Xueling Wu

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine Infectious Diseases

BMC Research

Immune profiling of antibodies and B cells that recognize HIV and substances in people who use substances and live with HIV (PWUSH)
09/01/2025 - 08/31/2027 (PI)
National Institute on Drug Abuse/NIH/DHHS
1R03DA064474-01

Characterization of HIV-1 IgA bNAbs and ADCP function
02/14/2025 - 11/30/2026 (PI)
National Institute of Allergy and Infectious Diseases/NIH/DHHS

Eliciting Broadly Neutralizing Antibody Responses against HIV-1 Fusion Peptide Epitope by AB Toxin B Subunit-Based Immunogens
01/01/2025 - 07/31/2026 (Subcontract PI)
PI: Xueling Wu
New York University NIH NIAID
5R01AI181676-02

Impacts of drug abuse-mediated inflammatory perturbations on affinity maturation of anti-CD4 autoantibodies and poor immune reconstitution from ART in HIV
12/16/2024 - 05/31/2026 (Subcontract PI)
PI: Xueling Wu
Medical University of South Carolina NIH NIDA
5R01DA059854-02

Functional Assays for HIV Antibody Fc
05/01/2025 - 04/30/2026 (Subcontract PI)
PI: Xueling Wu
The Miriam Hospital NIH NIAID
5P30AI042853-26

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Ma L, Nishimura Y, Wu X, Donau O, Vincent E, Lu H, Blair RV, Doyle-Meyers LA, Martin M, Veazey RS, Xu H, Wang X. Impact of Delayed Early Antiretroviral Therapy Initiation on Treatment Outcomes in Infant Macaques Exposed to SHIVAD8. Viruses. 2025 Jun 14; 17(6). PMID: 40573440; PMCID: PMC12197331; DOI: 10.3390/v17060849;

Guo Y, Waltari E, Lu H, Sheng Z, Wu X. Novel rhesus macaque immunoglobulin germline genes identified by three sequencing approaches. Front Immunol. 2024; 15:1506348. PMID: 39776901; PMCID: PMC11703713; DOI: 10.3389/fimmu.2024.1506348;

Jia M, Zhao H, Morano NC, Lu H, Lui YM, Du H, Becker JE, Yuen KY, Ho DD, Kwong PD, Shapiro L, To KK, Wu X. Human neutralizing antibodies target a conserved lateral patch on H7N9 hemagglutinin head. Nat Commun. 2024 May 27; 15(1):4505. PMID: 38802413; PMCID: PMC11130183; DOI: 10.1038/s41467-024-48758-4;

Yu Y, Wu X, Sun Y. Precise control of digital dental unit to reduce aerosol and splatter production: new challenges for future epidemics. BMC Oral Health. 2024 Feb 10; 24(1):213. PMID: 38341576; PMCID: PMC10859011; DOI: 10.1186/s12903-024-03980-w;

Jiang W, Johnson D, Adekunle R, Heather H, Xu W, Cong X, Wu X, Fan H, Andersson LM, Robertson J, Gisslén M. COVID-19 is associated with bystander polyclonal autoreactive B cell activation as reflected by a broad autoantibody production, but none is linked to disease severity. J Med Virol. 2023 Jan; 95(1):e28134. PMID: 36086941; PMCID: PMC9538121; DOI: 10.1002/jmv.28134;

Ning W, Xu W, Cong X, Fan H, Gilkeson G, Wu X, Hughes H, Jiang W. COVID-19 mRNA vaccine BNT162b2 induces autoantibodies against type I interferons in a healthy woman. J Autoimmun. 2022 Oct; 132:102896. PMID: 36029717; PMCID: PMC9385769; DOI: 10.1016/j.jaut.2022.102896;

Wang X, Vincent E, Siddiqui S, Turnbull K, Lu H, Blair R, Wu X, Watkins M, Ziani W, Shao J, Doyle-Meyers LA, Russell-Lodrigue KE, Bohm RP, Veazey RS, Xu H. Early treatment regimens achieve sustained virologic remission in infant macaques infected with SIV at birth. Nat Commun. 2022 Aug 16; 13(1):4823. PMID: 35973985; PMCID: PMC9381774; DOI: 10.1038/s41467-022-32554-z;

