Anthony Griffiths, PhD
Associate Professor
Boston University School of Medicine
Dept of Microbiology

PhD, University of Cambridge




The family Filoviridae includes Ebola virus and Marburg virus, which are associated with sporadic outbreaks and high case fatality rates. A maximum containment laboratory (Biosafety Level-4) is required to study the infectious forms of these viruses. Dr. Griffiths’ laboratory is interested in multiple aspects of filovirus biology with a view to exploiting this knowledge to further the development of vaccines and therapeutics.

Faculty
Boston University
National Emerging Infectious Disease Lab


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Exploratory Single-Dose Intramuscular Immunogenicity, Protection from SARS-CoV-2 and Evaluation of VAERD Study in Golden Syrian Hamsters
10/05/2020 - 10/04/2025 (Subcontract PI)
Merck, Sharp & Dohme Corp HHS ASPR BARDA
HHSO10020160031C

Discovery and development of antibody therapeutics for SARS-CoV-2 and other high-risk emerging viruses
10/30/2020 - 10/29/2023 (Subcontract PI)
President & Fellows of Harvard College on behalf of Harvard Medical School AbbVie


Pilot Study To Assess Protection against Filovirus challenge by an infused monoclonal antibody
10/31/2019 - 09/23/2023 (Subcontract PI)
Leidos NIH NCI
75N91019D00024

Restricted: Pilot Study To Assess Protection against Filovirus challenge by an infused monoclonal antibody
10/31/2019 - 09/23/2023 (Subcontract PI)
Leidos NIH NCI
75N91019D00024

Accelerated development of a SARS-CoV-2 vaccine based on the live VSVG chimeric virus platform
02/26/2021 - 06/30/2022 (Subcontract PI)
International AIDS Vaccine Initative Inc. DOD DTRA


Rationally Designed Pan-Ebolavirus Vaccine
12/01/2019 - 05/31/2022 (Subcontract PI)
Integrated BioTherapeutics, Inc. NIH NIAID
5R01AI132204-04

Model development/ refinement study Ebola virus Makona intranasal challenge
04/16/2021 - 04/16/2022 (PI)
Janssen Vaccines & Prevention B.V.


Efficacy of Wyss-vaccine platforms in hamster model of SARS-CoV-2 infection
12/01/2020 - 12/31/2021 (PI)
Hansjorg Wyss Institute for Biologically Inspired Engineering at Harvard


Immunogenicity and Efficacy Testing of Medical Countermeasures (Vaccines and Other Biologics) Against BSL-4 Pathogens in NHPs
06/23/2020 - 12/31/2021 (Subcontract PI)
Battelle Memorial Institute NIH NIAID


Moderna SARS-CoV-2 Hamster challenge study (150)
03/20/2021 - 09/20/2021 (PI)
Moderna Therapeutics


Showing 10 of 31 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Ai X, Wang D, Honko A, Duan Y, Gavrish I, Fang RH, Griffiths A, Gao W, Zhang L. Surface Glycan Modification of Cellular Nanosponges to Promote SARS-CoV-2 Inhibition. J Am Chem Soc. 2021 Oct 14.View Related Profiles. PMID: 34647745; PMCID: PMC8525344; DOI: 10.1021/jacs.1c07798;
     
  2. Langellotto F, Dellacherie MO, Yeager C, Ijaz H, Yu J, Cheng CA, Dimitrakakis N, Seiler BT, Gebre MS, Gilboa T, Johnson R, Storm N, Bardales S, Graveline A, White D, Tringides CM, Cartwright MJ, Doherty EJ, Honko A, Griffiths A, Barouch DH, Walt DR, Mooney DJ. A Modular Biomaterial Scaffold-Based Vaccine Elicits Durable Adaptive Immunity to Subunit SARS-CoV-2 Antigens. Adv Healthc Mater. 2021 Oct 04; e2101370.View Related Profiles. PMID: 34605223
     
