Yuzuru Sasamoto, MD, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine

MD, Osaka University
PhD, Osaka University

Yuzuru Sasamoto received his MD from Osaka University Medical School in Japan in 2006. After completion of his medical training in ophthalmology, he received a PhD degree from Osaka University Graduate School of Medicine in 2016. During his PhD program, he worked on corneal regeneration using techniques such as direct reprogramming and induced pluripotent stem (iPS) cell differentiation. He is currently an associate geneticist at the Brigham and Women’s Hospital. Yuzuru is currently working on the comprehensive characterization of the ABCB5 positive limbal stem cells using next-generation sequencing approaches.

Development of cell-free approaches to the treatment of limbal stem cell deficiency
03/01/2023 - 02/28/2026 (PI)
NIH/National Eye Institute

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 08/31/2024 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Rawat L, Balan M, Sasamoto Y, Sabarwal A, Pal S. A novel combination therapy with Cabozantinib and Honokiol effectively inhibits c-Met-Nrf2-induced renal tumor growth through increased oxidative stress. Redox Biol. 2023 Dec; 68:102945. PMID: 37898101; PMCID: PMC10628632; DOI: 10.1016/j.redox.2023.102945;
  2. Sasamoto Y, Yeung PC, Tran J, Frank MH, Frank NY. Protocol for isolating human BCAM-positive corneal progenitor cells by flow cytometry and cell sorting. STAR Protoc. 2023 Sep 15; 4(3):102503. PMID: 37669162; PMCID: PMC10485628; DOI: 10.1016/j.xpro.2023.102503;
  3. Sasamoto Y, Wu S, Lee CAA, Jiang JY, Ksander BR, Frank MH, Frank NY. Epigenetic Regulation of Corneal Epithelial Differentiation by TET2. Int J Mol Sci. 2023 Feb 02; 24(3). PMID: 36769164; PMCID: PMC9917645; DOI: 10.3390/ijms24032841;
  4. Sasamoto Y, Lee CAA, Wilson BJ, Buerger F, Martin G, Mishra A, Kiritoshi S, Tran J, Gonzalez G, Hildebrandt F, Jo VY, Lian CG, Murphy GF, Ksander BR, Frank MH, Frank NY. Limbal BCAM expression identifies a proliferative progenitor population capable of holoclone formation and corneal differentiation. Cell Rep. 2022 Aug 09; 40(6):111166. PMID: 35947947; PMCID: PMC9480518; DOI: 10.1016/j.celrep.2022.111166;
  5. Yoshinaga Y, Soma T, Azuma S, Maruyama K, Hashikawa Y, Katayama T, Sasamoto Y, Takayanagi H, Hosen N, Shiina T, Ogasawara K, Hayashi R, Nishida K. Long-term survival in non-human primates of stem cell-derived, MHC-unmatched corneal epithelial cell sheets. Stem Cell Reports. 2022 07 12; 17(7):1714-1729. PMID: 35750044; PMCID: PMC9287743; DOI: 10.1016/j.stemcr.2022.05.018;
  6. Sasamoto Y, Lee CAA, Yoshihara M, Martin G, Ksander BR, Frank MH, Frank NY. High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells. Ocul Surf. 2022 01; 23:197-200. PMID: 34653711; PMCID: PMC8511872; DOI: 10.1016/j.jtos.2021.10.002;
  7. Watanabe S, Hayashi R, Sasamoto Y, Tsujikawa M, Ksander BR, Frank MH, Quantock AJ, Frank NY, Nishida K. Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities. iScience. 2021 Jun 25; 24(6):102688. PMID: 34195566; PMCID: PMC8233200; DOI: 10.1016/j.isci.2021.102688;
  8. Sasamoto Y, Sasamoto N, Tran J, Mishra A, Ksander BR, Frank MH, Frank NY. Investigation of factors associated with ABCB5-positive limbal stem cell isolation yields from human donors. Ocul Surf. 2020 01; 18(1):114-120. PMID: 31655212; PMCID: PMC7840156; DOI: 10.1016/j.jtos.2019.10.009;
  9. Fujimoto S, Hayashi R, Hara S, Sasamoto Y, Harrington J, Tsujikawa M, Nishida K. KLF4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous TGF-ß2 suppression. Regen Ther. 2019 Dec; 11:249-257. PMID: 31538102; PMCID: PMC6745437; DOI: 10.1016/j.reth.2019.08.003;
  10. Sasamoto Y, Ksander BR, Frank MH, Frank NY. Repairing the corneal epithelium using limbal stem cells or alternative cell-based therapies. Expert Opin Biol Ther. 2018 05; 18(5):505-513. PMID: 29471701; PMCID: PMC6317528; DOI: 10.1080/14712598.2018.1443442;
Showing 10 of 40 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 40 publications over 21 distinct years, with a maximum of 5 publications in 2011


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72 E. Concord Street
Boston MA 02118
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