Chan KW, Luo CC, Lu H, Wu X, Kong XP. A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1. Nat Commun. 2021 Nov 09; 12(1):6464. PMID: 34753944; PMCID: PMC8578649; DOI: 10.1038/s41467-021-26846-z;

Ziani W, Bauer A, Lu H, Wang X, Wu X, Bar KJ, Li H, Liu D, Shaw GM, Veazey RS, Xu H. Immune Responses and Viral Persistence in Simian/Human Immunodeficiency Virus SHIV.C.CH848-Infected Rhesus Macaques. J Virol. 2021 Apr 12; 95(9). PMID: 33568508; PMCID: PMC8104099; DOI: 10.1128/JVI.02198-20;

Jia M, Liberatore RA, Guo Y, Chan KW, Pan R, Lu H, Waltari E, Mittler E, Chandran K, Finzi A, Kaufmann DE, Seaman MS, Ho DD, Shapiro L, Sheng Z, Kong XP, Bieniasz PD, Wu X. VSV-Displayed HIV-1 Envelope Identifies Broadly Neutralizing Antibodies Class-Switched to IgG and IgA. Cell Host Microbe. 2020 Jun 10; 27(6):963-975.e5. PMID: 32315598; PMCID: PMC7294236; DOI: 10.1016/j.chom.2020.03.024;

Showing 10 of 58 results. Show More

Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prévost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB. An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity. Cell Host Microbe. 2019 Apr 10; 25(4):578-587.e5. PMID: 30974085; PMCID: PMC6592637; DOI: 10.1016/j.chom.2019.03.002;

Luo Z, Li M, Wu Y, Meng Z, Martin L, Zhang L, Ogunrinde E, Zhou Z, Qin S, Wan Z, Westerink MAJ, Warth S, Liu H, Jin P, Stroncek D, Li QZ, Wang E, Wu X, Heath SL, Li Z, Alekseyenko AV, Jiang W. Systemic translocation of Staphylococcus drives autoantibody production in HIV disease. Microbiome. 2019 Feb 14; 7(1):25. PMID: 30764863; PMCID: PMC6376754; DOI: 10.1186/s40168-019-0646-1;

Jia M, Lu H, Kong XP, Cheng-Mayer C, Wu X. Gp120 V5 Is Targeted by the First Wave of Sequential Neutralizing Antibodies in SHIVSF162P3N-Infected Rhesus Macaques. Viruses. 2018 May 16; 10(5). PMID: 29772652; PMCID: PMC5977255; DOI: 10.3390/v10050262;

Waltari E, Jia M, Jiang CS, Lu H, Huang J, Fernandez C, Finzi A, Kaufmann DE, Markowitz M, Tsuji M, Wu X. 5' Rapid Amplification of cDNA Ends and Illumina MiSeq Reveals B Cell Receptor Features in Healthy Adults, Adults With Chronic HIV-1 Infection, Cord Blood, and Humanized Mice. Front Immunol. 2018; 9:628. PMID: 29632541; PMCID: PMC5879793; DOI: 10.3389/fimmu.2018.00628;

Zhou T, Zheng A, Baxa U, Chuang GY, Georgiev IS, Kong R, O'Dell S, Shahzad-Ul-Hussan S, Shen CH, Tsybovsky Y, Bailer RT, Gift SK, Louder MK, McKee K, Rawi R, Stevenson CH, Stewart-Jones GBE, Taft JD, Waltari E, Yang Y, Zhang B, Shivatare SS, Shivatare VS, Lee CD, Wu CY, Mullikin JC, Bewley CA, Burton DR, Polonis VR, Shapiro L, Wong CH, Mascola JR, Kwong PD, Wu X. A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope. Immunity. 2018 Mar 20; 48(3):500-513.e6. PMID: 29548671; PMCID: PMC6421865; DOI: 10.1016/j.immuni.2018.02.013;

Jiang X, Totrov M, Li W, Sampson JM, Williams C, Lu H, Wu X, Lu S, Wang S, Zolla-Pazner S, Kong XP. Rationally Designed Immunogens Targeting HIV-1 gp120 V1V2 Induce Distinct Conformation-Specific Antibody Responses in Rabbits. J Virol. 2016 Dec 15; 90(24):11007-11019. PMID: 27707920; PMCID: PMC5126360; DOI: 10.1128/JVI.01409-16;

