Arturo Vegas, PhD
Assistant Professor
Boston University College of Arts and Sciences
Dept of Chemistry

PhD, Harvard University



The Vegas group pursues general and systematic approaches to developing targeted therapeutic carriers for the treatment of multiple human diseases. Small-molecule drugs excel at altering disease states at the cellular level, but their therapeutic benefits are often hindered by physiological barriers that impact their toxicity, efficacy, and distribution. The ability to overcome these barriers can make major differences in both the safety and effectiveness of a therapeutic. Engineering-based approaches have successfully shown that formulation can overcome barriers associated with toxicity and bioavailability, and are increasingly focused on tissue distribution and selective targeting of diseased tissues. There are currently few examples of chemical approaches being used to develop and implement new targeting modalities for drug delivery, and key questions have arisen regarding implementation and outcome. Can we effectively utilize physiological targets to localize medicines to diseased tissues? What targets can be used to improve drug localization to tumor sites? Can we modulate the tumor microenvironment? Can we selectively destroy autoimmune-causing cells?
Projects in the lab are focused on developing novel chemical tools, materials and approaches for targeting therapeutics to diseased tissues, with an emphasis on cancer and diabetes. These new tools will facilitate studies in the lab to understand mechanisms that control the physiological distribution of therapeutics and informing future targeting element design.

-For cancer, the primary focus will be developing conjugate and nanoparticle based approaches that control the physiological distribution and uptake of therapeutic molecules to tumors and the use of biomaterials to manipulate the tumor microenvironment.

-For diabetes, our focus will be selective destruction and modulation of cells responsible for the underlying type 1 autoimmunity.

Researchers in the lab design and implement synthetic methods to create novel targeting moieties and materials and link them to payloads with therapeutic value or potential. These constructs will then be evaluated at the protein and cellular levels, with lead constructs being advanced into animal studies. Techniques, methods, and approaches from organic synthesis, chemical biology, materials science, and biomedical engineering will be integrated to address these challenging problems in drug delivery.


Targeted immunomodulation of the diabetic islet microenvironment
09/20/2016 - 06/30/2021 (PI)
NIH/National Diabetes & Digestive & Kidn
1DP2DK111913-01




Yr Title Project-Sub Proj Pubs
2016 Targeted immunomodulation of the diabetic islet microenvironment 1DP2DK111913-01
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Doloff JC, Veiseh O, Vegas AJ, Tam HH, Farah S, Ma M, Li J, Bader A, Chiu A, Sadraei A, Aresta-Dasilva S, Griffin M, Jhunjhunwala S, Webber M, Siebert S, Tang K, Chen M, Langan E, Dholokia N, Thakrar R, Qi M, Oberholzer J, Greiner DL, Langer R, Anderson DG. Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates. Nat Mater. 2017 Jun; 16(6):671-680. PMID: 28319612; DOI: 10.1038/nmat4866;.
  2. Xie X, Zhang W, Abbaspourrad A, Ahn J, Bader A, Bose S, Vegas A, Lin J, Tao J, Hang T, Lee H, Iverson N, Bisker G, Li L, Strano MS, Weitz DA, Anderson DG. Microfluidic Fabrication of Colloidal Nanomaterials-Encapsulated Microcapsules for Biomolecular Sensing. Nano Lett. 2017 Mar 08; 17(3):2015-2020. PMID: 28152589; DOI: 10.1021/acs.nanolett.7b00026;.
  3. Yesilyurt V, Veiseh O, Doloff JC, Li J, Bose S, Xie X, Bader AR, Chen M, Webber MJ, Vegas AJ, Langer R, Anderson DG. A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings. Adv Healthc Mater. 2017 Feb; 6(4). PMID: 27976536; DOI: 10.1002/adhm.201601091;.
  4. Kanasty RL, Vegas AJ, Ceo LM, Maier M, Charisse K, Nair JK, Langer R, Anderson DG. Sequence-Defined Oligomers from Hydroxyproline Building Blocks for Parallel Synthesis Applications. Angew Chem Int Ed Engl. 2016 Aug 08; 55(33):9529-33. PMID: 27365192; DOI: 10.1002/anie.201602748;.
  5. Vegas AJ, Veiseh O, Doloff JC, Ma M, Tam HH, Bratlie K, Li J, Bader AR, Langan E, Olejnik K, Fenton P, Kang JW, Hollister-Locke J, Bochenek MA, Chiu A, Siebert S, Tang K, Jhunjhunwala S, Aresta-Dasilva S, Dholakia N, Thakrar R, Vietti T, Chen M, Cohen J, Siniakowicz K, Qi M, McGarrigle J, Lyle S, Harlan DM, Greiner DL, Oberholzer J, Weir GC, Langer R, Anderson DG. Corrigendum: Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol. 2016 Jun 09; 34(6):666. PMID: 27281428; DOI: 10.1038/nbt0616-666e;.
  6. Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG. Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med. 2016 Apr; 22(4):446. PMID: 27050590; DOI: 10.1038/nm0416-446e;.
  7. Vegas AJ, Veiseh O, Doloff JC, Ma M, Tam HH, Bratlie K, Li J, Bader AR, Langan E, Olejnik K, Fenton P, Kang JW, Hollister-Locke J, Bochenek MA, Chiu A, Siebert S, Tang K, Jhunjhunwala S, Aresta-Dasilva S, Dholakia N, Thakrar R, Vietti T, Chen M, Cohen J, Siniakowicz K, Qi M, McGarrigle J, Lyle S, Harlan DM, Greiner DL, Oberholzer J, Weir GC, Langer R, Anderson DG. Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol. 2016 Mar; 34(3):345-52. PMID: 26807527; PMCID: PMC4904301; DOI: 10.1038/nbt.3462;.
  8. Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG. Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med. 2016 Mar; 22(3):306-11. PMID: 26808346; PMCID: PMC4825868; DOI: 10.1038/nm.4030;.
  9. Jaklenec A, Anselmo AC, Hong J, Vegas AJ, Kozminsky M, Langer R, Hammond PT, Anderson DG. High Throughput Layer-by-Layer Films for Extracting Film Forming Parameters and Modulating Film Interactions with Cells. ACS Appl Mater Interfaces. 2016 Jan 27; 8(3):2255-61. PMID: 26713554; DOI: 10.1021/acsami.5b11081;.
  10. Veiseh O, Doloff JC, Ma M, Vegas AJ, Tam HH, Bader AR, Li J, Langan E, Wyckoff J, Loo WS, Jhunjhunwala S, Chiu A, Siebert S, Tang K, Hollister-Lock J, Aresta-Dasilva S, Bochenek M, Mendoza-Elias J, Wang Y, Qi M, Lavin DM, Chen M, Dholakia N, Thakrar R, Lacík I, Weir GC, Oberholzer J, Greiner DL, Langer R, Anderson DG. Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates. Nat Mater. 2015 Jun; 14(6):643-51. PMID: 25985456; PMCID: PMC4477281; DOI: 10.1038/nmat4290;.
Showing 10 of 24 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 24 publications over 10 distinct years, with a maximum of 7 publications in 2016

YearPublications
20071
20081
20101
20112
20124
20132
20143
20151
20167
20172
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590 Commonwealth Ave
Boston MA 02215
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