Anna Honko | Profiles RNS

Anna Honko, PhD

Research Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Virology, Immunology & Microbiology

PhD, Wake Forest University
BS, Clemson University

Websites

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	ResearchGate
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ORCID : 000-0001-9165-148X

Anna Honko, PhD recently joined Boston University’s National Emerging Infectious Diseases Laboratories (NEIDL) as a Research Associate Professor. In the Nonclinical Studies Unit, she’ll be directing well-documented, Animal Rule and GLP studies to advance anti-viral medical countermeasure development. Dr. Honko's background is in immunology and vaccine development, with a later emphasis in biothreat and emerging infectious diseases. She has a focus on regulated studies as well a passion for radiotelemetry monitoring.

Faculty
Boston University
National Emerging Infectious Disease Lab

BU Research

Companion diagnostics and antivirals for COVID-19 using CRISPR-Cas13
12/01/2021 - 11/30/2022 (Subcontract PI)
President & Fellows of Harvard College on behalf of Harvard Medical School Bill/Mel. Gates MRIn

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Pittman PR, Martin JW, Kingebeni PM, Tamfum JM, Mwema G, Wan Q, Ewala P, Alonga J, Bilulu G, Reynolds MG, Quinn X, Norris S, Townsend MB, Satheshkumar PS, Wadding J, Soltis B, Honko A, Güereña FB, Korman L, Patterson K, Schwartz DA, Huggins JW. Clinical characterization and placental pathology of mpox infection in hospitalized patients in the Democratic Republic of the Congo. PLoS Negl Trop Dis. 2023 Apr; 17(4):e0010384. PMID: 37079637; PMCID: PMC10153724; DOI: 10.1371/journal.pntd.0010384;

Chang MR, Ke H, Losada Miguéns L, Coherd C, Nguyen K, Kamkaew M, Johnson R, Storm N, Honko A, Zhu Q, Griffiths A, Marasco WA. The variable conversion of neutralizing anti-SARS-CoV-2 single-chain antibodies to IgG provides insight into RBD epitope accessibility. Protein Eng Des Sel. 2023 Jan 21; 36.View Related Profiles.

Honko, Anna
Griffiths, Anthony
Storm, Nadia

PMID: 37561410; PMCID: PMC10505556; DOI: 10.1093/protein/gzad008;

Hunegnaw R, Honko AN, Wang L, Carr D, Murray T, Shi W, Nguyen L, Storm N, Dulan CNM, Foulds KE, Agans KN, Cross RW, Geisbert JB, Cheng C, Ploquin A, Stanley DA, Geisbert TW, Nabel GJ, Sullivan NJ. A single-shot ChAd3-MARV vaccine confers rapid and durable protection against Marburg virus in nonhuman primates. Sci Transl Med. 2022 Dec 14; 14(675):eabq6364.View Related Profiles.

Honko, Anna
Storm, Nadia
Sullivan, Nancy

PMID: 36516269; DOI: 10.1126/scitranslmed.abq6364;

Cross RW, Longini IM, Becker S, Bok K, Boucher D, Carroll MW, Díaz JV, Dowling WE, Draghia-Akli R, Duworko JT, Dye JM, Egan MA, Fast P, Finan A, Finch C, Fleming TR, Fusco J, Geisbert TW, Griffiths A, Günther S, Hensley LE, Honko A, Hunegnaw R, Jakubik J, Ledgerwood J, Luhn K, Matassov D, Meshulam J, Nelson EV, Parks CL, Rustomjee R, Safronetz D, Schwartz LM, Smith D, Smock P, Sow Y, Spiropoulou CF, Sullivan NJ, Warfield KL, Wolfe D, Woolsey C, Zahn R, Henao-Restrepo AM, Muñoz-Fontela C, Marzi A. An introduction to the Marburg virus vaccine consortium, MARVAC. PLoS Pathog. 2022 Oct; 18(10):e1010805.View Related Profiles.

Honko, Anna
Griffiths, Anthony
Nelson, Emily
Sullivan, Nancy

PMID: 36227853; PMCID: PMC9560149; DOI: 10.1371/journal.ppat.1010805;

Chang MR, Tomasovic L, Kuzmina NA, Ronk AJ, Byrne PO, Johnson R, Storm N, Olmedillas E, Hou YJ, Schäfer A, Leist SR, Tse LV, Ke H, Coherd C, Nguyen K, Kamkaew M, Honko A, Zhu Q, Alter G, Saphire EO, McLellan JS, Griffiths A, Baric RS, Bukreyev A, Marasco WA. IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern. Nat Commun. 2022 Oct 03; 13(1):5814.View Related Profiles.

Honko, Anna
Griffiths, Anthony
Storm, Nadia

PMID: 36192374; PMCID: PMC9528872; DOI: 10.1038/s41467-022-33030-4;

Nikitin PA, DiMuzio JM, Dowling JP, Patel NB, Bingaman-Steele JL, Heimbach BC, Henriquez N, Nicolescu C, Polley A, Sikorski EL, Howanski RJ, Nath M, Shukla H, Scheaffer SM, Finn JP, Liang LF, Smith T, Storm N, McKay LGA, Johnson RI, Malsick LE, Honko AN, Griffiths A, Diamond MS, Sarma P, Geising DH, Morin MJ, Robinson MK. IMM-BCP-01, a patient-derived anti-SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2. Sci Immunol. 2022 Sep 09; 7(75):eabl9943.View Related Profiles.

