mixtures data in order to understand neurodevelopmental effects of multiple metals. Other research interests include exposure to chemicals in consumer products, effects of toxicants on birth outcomes, and the development and use of novel biomarkers. Dr. Claus Henn also serves as the director of the PhD program in Environmental Health.

BU Research
NIH RePORTER Research

Metal-Nutrient Mixtures in Epidemiologic and Toxicologic Studies of Cardiovascular Disease
09/04/2020 - 06/30/2023 (Subcontract PI)
The Research Foundation for The State University of New York, Stony Brook University NIH NIEHS
1R01ES03093801A1

Manganese Exposure Windows and Neurologic function in Adolescence
09/30/2016 - 08/31/2021 (Subcontract PI)
Icahn School of Medicine at Mount Sinai NIH NIEHS
5R01ES019222-10

Novel Biomarker to Identify Critical Windows of Susceptibility to Metal Mixture
09/01/2016 - 08/31/2021 (Subcontract PI)
Icahn School of Medicine at Mount Sinai NIH NIEHS
5R01ES026033-04

The effects of multiple exposures and the risk of birth defects (project #1028)
11/25/2019 - 08/31/2020 (Subcontract PI)
Comm. of Mass./Department of Public Health HHS CDC
5U01DD001224-02-00

Metal Mixtures, children's cognition, and sensitive developmental windows
03/03/2015 - 12/31/2019 (PI)
NIH/National Institute of Environmental Health Sciences
5R00ES022986-05

Title

Yr	Title	Project-Sub Proj	Pubs
2017	Metal mixtures, children's cognition, and sensitive developmental windows	5R00ES022986-05	15
2016	Metal mixtures, children's cognition, and sensitive developmental windows	5R00ES022986-04	15
2015	Metal mixtures, children's cognition, and sensitive developmental windows	4R00ES022986-03	15
2014	Metal mixtures, children's cognition, and sensitive developmental windows	5K99ES022986-02	2
2013	Metal mixtures, children's cognition, and sensitive developmental windows	1K99ES022986-01	2

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Wesselink AK, Claus Henn B, Fruh V, Orta OR, Weuve J, Hauser R, Williams PL, McClean MD, Sjodin A, Bethea TN, Brasky TM, Baird DD, Wise LA. A PROSPECTIVE ULTRASOUND STUDY OF Plasma polychlorinated biphenyl concentrations and INCIDENCE of uterine leiomyomata. Epidemiology. 2021 Jan 06; Publish Ahead of Print.View Related Profiles.

Wesselink, Amelia
Claus Henn, Birgit
Weuve, Jennifer
Wise, Lauren
McClean, Michael
Orta, Olivia

PMID: 33427764

Fruh V, Claus Henn B, Weuve J, Wesselink AK, Orta OR, Heeren T, Hauser R, Calafat AM, Williams PL, Baird DD, Wise LA. Incidence of uterine leiomyoma in relation to urinary concentrations of phthalate and phthalate alternative biomarkers: A prospective ultrasound study. Environ Int. 2020 Dec 21; 147:106218.View Related Profiles.

Wesselink, Amelia
Claus Henn, Birgit
Weuve, Jennifer
Wise, Lauren
Orta, Olivia
Heeren, Timothy

PMID: 33360166

Levin-Schwartz Y, Claus Henn B, Gennings C, Coull BA, Placidi D, Horton MK, Smith DR, Lucchini RG, Wright RO. Integrated measures of lead and manganese exposure improve estimation of their joint effects on cognition in Italian school-age children. Environ Int. 2021 Jan; 146:106312. PMID: 33395951

Howe CG, Claus Henn B, Eckel SP, Farzan SF, Grubbs BH, Chavez TA, Hodes TL, Faham D, Al-Marayati L, Lerner D, Quimby A, Twogood S, Richards MJ, Meeker JD, Bastain TM, Breton CV. Prenatal Metal Mixtures and Birth Weight for Gestational Age in a Predominately Lower-Income Hispanic Pregnancy Cohort in Los Angeles. Environ Health Perspect. 2020 Nov; 128(11):117001. PMID: 33141601; DOI: 10.1289/EHP7201;

Howe CG, Claus Henn B, Farzan SF, Habre R, Eckel SP, Grubbs BH, Chavez TA, Faham D, Al-Marayati L, Lerner D, Quimby A, Twogood S, Richards MJ, Meeker JD, Bastain TM, Breton CV. Prenatal metal mixtures and fetal size in mid-pregnancy in the MADRES study. Environ Res. 2020 Oct 28; 110388. PMID: 33129852; DOI: 10.1016/j.envres.2020.110388;

Wesselink AK, Fruh V, Hauser R, Weuve J, Taylor KW, Orta OR, Claus Henn B, Bethea TN, McClean MD, Williams PL, Calafat AM, Baird DD, Wise LA. Correlates of urinary concentrations of phthalate and phthalate alternative metabolites among reproductive-aged Black women from Detroit, Michigan. J Expo Sci Environ Epidemiol. 2020 Sep 26.View Related Profiles.

