Anthony Griffiths, PhD
Associate Professor
Boston University School of Medicine
Dept of Microbiology

PhD, University of Cambridge




The family Filoviridae includes Ebola virus and Marburg virus, which are associated with sporadic outbreaks and high case fatality rates. A maximum containment laboratory (Biosafety Level-4) is required to study the infectious forms of these viruses. Dr. Griffiths’ laboratory is interested in multiple aspects of filovirus biology with a view to exploiting this knowledge to further the development of vaccines and therapeutics.

Faculty
Boston University
National Emerging Infectious Disease Lab


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Pilot Study To Assess Protection against Filovirus challenge by an infused monoclonal antibody
10/31/2019 - 09/23/2023 (Subcontract PI)
Leidos NIH NCI
75N91019D00024

Restricted: Pilot Study To Assess Protection against Filovirus challenge by an infused monoclonal antibody
10/31/2019 - 09/23/2023 (Subcontract PI)
Leidos NIH NCI
75N91019D00024

Rationally Designed Pan-Ebolavirus Vaccine
12/01/2019 - 05/31/2022 (Subcontract PI)
Integrated BioTherapeutics, Inc. NIH NIAID
5R01AI132204-04

Immunogenicity and Efficacy Testing of Medical Countermeasures (Vaccines and Other Biologics) Against BSL-4 Pathogens in NHPs
06/23/2020 - 12/31/2021 (Subcontract PI)
Battelle Memorial Institute NIH NIAID


Characterization of the Disease Course in Rhesus Macaques Infected with Ebola Virus
11/13/2018 - 09/16/2021 (Subcontract PI)
MRI Global HHS ASPR BARDA


Efficacy testing of antiviral drug in a hamster model of SARS CoV-2 infection
08/01/2020 - 08/01/2021 (PI)
Boston Pharmaceuticals, Inc.


Efficacy of Immunome antibodies against SARS CoV-2 in hamsters
09/22/2020 - 02/22/2021 (PI)
Immunome, Inc.


Evaluation of the efficacy of convalescent anti-Ebola virus intravenous immune globulin in the treatment of Ebola virus disease in a lethal mouse model
05/01/2020 - 12/31/2020 (PI)
Grifols Inc


Inactivation of SARS CoV-2 Using Rapiscan Trace Detection System
08/25/2020 - 11/30/2020 (PI)
Rapiscan Systems, Inc.


Inactivation of SARS CoV-2 Using light at various wavelengths
08/20/2020 - 11/20/2020 (PI)
EP Consultants, Inc.


Showing 10 of 21 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Clark SA, Clark LE, Pan J, Coscia A, McKay LGA, Shankar S, Johnson RI, Brusic V, Choudhary MC, Regan J, Li JZ, Griffiths A, Abraham J. SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms. Cell. 2021 Mar 16.View Related Profiles. PMID: 33831372
     
  2. Alfson KJ, Goez-Gazi Y, Gazi M, Staples H, Mattix M, Ticer A, Klaffke B, Stanfield K, Escareno P, Keiser P, Griffiths A, Chou YL, Niemuth N, Meister GT, Cirimotich CM, Carrion R. Development of a Well-Characterized Rhesus Macaque Model of Ebola Virus Disease for Support of Product Development. Microorganisms. 2021 Feb 26; 9(3). PMID: 33652589
     
  3. Atyeo C, Slein MD, Fischinger S, Burke J, Schäfer A, Leist SR, Kuzmina NA, Mire C, Honko A, Johnson R, Storm N, Bernett M, Tong P, Zuo T, Lin J, Zuiani A, Linde C, Suscovich T, Wesemann DR, Griffiths A, Desjarlais JR, Juelg BD, Goudsmit J, Bukreyev A, Baric R, Alter G. Dissecting strategies to tune the therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022. JCI Insight. 2021 01 11; 6(1).View Related Profiles. PMID: 33427208
     
  4. Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B. A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent. Nat Struct Mol Biol. 2021 02; 28(2):202-209.View Related Profiles. PMID: 33432247
     
  5. Zabaleta N, Dai W, Bhatt U, Chichester JA, Estelien R, Sanmiguel J, Michalson KT, Diop C, Maciorowski D, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Vandenberghe LH. Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates. bioRxiv. 2021 Jan 05.View Related Profiles. PMID: 33442684
     
  6. Storm N, McKay LGA, Downs SN, Johnson RI, Birru D, de Samber M, Willaert W, Cennini G, Griffiths A. Rapid and complete inactivation of SARS-CoV-2 by ultraviolet-C irradiation. Sci Rep. 2020 12 30; 10(1):22421.View Related Profiles. PMID: 33380727
     
  7. Clark SA, Clark LE, Pan J, Coscia A, McKay LGA, Shankar S, Johnson RI, Griffiths A, Abraham J. Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2. bioRxiv. 2020 Nov 13.View Related Profiles. PMID: 33200128
     