Honko, Anna
Griffiths, Anthony
McKay, Lindsay
Storm, Nadia

PMID: 35771946; PMCID: PMC9273042; DOI: 10.1126/sciimmunol.abl9943;

Das Adhikari U, Eng G, Farcasanu M, Avena LE, Choudhary MC, Triant VA, Flagg M, Schiff AE, Gomez I, Froehle LM, Diefenbach TJ, Ronsard L, Lingwood D, Lee GC, Rabi SA, Erstad D, Velmahos G, Li JZ, Hodin R, Stone JR, Honko AN, Griffiths A, Yilmaz ÖH, Kwon DS. Fecal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) RNA Is Associated With Decreased Coronavirus Disease 2019 (COVID-19) Survival. Clin Infect Dis. 2022 03 23; 74(6):1081-1084.View Related Profiles.

Honko, Anna
Griffiths, Anthony

PMID: 34245255; PMCID: PMC8406863; DOI: 10.1093/cid/ciab623;

Cline C, Bell TM, Facemire P, Zeng X, Briese T, Lipkin WI, Shamblin JD, Esham HL, Donnelly GC, Johnson JC, Hensley LE, Honko AN, Johnston SC. Detailed analysis of the pathologic hallmarks of Nipah virus (Malaysia) disease in the African green monkey infected by the intratracheal route. PLoS One. 2022; 17(2):e0263834. PMID: 35143571; PMCID: PMC8830707; DOI: 10.1371/journal.pone.0263834;

Downs I, Johnson JC, Rossi F, Dyer D, Saunders DL, Twenhafel NA, Esham HL, Pratt WD, Trefry J, Zumbrun E, Facemire PR, Johnston SC, Tompkins EL, Jansen NK, Honko A, Cardile AP. Natural History of Aerosol-Induced Ebola Virus Disease in Rhesus Macaques. Viruses. 2021 11 17; 13(11). PMID: 34835103; PMCID: PMC8619410; DOI: 10.3390/v13112297;

Ai X, Wang D, Honko A, Duan Y, Gavrish I, Fang RH, Griffiths A, Gao W, Zhang L. Surface Glycan Modification of Cellular Nanosponges to Promote SARS-CoV-2 Inhibition. J Am Chem Soc. 2021 10 27; 143(42):17615-17621.View Related Profiles.

Honko, Anna
Griffiths, Anthony

PMID: 34647745; PMCID: PMC8525344; DOI: 10.1021/jacs.1c07798;

Showing 10 of 76 results. Show More

Langellotto F, Dellacherie MO, Yeager C, Ijaz H, Yu J, Cheng CA, Dimitrakakis N, Seiler BT, Gebre MS, Gilboa T, Johnson R, Storm N, Bardales S, Graveline A, White D, Tringides CM, Cartwright MJ, Doherty EJ, Honko A, Griffiths A, Barouch DH, Walt DR, Mooney DJ. A Modular Biomaterial Scaffold-Based Vaccine Elicits Durable Adaptive Immunity to Subunit SARS-CoV-2 Antigens. Adv Healthc Mater. 2021 11; 10(22):e2101370.View Related Profiles.

Honko, Anna
Griffiths, Anthony
Storm, Nadia

PMID: 34605223; PMCID: PMC8652677; DOI: 10.1002/adhm.202101370;

Davis S, Milechin L, Patel T, Hernandez M, Ciccarelli G, Samsi S, Hensley L, Goff A, Trefry J, Johnston S, Purcell B, Cabrera C, Fleischman J, Reuther A, Claypool K, Rossi F, Honko A, Pratt W, Swiston A. Detecting Pathogen Exposure During the Non-symptomatic Incubation Period Using Physiological Data: Proof of Concept in Non-human Primates. Front Physiol. 2021; 12:691074. PMID: 34552498; PMCID: PMC8451540; DOI: 10.3389/fphys.2021.691074;

Zabaleta N, Dai W, Bhatt U, Hérate C, Maisonnasse P, Chichester JA, Sanmiguel J, Estelien R, Michalson KT, Diop C, Maciorowski D, Dereuddre-Bosquet N, Cavarelli M, Gallouët AS, Naninck T, Kahlaoui N, Lemaitre J, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Contreras V, Marlin R, Tsong Fang RH, Chapon C, van der Werf S, Zinn E, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Le Grand R, Vandenberghe LH. An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates. Cell Host Microbe. 2021 09 08; 29(9):1437-1453.e8.View Related Profiles.

Honko, Anna
Griffiths, Anthony
Storm, Nadia

PMID: 34428428; PMCID: PMC8346325; DOI: 10.1016/j.chom.2021.08.002;

Tong P, Gautam A, Windsor IW, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Storm N, Malsick LE, Honko AN, Lelis FJN, Habibi S, Jenni S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DR. Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike. Cell. 2021 09 16; 184(19):4969-4980.e15.View Related Profiles.

Honko, Anna
Rennick, Linda
McKay, Lindsay
Storm, Nadia

PMID: 34332650; PMCID: PMC8299219; DOI: 10.1016/j.cell.2021.07.025;

Atyeo C, Slein MD, Fischinger S, Burke J, Schäfer A, Leist SR, Kuzmina NA, Mire C, Honko A, Johnson R, Storm N, Bernett M, Tong P, Zuo T, Lin J, Zuiani A, Linde C, Suscovich T, Wesemann DR, Griffiths A, Desjarlais JR, Juelg BD, Goudsmit J, Bukreyev A, Baric R, Alter G. Dissecting strategies to tune the therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022. JCI Insight. 2021 01 11; 6(1).View Related Profiles.

