Yang Jin | Profiles RNS

Yang Jin, MD., PhD

Associate Professor

Boston University School of Medicine

Dept of Medicine

Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Beijing Medical University
PhD, State University of New Jersey

Websites

	School of Medicine Faculty
	Boston Medical Center Physician Provider Profile

Critical Care Medicine, chronic respiratory failure, acute lung injury/ARDS

BU Sponsored Research
NIH RePORTER Sponsored Research

MECHANISTIC INSIGHTS OF INFLAMMATION AND ORGAN FAILURE AFTER TRAUMA OR CRITICAL ILLNESS
04/01/2018 - 03/31/2022 (PI)
NIH/National Institute of General Medical Sciences
1R01GM127596-01

DEVELOPMENT OF THE RNA MOLECULE-ENRICHED, CELL TYPE-SPECIFIC EXOSOMES
12/13/2017 - 11/30/2020 (PI)
NIH/National Institute of Allergy & Infectious Diseases
4R33AI121644-03

MECHANISTIC INSIGHTS INTO THE SYSTEMIC INFLAMMATION AND ORGAN FAILURE IN SEPSIS
07/01/2015 - 05/31/2019 (PI)
NIH/National Institute of General Medical Sciences
5R01GM111313-05

CROSS TALK BETWEEN CAV-1 AND FLOT1 IN LUNG INJURY
07/01/2015 - 03/31/2018 (PI)
NIH/National Heart, Lung, and Blood Institute
7R01HL102076-06

DEVELOPMENT OF THE RNA MOLECULE-ENRICHED, CELL TYPE-SPECIFIC EXOSOMES
12/01/2015 - 11/30/2017 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI121644-02

Yr	Title	Project-Sub Proj	Pubs
2018	Mechanistic insights of inflammation and organ failure after trauma or critical illness	1R01GM127596-01
2018	Development of the RNA molecule-enriched, cell type-specific exosomes	4R33AI121644-03
2017	Development of the RNA molecule-enriched, cell type-specific exosomes	5R21AI121644-02	5
2016	Development of the RNA molecule-enriched, cell type-specific exosomes	1R21AI121644-01	5
2016	Mechanistic insights into the systemic inflammation and organ failure in sepsis	5R01GM111313-04	6
2015	Mechanistic insights into the systemic inflammation and organ failure in sepsis	7R01GM111313-03	6
2015	Cross talk between cav-1 and flot1 in lung injury	5R01HL102076-05	13
2015	Cross talk between cav-1 and flot1 in lung injury	7R01HL102076-06	13
2014	Mechanistic insights into the systemic inflammation and organ failure in sepsis	1R01GM111313-01	6
2014	Cross talk between cav-1 and flot1 in lung injury	5R01HL102076-04	13

Showing 10 of 19 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Zhang D, Lee H, Wang X, Rai A, Groot M, Jin Y. Exosome-Mediated Small RNA Delivery: A Novel Therapeutic Approach for Inflammatory Lung Responses. Mol Ther. 2018 Sep 05; 26(9):2119-2130. PMID: 30005869.
Lee H, Abston E, Zhang D, Rai A, Jin Y. Extracellular Vesicle: An Emerging Mediator of Intercellular Crosstalk in Lung Inflammation and Injury. Front Immunol. 2018; 9:924. PMID: 29780385.
Zhang D, Lee H, Zhu Z, Minhas JK, Jin Y. Enrichment of selective miRNAs in exosomes and delivery of exosomal miRNAs in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol. 2017 Jan 01; 312(1):L110-L121. PMID: 27881406; DOI: 10.1152/ajplung.00423.2016;.
Lee H, Zhang D, Zhu Z, Dela Cruz CS, Jin Y. Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs. Sci Rep. 2016 10 12; 6:35250. PMID: 27731391; DOI: 10.1038/srep35250;.
Lee H, Zhang D, Minhas J, Jin Y. Extracellular Vesicles Facilitate the Intercellular Communications in the Pathogenesis of Lung Injury. Cell Dev Biol. 2016 Aug; 5(2). PMID: 27722038.
Cao Y, Zhang D, Moon HG, Lee H, Haspel JA, Hu K, Xie L, Jin Y. MiR-15a/16 Regulates Apoptosis of Lung Epithelial Cells after Oxidative Stress. Mol Med. 2016 Sep; 22:233-243. PMID: 27257854; DOI: 10.2119/molmed.2015.00136;.
Zhang D, Lee H, Cao Y, Dela Cruz CS, Jin Y. miR-185 mediates lung epithelial cell death after oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 01; 310(7):L700-10. PMID: 26747785; PMCID: PMC4824162; DOI: 10.1152/ajplung.00392.2015;.
Lee SJ, Zhang M, Hu K, Lin L, Zhang D, Jin Y. CCN1 suppresses pulmonary vascular smooth muscle contraction in response to hypoxia. Pulm Circ. 2015 Dec; 5(4):716-22. PMID: 26697179; PMCID: PMC4671746; DOI: 10.1086/683812;.
Lin L, Jin Y, Hu K. Tissue-type plasminogen activator (tPA) promotes M1 macrophage survival through p90 ribosomal S6 kinase (RSK) and p38 mitogen-activated protein kinase (MAPK) pathway. J Biol Chem. 2015 Mar 20; 290(12):7910-7. PMID: 25670857; PMCID: PMC4367289; DOI: 10.1074/jbc.M114.599688;.
Wang H, Yu B, Deng J, Jin Y, Xie L. Serum miR-122 correlates with short-term mortality in sepsis patients. Crit Care. 2014 Dec 12; 18(6):704. PMID: 25672224; PMCID: PMC4262971; DOI: 10.1186/s13054-014-0704-9;.

