Yuzuru Sasamoto | Profiles RNS

Yuzuru Sasamoto, MD, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Ophthalmology

MD, Osaka University
PhD, Osaka University

Websites

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	Frank Lab
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	Harvard Catalyst Profile

ORCID : 0009-0006-3249-8546

Yuzuru Sasamoto received his MD from Osaka University Medical School in Japan in 2006. After completion of his medical training in ophthalmology, he received a PhD degree from Osaka University Graduate School of Medicine in 2016. During his PhD program, he worked on corneal regeneration using techniques such as direct reprogramming and induced pluripotent stem (iPS) cell differentiation. He is currently an associate geneticist at the Brigham and Women’s Hospital. Yuzuru is currently working on the comprehensive characterization of the ABCB5 positive limbal stem cells using next-generation sequencing approaches.

BU Research
NIH RePORTER Research

The role of BCAM-positive cells in central cornea, limbus and conjunctiva
08/01/2024 - 05/31/2029 (PI)
NIH/National Eye Institute
1R01EY036399-01

The role of limbal fibroblasts for the maintenance of limbal stem cells
08/01/2024 - 07/31/2026 (PI)
NIH/National Eye Institute
1R21EY035735-01A1

Development of cell-free approaches to the treatment of limbal stem cell deficiency
03/01/2023 - 02/28/2026 (PI)
NIH/National Eye Institute
5R00EY031741-04

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 08/31/2024 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.

Title

Yr	Title	Project-Sub Proj
2024	The role of BCAM-positive cells in central cornea, limbus and conjunctiva	1R01EY036399-01
2024	The role of limbal fibroblasts for the maintenance of limbal stem cells	1R21EY035735-01A1
2024	Development of cell-free approaches to the treatment of limbal stem cell deficiency	5R00EY031741-04
2023	Development of cell-free approaches to the treatment of limbal stem cell deficiency	4R00EY031741-03
2021	Development of cell-free approaches to the treatment of limbal stem cell deficiency	5K99EY031741-02
2020	Development of cell-free approaches to the treatment of limbal stem cell deficiency	1K99EY031741-01

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Rawat L, Balan M, Sasamoto Y, Sabarwal A, Pal S. A novel combination therapy with Cabozantinib and Honokiol effectively inhibits c-Met-Nrf2-induced renal tumor growth through increased oxidative stress. Redox Biol. 2023 Dec; 68:102945. PMID: 37898101; PMCID: PMC10628632; DOI: 10.1016/j.redox.2023.102945;

Sasamoto Y, Yeung PC, Tran J, Frank MH, Frank NY. Protocol for isolating human BCAM-positive corneal progenitor cells by flow cytometry and cell sorting. STAR Protoc. 2023 Sep 15; 4(3):102503. PMID: 37669162; PMCID: PMC10485628; DOI: 10.1016/j.xpro.2023.102503;

Sasamoto Y, Wu S, Lee CAA, Jiang JY, Ksander BR, Frank MH, Frank NY. Epigenetic Regulation of Corneal Epithelial Differentiation by TET2. Int J Mol Sci. 2023 Feb 02; 24(3). PMID: 36769164; PMCID: PMC9917645; DOI: 10.3390/ijms24032841;

Sasamoto Y, Lee CAA, Wilson BJ, Buerger F, Martin G, Mishra A, Kiritoshi S, Tran J, Gonzalez G, Hildebrandt F, Jo VY, Lian CG, Murphy GF, Ksander BR, Frank MH, Frank NY. Limbal BCAM expression identifies a proliferative progenitor population capable of holoclone formation and corneal differentiation. Cell Rep. 2022 Aug 09; 40(6):111166. PMID: 35947947; PMCID: PMC9480518; DOI: 10.1016/j.celrep.2022.111166;

Yoshinaga Y, Soma T, Azuma S, Maruyama K, Hashikawa Y, Katayama T, Sasamoto Y, Takayanagi H, Hosen N, Shiina T, Ogasawara K, Hayashi R, Nishida K. Long-term survival in non-human primates of stem cell-derived, MHC-unmatched corneal epithelial cell sheets. Stem Cell Reports. 2022 07 12; 17(7):1714-1729. PMID: 35750044; PMCID: PMC9287743; DOI: 10.1016/j.stemcr.2022.05.018;

Sasamoto Y, Lee CAA, Yoshihara M, Martin G, Ksander BR, Frank MH, Frank NY. High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells. Ocul Surf. 2022 01; 23:197-200. PMID: 34653711; PMCID: PMC8511872; DOI: 10.1016/j.jtos.2021.10.002;