Honko, Anna
Griffiths, Anthony
Mire, Chad
Storm, Nadia

PMID: 33427208; PMCID: PMC7821590; DOI: 10.1172/jci.insight.143129;

Zabaleta N, Dai W, Bhatt U, Chichester JA, Estelien R, Sanmiguel J, Michalson KT, Diop C, Maciorowski D, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Vandenberghe LH. Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates. bioRxiv. 2021 Jan 05.View Related Profiles.

Honko, Anna
Griffiths, Anthony
Storm, Nadia

PMID: 33442684; PMCID: PMC7805441; DOI: 10.1101/2021.01.05.422952;

Zhang Q, Honko A, Zhou J, Gong H, Downs SN, Vasquez JH, Fang RH, Gao W, Griffiths A, Zhang L. Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity. Nano Lett. 2020 07 08; 20(7):5570-5574.View Related Profiles.

Honko, Anna
Griffiths, Anthony

PMID: 32551679; PMCID: PMC7301960; DOI: 10.1021/acs.nanolett.0c02278;

Speranza E, Caballero I, Honko AN, Johnson JC, Bohannon JK, Evans DeWald L, Gerhardt DM, Sword J, Hensley LE, Bennett RS, Connor JH. Previremic Identification of Ebola or Marburg Virus Infection Using Integrated Host-Transcriptome and Viral Genome Detection. mBio. 2020 06 16; 11(3).View Related Profiles.

Honko, Anna
Connor, John

PMID: 32546624; PMCID: PMC7298714; DOI: 10.1128/mBio.01157-20;

Downs IL, Shaia CI, Zeng X, Johnson JC, Hensley L, Saunders DL, Rossi F, Cashman KA, Esham HL, Gregory MK, Pratt WD, Trefry JC, Everson KA, Larcom CB, Okwesili AC, Cardile AP, Honko A. Natural History of Aerosol Induced Lassa Fever in Non-Human Primates. Viruses. 2020 05 29; 12(6). PMID: 32485952; PMCID: PMC7354473; DOI: 10.3390/v12060593;

DeWald LE, Johnson JC, Gerhardt DM, Torzewski LM, Postnikova E, Honko AN, Janosko K, Huzella L, Dowling WE, Eakin AE, Osborn BL, Gahagen J, Tang L, Green CE, Mirsalis JC, Holbrook MR, Jahrling PB, Dyall J, Hensley LE. In Vivo Activity of Amodiaquine against Ebola Virus Infection. Sci Rep. 2019 12 27; 9(1):20199. PMID: 31882748; PMCID: PMC6934550; DOI: 10.1038/s41598-019-56481-0;

Liu J, Coffin KM, Johnston SC, Babka AM, Bell TM, Long SY, Honko AN, Kuhn JH, Zeng X. Nipah virus persists in the brains of nonhuman primate survivors. JCI Insight. 2019 07 25; 4(14). PMID: 31341108; PMCID: PMC6675545; DOI: 10.1172/jci.insight.129629;

Sebba D, Lastovich AG, Kuroda M, Fallows E, Johnson J, Ahouidi A, Honko AN, Fu H, Nielson R, Carruthers E, Diédhiou C, Ahmadou D, Soropogui B, Ruedas J, Peters K, Bartkowiak M, Magassouba N, Mboup S, Ben Amor Y, Connor JH, Weidemaier K. A point-of-care diagnostic for differentiating Ebola from endemic febrile diseases. Sci Transl Med. 2018 12 12; 10(471).View Related Profiles.

Honko, Anna
Connor, John

PMID: 30541788

Dyall J, Johnson JC, Hart BJ, Postnikova E, Cong Y, Zhou H, Gerhardt DM, Michelotti J, Honko AN, Kern S, DeWald LE, O'Loughlin KG, Green CE, Mirsalis JC, Bennett RS, Olinger GG, Jahrling PB, Hensley LE. In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus. J Infect Dis. 2018 11 22; 218(suppl_5):S592-S596.View Related Profiles.

Honko, Anna
Olinger, Gene

PMID: 30016444; PMCID: PMC6249586; DOI: 10.1093/infdis/jiy345;

Cross RW, Speranza E, Borisevich V, Widen SG, Wood TG, Shim RS, Adams RD, Gerhardt DM, Bennett RS, Honko AN, Johnson JC, Hensley LE, Geisbert TW, Connor JH. Comparative Transcriptomics in Ebola Makona-Infected Ferrets, Nonhuman Primates, and Humans. J Infect Dis. 2018 11 22; 218(suppl_5):S486-S495.View Related Profiles.

Honko, Anna
Connor, John

PMID: 30476250; PMCID: PMC6249602; DOI: 10.1093/infdis/jiy455;

Luke T, Bennett RS, Gerhardt DM, Burdette T, Postnikova E, Mazur S, Honko AN, Oberlander N, Byrum R, Ragland D, St Claire M, Janosko KB, Smith G, Glenn G, Hooper J, Dye J, Pal S, Bishop-Lilly KA, Hamilton T, Frey K, Bollinger L, Wada J, Wu H, Jiao JA, Olinger GG, Gunn B, Alter G, Khurana S, Hensley LE, Sullivan E, Jahrling PB. Fully Human Immunoglobulin G From Transchromosomic Bovines Treats Nonhuman Primates Infected With Ebola Virus Makona Isolate. J Infect Dis. 2018 11 22; 218(suppl_5):S636-S648.View Related Profiles.