Showing 10 of 33 results. Show More

Moon HG, Yang J, Zheng Y, Jin Y. miR-15a/16 regulates macrophage phagocytosis after bacterial infection. J Immunol. 2014 Nov 1; 193(9):4558-67.View Related Profiles.
Moon, Hyung-Geun
Jin, Yang
PMID: 25261473; PMCID: PMC4216178; DOI: 10.4049/jimmunol.1401372;.
Lin L, Jin Y, Mars WM, Reeves WB, Hu K. Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-?B pathways. Am J Pathol. 2014 Oct; 184(10):2757-67. PMID: 25131752; PMCID: PMC4715214; DOI: 10.1016/j.ajpath.2014.06.013;.
Moon HG, Kim SH, Gao J, Quan T, Qin Z, Osorio JC, Rosas IO, Wu M, Tesfaigzi Y, Jin Y. CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke. Am J Physiol Lung Cell Mol Physiol. 2014 Aug 15; 307(4):L326-37.View Related Profiles.
Moon, Hyung-Geun
Jin, Yang
PMID: 24973403; PMCID: PMC4137167; DOI: 10.1152/ajplung.00102.2014;.
Yang J, Moon HG, Chettimada S, Jin Y. Cross-talk between apoptosis and autophagy in lung epithelial cell death. J Biochem Pharmacol Res. 2014 Jun; 2(2):99-109. PMID: 27747144.
Wei S, Moon HG, Zheng Y, Liang X, An CH, Jin Y. Flotillin-2 modulates fas signaling mediated apoptosis after hyperoxia in lung epithelial cells. PLoS One. 2013; 8(10):e77519.View Related Profiles.
Moon, Hyung-Geun
Jin, Yang
PMID: 24204853; PMCID: PMC3799625; DOI: 10.1371/journal.pone.0077519;.
Li G, Fox J, Liu Z, Liu J, Gao GF, Jin Y, Gao H, Wu M. Lyn mitigates mouse airway remodeling by downregulating the TGF-ß3 isoform in house dust mite models. J Immunol. 2013 Dec 01; 191(11):5359-70. PMID: 24127553; PMCID: PMC3863691; DOI: 10.4049/jimmunol.1301596;.
Zheng Y, Lee S, Liang X, Wei S, Moon HG, Jin Y. Suppression of PTRF alleviates the polymicrobial sepsis induced by cecal ligation and puncture in mice. J Infect Dis. 2013 Dec 1; 208(11):1803-12.View Related Profiles.
Moon, Hyung-Geun
Jin, Yang
PMID: 23908488; PMCID: PMC3814834; DOI: 10.1093/infdis/jit364;.
Moon HG, Zheng Y, An CH, Kim YK, Jin Y. CCN1 secretion induced by cigarette smoking extracts augments IL-8 release from bronchial epithelial cells. PLoS One. 2013; 8(7):e68199.View Related Profiles.
Moon, Hyung-Geun
Jin, Yang
PMID: 23874538; PMCID: PMC3706594; DOI: 10.1371/journal.pone.0068199;.
Liang X, Wei SQ, Lee SJ, Fung JK, Zhang M, Tanaka A, Choi AM, Jin Y. p62 sequestosome 1/light chain 3b complex confers cytoprotection on lung epithelial cells after hyperoxia. Am J Respir Cell Mol Biol. 2013 Apr; 48(4):489-96. PMID: 23333919; PMCID: PMC3653608; DOI: 10.1165/rcmb.2012-0017OC;.
Jin Y, Choi AM. Cross talk between autophagy and apoptosis in pulmonary hypertension. Pulm Circ. 2012 Oct; 2(4):407-14. PMID: 23372925; PMCID: PMC3555411; DOI: 10.4103/2045-8932.105029;.
Jin Y, Tanaka A, Choi AM, Ryter SW. Autophagic proteins: new facets of the oxygen paradox. Autophagy. 2012 Mar; 8(3):426-8. PMID: 22302001; PMCID: PMC3337844; DOI: 10.4161/auto.19258;.
Tanaka A, Jin Y, Lee SJ, Zhang M, Kim HP, Stolz DB, Ryter SW, Choi AM. Hyperoxia-induced LC3B interacts with the Fas apoptotic pathway in epithelial cell death. Am J Respir Cell Mol Biol. 2012 Apr; 46(4):507-14. PMID: 22095627; PMCID: PMC3359946; DOI: 10.1165/rcmb.2009-0415OC;.
