Yang Jin | Profiles RNS

Yang Jin, MD., PhD

Associate Professor

Boston University School of Medicine

Dept of Medicine

Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Beijing Medical University
PhD, Rutgers University New Brunswick

Websites

	School of Medicine Faculty
	Boston Medical Center Provider Profile

Critical Care Medicine, chronic respiratory failure, acute lung injury/ARDS

Member
Boston University
Pulmonary Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

BU Research
NIH RePORTER Research

LncRNA regulates lung inflammation
09/01/2019 - 06/30/2023 (PI)
NIH/National Heart, Lung, and Blood Institute
1R01HL142758-01A1

Mechanistic insights of inflammation and organ failure after trauma or critical illness
04/01/2018 - 03/31/2022 (PI)
NIH/National Institute of General Medical Sciences
5R01GM127596-02

Development of the RNA molecule-enriched, cell type-specific exosomes
12/13/2017 - 11/30/2020 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R33AI121644-05

Mechanistic Insights into the Systemic Inflammation and Organ Failure in Sepsis
07/01/2015 - 05/31/2020 (PI)
NIH/National Institute of General Medical Sciences
5R01GM111313-05

Cross Talk Between Cav-1 and Flot1 in Lung Injury
07/01/2015 - 03/31/2018 (PI)
NIH/National Heart, Lung, and Blood Institute
7R01HL102076-06

Development of the RNA molecule-enriched, cell type-specific exosomes
12/01/2015 - 11/30/2017 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI121644-02

Title

Yr	Title	Project-Sub Proj	Pubs
2020	Mechanistic insights of inflammation and organ failure after trauma or critical illness	5R01GM127596-03	8
2020	Mechanistic insights of inflammation and organ failure after trauma or critical illness	5R01GM127596-03	8
2020	Development of the RNA molecule-enriched, cell type-specific exosomes	5R33AI121644-05	9
2019	LncRNA regulates lung inflammation	1R01HL142758-01A1	2
2019	Mechanistic insights of inflammation and organ failure after trauma or critical illness	5R01GM127596-02	8
2019	Development of the RNA molecule-enriched, cell type-specific exosomes	5R33AI121644-04	9
2018	Mechanistic insights of inflammation and organ failure after trauma or critical illness	1R01GM127596-01	8
2018	Development of the RNA molecule-enriched, cell type-specific exosomes	4R33AI121644-03	9
2017	Development of the RNA molecule-enriched, cell type-specific exosomes	5R21AI121644-02	17
2017	Mechanistic insights into the systemic inflammation and organ failure in sepsis	5R01GM111313-05	27

Showing 10 of 27 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Liu Y, Xiao J, Zhang B, Shelite TR, Su Z, Chang Q, Judy B, Li X, Drelich A, Bei J, Zhou Y, Zheng J, Jin Y, Rossi SL, Tang SJ, Wakamiya M, Saito T, Ksiazek T, Kaphalia B, Gong B. Increased talin-vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections. Lab Invest. 2020 Aug; 100(8):1030-1041. PMID: 32238906; DOI: 10.1038/s41374-020-0420-9;

Lee H, He X, Le T, Carnino JM, Jin Y. Single-step RT-qPCR for detection of extracellular vesicle microRNAs in vivo: a time- and cost-effective method. Am J Physiol Lung Cell Mol Physiol. 2020 04 01; 318(4):L742-L749. PMID: 32073880

Zhang D, Lee H, Jin Y. Delivery of Functional Small RNAs via Extracellular Vesicles In Vitro and In Vivo. Methods Mol Biol. 2020; 2115:107-117. PMID: 32006397; DOI: 10.1007/978-1-0716-0290-4_6;

Andres J, Smith LC, Murray A, Jin Y, Businaro R, Laskin JD, Laskin DL. Role of extracellular vesicles in cell-cell communication and inflammation following exposure to pulmonary toxicants. Cytokine Growth Factor Rev. 2020 02; 51:12-18. PMID: 31901309; DOI: 10.1016/j.cytogfr.2019.12.001;

Carnino JM, Lee H, Jin Y. Isolation and characterization of extracellular vesicles from Broncho-alveolar lavage fluid: a review and comparison of different methods. Respir Res. 2019 Oct 30; 20(1):240. PMID: 31666080