Honko, Anna
Olinger, Gene

PMID: 30010950; PMCID: PMC6249570; DOI: 10.1093/infdis/jiy377;

Wang MK, Ren T, Liu H, Lim SY, Lee K, Honko A, Zhou H, Dyall J, Hensley L, Gartin AK, Cunningham JM. Critical role for cholesterol in Lassa fever virus entry identified by a novel small molecule inhibitor targeting the viral receptor LAMP1. PLoS Pathog. 2018 09; 14(9):e1007322. PMID: 30265711; PMCID: PMC6179309; DOI: 10.1371/journal.ppat.1007322;

Duy J, Honko AN, Altamura LA, Bixler SL, Wollen-Roberts S, Wauquier N, O'Hearn A, Mucker EM, Johnson JC, Shamblin JD, Zelko J, Botto MA, Bangura J, Coomber M, Pitt ML, Gonzalez JP, Schoepp RJ, Goff AJ, Minogue TD. Virus-encoded miRNAs in Ebola virus disease. Sci Rep. 2018 04 24; 8(1):6480. PMID: 29691416; PMCID: PMC5915558; DOI: 10.1038/s41598-018-23916-z;

Postnikova E, Cong Y, DeWald LE, Dyall J, Yu S, Hart BJ, Zhou H, Gross R, Logue J, Cai Y, Deiuliis N, Michelotti J, Honko AN, Bennett RS, Holbrook MR, Olinger GG, Hensley LE, Jahrling PB. Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs. PLoS One. 2018; 13(3):e0194880.View Related Profiles.

Honko, Anna
Olinger, Gene

PMID: 29566079; PMCID: PMC5864066; DOI: 10.1371/journal.pone.0194880;

Honko AN, Johnson JC, Marchand JS, Huzella L, Adams RD, Oberlander N, Torzewski LM, Bennett RS, Hensley LE, Jahrling PB, Olinger GG. High dose sertraline monotherapy fails to protect rhesus macaques from lethal challenge with Ebola virus Makona. Sci Rep. 2017 07 19; 7(1):5886.View Related Profiles.

Honko, Anna
Olinger, Gene

PMID: 28725019; PMCID: PMC5517626; DOI: 10.1038/s41598-017-06179-y;

Dyall J, Hart BJ, Postnikova E, Cong Y, Zhou H, Gerhardt DM, Freeburger D, Michelotti J, Honko AN, DeWald LE, Bennett RS, Olinger GG, Jahrling PB, Hensley LE. Interferon-ß and Interferon-? Are Weak Inhibitors of Ebola Virus in Cell-Based Assays. J Infect Dis. 2017 May 01; 215(9):1416-1420.View Related Profiles.

Honko, Anna
Olinger, Gene

PMID: 28368541; PMCID: PMC5853567; DOI: 10.1093/infdis/jix134;

Bohannon JK, Honko AN, Reeder RJ, Cooper K, Byrum R, Bollinger L, Kuhn JH, Wada J, Qin J, Jahrling PB, Lackemeyer MG. Comparison of respiratory inductive plethysmography versus head-out plethysmography for anesthetized nonhuman primates in an animal biosafety level 4 facility. Inhal Toxicol. 2016 12; 28(14):670-676. PMID: 27919178; DOI: 10.1080/08958378.2016.1247199;

Cong Y, Dyall J, Hart BJ, DeWald LE, Johnson JC, Postnikova E, Zhou H, Gross R, Rojas O, Alexander I, Josleyn N, Zhang T, Michelotti J, Janosko K, Glass PJ, Flint M, McMullan LK, Spiropoulou CF, Mierzwa T, Guha R, Shinn P, Michael S, Klumpp-Thomas C, McKnight C, Thomas C, Eakin AE, O'Loughlin KG, Green CE, Catz P, Mirsalis JC, Honko AN, Olinger GG, Bennett RS, Holbrook MR, Hensley LE, Jahrling PB. Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus. PLoS One. 2016; 11(11):e0166318.View Related Profiles.

Honko, Anna
Olinger, Gene

PMID: 27902714; PMCID: PMC5130197; DOI: 10.1371/journal.pone.0166318;

Cnops L, van Griensven J, Honko AN, Bausch DG, Sprecher A, Hill CE, Colebunders R, Johnson JC, Griffiths A, Palacios GF, Kraft CS, Kobinger G, Hewlett A, Norwood DA, Sabeti P, Jahrling PB, Formenty P, Kuhn JH, Ariën KK. Overlooking the importance of immunoassays - Authors' reply. Lancet Infect Dis. 2016 10; 16(10):1110.View Related Profiles.

Honko, Anna
Griffiths, Anthony

PMID: 27676345; DOI: 10.1016/S1473-3099(16)30339-5;

Caballero IS, Honko AN, Gire SK, Winnicki SM, Melé M, Gerhardinger C, Lin AE, Rinn JL, Sabeti PC, Hensley LE, Connor JH. In vivo Ebola virus infection leads to a strong innate response in circulating immune cells. BMC Genomics. 2016 Sep 05; 17:707.View Related Profiles.

Honko, Anna
Connor, John

PMID: 27595844; PMCID: PMC5011782; DOI: 10.1186/s12864-016-3060-0;

Kilianski A, Roth PA, Liem AT, Hill JM, Willis KL, Rossmaier RD, Marinich AV, Maughan MN, Karavis MA, Kuhn JH, Honko AN, Rosenzweig CN. Use of Unamplified RNA/cDNA-Hybrid Nanopore Sequencing for Rapid Detection and Characterization of RNA Viruses. Emerg Infect Dis. 2016 08; 22(8):1448-51. PMID: 27191483; PMCID: PMC4982148; DOI: 10.3201/eid2208.160270;

Cnops L, van Griensven J, Honko AN, Bausch DG, Sprecher A, Hill CE, Colebunders R, Johnson JC, Griffiths A, Palacios GF, Kraft CS, Kobinger G, Hewlett A, Norwood DA, Sabeti P, Jahrling PB, Formenty P, Kuhn JH, Ariën KK. Essentials of filoviral load quantification. Lancet Infect Dis. 2016 07; 16(7):e134-e138.View Related Profiles.