Wesselink, Amelia
Claus Henn, Birgit
Weuve, Jennifer
Wise, Lauren
McClean, Michael
Orta, Olivia

PMID: 32980856

Bauer JA, Devick KL, Bobb JF, Coull BA, Bellinger D, Benedetti C, Cagna G, Fedrighi C, Guazzetti S, Oppini M, Placidi D, Webster TF, White RF, Yang Q, Zoni S, Wright RO, Smith DR, Lucchini RG, Claus Henn B. Associations of a Metal Mixture Measured in Multiple Biomarkers with IQ: Evidence from Italian Adolescents Living near Ferroalloy Industry. Environ Health Perspect. 2020 09; 128(9):97002.View Related Profiles.

Claus Henn, Birgit
Yang, Qiong
White, Roberta
Webster, Thomas

PMID: 32897104; DOI: 10.1289/EHP6803;

Preston EV, Webster TF, Claus Henn B, McClean MD, Gennings C, Oken E, Rifas-Shiman SL, Pearce EN, Calafat AM, Fleisch AF, Sagiv SK. Prenatal exposure to per- and polyfluoroalkyl substances and maternal and neonatal thyroid function in the Project Viva Cohort: A mixtures approach. Environ Int. 2020 06; 139:105728.View Related Profiles.

Claus Henn, Birgit
Pearce, Elizabeth
McClean, Michael
Webster, Thomas

PMID: 32311629

Orta OR, Wesselink AK, Bethea TN, Claus Henn B, Sjödin A, Wegienka G, Baird DD, Wise LA. Correlates of organochlorine pesticide plasma concentrations among reproductive-aged black women. Environ Res. 2020 05; 184:109352.View Related Profiles.

Wesselink, Amelia
Claus Henn, Birgit
Wise, Lauren
Orta, Olivia

PMID: 32182481; DOI: 10.1016/j.envres.2020.109352;

Levin-Schwartz Y, Gennings C, Henn BC, Coull BA, Placidi D, Lucchini R, Smith DR, Wright RO. Multi-media biomarkers: Integrating information to improve lead exposure assessment. Environ Res. 2020 04; 183:109148. PMID: 32004829; DOI: 10.1016/j.envres.2020.109148;

Showing 10 of 46 results. Show More

Orta OR, Wesselink AK, Bethea TN, Claus Henn B, McClean MD, Sjödin A, Baird DD, Wise LA. Correlates of plasma concentrations of brominated flame retardants in a cohort of U.S. Black women residing in the Detroit, Michigan metropolitan area. Sci Total Environ. 2020 Apr 20; 714:136777.View Related Profiles.

Wesselink, Amelia
Claus Henn, Birgit
Wise, Lauren
McClean, Michael
Orta, Olivia

PMID: 32018967; DOI: 10.1016/j.scitotenv.2020.136777;

Zheng Y, Zhang C, Weisskopf MG, Williams PL, Claus Henn B, Parsons PJ, Palmer CD, Buck Louis GM, James-Todd T. Evaluating associations between early pregnancy trace elements mixture and 2nd trimester gestational glucose levels: A comparison of three statistical approaches. Int J Hyg Environ Health. 2020 03; 224:113446. PMID: 31978739; DOI: 10.1016/j.ijheh.2019.113446;

Fruh V, Rifas-Shiman SL, Amarasiriwardena C, Cardenas A, Bellinger DC, Wise LA, White RF, Wright RO, Oken E, Claus Henn B. Prenatal lead exposure and childhood executive function and behavioral difficulties in project viva. Neurotoxicology. 2019 12; 75:105-115.View Related Profiles.

