Arturo Vegas, PhD
Assistant Professor
Boston University College of Arts and Sciences
Dept of Chemistry

PhD, Harvard University

The Vegas group pursues general and systematic approaches to developing targeted therapeutic carriers for the treatment of multiple human diseases. Small-molecule drugs excel at altering disease states at the cellular level, but their therapeutic benefits are often hindered by physiological barriers that impact their toxicity, efficacy, and distribution. The ability to overcome these barriers can make major differences in both the safety and effectiveness of a therapeutic. Engineering-based approaches have successfully shown that formulation can overcome barriers associated with toxicity and bioavailability, and are increasingly focused on tissue distribution and selective targeting of diseased tissues. There are currently few examples of chemical approaches being used to develop and implement new targeting modalities for drug delivery, and key questions have arisen regarding implementation and outcome. Can we effectively utilize physiological targets to localize medicines to diseased tissues? What targets can be used to improve drug localization to tumor sites? Can we modulate the tumor microenvironment? Can we selectively destroy autoimmune-causing cells?
Projects in the lab are focused on developing novel chemical tools, materials and approaches for targeting therapeutics to diseased tissues, with an emphasis on cancer and diabetes. These new tools will facilitate studies in the lab to understand mechanisms that control the physiological distribution of therapeutics and informing future targeting element design.

-For cancer, the primary focus will be developing conjugate and nanoparticle based approaches that control the physiological distribution and uptake of therapeutic molecules to tumors and the use of biomaterials to manipulate the tumor microenvironment.

-For diabetes, our focus will be selective destruction and modulation of cells responsible for the underlying type 1 autoimmunity.

Researchers in the lab design and implement synthetic methods to create novel targeting moieties and materials and link them to payloads with therapeutic value or potential. These constructs will then be evaluated at the protein and cellular levels, with lead constructs being advanced into animal studies. Techniques, methods, and approaches from organic synthesis, chemical biology, materials science, and biomedical engineering will be integrated to address these challenging problems in drug delivery.

Boston University
BU-BMC Cancer Center

Boston University
Evans Center for Interdisciplinary Biomedical Research

Targeted immunomodulation of the diabetic islet microenvironment
09/20/2016 - 08/31/2021 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases

Hepatocyte-Specific Viral Tropism with GalNAc Targeted Viruses
10/30/2017 - 10/29/2019 (PI)
Combined Therapeutics Inc.


Yr Title Project-Sub Proj Pubs
2016 Targeted immunomodulation of the diabetic islet microenvironment 1DP2DK111913-01 2

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Feng Y, Quinnell SP, Lanzi AM, Vegas AJ. Alginate-Based Amphiphilic Block Copolymers as a Drug Codelivery Platform. Nano Lett. 2021 Sep 08. PMID: 34495662
  2. Doloff JC, Veiseh O, Vegas AJ, Tam HH, Farah S, Ma M, Li J, Bader A, Chiu A, Sadraei A, Aresta-Dasilva S, Griffin M, Jhunjhunwala S, Webber M, Siebert S, Tang K, Chen M, Langan E, Dholakia N, Thakrar R, Qi M, Oberholzer J, Greiner DL, Langer R, Anderson DG. Author Correction: Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates. Nat Mater. 2021 Jul; 20(7):1038. PMID: 34012046
  3. Quinnell SP, Leifer BS, Nestor ST, Tan K, Sheehy DF, Ceo L, Doyle SK, Koehler AN, Vegas AJ. A Small-Molecule Inhibitor to the Cytokine Interleukin-4. ACS Chem Biol. 2020 10 16; 15(10):2649-2654. PMID: 32902255
  4. Veiseh O, Vegas AJ. Domesticating the foreign body response: Recent advances and applications. Adv Drug Deliv Rev. 2019 04; 144:148-161. PMID: 31491445; PMCID: PMC6774350; DOI: 10.1016/j.addr.2019.08.010;
  5. Sheehy DF, Quinnell SP, Vegas AJ. Targeting Type 1 Diabetes: Selective Approaches for New Therapies. Biochemistry. 2019 01 29; 58(4):214-233. PMID: 30608114; PMCID: PMC6774349; DOI: 10.1021/acs.biochem.8b01118;
  6. Bochenek MA, Veiseh O, Vegas AJ, McGarrigle JJ, Qi M, Marchese E, Omami M, Doloff JC, Mendoza-Elias J, Nourmohammadzadeh M, Khan A, Yeh CC, Xing Y, Isa D, Ghani S, Li J, Landry C, Bader AR, Olejnik K, Chen M, Hollister-Lock J, Wang Y, Greiner DL, Weir GC, Løkensgard Strand B, Rokstad AMA, Lacik I, Langer R, Anderson DG, Oberholzer J. Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques. Nat Biomed Eng. 2018 Nov; 2(11):810-821. PMID: 30873298; PMCID: PMC6413527; DOI: 10.1038/s41551-018-0275-1;
  7. Xie X, Doloff JC, Yesilyurt V, Sadraei A, McGarrigle JJ, Omami M, Veiseh O, Farah S, Isa D, Ghani S, Joshi I, Vegas A, Li J, Wang W, Bader A, Tam HH, Tao J, Chen HJ, Yang B, Williamson KA, Oberholzer J, Langer R, Anderson DG. Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer. Nat Biomed Eng. 2018 12; 2(12):894-906. PMID: 30931173; PMCID: PMC6436621; DOI: 10.1038/s41551-018-0273-3;
  8. Doloff JC, Veiseh O, Vegas AJ, Tam HH, Farah S, Ma M, Li J, Bader A, Chiu A, Sadraei A, Aresta-Dasilva S, Griffin M, Jhunjhunwala S, Webber M, Siebert S, Tang K, Chen M, Langan E, Dholokia N, Thakrar R, Qi M, Oberholzer J, Greiner DL, Langer R, Anderson DG. Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates. Nat Mater. 2017 06; 16(6):671-680. PMID: 28319612; PMCID: PMC5445003; DOI: 10.1038/nmat4866;
  9. Xie X, Zhang W, Abbaspourrad A, Ahn J, Bader A, Bose S, Vegas A, Lin J, Tao J, Hang T, Lee H, Iverson N, Bisker G, Li L, Strano MS, Weitz DA, Anderson DG. Microfluidic Fabrication of Colloidal Nanomaterials-Encapsulated Microcapsules for Biomolecular Sensing. Nano Lett. 2017 03 08; 17(3):2015-2020. PMID: 28152589; DOI: 10.1021/acs.nanolett.7b00026;
  10. Yesilyurt V, Veiseh O, Doloff JC, Li J, Bose S, Xie X, Bader AR, Chen M, Webber MJ, Vegas AJ, Langer R, Anderson DG. A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings. Adv Healthc Mater. 2017 Feb; 6(4). PMID: 27976536; PMCID: PMC5322155; DOI: 10.1002/adhm.201601091;
Showing 10 of 31 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 31 publications over 14 distinct years, with a maximum of 7 publications in 2016


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590 Commonwealth Ave
Boston MA 02215
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