Honko, Anna
Griffiths, Anthony

PMID: 27296694; DOI: 10.1016/S1473-3099(16)30063-9;

Duy J, Koehler JW, Honko AN, Schoepp RJ, Wauquier N, Gonzalez JP, Pitt ML, Mucker EM, Johnson JC, O'Hearn A, Bangura J, Coomber M, Minogue TD. Circulating microRNA profiles of Ebola virus infection. Sci Rep. 2016 Apr 21; 6:24496. PMID: 27098369; PMCID: PMC4838880; DOI: 10.1038/srep24496;

Zeitlin L, Geisbert JB, Deer DJ, Fenton KA, Bohorov O, Bohorova N, Goodman C, Kim D, Hiatt A, Pauly MH, Velasco J, Whaley KJ, Altmann F, Gruber C, Steinkellner H, Honko AN, Kuehne AI, Aman MJ, Sahandi S, Enterlein S, Zhan X, Enria D, Geisbert TW. Monoclonal antibody therapy for Junin virus infection. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4458-63. PMID: 27044104; PMCID: PMC4843420; DOI: 10.1073/pnas.1600996113;

Trefry JC, Wollen SE, Nasar F, Shamblin JD, Kern SJ, Bearss JJ, Jefferson MA, Chance TB, Kugelman JR, Ladner JT, Honko AN, Kobs DJ, Wending MQ, Sabourin CL, Pratt WD, Palacios GF, Pitt ML. Ebola Virus Infections in Nonhuman Primates Are Temporally Influenced by Glycoprotein Poly-U Editing Site Populations in the Exposure Material. Viruses. 2015 Dec 19; 7(12):6739-54. PMID: 26703716; PMCID: PMC4690892; DOI: 10.3390/v7122969;

Lin KL, Twenhafel NA, Connor JH, Cashman KA, Shamblin JD, Donnelly GC, Esham HL, Wlazlowski CB, Johnson JC, Honko AN, Botto MA, Yen J, Hensley LE, Goff AJ. Temporal Characterization of Marburg Virus Angola Infection following Aerosol Challenge in Rhesus Macaques. J Virol. 2015 Oct; 89(19):9875-85.View Related Profiles.

Honko, Anna
Connor, John

PMID: 26202230; PMCID: PMC4577920; DOI: 10.1128/JVI.01147-15;

Alves DA, Honko AN, Kortepeter MG, Sun M, Johnson JC, Lugo-Roman LA, Hensley LE. Necrotizing Scleritis, Conjunctivitis, and Other Pathologic Findings in the Left Eye and Brain of an Ebola Virus-Infected Rhesus Macaque (Macaca mulatta) With Apparent Recovery and a Delayed Time of Death. J Infect Dis. 2016 Jan 01; 213(1):57-60. PMID: 26153408; PMCID: PMC4707191; DOI: 10.1093/infdis/jiv357;

Clark DV, Kibuuka H, Millard M, Wakabi S, Lukwago L, Taylor A, Eller MA, Eller LA, Michael NL, Honko AN, Olinger GG, Schoepp RJ, Hepburn MJ, Hensley LE, Robb ML. Long-term sequelae after Ebola virus disease in Bundibugyo, Uganda: a retrospective cohort study. Lancet Infect Dis. 2015 Aug; 15(8):905-12.View Related Profiles.

Honko, Anna
Olinger, Gene

PMID: 25910637; DOI: 10.1016/S1473-3099(15)70152-0;

Johnston SC, Briese T, Bell TM, Pratt WD, Shamblin JD, Esham HL, Donnelly GC, Johnson JC, Hensley LE, Lipkin WI, Honko AN. Detailed analysis of the African green monkey model of Nipah virus disease. PLoS One. 2015; 10(2):e0117817. PMID: 25706617; PMCID: PMC4338303; DOI: 10.1371/journal.pone.0117817;

Duy J, Koehler JW, Honko AN, Minogue TD. Optimized microRNA purification from TRIzol-treated plasma. BMC Genomics. 2015 Feb 18; 16:95. PMID: 25765146; PMCID: PMC4342875; DOI: 10.1186/s12864-015-1299-5;

Warren TK, Trefry JC, Marko ST, Chance TB, Wells JB, Pratt WD, Johnson JC, Mucker EM, Norris SL, Chappell M, Dye JM, Honko AN. Euthanasia assessment in ebola virus infected nonhuman primates. Viruses. 2014 Nov 24; 6(11):4666-82. PMID: 25421892; PMCID: PMC4246243; DOI: 10.3390/v6114666;

Caballero IS, Yen JY, Hensley LE, Honko AN, Goff AJ, Connor JH. Lassa and Marburg viruses elicit distinct host transcriptional responses early after infection. BMC Genomics. 2014; 15:960.View Related Profiles.