Claus Henn, Birgit
Wise, Lauren

PMID: 31513824; DOI: 10.1016/j.neuro.2019.09.006;

Mullin AM, Amarasiriwardena C, Cantoral-Preciado A, Claus Henn B, Leon Hsu HH, Sanders AP, Svensson K, Tamayo-Ortiz M, Téllez-Rojo MM, Wright RO, Burris HH. Maternal blood arsenic levels and associations with birth weight-for-gestational age. Environ Res. 2019 10; 177:108603. PMID: 31357156

White RF, Brand C, Claus Henn B, Janulewicz PA. Oxford Handbook of Adult Cognitive Disorders. Neurotoxicant Exposures. Oxford University Press. 2019.

Crawford KA, Clark BW, Heiger-Bernays WJ, Karchner SI, Claus Henn BG, Griffith KN, Howes BL, Schlezinger DR, Hahn ME, Nacci DE, Schlezinger JJ. Altered lipid homeostasis in a PCB-resistant Atlantic killifish (Fundulus heteroclitus) population from New Bedford Harbor, MA, U.S.A. Aquat Toxicol. 2019 May; 210:30-43.View Related Profiles.

Claus Henn, Birgit
Schlezinger, Jennifer
Heiger-Bernays, Wendy

PMID: 30822701; DOI: 10.1016/j.aquatox.2019.02.011;

Butler L, Gennings C, Peli M, Borgese L, Placidi D, Zimmerman N, Hsu HL, Coull BA, Wright RO, Smith DR, Lucchini RG, Claus Henn B. Assessing the contributions of metals in environmental media to exposure biomarkers in a region of ferroalloy industry. J Expo Sci Environ Epidemiol. 2019 09; 29(5):674-687. PMID: 30337680; DOI: 10.1038/s41370-018-0081-6;

Liu SH, Bobb JF, Claus Henn B, Gennings C, Schnaas L, Tellez-Rojo M, Bellinger D, Arora M, Wright RO, Coull BA. Bayesian varying coefficient kernel machine regression to assess neurodevelopmental trajectories associated with exposure to complex mixtures. Stat Med. 2018 12 30; 37(30):4680-4694. PMID: 30277584

Horton MK, Hsu L, Claus Henn B, Margolis A, Austin C, Svensson K, Schnaas L, Gennings C, Hu H, Wright R, Rojo MMT, Arora M. Dentine biomarkers of prenatal and early childhood exposure to manganese, zinc and lead and childhood behavior. Environ Int. 2018 12; 121(Pt 1):148-158. PMID: 30205321; DOI: 10.1016/j.envint.2018.08.045;

Bobb JF, Claus Henn B, Valeri L, Coull BA. Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression. Environ Health. 2018 08 20; 17(1):67. PMID: 30126431; DOI: 10.1186/s12940-018-0413-y;

Sun R, Wang Z, Claus Henn B, Su L, Lu Q, Lin X, Wright RO, Bellinger DC, Kile M, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. Identification of novel loci associated with infant cognitive ability. Mol Psychiatry. 2020 11; 25(11):3010-3019. PMID: 30120420

Liu SH, Bobb JF, Lee KH, Gennings C, Claus Henn B, Bellinger D, Austin C, Schnaas L, Tellez-Rojo MM, Hu H, Wright RO, Arora M, Coull BA. Lagged kernel machine regression for identifying time windows of susceptibility to exposures of complex mixtures. Biostatistics. 2018 07 01; 19(3):325-341. PMID: 28968676; DOI: 10.1093/biostatistics/kxx036;

Liu SH, Bobb JF, Henn BC, Schnaas L, Tellez-Rojo MM, Gennings C, Arora M, Wright RO, Coull BA, Wand MP. Modeling the health effects of time-varying complex environmental mixtures: Mean field variational Bayes for lagged kernel machine regression. Environmetrics. 2018 Jun; 29(4). PMID: 30686915; DOI: 10.1002/env.2504;

Preston EV, Webster TF, Oken E, Claus Henn B, McClean MD, Rifas-Shiman SL, Pearce EN, Braverman LE, Calafat AM, Ye X, Sagiv SK. Maternal Plasma per- and Polyfluoroalkyl Substance Concentrations in Early Pregnancy and Maternal and Neonatal Thyroid Function in a Prospective Birth Cohort: Project Viva (USA). Environ Health Perspect. 2018 02 27; 126(2):027013.View Related Profiles.