Watanabe S, Hayashi R, Sasamoto Y, Tsujikawa M, Ksander BR, Frank MH, Quantock AJ, Frank NY, Nishida K. Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities. iScience. 2021 Jun 25; 24(6):102688. PMID: 34195566; PMCID: PMC8233200; DOI: 10.1016/j.isci.2021.102688;

Sasamoto Y, Sasamoto N, Tran J, Mishra A, Ksander BR, Frank MH, Frank NY. Investigation of factors associated with ABCB5-positive limbal stem cell isolation yields from human donors. Ocul Surf. 2020 01; 18(1):114-120. PMID: 31655212; PMCID: PMC7840156; DOI: 10.1016/j.jtos.2019.10.009;

Fujimoto S, Hayashi R, Hara S, Sasamoto Y, Harrington J, Tsujikawa M, Nishida K. KLF4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous TGF-ß2 suppression. Regen Ther. 2019 Dec; 11:249-257. PMID: 31538102; PMCID: PMC6745437; DOI: 10.1016/j.reth.2019.08.003;

Sasamoto Y, Ksander BR, Frank MH, Frank NY. Repairing the corneal epithelium using limbal stem cells or alternative cell-based therapies. Expert Opin Biol Ther. 2018 05; 18(5):505-513. PMID: 29471701; PMCID: PMC6317528; DOI: 10.1080/14712598.2018.1443442;

Showing 10 of 40 results. Show More

Iwama Y, Soma T, Maeda N, Sasamoto Y, Oie Y, Koh S, Nishida K. Factors Limiting the Visual Outcome After Descemet Stripping Automated Endothelial Keratoplasty: Comprehensive Analysis Including the Graft Position and Irregularity. Cornea. 2018 Jan; 37(1):20-27. PMID: 29040117

Gonzalez G, Sasamoto Y, Ksander BR, Frank MH, Frank NY. Limbal stem cells: identity, developmental origin, and therapeutic potential. Wiley Interdiscip Rev Dev Biol. 2018 03; 7(2). PMID: 29105366; PMCID: PMC5814333; DOI: 10.1002/wdev.303;

Yoshihara M, Sasamoto Y, Hayashi R, Ishikawa Y, Tsujikawa M, Hayashizaki Y, Itoh M, Kawaji H, Nishida K. High-resolution promoter map of human limbal epithelial cells cultured with keratinocyte growth factor and rho kinase inhibitor. Sci Rep. 2017 06 06; 7(1):2845. PMID: 28588247

Hayashi R, Ishikawa Y, Katori R, Sasamoto Y, Taniwaki Y, Takayanagi H, Tsujikawa M, Sekiguchi K, Quantock AJ, Nishida K. Coordinated generation of multiple ocular-like cell lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells. Nat Protoc. 2017 04; 12(4):683-696. PMID: 28253236

Hayashi R, Ishikawa Y, Sasamoto Y, Katori R, Nomura N, Ichikawa T, Araki S, Soma T, Kawasaki S, Sekiguchi K, Quantock AJ, Tsujikawa M, Nishida K. Co-ordinated ocular development from human iPS cells and recovery of corneal function. Nature. 2016 Mar 17; 531(7594):376-80. PMID: 26958835

Sasamoto Y, Hayashi R, Park SJ, Saito-Adachi M, Suzuki Y, Kawasaki S, Quantock AJ, Nakai K, Tsujikawa M, Nishida K. PAX6 Isoforms, along with Reprogramming Factors, Differentially Regulate the Induction of Cornea-specific Genes. Sci Rep. 2016 Feb 22; 6:20807. PMID: 26899008

Kisamori K, Shimoura S, Miya H, Michimasa S, Ota S, Assie M, Baba H, Baba T, Beaumel D, Dozono M, Fujii T, Fukuda N, Go S, Hammache F, Ideguchi E, Inabe N, Itoh M, Kameda D, Kawase S, Kawabata T, Kobayashi M, Kondo Y, Kubo T, Kubota Y, Kurata-Nishimura M, Lee CS, Maeda Y, Matsubara H, Miki K, Nishi T, Noji S, Sakaguchi S, Sakai H, Sasamoto Y, Sasano M, Sato H, Shimizu Y, Stolz A, Suzuki H, Takaki M, Takeda H, Takeuchi S, Tamii A, Tang L, Tokieda H, Tsumura M, Uesaka T, Yako K, Yanagisawa Y, Yokoyama R, Yoshida K. Candidate Resonant Tetraneutron State Populated by the ^{4}He(^{8}He,^{8}Be) Reaction. Phys Rev Lett. 2016 Feb 05; 116(5):052501. PMID: 26894705