Richard J, Pacheco B, Gohain N, Veillette M, Ding S, Alsahafi N, Tolbert WD, Prévost J, Chapleau JP, Coutu M, Jia M, Brassard N, Park J, Courter JR, Melillo B, Martin L, Tremblay C, Hahn BH, Kaufmann DE, Wu X, Smith AB, Sodroski J, Pazgier M, Finzi A. Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins. EBioMedicine. 2016 Oct; 12:208-218. PMID: 27633463; PMCID: PMC5078604; DOI: 10.1016/j.ebiom.2016.09.004;

Wu X, Kong XP. Antigenic landscape of the HIV-1 envelope and new immunological concepts defined by HIV-1 broadly neutralizing antibodies. Curr Opin Immunol. 2016 Oct; 42:56-64. PMID: 27289425; PMCID: PMC5086270; DOI: 10.1016/j.coi.2016.05.013;

Lin N, Gonzalez OA, Registre L, Becerril C, Etemad B, Lu H, Wu X, Lockman S, Essex M, Moyo S, Kuritzkes DR, Sagar M. Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants. EBioMedicine. 2016 Jun; 8:237-47.View Related Profiles.

Etemad, Behzad
Registre, Ludy
Sagar, Manish
Lin, Nina
Wu, Xueling

PMID: 27428434; PMCID: PMC4919596; DOI: 10.1016/j.ebiom.2016.04.040;

Jia M, Lu H, Markowitz M, Cheng-Mayer C, Wu X. Development of Broadly Neutralizing Antibodies and Their Mapping by Monomeric gp120 in Human Immunodeficiency Virus Type 1-Infected Humans and Simian-Human Immunodeficiency Virus SHIVSF162P3N-Infected Macaques. J Virol. 2016 Apr; 90(8):4017-4031. PMID: 26842476; PMCID: PMC4810546; DOI: 10.1128/JVI.02898-15;

Zhou T, Lynch RM, Chen L, Acharya P, Wu X, Doria-Rose NA, Joyce MG, Lingwood D, Soto C, Bailer RT, Ernandes MJ, Kong R, Longo NS, Louder MK, McKee K, O'Dell S, Schmidt SD, Tran L, Yang Z, Druz A, Luongo TS, Moquin S, Srivatsan S, Yang Y, Zhang B, Zheng A, Pancera M, Kirys T, Georgiev IS, Gindin T, Peng HP, Yang AS, Mullikin JC, Gray MD, Stamatatos L, Burton DR, Koff WC, Cohen MS, Haynes BF, Casazza JP, Connors M, Corti D, Lanzavecchia A, Sattentau QJ, Weiss RA, West AP, Bjorkman PJ, Scheid JF, Nussenzweig MC, Shapiro L, Mascola JR, Kwong PD. Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell. 2015 Jun 04; 161(6):1280-92. PMID: 26004070; PMCID: PMC4683157; DOI: 10.1016/j.cell.2015.05.007;

Wu X, Zhang Z, Schramm CA, Joyce MG, Kwon YD, Zhou T, Sheng Z, Zhang B, O'Dell S, McKee K, Georgiev IS, Chuang GY, Longo NS, Lynch RM, Saunders KO, Soto C, Srivatsan S, Yang Y, Bailer RT, Louder MK, Mullikin JC, Connors M, Kwong PD, Mascola JR, Shapiro L. Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. Cell. 2015 Apr 23; 161(3):470-485. PMID: 25865483; PMCID: PMC4706178; DOI: 10.1016/j.cell.2015.03.004;

Lynch RM, Wong P, Tran L, O'Dell S, Nason MC, Li Y, Wu X, Mascola JR. HIV-1 fitness cost associated with escape from the VRC01 class of CD4 binding site neutralizing antibodies. J Virol. 2015 Apr; 89(8):4201-13. PMID: 25631091; PMCID: PMC4442379; DOI: 10.1128/JVI.03608-14;

Kepler TB, Liao HX, Alam SM, Bhaskarabhatla R, Zhang R, Yandava C, Stewart S, Anasti K, Kelsoe G, Parks R, Lloyd KE, Stolarchuk C, Pritchett J, Solomon E, Friberg E, Morris L, Karim SS, Cohen MS, Walter E, Moody MA, Wu X, Altae-Tran HR, Georgiev IS, Kwong PD, Boyd SD, Fire AZ, Mascola JR, Haynes BF. Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies. Cell Host Microbe. 2014 Sep 10; 16(3):304-13.View Related Profiles.