Claus Henn, Birgit
Pearce, Elizabeth
Braverman, Lewis
McClean, Michael
Sagiv, Sharon
Webster, Thomas

PMID: 29488882; DOI: 10.1289/EHP2534;

Claus Henn B, Austin C, Coull BA, Schnaas L, Gennings C, Horton MK, Hernández-Ávila M, Hu H, Téllez-Rojo MM, Wright RO, Arora M. Uncovering neurodevelopmental windows of susceptibility to manganese exposure using dentine microspatial analyses. Environ Res. 2018 02; 161:588-598. PMID: 29247915; DOI: 10.1016/j.envres.2017.12.003;

Claus Henn B, Ogneva-Himmelberger Y, Denehy A, Randall M, Cordon N, Basu B, Caccavale B, Covino S, Hanumantha R, Longo K, Maiorano A, Pillsbury S, Rigutto G, Shields K, Sarkis M, Downs TJ. Integrated Assessment of Shallow-Aquifer Vulnerability to Multiple Contaminants and Drinking-Water Exposure Pathways in Holliston, Massachusetts. Water. 2017; 10(1):23.

Bauer JA, Claus Henn B, Austin C, Zoni S, Fedrighi C, Cagna G, Placidi D, White RF, Yang Q, Coull BA, Smith D, Lucchini RG, Wright RO, Arora M. Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility. Environ Int. 2017 Nov; 108:299-308.View Related Profiles.

Claus Henn, Birgit
Yang, Qiong
White, Roberta

PMID: 28941415; DOI: 10.1016/j.envint.2017.08.013;

Chiu YM, Claus Henn B, Hsu HL, Pendo MP, Coull BA, Austin C, Cagna G, Fedrighi C, Placidi D, Smith DR, Wright RO, Lucchini RG, Arora M. Sex differences in sensitivity to prenatal and early childhood manganese exposure on neuromotor function in adolescents. Environ Res. 2017 Nov; 159:458-465. PMID: 28858760; DOI: 10.1016/j.envres.2017.08.035;

Wang Z, Claus Henn B, Wang C, Wei Y, Su L, Sun R, Chen H, Wagner PJ, Lu Q, Lin X, Wright R, Bellinger D, Kile M, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environ Health. 2017 Jul 28; 16(1):81. PMID: 28754176; DOI: 10.1186/s12940-017-0288-3;

Muñoz-Rocha TV, Tamayo Y Ortiz M, Romero M, Pantic I, Schnaas L, Bellinger D, Claus-Henn B, Wright R, Wright RO, Téllez-Rojo MM. Prenatal co-exposure to manganese and depression and 24-months neurodevelopment. Neurotoxicology. 2018 01; 64:134-141. PMID: 28728787; DOI: 10.1016/j.neuro.2017.07.007;

Claus Henn B, Bellinger DC, Hopkins MR, Coull BA, Ettinger AS, Jim R, Hatley E, Christiani DC, Wright RO. Maternal and Cord Blood Manganese Concentrations and Early Childhood Neurodevelopment among Residents near a Mining-Impacted Superfund Site. Environ Health Perspect. 2017 06 28; 125(6):067020. PMID: 28665786; DOI: 10.1289/EHP925;

Valeri L, Mazumdar MM, Bobb JF, Claus Henn B, Rodrigues E, Sharif OIA, Kile ML, Quamruzzaman Q, Afroz S, Golam M, Amarasiriwardena C, Bellinger DC, Christiani DC, Coull BA, Wright RO. The Joint Effect of Prenatal Exposure to Metal Mixtures on Neurodevelopmental Outcomes at 20-40 Months of Age: Evidence from Rural Bangladesh. Environ Health Perspect. 2017 06 26; 125(6):067015. PMID: 28669934

Harley KG, Berger K, Rauch S, Kogut K, Claus Henn B, Calafat AM, Huen K, Eskenazi B, Holland N. Association of prenatal urinary phthalate metabolite concentrations and childhood BMI and obesity. Pediatr Res. 2017 Sep; 82(3):405-415. PMID: 28426647; DOI: 10.1038/pr.2017.112;

Preston EV, McClean MD, Claus Henn B, Stapleton HM, Braverman LE, Pearce EN, Makey CM, Webster TF. Associations between urinary diphenyl phosphate and thyroid function. Environ Int. 2017 Apr; 101:158-164.View Related Profiles.

