Anthony Griffiths, PhD
Professor
Boston University Chobanian & Avedisian School of Medicine
Virology, Immunology & Microbiology

PhD, University of Cambridge
BSc, University of Reading



The family Filoviridae includes Ebola virus and Marburg virus, which are associated with sporadic outbreaks and high case fatality rates. A maximum containment laboratory (Biosafety Level-4) is required to study the infectious forms of these viruses. Dr. Griffiths’ laboratory is interested in multiple aspects of filovirus biology with a view to exploiting this knowledge to further the development of vaccines and therapeutics.

Faculty
Boston University
National Emerging Infectious Disease Lab


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Efficacy testing of a Marburg Virus Monoclonal Antibody Medical Countermeasure
01/16/2023 - 08/31/2028 (Subcontract PI)
Mapp Biopharmaceutical, Inc. HHS ASPR BARDA


Vaccines for Prevention of RG3 and RG4 Emerging Tickborne Viral Diseases
08/20/2021 - 07/31/2026 (Subcontract PI)
University of Connecticut NIH NIAID
1R01AI152241-01

National Emerging Infectious Diseases Laboratories Operations
07/08/2021 - 06/30/2026 (Key Person)
PI: Nancy J. Sullivan, ScD
NIH/National Institute of Allergy & Infectious Diseases
5UC7AI095321-09

Cellular Nanosponges as a Medical Countermeasure to Emerging Virus Threats
05/13/2021 - 05/12/2026 (Subcontract PI)
University of California, San Diego DOD Threat Reduction


Immunogenicity and Efficacy Testing of Medical Countermeasures (Vaccines and Other Biologics) Against BSL-4 Pathogens in NHPs
06/23/2020 - 11/28/2025 (Subcontract PI)
Battelle Memorial Institute NIH NIAID


Exploratory Single-Dose Intramuscular Immunogenicity, Protection from SARS-CoV-2 and Evaluation of VAERD Study in Golden Syrian Hamsters
10/05/2020 - 10/04/2025 (Subcontract PI)
Merck, Sharp & Dohme LLC HHS ASPR BARDA
HHSO10020160031C

Uncovering the RNA regulatory Mechanisms driving pathogenicity at mass-caualty viruses: Merging the technologies of RNA biology and enhanced biosafety to create the next generation of broad spectrum,
10/01/2022 - 09/30/2025 (Multi-PI)
PI: Anthony Griffiths, PhD
Howard Hughes Medical Institute


Efficacy of Wyss-vaccine platforms in hamster model of SARS-CoV-2 infection
12/01/2020 - 01/31/2025 (PI)
Hansjorg Wyss Institute for Biologically Inspired Engineering at Harvard


Assays in Support of Filovirus Nonhuman Primate Studies for Advancement of Medical Countermeasures
04/14/2022 - 12/31/2024 (Subcontract PI)
Battelle Memorial Institute HHS ASPR BARDA


Serologic and Molecular Studies of human anti-hCoV antibody cross-immunity and protective responses among endemic HCoVs and SARS-CoV2
09/17/2021 - 08/31/2024 (Subcontract PI)
Dana-Farber Cancer Institute NIH NIAID
5R01Al161152-02

Showing 10 of 55 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Shrock EL, Timms RT, Kula T, Mena EL, West AP, Guo R, Lee IH, Cohen AA, McKay LGA, Bi C, Leng Y, Fujimura E, Horns F, Li M, Wesemann DR, Griffiths A, Gewurz BE, Bjorkman PJ, Elledge SJ. Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses. Science. 2023 Apr 07; 380(6640):eadc9498.View Related Profiles. PMID: 37023193
     
  2. Carter B, Huang P, Liu G, Liang Y, Lin PJC, Peng BH, McKay LGA, Dimitrakakis A, Hsu J, Tat V, Saenkham-Huntsinger P, Chen J, Kaseke C, Gaiha GD, Xu Q, Griffiths A, Tam YK, Tseng CK, Gifford DK. A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta. Front Immunol. 2023; 14:1135815.View Related Profiles. PMID: 36969239; PMCID: PMC10033589; DOI: 10.3389/fimmu.2023.1135815;
     