Honko, Anna
Connor, John

PMID: 25377889; PMCID: PMC4232721; DOI: 10.1186/1471-2164-15-960;

Kuhn JH, Andersen KG, Bào Y, Bavari S, Becker S, Bennett RS, Bergman NH, Blinkova O, Bradfute S, Brister JR, Bukreyev A, Chandran K, Chepurnov AA, Davey RA, Dietzgen RG, Doggett NA, Dolnik O, Dye JM, Enterlein S, Fenimore PW, Formenty P, Freiberg AN, Garry RF, Garza NL, Gire SK, Gonzalez JP, Griffiths A, Happi CT, Hensley LE, Herbert AS, Hevey MC, Hoenen T, Honko AN, Ignatyev GM, Jahrling PB, Johnson JC, Johnson KM, Kindrachuk J, Klenk HD, Kobinger G, Kochel TJ, Lackemeyer MG, Lackner DF, Leroy EM, Lever MS, Mühlberger E, Netesov SV, Olinger GG, Omilabu SA, Palacios G, Panchal RG, Park DJ, Patterson JL, Paweska JT, Peters CJ, Pettitt J, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Sabeti PC, Sealfon R, Shestopalov AM, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Volchkova VA, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST. Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names. Viruses. 2014 Sep; 6(9):3663-82.View Related Profiles.

Honko, Anna
Griffiths, Anthony
Muhlberger, Elke
Olinger, Gene
Sullivan, Nancy
Davey, Robert

PMID: 25256396; PMCID: PMC4189044; DOI: 10.3390/v6093663;

Koehler JW, Hall AT, Rolfe PA, Honko AN, Palacios GF, Fair JN, Muyembe JJ, Mulembekani P, Schoepp RJ, Adesokan A, Minogue TD. Development and evaluation of a panel of filovirus sequence capture probes for pathogen detection by next-generation sequencing. PLoS One. 2014; 9(9):e107007. PMID: 25207553; PMCID: PMC4160210; DOI: 10.1371/journal.pone.0107007;

Stanley DA, Honko AN, Asiedu C, Trefry JC, Lau-Kilby AW, Johnson JC, Hensley L, Ammendola V, Abbate A, Grazioli F, Foulds KE, Cheng C, Wang L, Donaldson MM, Colloca S, Folgori A, Roederer M, Nabel GJ, Mascola J, Nicosia A, Cortese R, Koup RA, Sullivan NJ. Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge. Nat Med. 2014 Oct; 20(10):1126-9.View Related Profiles.

Honko, Anna
Sullivan, Nancy

PMID: 25194571; DOI: 10.1038/nm.3702;

Garamszegi S, Yen JY, Honko AN, Geisbert JB, Rubins KH, Geisbert TW, Xia Y, Hensley LE, Connor JH. Transcriptional correlates of disease outcome in anticoagulant-treated non-human primates infected with ebolavirus. PLoS Negl Trop Dis. 2014; 8(7):e3061.View Related Profiles.

Honko, Anna
Connor, John

PMID: 25079789; PMCID: PMC4117489; DOI: 10.1371/journal.pntd.0003061;

Johnson JC, Martinez O, Honko AN, Hensley LE, Olinger GG, Basler CF. Pyridinyl imidazole inhibitors of p38 MAP kinase impair viral entry and reduce cytokine induction by Zaire ebolavirus in human dendritic cells. Antiviral Res. 2014 Jul; 107:102-9.View Related Profiles.

Honko, Anna
Olinger, Gene

PMID: 24815087; PMCID: PMC4103912; DOI: 10.1016/j.antiviral.2014.04.014;

Kelly R, Carlson A, Kern SJ, Field A, Marko S, Bailey E, Norris S, Honko A, Rico P. Evaluation of the use of primate undershirts as a refinement practice for jacketed rhesus macaques (Macaca mulatta). J Am Assoc Lab Anim Sci. 2014 May; 53(3):267-72. PMID: 24827568; PMCID: PMC4128564

Matranga CB, Andersen KG, Winnicki S, Busby M, Gladden AD, Tewhey R, Stremlau M, Berlin A, Gire SK, England E, Moses LM, Mikkelsen TS, Odia I, Ehiane PE, Folarin O, Goba A, Kahn SH, Grant DS, Honko A, Hensley L, Happi C, Garry RF, Malboeuf CM, Birren BW, Gnirke A, Levin JZ, Sabeti PC. Enhanced methods for unbiased deep sequencing of Lassa and Ebola RNA viruses from clinical and biological samples. Genome Biol. 2014; 15(11):519. PMID: 25403361; PMCID: PMC4262991; DOI: 10.1186/PREACCEPT-1698056557139770;

Kuhn JH, Bào Y, Bavari S, Becker S, Bradfute S, Brauburger K, Rodney Brister J, Bukreyev AA, Caì Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Gonzalez JP, Formenty P, Freiberg AN, Hensley LE, Hoenen T, Honko AN, Ignatyev GM, Jahrling PB, Johnson KM, Klenk HD, Kobinger G, Lackemeyer MG, Leroy EM, Lever MS, Mühlberger E, Netesov SV, Olinger GG, Palacios G, Patterson JL, Paweska JT, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Shestopalov AM, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Volchkova VA, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST. Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA. Arch Virol. 2014 May; 159(5):1229-37.View Related Profiles.

Honko, Anna
Muhlberger, Elke
Olinger, Gene
Brauburger, Kristina
Sullivan, Nancy
Davey, Robert

PMID: 24190508; PMCID: PMC4010566; DOI: 10.1007/s00705-013-1877-2;

Malhotra S, Yen JY, Honko AN, Garamszegi S, Caballero IS, Johnson JC, Mucker EM, Trefry JC, Hensley LE, Connor JH. Transcriptional profiling of the circulating immune response to lassa virus in an aerosol model of exposure. PLoS Negl Trop Dis. 2013; 7(4):e2171.View Related Profiles.