Lee H, Carnino JM, Jin Y. Caveolin-1 regulates extracellular vesicle-miRNA packaging. Aging (Albany NY). 2019 10 24; 11(20):8733-8735. PMID: 31652419

Zhang D, Lee H, Wang X, Groot M, Sharma L, Dela Cruz CS, Jin Y. A potential role of microvesicle-containing miR-223/142 in lung inflammation. Thorax. 2019 09; 74(9):865-874.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 31331947

Lee H, Li C, Zhang Y, Zhang D, Otterbein LE, Jin Y. Caveolin-1 selectively regulates microRNA sorting into microvesicles after noxious stimuli. J Exp Med. 2019 09 02; 216(9):2202-2220.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 31235510

Lee H, Groot M, Pinilla-Vera M, Fredenburgh LE, Jin Y. Identification of miRNA-rich vesicles in bronchoalveolar lavage fluid: Insights into the function and heterogeneity of extracellular vesicles. J Control Release. 2019 01 28; 294:43-52. PMID: 30529727

Lee H, Zhang D, Laskin DL, Jin Y. Functional Evidence of Pulmonary Extracellular Vesicles in Infectious and Noninfectious Lung Inflammation. J Immunol. 2018 09 01; 201(5):1500-1509.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 29997122; DOI: 10.4049/jimmunol.1800264;

Showing 10 of 58 results. Show More

Zhang D, Lee H, Wang X, Rai A, Groot M, Jin Y. Exosome-Mediated Small RNA Delivery: A Novel Therapeutic Approach for Inflammatory Lung Responses. Mol Ther. 2018 09 05; 26(9):2119-2130.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 30005869

Groot M, Zhang D, Jin Y. Long Non-Coding RNA Review and Implications in Lung Diseases. JSM Bioinform Genom Proteom. 2018; 3(2).View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 30854513

Hu K, Jin Y, Chroneos Z, Han X, Liu H, Lin L. Macrophage Functions and Regulation: Roles in Diseases and Implications in Therapeutics. J Immunol Res. 2018; 2018:7590350. PMID: 29967802; DOI: 10.1155/2018/7590350;

Lee H, Abston E, Zhang D, Rai A, Jin Y. Extracellular Vesicle: An Emerging Mediator of Intercellular Crosstalk in Lung Inflammation and Injury. Front Immunol. 2018; 9:924.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 29780385

Lee H, Zhang D, Rai A, Jin Y. The Obstacles to Current Extracellular Vesicle-Mediated Drug Delivery Research. J Pharm Pharm. 2017; 4(2):156-158.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 29355245; DOI: 10.15436/2377-1313.17.1331;

Lee H, Zhang D, Wu J, Otterbein LE, Jin Y. Lung Epithelial Cell-Derived Microvesicles Regulate Macrophage Migration via MicroRNA-17/221-Induced Integrin ß1 Recycling. J Immunol. 2017 08 15; 199(4):1453-1464.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 28674181; DOI: 10.4049/jimmunol.1700165;

Zhang D, Lee H, Haspel JA, Jin Y. Long noncoding RNA FOXD3-AS1 regulates oxidative stress-induced apoptosis via sponging microRNA-150. FASEB J. 2017 10; 31(10):4472-4481.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 28655711; DOI: 10.1096/fj.201700091R;

Zhu Z, Zhang D, Lee H, Menon AA, Wu J, Hu K, Jin Y. Macrophage-derived apoptotic bodies promote the proliferation of the recipient cells via shuttling microRNA-221/222. J Leukoc Biol. 2017 06; 101(6):1349-1359.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 28274991; DOI: 10.1189/jlb.3A1116-483R;

Zhang D, Lee H, Zhu Z, Minhas JK, Jin Y. Enrichment of selective miRNAs in exosomes and delivery of exosomal miRNAs in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol. 2017 Jan 01; 312(1):L110-L121.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 27881406; DOI: 10.1152/ajplung.00423.2016;

Lee H, Zhang D, Zhu Z, Dela Cruz CS, Jin Y. Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs. Sci Rep. 2016 10 12; 6:35250.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 27731391; DOI: 10.1038/srep35250;

Zhu Z, Zhang D, Lee H, Jin Y. Caenorhabditis elegans: An important tool for dissecting microRNA functions. Biomed Genet Genom. 2016 Jun; 1(2):34-36.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 28529981; DOI: 10.15761/BGG.1000106;