  8. Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B. A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro. bioRxiv. 2020 Sep 18.View Related Profiles. PMID: 32995768
     
  9. Kuhn JH, Adkins S, Alioto D, Alkhovsky SV, Amarasinghe GK, Anthony SJ, Avšic-Županc T, Ayllón MA, Bahl J, Balkema-Buschmann A, Ballinger MJ, Bartonicka T, Basler C, Bavari S, Beer M, Bente DA, Bergeron É, Bird BH, Blair C, Blasdell KR, Bradfute SB, Breyta R, Briese T, Brown PA, Buchholz UJ, Buchmeier MJ, Bukreyev A, Burt F, Buzkan N, Calisher CH, Cao M, Casas I, Chamberlain J, Chandran K, Charrel RN, Chen B, Chiumenti M, Choi IR, Clegg JCS, Crozier I, da Graça JV, Dal Bó E, Dávila AMR, de la Torre JC, de Lamballerie X, de Swart RL, Di Bello PL, Di Paola N, Di Serio F, Dietzgen RG, Digiaro M, Dolja VV, Dolnik O, Drebot MA, Drexler JF, Dürrwald R, Dufkova L, Dundon WG, Duprex WP, Dye JM, Easton AJ, Ebihara H, Elbeaino T, Ergünay K, Fernandes J, Fooks AR, Formenty PBH, Forth LF, Fouchier RAM, Freitas-Astúa J, Gago-Zachert S, Gao GF, García ML, García-Sastre A, Garrison AR, Gbakima A, Goldstein T, Gonzalez JJ, Griffiths A, Groschup MH, Günther S, Guterres A, Hall RA, Hammond J, Hassan M, Hepojoki J, Hepojoki S, Hetzel U, Hewson R, Hoffmann B, Hongo S, Höper D, Horie M, Hughes HR, Hyndman TH, Jambai A, Jardim R, Jiang D, Jin Q, Jonson GB, Junglen S, Karadag S, Keller KE, Klempa B, Klingström J, Kobinger G, Kondo H, Koonin EV, Krupovic M, Kurath G, Kuzmin IV, Laenen L, Lamb RA, Lambert AJ, Langevin SL, Lee B, Lemos ERS, Leroy EM, Li D, Li J, Liang M, Liú W, Liú Y, Lukashevich IS, Maes P, Marciel de Souza W, Marklewitz M, Marshall SH, Martelli GP, Martin RR, Marzano SL, Massart S, McCauley JW, Mielke-Ehret N, Minafra A, Minutolo M, Mirazimi A, Mühlbach HP, Mühlberger E, Naidu R, Natsuaki T, Navarro B, Navarro JA, Netesov SV, Neumann G, Nowotny N, Nunes MRT, Nylund A, Økland AL, Oliveira RC, Palacios G, Pallas V, Pályi B, Papa A, Parrish CR, Pauvolid-Corrêa A, Paweska JT, Payne S, Pérez DR, Pfaff F, Radoshitzky SR, Rahman AU, Ramos-González PL, Resende RO, Reyes CA, Rima BK, Romanowski V, Robles Luna G, Rota P, Rubbenstroth D, Runstadler JA, Ruzek D, Sabanadzovic S, Salát J, Sall AA, Salvato MS, Sarpkaya K, Sasaya T, Schwemmle M, Shabbir MZ, Shí X, Shí Z, Shirako Y, Simmonds P, Širmarová J, Sironi M, Smither S, Smura T, Song JW, Spann KM, Spengler JR, Stenglein MD, Stone DM, Straková P, Takada A, Tesh RB, Thornburg NJ, Tomonaga K, Tordo N, Towner JS, Turina M, Tzanetakis I, Ulrich RG, Vaira AM, van den Hoogen B, Varsani A, Vasilakis N, Verbeek M, Wahl V, Walker PJ, Wang H, Wang J, Wang X, Wang LF, Wèi T, Wells H, Whitfield AE, Williams JV, Wolf YI, Wú Z, Yang X, Yáng X, Yu X, Yutin N, Zerbini FM, Zhang T, Zhang YZ, Zhou G, Zhou X. 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Arch Virol. 2020 Dec; 165(12):3023-3072.View Related Profiles. PMID: 32888050
     
  10. Zhang Q, Honko A, Zhou J, Gong H, Downs SN, Vasquez JH, Fang RH, Gao W, Griffiths A, Zhang L. Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity. Nano Lett. 2020 07 08; 20(7):5570-5574.View Related Profiles. PMID: 32551679
     
Showing 10 of 54 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 54 publications over 16 distinct years, with a maximum of 7 publications in 2020

YearPublications
19981
20032
20051
20063
20071
20091
20115
20123
20143
20156
20163
20174
20184
20195
20207
20215
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620 Albany Street
Boston MA 02118
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