Honko, Anna
Connor, John

PMID: 23638192; PMCID: PMC3636129; DOI: 10.1371/journal.pntd.0002171;

Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brister JR, Bukreyev AA, Caì Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Gonzalez JP, Formenty P, Freiberg AN, Hensley LE, Honko AN, Ignatyev GM, Jahrling PB, Johnson KM, Klenk HD, Kobinger G, Lackemeyer MG, Leroy EM, Lever MS, Lofts LL, Mühlberger E, Netesov SV, Olinger GG, Palacios G, Patterson JL, Paweska JT, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Shestopalov AM, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST. Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae. Arch Virol. 2013 Jun; 158(6):1425-32.View Related Profiles.

Honko, Anna
Muhlberger, Elke
Olinger, Gene
Sullivan, Nancy
Davey, Robert

PMID: 23358612; PMCID: PMC3669655; DOI: 10.1007/s00705-012-1594-2;

Martinez O, Johnson JC, Honko A, Yen B, Shabman RS, Hensley LE, Olinger GG, Basler CF. Ebola virus exploits a monocyte differentiation program to promote its entry. J Virol. 2013 Apr; 87(7):3801-14.View Related Profiles.

Honko, Anna
Olinger, Gene

PMID: 23345511; PMCID: PMC3624207; DOI: 10.1128/JVI.02695-12;

Twenhafel NA, Mattix ME, Johnson JC, Robinson CG, Pratt WD, Cashman KA, Wahl-Jensen V, Terry C, Olinger GG, Hensley LE, Honko AN. Pathology of experimental aerosol Zaire ebolavirus infection in rhesus macaques. Vet Pathol. 2013 May; 50(3):514-29.View Related Profiles.

Honko, Anna
Olinger, Gene

PMID: 23262834; DOI: 10.1177/0300985812469636;

Smith LM, Hensley LE, Geisbert TW, Johnson J, Stossel A, Honko A, Yen JY, Geisbert J, Paragas J, Fritz E, Olinger G, Young HA, Rubins KH, Karp CL. Interferon-ß therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever. J Infect Dis. 2013 Jul 15; 208(2):310-8.View Related Profiles.

Honko, Anna
Olinger, Gene

PMID: 23255566; PMCID: PMC3685222; DOI: 10.1093/infdis/jis921;

Kugelman JR, Lee MS, Rossi CA, McCarthy SE, Radoshitzky SR, Dye JM, Hensley LE, Honko A, Kuhn JH, Jahrling PB, Warren TK, Whitehouse CA, Bavari S, Palacios G. Ebola virus genome plasticity as a marker of its passaging history: a comparison of in vitro passaging to non-human primate infection. PLoS One. 2012; 7(11):e50316. PMID: 23209706; PMCID: PMC3509072; DOI: 10.1371/journal.pone.0050316;

Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brister JR, Bukreyev AA, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Hensley LE, Honko AN, Jahrling PB, Johnson KM, Kobinger G, Leroy EM, Lever MS, Mühlberger E, Netesov SV, Olinger GG, Palacios G, Patterson JL, Paweska JT, Pitt L, Radoshitzky SR, Saphire EO, Smither SJ, Swanepoel R, Towner JS, van der Groen G, Volchkov VE, Wahl-Jensen V, Warren TK, Weidmann M, Nichol ST. Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae. Arch Virol. 2013 Jan; 158(1):301-11.View Related Profiles.

Honko, Anna
Muhlberger, Elke
Olinger, Gene
Davey, Robert

PMID: 23001720; PMCID: PMC3535543; DOI: 10.1007/s00705-012-1454-0;

Friedrich BM, Trefry JC, Biggins JE, Hensley LE, Honko AN, Smith DR, Olinger GG. Potential vaccines and post-exposure treatments for filovirus infections. Viruses. 2012 Sep; 4(9):1619-50.View Related Profiles.

Honko, Anna
Olinger, Gene

PMID: 23170176; PMCID: PMC3499823; DOI: 10.3390/v4091619;

Reed C, Steele KE, Honko A, Shamblin J, Hensley LE, Smith DR. Ultrastructural study of Rift Valley fever virus in the mouse model. Virology. 2012 Sep 15-30; 431(1-2):58-70. PMID: 22687428; DOI: 10.1016/j.virol.2012.05.012;

Kortepeter MG, Lawler JV, Honko A, Bray M, Johnson JC, Purcell BK, Olinger GG, Rivard R, Hepburn MJ, Hensley LE. Real-time monitoring of cardiovascular function in rhesus macaques infected with Zaire ebolavirus. J Infect Dis. 2011 Nov; 204 Suppl 3:S1000-10.View Related Profiles.

Honko, Anna
Olinger, Gene

PMID: 21987736; DOI: 10.1093/infdis/jir337;

Yen JY, Garamszegi S, Geisbert JB, Rubins KH, Geisbert TW, Honko A, Xia Y, Connor JH, Hensley LE. Therapeutics of Ebola hemorrhagic fever: whole-genome transcriptional analysis of successful disease mitigation. J Infect Dis. 2011 Nov; 204 Suppl 3:S1043-52.View Related Profiles.

Honko, Anna
Connor, John

PMID: 21987740; DOI: 10.1093/infdis/jir345;

Sullivan NJ, Hensley L, Asiedu C, Geisbert TW, Stanley D, Johnson J, Honko A, Olinger G, Bailey M, Geisbert JB, Reimann KA, Bao S, Rao S, Roederer M, Jahrling PB, Koup RA, Nabel GJ. CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates. Nat Med. 2011 Sep; 17(9):1128-31.View Related Profiles.