Lee H, Zhang D, Minhas J, Jin Y. Extracellular Vesicles Facilitate the Intercellular Communications in the Pathogenesis of Lung Injury. Cell Dev Biol. 2016 Aug; 5(2).View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 27722038

Cao Y, Zhang D, Moon HG, Lee H, Haspel JA, Hu K, Xie L, Jin Y. MiR-15a/16 Regulates Apoptosis of Lung Epithelial Cells after Oxidative Stress. Mol Med. 2016 Sep; 22:233-243.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 27257854; DOI: 10.2119/molmed.2015.00136;

Zhang D, Lee H, Cao Y, Dela Cruz CS, Jin Y. miR-185 mediates lung epithelial cell death after oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 01; 310(7):L700-10.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 26747785; PMCID: PMC4824162; DOI: 10.1152/ajplung.00392.2015;

Moon HG, Cao Y, Yang J, Lee JH, Choi HS, Jin Y. Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway. Cell Death Dis. 2015; 6:e2016.View Related Profiles.

Moon, Hyung-Geun
Jin, Yang

PMID: 26658190; PMCID: PMC4720875; DOI: 10.1038/cddis.2015.282;

Lee SJ, Zhang M, Hu K, Lin L, Zhang D, Jin Y. CCN1 suppresses pulmonary vascular smooth muscle contraction in response to hypoxia. Pulm Circ. 2015 Dec; 5(4):716-22.View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 26697179; PMCID: PMC4671746; DOI: 10.1086/683812;

Chettimada S, Yang J, Moon HG, Jin Y. Caveolae, caveolin-1 and cavin-1: Emerging roles in pulmonary hypertension. World J Respirol. 2015 Jul 28; 5(2):126-134. PMID: 28529892; DOI: 10.5320/wjr.v5.i2.126;

Zhang D, Xie L, Jin Y. In situ Detection of MicroRNAs: The Art of MicroRNA Research in Human Diseases. J Cytol Histol. 2015; Suppl 3(1).View Related Profiles.

Zhang, Duo
Jin, Yang

PMID: 28529819; DOI: 10.4172/2157-7099.S3-013;

Lin L, Jin Y, Hu K. Tissue-type plasminogen activator (tPA) promotes M1 macrophage survival through p90 ribosomal S6 kinase (RSK) and p38 mitogen-activated protein kinase (MAPK) pathway. J Biol Chem. 2015 Mar 20; 290(12):7910-7. PMID: 25670857; PMCID: PMC4367289; DOI: 10.1074/jbc.M114.599688;

Wang H, Yu B, Deng J, Jin Y, Xie L. Serum miR-122 correlates with short-term mortality in sepsis patients. Crit Care. 2014 Dec 12; 18(6):704. PMID: 25672224; PMCID: PMC4262971; DOI: 10.1186/s13054-014-0704-9;

Li JR, Zhou WX, Huang KW, Jin Y, Gao JM. Interleukin-22 exacerbates airway inflammation induced by short-term exposure to cigarette smoke in mice. Acta Pharmacol Sin. 2014 Nov; 35(11):1393-401. PMID: 25345745; DOI: 10.1038/aps.2014.91;

Moon HG, Yang J, Zheng Y, Jin Y. miR-15a/16 regulates macrophage phagocytosis after bacterial infection. J Immunol. 2014 Nov 1; 193(9):4558-67.View Related Profiles.

Moon, Hyung-Geun
Jin, Yang

PMID: 25261473; PMCID: PMC4216178; DOI: 10.4049/jimmunol.1401372;

Lin L, Jin Y, Mars WM, Reeves WB, Hu K. Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-?B pathways. Am J Pathol. 2014 Oct; 184(10):2757-67. PMID: 25131752; PMCID: PMC4715214; DOI: 10.1016/j.ajpath.2014.06.013;

Moon HG, Qin Z, Quan T, Xie L, Dela Cruz CS, Jin Y. Matrix protein CCN1 induced by bacterial DNA and CpG ODN limits lung inflammation and contributes to innate immune homeostasis. Mucosal Immunol. 2015 Mar; 8(2):243-53.View Related Profiles.