Matsubara H, Tamii A, Nakada H, Adachi T, Carter J, Dozono M, Fujita H, Fujita K, Fujita Y, Hatanaka K, Horiuchi W, Itoh M, Kawabata T, Kuroita S, Maeda Y, Navrátil P, von Neumann-Cosel P, Neveling R, Okamura H, Popescu L, Poltoratska I, Richter A, Rubio B, Sakaguchi H, Sakaguchi S, Sakemi Y, Sasamoto Y, Shimbara Y, Shimizu Y, Smit FD, Suda K, Tameshige Y, Tokieda H, Yamada Y, Yosoi M, Zenihiro J. Nonquenched Isoscalar Spin-M1 Excitations in sd-Shell Nuclei. Phys Rev Lett. 2015 Sep 04; 115(10):102501. PMID: 26382672

Sasamoto Y, Oshima Y, Miki A, Wakabayashi T, Song D, Matsushita K, Hamasaki T, Nishida K. Clinical outcomes and changes in aqueous vascular endothelial growth factor levels after intravitreal bevacizumab for iris neovascularization and neovascular glaucoma: a retrospective two-dose comparative study. J Ocul Pharmacol Ther. 2012 Feb; 28(1):41-8. PMID: 21992534

Fujinaga A, Uchiyama I, Morisawa S, Yoneda M, Sasamoto Y. Methodology for setting risk-based concentrations of contaminants in soil and groundwater and application to a model contaminated site. Risk Anal. 2012 Jan; 32(1):122-37. PMID: 21978276

Sasamoto Y, Gomi F, Sawa M, Tsujikawa M, Nishida K. Effect of 1-year lutein supplementation on macular pigment optical density and visual function. Graefes Arch Clin Exp Ophthalmol. 2011 Dec; 249(12):1847-54. PMID: 21850440

Tamii A, Poltoratska I, von Neumann-Cosel P, Fujita Y, Adachi T, Bertulani CA, Carter J, Dozono M, Fujita H, Fujita K, Hatanaka K, Ishikawa D, Itoh M, Kawabata T, Kalmykov Y, Krumbholz AM, Litvinova E, Matsubara H, Nakanishi K, Neveling R, Okamura H, Ong HJ, Ozel-Tashenov B, Ponomarev VY, Richter A, Rubio B, Sakaguchi H, Sakemi Y, Sasamoto Y, Shimbara Y, Shimizu Y, Smit FD, Suzuki T, Tameshige Y, Wambach J, Yamada R, Yosoi M, Zenihiro J. Complete electric dipole response and the neutron skin in 208Pb. Phys Rev Lett. 2011 Aug 05; 107(6):062502. PMID: 21902316

Sasamoto Y, Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Nishida K. Effect of cataract in evaluation of macular pigment optical density by autofluorescence spectrometry. Invest Ophthalmol Vis Sci. 2011 Feb 16; 52(2):927-32. PMID: 21071730

Gomi F, Sawa M, Wakabayashi T, Sasamoto Y, Suzuki M, Tsujikawa M. Efficacy of intravitreal bevacizumab combined with photodynamic therapy for polypoidal choroidal vasculopathy. Am J Ophthalmol. 2010 Jul; 150(1):48-54.e1. PMID: 20609707

Sasamoto Y, Gomi F, Sawa M, Tsujikawa M, Hamasaki T. Macular pigment optical density in central serous chorioretinopathy. Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5219-25. PMID: 20445108

Yako K, Sasano M, Miki K, Sakai H, Dozono M, Frekers D, Greenfield MB, Hatanaka K, Ihara E, Kato M, Kawabata T, Kuboki H, Maeda Y, Matsubara H, Muto K, Noji S, Okamura H, Okabe TH, Sakaguchi S, Sakemi Y, Sasamoto Y, Sekiguchi K, Shimizu Y, Suda K, Tameshige Y, Tamii A, Uesaka T, Wakasa T, Zheng H. Gamow-Teller strength distributions in 48Sc by the 48Ca(p,n) and 48Ti(n,p) reactions and two-neutrino double-beta decay nuclear matrix elements. Phys Rev Lett. 2009 Jul 03; 103(1):012503. PMID: 19659141

Namba K, Ogasawara K, Kitaichi N, Morohashi T, Sasamoto Y, Kotake S, Matsuda H, Iwabuchi K, Iwabuchi C, Ohno S, Onoé K. Amelioration of experimental autoimmune uveoretinitis by pretreatment with a pathogenic peptide in liposome and anti-CD40 ligand monoclonal antibody. J Immunol. 2000 Sep 15; 165(6):2962-9. PMID: 10975803