Claus Henn, Birgit
Pearce, Elizabeth
Braverman, Lewis
McClean, Michael
Webster, Thomas

PMID: 28162782; DOI: 10.1016/j.envint.2017.01.020;

Claus Henn B, Ettinger AS, Hopkins MR, Jim R, Amarasiriwardena C, Christiani DC, Coull BA, Bellinger DC, Wright RO. Prenatal Arsenic Exposure and Birth Outcomes among a Population Residing near a Mining-Related Superfund Site. Environ Health Perspect. 2016 Aug; 124(8):1308-15. PMID: 26859631; PMCID: PMC4977047; DOI: 10.1289/ehp.1510070;

Sanders AP, Claus Henn B, Wright RO. Perinatal and Childhood Exposure to Cadmium, Manganese, and Metal Mixtures and Effects on Cognition and Behavior: A Review of Recent Literature. Curr Environ Health Rep. 2015 Sep; 2(3):284-94. PMID: 26231505; PMCID: PMC4531257; DOI: 10.1007/s40572-015-0058-8;

von Stackelberg K, Guzy E, Chu T, Claus Henn B. Exposure to Mixtures of Metals and Neurodevelopmental Outcomes: A Multidisciplinary Review Using an Adverse Outcome Pathway Framework. Risk Anal. 2015 Jun; 35(6):971-1016. PMID: 26096925; DOI: 10.1111/risa.12425;

Bobb JF, Valeri L, Claus Henn B, Christiani DC, Wright RO, Mazumdar M, Godleski JJ, Coull BA. Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Biostatistics. 2015 Jul; 16(3):493-508. PMID: 25532525; DOI: 10.1093/biostatistics/kxu058;

Claus Henn B, Coull BA, Wright RO. Chemical mixtures and children's health. Curr Opin Pediatr. 2014 Apr; 26(2):223-9. PMID: 24535499; PMCID: PMC4043217; DOI: 10.1097/MOP.0000000000000067;

Roels HA, Bowler RM, Kim Y, Claus Henn B, Mergler D, Hoet P, Gocheva VV, Bellinger DC, Wright RO, Harris MG, Chang Y, Bouchard MF, Riojas-Rodriguez H, Menezes-Filho JA, Téllez-Rojo MM. Manganese exposure and cognitive deficits: a growing concern for manganese neurotoxicity. Neurotoxicology. 2012 Aug; 33(4):872-80. PMID: 22498092; DOI: 10.1016/j.neuro.2012.03.009;

Claus Henn B, Kim J, Wessling-Resnick M, Téllez-Rojo MM, Jayawardene I, Ettinger AS, Hernández-Avila M, Schwartz J, Christiani DC, Hu H, Wright RO. Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models. Environ Health. 2011; 10:97. PMID: 22074419; DOI: 10.1186/1476-069X-10-97;

Claus Henn B, Schnaas L, Ettinger AS, Schwartz J, Lamadrid-Figueroa H, Hernández-Avila M, Amarasiriwardena C, Hu H, Bellinger DC, Wright RO, Téllez-Rojo MM. Associations of early childhood manganese and lead coexposure with neurodevelopment. Environ Health Perspect. 2012 Jan; 120(1):126-31. PMID: 21885384; PMCID: PMC3261931; DOI: 10.1289/ehp.1003300;

Claus Henn B, Ettinger AS, Schwartz J, Téllez-Rojo MM, Lamadrid-Figueroa H, Hernández-Avila M, Schnaas L, Amarasiriwardena C, Bellinger DC, Hu H, Wright RO. Early postnatal blood manganese levels and children's neurodevelopment. Epidemiology. 2010 Jul; 21(4):433-9. PMID: 20549838; PMCID: PMC3127440

Claus Henn B, McMaster S, Padilla S. Measuring cholinesterase activity in human saliva. J Toxicol Environ Health A. 2006 Oct; 69(19):1805-18. PMID: 16905510

Bradman A, Whitaker D, Quirós L, Castorina R, Claus Henn B, Nishioka M, Morgan J, Barr DB, Harnly M, Brisbin JA, Sheldon LS, McKone TE, Eskenazi B. Pesticides and their metabolites in the homes and urine of farmworker children living in the Salinas Valley, CA. J Expo Sci Environ Epidemiol. 2007 Jul; 17(4):331-49. PMID: 16736054

Bradman A, Barr DB, Claus Henn BG, Drumheller T, Curry C, Eskenazi B. Measurement of pesticides and other toxicants in amniotic fluid as a potential biomarker of prenatal exposure: a validation study. Environ Health Perspect. 2003 Nov; 111(14):1779-82. PMID: 14594631; PMCID: PMC1241723

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 46 publications over 13 distinct years, with a maximum of 10 publications in 2020