  3. Kuhn JH, Adkins S, Agwanda BR, Al Kubrusli R, Alkhovsky A??xo?c??? Cep?e? B?a????po??? SV, Amarasinghe GK, Avšic-Županc T, Ayllón MA, Bahl J, Balkema-Buschmann A, Ballinger MJ, Basler CF, Bavari S, Beer M, Bejerman N, Bennett AJ, Bente DA, Bergeron É, Bird BH, Blair CD, Blasdell KR, Blystad DR, Bojko J, Borth WB, Bradfute S, Breyta R, Briese T, Brown PA, Brown JK, Buchholz UJ, Buchmeier MJ, Bukreyev A, Burt F, Büttner C, Calisher CH, Cao ??? M, Casas I, Chandran K, Charrel RN, Cheng Q, Chiaki ???? Y, Chiapello M, Choi IR, Ciuffo M, Clegg JCS, Crozier I, Dal Bó E, de la Torre JC, de Lamballerie X, de Swart RL, Debat H, Dheilly NM, Di Cicco E, Di Paola N, Di Serio F, Dietzgen RG, Digiaro M, Dolnik O, Drebot MA, Drexler JF, Dundon WG, Duprex WP, Dürrwald R, Dye JM, Easton AJ, Ebihara ????? H, Elbeaino T, Ergünay K, Ferguson HW, Fooks AR, Forgia M, Formenty PBH, Fránová J, Freitas-Astúa J, Fu ??? J, Fürl S, Gago-Zachert S, Gao ?? GF, García ML, García-Sastre A, Garrison AR, Gaskin T, Gonzalez JJ, Griffiths A, Goldberg TL, Groschup MH, Günther S, Hall RA, Hammond J, Han ?? T, Hepojoki J, Hewson R, Hong ?? J, Hong ?? N, Hongo ???? S, Horie ???? M, Hu JS, Hu T, Hughes HR, Hüttner F, Hyndman TH, Ilyas M, Jalkanen R, Jiang ??? D, Jonson GB, Junglen S, Kadono ?????? F, Kaukinen KH, Kawate M, Klempa B, Klingström J, Kobinger G, Koloniuk I, Kondo ???? H, Koonin EV, Krupovic M, Kubota ????? K, Kurath G, Laenen L, Lambert AJ, Langevin SL, Lee B, Lefkowitz EJ, Leroy EM, Li ??? S, Li ??? L, Li ??? J, Liu ??? H, Lukashevich IS, Maes P, de Souza WM, Marklewitz M, Marshall SH, Marzano SL, Massart S, McCauley JW, Melzer M, Mielke-Ehret N, Miller KM, Ming TJ, Mirazimi A, Mordecai GJ, Mühlbach HP, Mühlberger E, Naidu R, Natsuaki ???? T, Navarro JA, Netesov He??co? Cep?e? B???opo??? SV, Neumann G, Nowotny N, Nunes MRT, Olmedo-Velarde A, Palacios G, Pallás V, Pályi B, Papa ???a ?ap? A, Paraskevopoulou S?f?a ?a?as?e??p????? S, Park AC, Parrish CR, Patterson DA, Pauvolid-Corrêa A, Paweska JT, Payne S, Peracchio C, Pérez DR, Postler TS, Qi ??? L, Radoshitzky SR, Resende RO, Reyes CA, Rima BK, Luna GR, Romanowski V, Rota P, Rubbenstroth D, Rubino L, Runstadler JA, Sabanadzovic S, Sall AA, Salvato MS, Sang R, Sasaya ???? T, Schulze AD, Schwemmle M, Shi ?? M, Shí ??? X, Shí ??? Z, Shimomoto ???? Y, Shirako Y, Siddell SG, Simmonds P, Sironi M, Smagghe G, Smither S, Song ??? JW, Spann K, Spengler JR, Stenglein MD, Stone DM, Sugano J, Suttle CA, Tabata A, Takada ???? A, Takeuchi ???? S, Tchouassi DP, Teffer A, Tesh RB, Thornburg NJ, Tomitaka ???? Y, Tomonaga ???? K, Tordo N, Torto B, Towner JS, Tsuda ???? S, Tu ??? C, Turina M, Tzanetakis IE, Uchida J, Usugi ???? T, Vaira AM, Vallino M, van den Hoogen B, Varsani A, Vasilakis ????? ?as?????? N, Verbeek M, von Bargen S, Wada ???? J, Wahl V, Walker PJ, Wang ??? LF, Wang ??? G, Wang ??? Y, Wang ??? Y, Waqas M, Wèi ??? T, Wen ??? S, Whitfield AE, Williams JV, Wolf YI, Wu ??? J, Xu ?? L, Yanagisawa ???? H, Yang ??? C, Yang ??? Z, Zerbini FM, Zhai ??? L, Zhang ??? YZ, Zhang ?? S, Zhang ??? J, Zhang ?? Z, Zhou ??? X. 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Arch Virol. 2021 Aug 31.View Related Profiles. PMID: 34463877
     