Moon, Hyung-Geun
Jin, Yang

PMID: 25005359; PMCID: PMC4289128; DOI: 10.1038/mi.2014.62;

Moon HG, Kim SH, Gao J, Quan T, Qin Z, Osorio JC, Rosas IO, Wu M, Tesfaigzi Y, Jin Y. CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke. Am J Physiol Lung Cell Mol Physiol. 2014 Aug 15; 307(4):L326-37.View Related Profiles.

Moon, Hyung-Geun
Jin, Yang

PMID: 24973403; PMCID: PMC4137167; DOI: 10.1152/ajplung.00102.2014;

Yang J, Moon HG, Chettimada S, Jin Y. Cross-talk between apoptosis and autophagy in lung epithelial cell death. J Biochem Pharmacol Res. 2014 Jun; 2(2):99-109. PMID: 27747144

Wang W, Ye Y, Li J, Li X, Zhou X, Tan D, Jin Y, Wu E, Cui Q, Wu M. Lyn regulates cytotoxicity in respiratory epithelial cells challenged by cigarette smoke extracts. Curr Mol Med. 2014; 14(5):663-72. PMID: 24894179

Wei S, Moon HG, Zheng Y, Liang X, An CH, Jin Y. Flotillin-2 modulates fas signaling mediated apoptosis after hyperoxia in lung epithelial cells. PLoS One. 2013; 8(10):e77519.View Related Profiles.

Moon, Hyung-Geun
Jin, Yang

PMID: 24204853; PMCID: PMC3799625; DOI: 10.1371/journal.pone.0077519;

Li G, Fox J, Liu Z, Liu J, Gao GF, Jin Y, Gao H, Wu M. Lyn mitigates mouse airway remodeling by downregulating the TGF-ß3 isoform in house dust mite models. J Immunol. 2013 Dec 01; 191(11):5359-70. PMID: 24127553; PMCID: PMC3863691; DOI: 10.4049/jimmunol.1301596;

Zheng Y, Lee S, Liang X, Wei S, Moon HG, Jin Y. Suppression of PTRF alleviates the polymicrobial sepsis induced by cecal ligation and puncture in mice. J Infect Dis. 2013 Dec 1; 208(11):1803-12.View Related Profiles.

Moon, Hyung-Geun
Jin, Yang

PMID: 23908488; PMCID: PMC3814834; DOI: 10.1093/infdis/jit364;

Moon HG, Zheng Y, An CH, Kim YK, Jin Y. CCN1 secretion induced by cigarette smoking extracts augments IL-8 release from bronchial epithelial cells. PLoS One. 2013; 8(7):e68199.View Related Profiles.

Moon, Hyung-Geun
Jin, Yang

PMID: 23874538; PMCID: PMC3706594; DOI: 10.1371/journal.pone.0068199;

Liang X, Wei SQ, Lee SJ, Fung JK, Zhang M, Tanaka A, Choi AM, Jin Y. p62 sequestosome 1/light chain 3b complex confers cytoprotection on lung epithelial cells after hyperoxia. Am J Respir Cell Mol Biol. 2013 Apr; 48(4):489-96. PMID: 23333919; PMCID: PMC3653608; DOI: 10.1165/rcmb.2012-0017OC;

Jin Y, Choi AM. Cross talk between autophagy and apoptosis in pulmonary hypertension. Pulm Circ. 2012 Oct; 2(4):407-14. PMID: 23372925; PMCID: PMC3555411; DOI: 10.4103/2045-8932.105029;

Jin Y, Tanaka A, Choi AM, Ryter SW. Autophagic proteins: new facets of the oxygen paradox. Autophagy. 2012 Mar; 8(3):426-8. PMID: 22302001; PMCID: PMC3337844; DOI: 10.4161/auto.19258;

Tanaka A, Jin Y, Lee SJ, Zhang M, Kim HP, Stolz DB, Ryter SW, Choi AM. Hyperoxia-induced LC3B interacts with the Fas apoptotic pathway in epithelial cell death. Am J Respir Cell Mol Biol. 2012 Apr; 46(4):507-14. PMID: 22095627; PMCID: PMC3359946; DOI: 10.1165/rcmb.2009-0415OC;

Lee SJ, Kim HP, Jin Y, Choi AM, Ryter SW. Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis. Autophagy. 2011 Aug; 7(8):829-39. PMID: 21685724; PMCID: PMC3149693