Lee SJ, Kim HP, Jin Y, Choi AM, Ryter SW. Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis. Autophagy. 2011 Aug; 7(8):829-39. PMID: 21685724; PMCID: PMC3149693.
Zhang M, Lee SJ, An C, Xu JF, Joshi B, Nabi IR, Choi AM, Jin Y. Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis. Free Radic Biol Med. 2011 May 15; 50(10):1252-62. PMID: 21382479; PMCID: PMC4134776; DOI: 10.1016/j.freeradbiomed.2011.02.031;.
Jin Y, Lee SJ, Minshall RD, Choi AM. Caveolin-1: a critical regulator of lung injury. Am J Physiol Lung Cell Mol Physiol. 2011 Feb; 300(2):L151-60. PMID: 21097526; PMCID: PMC4380484; DOI: 10.1152/ajplung.00170.2010;.
Chen ZH, Lam HC, Jin Y, Kim HP, Cao J, Lee SJ, Ifedigbo E, Parameswaran H, Ryter SW, Choi AM. Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):18880-5. PMID: 20956295; PMCID: PMC2973911; DOI: 10.1073/pnas.1005574107;.
Lee SJ, Smith A, Guo L, Alastalo TP, Li M, Sawada H, Liu X, Chen ZH, Ifedigbo E, Jin Y, Feghali-Bostwick C, Ryter SW, Kim HP, Rabinovitch M, Choi AM. Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med. 2011 Mar 01; 183(5):649-58. PMID: 20889906; PMCID: PMC3081281; DOI: 10.1164/rccm.201005-0746OC;.
Zhang M, Lin L, Lee SJ, Mo L, Cao J, Ifedigbo E, Jin Y. Deletion of caveolin-1 protects hyperoxia-induced apoptosis via survivin-mediated pathways. Am J Physiol Lung Cell Mol Physiol. 2009 Nov; 297(5):L945-53. PMID: 19767411; PMCID: PMC2777493; DOI: 10.1152/ajplung.00081.2009;.
Jin Y, Kim HP, Cao J, Zhang M, Ifedigbo E, Choi AM. Caveolin-1 regulates the secretion and cytoprotection of Cyr61 in hyperoxic cell death. FASEB J. 2009 Feb; 23(2):341-50. PMID: 18801924; DOI: 10.1096/fj.08-108423;.
Jin Y, Kim HP, Chi M, Ifedigbo E, Ryter SW, Choi AM. Deletion of caveolin-1 protects against oxidative lung injury via up-regulation of heme oxygenase-1. Am J Respir Cell Mol Biol. 2008 Aug; 39(2):171-9. PMID: 18323531; PMCID: PMC2542454; DOI: 10.1165/rcmb.2007-0323OC;.
Suh GY, Jin Y, Yi AK, Wang XM, Choi AM. CCAAT/enhancer-binding protein mediates carbon monoxide-induced suppression of cyclooxygenase-2. Am J Respir Cell Mol Biol. 2006 Aug; 35(2):220-6. PMID: 16543610; PMCID: PMC2643257; DOI: 10.1165/rcmb.2005-0154OC;.
Jin Y, Kim HP, Ifedigbo E, Lau LF, Choi AM. Cyr61 protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells. Am J Respir Cell Mol Biol. 2005 Sep; 33(3):297-302. PMID: 15961723; DOI: 10.1165/rcmb.2005-0144OC;.
Jin Y, Choi AM. Cytoprotection of heme oxygenase-1/carbon monoxide in lung injury. Proc Am Thorac Soc. 2005; 2(3):232-5. PMID: 16222043; DOI: 10.1513/pats.200503-023AC;.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 33 publications over 12 distinct years, with a maximum of 5 publications in 2013 and 2014 and 2016

Bar chart showing 33 publications over 12 distinct years, with a maximum of 5 publications in 2013 and 2014 and 2016

Year	Publications
2005	2
2006	1
2008	2
2009	1
2010	3
2011	3
2012	2
2013	5
2014	5
2015	2
2016	5
2018	2

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

COPD
Inflammation
Lung injury
Sepsis

Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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617.638.4860

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