Basilis (Vasileios) Zikopoulos, PhD
Associate Professor
Boston University College of Health & Rehabilitation Sciences: Sargent College
Health Sciences

PhD, University of Crete
MS, University of Crete
BS, University of Crete

Dr. Zikopoulos earned his undergraduate and master’s degrees in Biology in 1996 and 1998, and then continued his graduate studies to earn a PhD in Neurobiology from the department of Biology, University of Crete, Greece in 2004. During his studies, Dr. Zikopoulos received research fellowships and additional training from the Department of Physiology and Pharmacology, University of Manchester, UK, the Department of Biological Sciences, Open University, Milton Keynes, UK, and the Institute of Marine Biology of Crete, Greece. Dr. Zikopoulos then completed a post-doctoral fellowship in the Department of Health Sciences at Boston University, under the mentorship of Dr. Barbas. In 2008, Dr. Zikopoulos joined the Research Faculty of the Human Physiology Program of the Department of Health Sciences at Boston University and has been an Assistant Professor since 2015.

Dr. Zikopoulos is the director of the Human Systems Neuroscience Laboratory and a co-Investigator in the Neural Systems Laboratory. Dr. Zikopoulos’ research interests focus on the investigation of structural, neurochemical and molecular features, underlying the organization and synaptic interactions of cortical, thalamic, and amygdalar brain circuits in primates, including humans, and their disruption in disease. Increasingly, the lab’s research has been focusing on processes that shape network dynamics and the delicate balance of excitation and inhibition, which are consistently disrupted in neurologic and psychiatric disorders, like autism, schizophrenia, depression, and anxiety. Dr. Zikopoulos’ laboratory develops, optimizes, and uses high-resolution experimental and imaging approaches and is equipped with state of the art optical, laser-confocal, and electron microscopes. Experimental approaches are complemented by advanced computational techniques that make it possible to quantitatively study human brain tissue at very high resolution and model complex relationships between brain structure and function in health and disease, providing a solid foundation to integrate bench and clinical research across neuroscience disciplines.

Boston University College of Health & Rehabilitation Sciences: Sargent College
Human Systems Neuroscience Laboratory

Boston University College of Health & Rehabilitation Sciences: Sargent College
Neural Systems Laboratory

Short and long range cortical pathway and axon pathology in ASD: high resolution microscopic histopathology combined with machine learning and deep neural network analyses
10/01/2022 - 09/30/2024 (PI)
Simons Foundation

Organization and Circuit Interactions of Thalamocortical Attentional Networks in Health and Disease
02/15/2019 - 11/30/2023 (Multi-PI)
PI: Basilis (Vasileios) Zikopoulos, PhD
NIH/National Institute of Mental Health

Organization of Excitatory and Inhibitory Prefrontal Circuits in Children with Autism
04/04/2014 - 01/31/2020 (PI)
NIH/National Institute of Mental Health


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Zikopoulos B, Liu X, Tepe J, Trutzer I, John YJ, Barbas H. Opposite development of short- and long-range anterior cingulate pathways in autism. Acta Neuropathol. 2018 11; 136(5):759-778.View Related Profiles. PMID: 30191402; PMCID: PMC6208731; DOI: 10.1007/s00401-018-1904-1;
  2. Zikopoulos B, García-Cabezas MÁ, Barbas H. Parallel trends in cortical gray and white matter architecture and connections in primates allow fine study of pathways in humans and reveal network disruptions in autism. PLoS Biol. 2018 02; 16(2):e2004559. PMID: 29401206; PMCID: PMC5814101; DOI: 10.1371/journal.pbio.2004559;
  3. Zikopoulos B, Liu X, Tepe J, Trutzer I, John YJ, Barbas H. Opposite development of short- and long-range anterior cingulate pathways in autism. 2018.
  4. John YJ, Zikopoulos B, Bullock D and Barbas H. Visual Attention Deficits in Schizophrenia Can Arise from Inhibitory Dysfunction in Thalamus or Cortex. 2018.
  5. García-Cabezas MÁ, Barbas H, Zikopoulos B. Parallel development of chromatin patterns, neuron morphology, connections, and disruption in autism. Frontiers in Neuroanatomy. 2018.
  6. García-Cabezas MÁ, Joyce MKP, John YJ, Zikopoulos B, Barbas H. Mirror trends of plasticity and stability indicators in primate prefrontal cortex. Eur J Neurosci. 2017 Oct; 46(8):2392-2405. PMID: 28921934; PMCID: PMC5656436; DOI: 10.1111/ejn.13706;
  7. Zikopoulos B, Höistad M, John Y, Barbas H. Posterior Orbitofrontal and Anterior Cingulate Pathways to the Amygdala Target Inhibitory and Excitatory Systems with Opposite Functions. J Neurosci. 2017 May 17; 37(20):5051-5064. PMID: 28411274; PMCID: PMC5444191; DOI: 10.1523/JNEUROSCI.3940-16.2017;
  8. García-Cabezas MÁ, John YJ, Barbas H, Zikopoulos B. Distinction of Neurons, Glia and Endothelial Cells in the Cerebral Cortex: An Algorithm Based on Cytological Features. Front Neuroanat. 2016; 10:107. PMID: 27847469; PMCID: PMC5088408; DOI: 10.3389/fnana.2016.00107;
  9. Zikopoulos B, John YJ, García-Cabezas MÁ, Bunce JG, Barbas H. The intercalated nuclear complex of the primate amygdala. Neuroscience. 2016 08 25; 330:267-90. PMID: 27256508; PMCID: PMC4928580; DOI: 10.1016/j.neuroscience.2016.05.052;
  10. John YJ, Zikopoulos B, Bullock D, Barbas H. The Emotional Gatekeeper: A Computational Model of Attentional Selection and Suppression through the Pathway from the Amygdala to the Inhibitory Thalamic Reticular Nucleus. PLoS Comput Biol. 2016 Feb; 12(2):e1004722. PMID: 26828203; PMCID: PMC4734702; DOI: 10.1371/journal.pcbi.1004722;
Showing 10 of 32 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 32 publications over 14 distinct years, with a maximum of 5 publications in 2007 and 2018


2008-2011 Autism Speaks: Mentor-based Fellowship / Award
2003 Hellenic Neuroscience Society: HNS Research Achievement/Presentation Award
2003 Federation of European Neuroscience Societies (FENS): IBRO Travel Grant Award
2000 GGSRT, The British Council, and Department of Biology, Open University, Milton Keynes, UK: Research Fellowship
1998 University of Crete – Aristotle’s University of Thessaloniki, Greece, and European Union: Research Fellowship
1998 MS in Biology: Summa Cum Laude
1996 Institute of Marine Biology of Crete, and Department of Biology, University of Crete, Greece: Research Scholarship
1994 Greek State Scholarship Foundation and European Union: ERASMUS Scholarship
Contact for Mentoring:

635 Commonwealth Avenue, rm. 410D
Boston MA 02215
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617.353.7567 (fax)

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