Zhang M, Lee SJ, An C, Xu JF, Joshi B, Nabi IR, Choi AM, Jin Y. Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis. Free Radic Biol Med. 2011 May 15; 50(10):1252-62. PMID: 21382479; PMCID: PMC4134776; DOI: 10.1016/j.freeradbiomed.2011.02.031;

Jin Y, Lee SJ, Minshall RD, Choi AM. Caveolin-1: a critical regulator of lung injury. Am J Physiol Lung Cell Mol Physiol. 2011 Feb; 300(2):L151-60. PMID: 21097526; PMCID: PMC4380484; DOI: 10.1152/ajplung.00170.2010;

Chen ZH, Lam HC, Jin Y, Kim HP, Cao J, Lee SJ, Ifedigbo E, Parameswaran H, Ryter SW, Choi AM. Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):18880-5. PMID: 20956295; PMCID: PMC2973911; DOI: 10.1073/pnas.1005574107;

Lee SJ, Smith A, Guo L, Alastalo TP, Li M, Sawada H, Liu X, Chen ZH, Ifedigbo E, Jin Y, Feghali-Bostwick C, Ryter SW, Kim HP, Rabinovitch M, Choi AM. Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med. 2011 Mar 01; 183(5):649-58. PMID: 20889906; PMCID: PMC3081281; DOI: 10.1164/rccm.201005-0746OC;

Zhang M, Lin L, Lee SJ, Mo L, Cao J, Ifedigbo E, Jin Y. Deletion of caveolin-1 protects hyperoxia-induced apoptosis via survivin-mediated pathways. Am J Physiol Lung Cell Mol Physiol. 2009 Nov; 297(5):L945-53. PMID: 19767411; PMCID: PMC2777493; DOI: 10.1152/ajplung.00081.2009;

Jin Y, Kim HP, Cao J, Zhang M, Ifedigbo E, Choi AM. Caveolin-1 regulates the secretion and cytoprotection of Cyr61 in hyperoxic cell death. FASEB J. 2009 Feb; 23(2):341-50. PMID: 18801924; DOI: 10.1096/fj.08-108423;

Jin Y, Kim HP, Chi M, Ifedigbo E, Ryter SW, Choi AM. Deletion of caveolin-1 protects against oxidative lung injury via up-regulation of heme oxygenase-1. Am J Respir Cell Mol Biol. 2008 Aug; 39(2):171-9. PMID: 18323531; PMCID: PMC2542454; DOI: 10.1165/rcmb.2007-0323OC;

Suh GY, Jin Y, Yi AK, Wang XM, Choi AM. CCAAT/enhancer-binding protein mediates carbon monoxide-induced suppression of cyclooxygenase-2. Am J Respir Cell Mol Biol. 2006 Aug; 35(2):220-6. PMID: 16543610; PMCID: PMC2643257; DOI: 10.1165/rcmb.2005-0154OC;

Jin Y, Kim HP, Ifedigbo E, Lau LF, Choi AM. Cyr61 protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells. Am J Respir Cell Mol Biol. 2005 Sep; 33(3):297-302. PMID: 15961723; DOI: 10.1165/rcmb.2005-0144OC;

Jin Y, Choi AM. Cytoprotection of heme oxygenase-1/carbon monoxide in lung injury. Proc Am Thorac Soc. 2005; 2(3):232-5. PMID: 16222043; DOI: 10.1513/pats.200503-023AC;

Sur R, Heck DE, Mariano TM, Jin Y, Murphy WJ, Laskin JD. UVB light suppresses nitric oxide production by murine keratinocytes and macrophages. Biochem Pharmacol. 2002 Nov 15; 64(10):1469-81. PMID: 12417260

Jin Y, Heck DE, DeGeorge G, Tian Y, Laskin JD. 5-Fluorouracil suppresses nitric oxide biosynthesis in colon carcinoma cells. Cancer Res. 1996 May 01; 56(9):1978-82. PMID: 8616835

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 58 publications over 17 distinct years, with a maximum of 8 publications in 2014

Bar chart showing 58 publications over 17 distinct years, with a maximum of 8 publications in 2014

Year	Publications
1996	1
2002	1
2005	2
2006	1
2008	2
2009	1
2010	3
2011	3
2012	2
2013	5
2014	8
2015	5
2016	6
2017	4
2018	6
2019	5
2020	3

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

COPD
Inflammation
Lung injury
Sepsis

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