  3. Carter B, Huang P, Liu G, Liang Y, Lin PJC, Peng BH, McKay LGA, Dimitrakakis A, Hsu J, Tat V, Saenkham-Huntsinger P, Chen J, Kaseke C, Gaiha GD, Xu Q, Griffiths A, Tam YK, Tseng CK, Gifford DK. A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta. Front Immunol. 2023; 14:1135815.View Related Profiles. PMID: 36969239; PMCID: PMC10033589; DOI: 10.3389/fimmu.2023.1135815;
     
  4. Kuhn JH, Adkins S, Alkhovsky SV, Avšic-Županc T, Ayllón MA, Bahl J, Balkema-Buschmann A, Ballinger MJ, Bandte M, Beer M, Bejerman N, Bergeron É, Biedenkopf N, Bigarré L, Blair CD, Blasdell KR, Bradfute SB, Briese T, Brown PA, Bruggmann R, Buchholz UJ, Buchmeier MJ, Bukreyev A, Burt F, Büttner C, Calisher CH, Candresse T, Carson J, Casas I, Chandran K, Charrel RN, Chiaki Y, Crane A, Crane M, Dacheux L, Bó ED, de la Torre JC, de Lamballerie X, de Souza WM, de Swart RL, Dheilly NM, Di Paola N, Di Serio F, Dietzgen RG, Digiaro M, Drexler JF, Duprex WP, Dürrwald R, Easton AJ, Elbeaino T, Ergünay K, Feng G, Feuvrier C, Firth AE, Fooks AR, Formenty PBH, Freitas-Astúa J, Gago-Zachert S, García ML, García-Sastre A, Garrison AR, Godwin SE, Gonzalez JJ, de Bellocq JG, Griffiths A, Groschup MH, Günther S, Hammond J, Hepojoki J, Hierweger MM, Hongo S, Horie M, Horikawa H, Hughes HR, Hume AJ, Hyndman TH, Jiang D, Jonson GB, Junglen S, Kadono F, Karlin DG, Klempa B, Klingström J, Koch MC, Kondo H, Koonin EV, Krásová J, Krupovic M, Kubota K, Kuzmin IV, Laenen L, Lambert AJ, Li J, Li JM, Lieffrig F, Lukashevich IS, Luo D, Maes P, Marklewitz M, Marshall SH, Marzano SL, McCauley JW, Mirazimi A, Mohr PG, Moody NJG, Morita Y, Morrison RN, Mühlberger E, Naidu R, Natsuaki T, Navarro JA, Neriya Y, Netesov SV, Neumann G, Nowotny N, Ochoa-Corona FM, Palacios G, Pallandre L, Pallás V, Papa A, Paraskevopoulou S, Parrish CR, Pauvolid-Corrêa A, Paweska JT, Pérez DR, Pfaff F, Plemper RK, Postler TS, Pozet F, Radoshitzky SR, Ramos-González PL, Rehanek M, Resende RO, Reyes CA, Romanowski V, Rubbenstroth D, Rubino L, Rumbou A, Runstadler JA, Rupp M, Sabanadzovic S, Sasaya T, Schmidt-Posthaus H, Schwemmle M, Seuberlich T, Sharpe SR, Shi M, Sironi M, Smither S, Song JW, Spann KM, Spengler JR, Stenglein MD, Takada A, Tesh RB, Tešíková J, Thornburg NJ, Tischler ND, Tomitaka Y, Tomonaga K, Tordo N, Tsunekawa K, Turina M, Tzanetakis IE, Vaira AM, van den Hoogen B, Vanmechelen B, Vasilakis N, Verbeek M, von Bargen S, Wada J, Wahl V, Walker PJ, Whitfield AE, Williams JV, Wolf YI, Yamasaki J, Yanagisawa H, Ye G, Zhang YZ, Økland AL. 2022 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Arch Virol. 2022 Dec; 167(12):2857-2906.View Related Profiles. PMID: 36437428; PMCID: PMC9847503; DOI: 10.1007/s00705-022-05546-z;
     