Honko, Anna
Olinger, Gene
Sullivan, Nancy

PMID: 21857654; DOI: 10.1038/nm.2447;

Geisbert TW, Bailey M, Hensley L, Asiedu C, Geisbert J, Stanley D, Honko A, Johnson J, Mulangu S, Pau MG, Custers J, Vellinga J, Hendriks J, Jahrling P, Roederer M, Goudsmit J, Koup R, Sullivan NJ. Recombinant adenovirus serotype 26 (Ad26) and Ad35 vaccine vectors bypass immunity to Ad5 and protect nonhuman primates against ebolavirus challenge. J Virol. 2011 May; 85(9):4222-33.View Related Profiles.

Honko, Anna
Sullivan, Nancy

PMID: 21325402; PMCID: PMC3126236; DOI: 10.1128/JVI.02407-10;

Smith DR, Steele KE, Shamblin J, Honko A, Johnson J, Reed C, Kennedy M, Chapman JL, Hensley LE. The pathogenesis of Rift Valley fever virus in the mouse model. Virology. 2010 Nov 25; 407(2):256-67. PMID: 20850165; DOI: 10.1016/j.virol.2010.08.016;

Geisbert TW, Lee AC, Robbins M, Geisbert JB, Honko AN, Sood V, Johnson JC, de Jong S, Tavakoli I, Judge A, Hensley LE, Maclachlan I. Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study. Lancet. 2010 May 29; 375(9729):1896-905. PMID: 20511019; PMCID: PMC7138079; DOI: 10.1016/S0140-6736(10)60357-1;

Hensley LE, Mulangu S, Asiedu C, Johnson J, Honko AN, Stanley D, Fabozzi G, Nichol ST, Ksiazek TG, Rollin PE, Wahl-Jensen V, Bailey M, Jahrling PB, Roederer M, Koup RA, Sullivan NJ. Demonstration of cross-protective vaccine immunity against an emerging pathogenic Ebolavirus Species. PLoS Pathog. 2010 May 20; 6(5):e1000904.View Related Profiles.

Honko, Anna
Sullivan, Nancy

PMID: 20502688; PMCID: PMC2873919; DOI: 10.1371/journal.ppat.1000904;

Wolf MC, Freiberg AN, Zhang T, Akyol-Ataman Z, Grock A, Hong PW, Li J, Watson NF, Fang AQ, Aguilar HC, Porotto M, Honko AN, Damoiseaux R, Miller JP, Woodson SE, Chantasirivisal S, Fontanes V, Negrete OA, Krogstad P, Dasgupta A, Moscona A, Hensley LE, Whelan SP, Faull KF, Holbrook MR, Jung ME, Lee B. A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3157-62. PMID: 20133606; PMCID: PMC2840368; DOI: 10.1073/pnas.0909587107;

Bates JT, Honko AN, Graff AH, Kock ND, Mizel SB. Mucosal adjuvant activity of flagellin in aged mice. Mech Ageing Dev. 2008 May; 129(5):271-81. PMID: 18367233; PMCID: PMC2366812; DOI: 10.1016/j.mad.2008.01.009;

Honko AN, Sriranganathan N, Lees CJ, Mizel SB. Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis. Infect Immun. 2006 Feb; 74(2):1113-20. PMID: 16428759; PMCID: PMC1360354; DOI: 10.1128/IAI.74.2.1113-1120.2006;

Honko AN, Mizel SB. Effects of flagellin on innate and adaptive immunity. Immunol Res. 2005; 33(1):83-101. PMID: 16120974; DOI: 10.1385/IR:33:1:083;

Honko AN, Mizel SB. Mucosal administration of flagellin induces innate immunity in the mouse lung. Infect Immun. 2004 Nov; 72(11):6676-9. PMID: 15501801; PMCID: PMC523048; DOI: 10.1128/IAI.72.11.6676-6679.2004;

Mizel SB, Honko AN, Moors MA, Smith PS, West AP. Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes. J Immunol. 2003 Jun 15; 170(12):6217-23. PMID: 12794153; DOI: 10.4049/jimmunol.170.12.6217;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 76 publications over 19 distinct years, with a maximum of 9 publications in 2014

Bar chart showing 76 publications over 19 distinct years, with a maximum of 9 publications in 2014

Year	Publications
2003	1
2004	1
2005	1
2006	1
2008	1
2010	4
2011	4
2012	6
2013	4
2014	9
2015	6
2016	8
2017	2
2018	7
2019	2
2020	3
2021	8
2022	6
2023	2

Media Mentions

Where is COVD research going next?

BU Today 3/26/2021

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BU Today 1/20/2021

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Medical Daily 6/23/2020

Nanosponges Could Protect The Lungs By Soaking Up Coronavirus, Study Suggests

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Coronavirus Latches on to Membrane-Wrapped Nanosponges, Dramatically Reducing Infectivity

Genetic Engineering & Biotechnology News 6/18/2020

Tiny, Decoy “Sponges” Attract Coronavirus Away from Lung Cells

BU Today 6/18/2020

2014 Department of Army Civilian Performance Award

2013 Army Certificate of Achievement Award: Filovirus Euthanasia Criteria IPT

2011 Army Certificate of Achievement Award: Ebola virus Kikwit stock IPT

2011 Department of Army Civilian Performance Award

2006-2010 National Research Council post-doctoral training fellowship

2005 Alumni Student travel award

Contact for Mentoring:

617.358.2900

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