  4. Ciencewicki JM, Herbert AS, Storm N, Josleyn NM, Huie K, McKay LGA, Griffiths A, Dye JM, Willis T, Arora V. Characterization of an Anti-Ebola virus Hyperimmune Globulin Derived from Convalescent Plasma. J Infect Dis. 2021 Aug 27.View Related Profiles. PMID: 34448858
     
  5. Johnson RI, Boczkowska B, Alfson K, Weary T, Menzie H, Delgado J, Rodriguez G, Carrion R, Griffiths A. Identification and Characterization of Defective Viral Genomes in Ebola Virus-Infected Rhesus Macaques. J Virol. 2021 08 10; 95(17):e0071421. PMID: 34160256; PMCID: PMC8354239; DOI: 10.1128/JVI.00714-21;
     
  6. Zabaleta N, Dai W, Bhatt U, Hérate C, Maisonnasse P, Chichester JA, Sanmiguel J, Estelien R, Michalson KT, Diop C, Maciorowski D, Dereuddre-Bosquet N, Cavarelli M, Gallouët AS, Naninck T, Kahlaoui N, Lemaitre J, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Contreras V, Marlin R, Tsong Fang RH, Chapon C, van der Werf S, Zinn E, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Le Grand R, Vandenberghe LH. An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates. Cell Host Microbe. 2021 09 08; 29(9):1437-1453.e8.View Related Profiles. PMID: 34428428; PMCID: PMC8346325; DOI: 10.1016/j.chom.2021.08.002;
     
  7. Colombani T, Eggermont LJ, Rogers ZJ, McKay LGA, Avena LE, Johnson RI, Storm N, Griffiths A, Bencherif SA. Biomaterials and Oxygen Join Forces to Shape the Immune Response and Boost COVID-19 Vaccines. Adv Sci (Weinh). 2021 09; 8(18):2100316.View Related Profiles. PMID: 34580619; PMCID: PMC8209904; DOI: 10.1002/advs.202100316;
     
  8. Das Adhikari U, Eng G, Farcasanu M, Avena LE, Choudhary MC, Triant VA, Flagg M, Schiff AE, Gomez I, Froehle LM, Diefenbach TJ, Ronsard L, Lingwood D, Lee GC, Rabi SA, Erstad D, Velmahos G, Li JZ, Hodin R, Stone JR, Honko AN, Griffiths A, Yilmaz O, Kwon DS. Fecal SARS-CoV-2 RNA is associated with decreased COVID-19 survival. Clin Infect Dis. 2021 Jul 10.View Related Profiles. PMID: 34245255; PMCID: PMC8406863; DOI: 10.1093/cid/ciab623;
     
  9. Niemuth NA, Fallacara D, Triplett CA, Tamrakar SM, Rajbhandari A, Florence C, Ward L, Griffiths A, Carrion R, Goez-Gazi Y, Alfson KJ, Staples HM, Brasel T, Comer JE, Massey S, Smith J, Kocsis A, Lowry J, Johnston SC, Nalca A, Goff AJ, Shurtleff AC, Pitt ML, Trefry J, Fay MP. Natural history of disease in cynomolgus monkeys exposed to Ebola virus Kikwit strain demonstrates the reliability of this non-human primate model for Ebola virus disease. PLoS One. 2021; 16(7):e0252874. PMID: 34214118; PMCID: PMC8253449; DOI: 10.1371/journal.pone.0252874;
     
  10. Clark SA, Clark LE, Pan J, Coscia A, McKay LGA, Shankar S, Johnson RI, Brusic V, Choudhary MC, Regan J, Li JZ, Griffiths A, Abraham J. SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms. Cell. 2021 05 13; 184(10):2605-2617.e18.View Related Profiles. PMID: 33831372; PMCID: PMC7962548; DOI: 10.1016/j.cell.2021.03.027;
     
Showing 10 of 64 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 64 publications over 16 distinct years, with a maximum of 15 publications in 2021

YearPublications
19981
20032
20051
20063
20071
20091
20115
20123
20143
20156
20163
20174
20184
20195
20207
202115
Contact for Mentoring:

620 Albany Street
Boston MA 02118
Google Map


Griffiths's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Media Mentions
_
Co-Authors
_
Similar People
_
Same Department