  5. Alfson KJ, Goez-Gazi Y, Gazi M, Chou YL, Niemuth NA, Mattix ME, Staples H, Klaffke B, Rodriguez GF, Escareno P, Bartley C, Ticer A, Clemmons EA, Dutton Iii JW, Griffiths A, Meister GT, Sanford DC, Cirimotich CM, Carrion R. Development of a Well-Characterized Cynomolgus Macaque Model of Sudan Virus Disease for Support of Product Development. Vaccines (Basel). 2022 Oct 15; 10(10). PMID: 36298588; PMCID: PMC9611481; DOI: 10.3390/vaccines10101723;
     
  6. Cross RW, Longini IM, Becker S, Bok K, Boucher D, Carroll MW, Díaz JV, Dowling WE, Draghia-Akli R, Duworko JT, Dye JM, Egan MA, Fast P, Finan A, Finch C, Fleming TR, Fusco J, Geisbert TW, Griffiths A, Günther S, Hensley LE, Honko A, Hunegnaw R, Jakubik J, Ledgerwood J, Luhn K, Matassov D, Meshulam J, Nelson EV, Parks CL, Rustomjee R, Safronetz D, Schwartz LM, Smith D, Smock P, Sow Y, Spiropoulou CF, Sullivan NJ, Warfield KL, Wolfe D, Woolsey C, Zahn R, Henao-Restrepo AM, Muñoz-Fontela C, Marzi A. An introduction to the Marburg virus vaccine consortium, MARVAC. PLoS Pathog. 2022 Oct; 18(10):e1010805.View Related Profiles. PMID: 36227853; PMCID: PMC9560149; DOI: 10.1371/journal.ppat.1010805;
     
  7. Chang MR, Tomasovic L, Kuzmina NA, Ronk AJ, Byrne PO, Johnson R, Storm N, Olmedillas E, Hou YJ, Schäfer A, Leist SR, Tse LV, Ke H, Coherd C, Nguyen K, Kamkaew M, Honko A, Zhu Q, Alter G, Saphire EO, McLellan JS, Griffiths A, Baric RS, Bukreyev A, Marasco WA. IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern. Nat Commun. 2022 Oct 03; 13(1):5814.View Related Profiles. PMID: 36192374; PMCID: PMC9528872; DOI: 10.1038/s41467-022-33030-4;
     
  8. Schwake C, McKay L, Griffiths A, Scartelli C, Flaumenhaft R, Chishti AH. BDA-410 inhibits SARS-CoV-2 main protease activity and viral replication in mammalian cells. J Cell Mol Med. 2022 Oct; 26(19):5095-5098.View Related Profiles. PMID: 36082511; PMCID: PMC9537889; DOI: 10.1111/jcmm.17442;
     
  9. Nikitin PA, DiMuzio JM, Dowling JP, Patel NB, Bingaman-Steele JL, Heimbach BC, Henriquez N, Nicolescu C, Polley A, Sikorski EL, Howanski RJ, Nath M, Shukla H, Scheaffer SM, Finn JP, Liang LF, Smith T, Storm N, McKay LGA, Johnson RI, Malsick LE, Honko AN, Griffiths A, Diamond MS, Sarma P, Geising DH, Morin MJ, Robinson MK. IMM-BCP-01, a patient-derived anti-SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2. Sci Immunol. 2022 Sep 09; 7(75):eabl9943.View Related Profiles. PMID: 35771946; PMCID: PMC9273042; DOI: 10.1126/sciimmunol.abl9943;
     
  10. Alfson KJ, Goez-Gazi Y, Gazi M, Chou YL, Niemuth NA, Mattix ME, Staples HM, Klaffke B, Rodriguez GF, Bartley C, Ticer A, Clemmons EA, Dutton JW, Griffiths A, Meister GT, Sanford DC, Cirimotich CM, Carrion R. Development of a Well-Characterized Cynomolgus Macaque Model of Marburg Virus Disease for Support of Vaccine and Therapy Development. Vaccines (Basel). 2022 Aug 14; 10(8). PMID: 36016203; PMCID: PMC9414819; DOI: 10.3390/vaccines10081314;
     
Showing 10 of 77 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 76 publications over 18 distinct years, with a maximum of 14 publications in 2021

YearPublications
19981
20032
20051
20063
20071
20091
20115
20123
20143
20156
20163
20174
20184
20195
20207
202114
202211
20232
Contact for Mentoring:

620 Albany Street
Boston MA 02118
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