Kitaichi N, Matsuda A, Kotake S, Namba K, Tagawa Y, Sasamoto Y, Ogasawara K, Iwabuchi K, Onoé K, Matsuda H, Nishihira J. Inhibition of experimental autoimmune uveoretinitis with anti-macrophage migration inhibitory factor antibodies. Curr Eye Res. 2000 Feb; 20(2):109-14. PMID: 10617911

Kitaichi N, Kotake S, Mizue Y, Sasamoto Y, Goda C, Iwabuchi K, Onoé K, Matsuda H, Nishihira J. High-dose corticosteroid administration induces increase of serum macrophage migration inhibitory factor in patients with Vogt-Koyanagi-Harada's disease. Microbiol Immunol. 2000; 44(12):1075-7. PMID: 11220683

Kitaichi N, Kotake S, Sasamoto Y, Namba K, Matsuda A, Ogasawara K, Onoé K, Matsuda H, Nishihira J. Prominent increase of macrophage migration inhibitory factor in the sera of patients with uveitis. Invest Ophthalmol Vis Sci. 1999 Jan; 40(1):247-50. PMID: 9888451

Muramatsu M, Kotake S, Yoshikawa K, Sasamoto Y, Matsuda H, Yamawaki S. The development of malignant rhabdoid tumor in a patient with Behçet's disease treated with ciclosporin. Graefes Arch Clin Exp Ophthalmol. 1998 Oct; 236(10):798-9. PMID: 9801898

Namba K, Ogasawara K, Kitaichi N, Matsuki N, Takahashi A, Sasamoto Y, Kotake S, Matsuda H, Iwabuchi K, Ohno S, Onoé K. Identification of a peptide inducing experimental autoimmune uveoretinitis (EAU) in H-2Ak-carrying mice. Clin Exp Immunol. 1998 Feb; 111(2):442-9. PMID: 9486417

Kotake S, Furudate N, Sasamoto Y, Yoshikawa K, Goda C, Matsuda H. Characteristics of endogenous uveitis in Hokkaido, Japan. Graefes Arch Clin Exp Ophthalmol. 1997 Jan; 235(1):5-9. PMID: 9034835

Kotake S, Furudate N, Sasamoto Y, Yoshikawa K, Goda C, Matsuda H. Characteristics of endogenous uveitis in Hokkaido, Japan. Graefes Arch Clin Exp Ophthalmol. 1996 Oct; 234(10):599-603. PMID: 8897050

Furudate N, Sasamoto Y, Kotake S, Ogasawara K, Onoé K, Matsuda H. [MHC and non-MHC gene effects on the development of experimental autoimmune uveoretinitis]. Nippon Ganka Gakkai Zasshi. 1995 May; 99(5):537-40. PMID: 7785511

Yoshikawa K, Kotake S, Ichiishi A, Sasamoto Y, Kosaka S, Matsuda H. Posterior sub-Tenon injections of repository corticosteroids in uveitis patients with cystoid macular edema. Jpn J Ophthalmol. 1995; 39(1):71-6. PMID: 7643487

Kotake S, Kimura K, Yoshikawa K, Sasamoto Y, Matsuda A, Nishikawa T, Fujii N, Matsuda H. Polymerase chain reaction for the detection of Mycobacterium tuberculosis in ocular tuberculosis. Am J Ophthalmol. 1994 Jun 15; 117(6):805-6. PMID: 8198167

Sasamoto Y, Kawano YI, Bouligny R, Wiggert B, Chader GJ, Gery I. Immunomodulation of experimental autoimmune uveoretinitis by intravenous injection of uveitogenic peptides. Invest Ophthalmol Vis Sci. 1992 Aug; 33(9):2641-9. PMID: 1639611

Hirose S, Ogasawara K, Natori T, Sasamoto Y, Ohno S, Matsuda H, Onoé K. Regulation of experimental autoimmune uveitis in rats--separation of MHC and non-MHC gene effects. Clin Exp Immunol. 1991 Dec; 86(3):419-25. PMID: 1747950

Sasamoto Y, Ohno S, Matsuda H. Studies on corticosteroid therapy in Vogt-Koyanagi-Harada disease. Ophthalmologica. 1990; 201(3):162-7. PMID: 2089358

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 40 publications over 21 distinct years, with a maximum of 5 publications in 2011

Bar chart showing 40 publications over 21 distinct years, with a maximum of 5 publications in 2011

Year	Publications
1990	1
1991	1
1992	1
1994	1
1995	2
1996	1
1997	1
1998	2
1999	1
2000	3
2009	1
2010	2
2011	5
2015	1
2016	3
2017	3
2018	2
2019	2
2021	2
2022	2
2023	3

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