Kepler, Thomas
Wu, Xueling

PMID: 25211073; PMCID: PMC4163498; DOI: 10.1016/j.chom.2014.08.006;

Rudicell RS, Kwon YD, Ko SY, Pegu A, Louder MK, Georgiev IS, Wu X, Zhu J, Boyington JC, Chen X, Shi W, Yang ZY, Doria-Rose NA, McKee K, O'Dell S, Schmidt SD, Chuang GY, Druz A, Soto C, Yang Y, Zhang B, Zhou T, Todd JP, Lloyd KE, Eudailey J, Roberts KE, Donald BR, Bailer RT, Ledgerwood J, Mullikin JC, Shapiro L, Koup RA, Graham BS, Nason MC, Connors M, Haynes BF, Rao SS, Roederer M, Kwong PD, Mascola JR, Nabel GJ. Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo. J Virol. 2014 Nov; 88(21):12669-82. PMID: 25142607; PMCID: PMC4248941; DOI: 10.1128/JVI.02213-14;

Zhu J, Wu X, Zhang B, McKee K, O'Dell S, Soto C, Zhou T, Casazza JP, Mullikin JC, Kwong PD, Mascola JR, Shapiro L. De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):E4088-97. PMID: 24106303; PMCID: PMC3808619; DOI: 10.1073/pnas.1306262110;

Zhou T, Zhu J, Wu X, Moquin S, Zhang B, Acharya P, Georgiev IS, Altae-Tran HR, Chuang GY, Joyce MG, Kwon YD, Longo NS, Louder MK, Luongo T, McKee K, Schramm CA, Skinner J, Yang Y, Yang Z, Zhang Z, Zheng A, Bonsignori M, Haynes BF, Scheid JF, Nussenzweig MC, Simek M, Burton DR, Koff WC, Mullikin JC, Connors M, Shapiro L, Nabel GJ, Mascola JR, Kwong PD. Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. Immunity. 2013 Aug 22; 39(2):245-58. PMID: 23911655; PMCID: PMC3985390; DOI: 10.1016/j.immuni.2013.04.012;

Lalonde JM, Le-Khac M, Jones DM, Courter JR, Park J, Schön A, Princiotto AM, Wu X, Mascola JR, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith AB. Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization. ACS Med Chem Lett. 2013 Mar 14; 4(3):338-343. PMID: 23667716; PMCID: PMC3647702; DOI: 10.1021/ml300407y;

Joyce MG, Kanekiyo M, Xu L, Biertümpfel C, Boyington JC, Moquin S, Shi W, Wu X, Yang Y, Yang ZY, Zhang B, Zheng A, Zhou T, Zhu J, Mascola JR, Kwong PD, Nabel GJ. Outer domain of HIV-1 gp120: antigenic optimization, structural malleability, and crystal structure with antibody VRC-PG04. J Virol. 2013 Feb; 87(4):2294-306. PMID: 23236069; PMCID: PMC3571475; DOI: 10.1128/JVI.02717-12;

Ota T, Doyle-Cooper C, Cooper AB, Huber M, Falkowska E, Doores KJ, Hangartner L, Le K, Sok D, Jardine J, Lifson J, Wu X, Mascola JR, Poignard P, Binley JM, Chakrabarti BK, Schief WR, Wyatt RT, Burton DR, Nemazee D. Anti-HIV B Cell lines as candidate vaccine biosensors. J Immunol. 2012 Nov 15; 189(10):4816-24. PMID: 23066156; PMCID: PMC3626558; DOI: 10.4049/jimmunol.1202165;

Zhu J, O'Dell S, Ofek G, Pancera M, Wu X, Zhang B, Zhang Z, Mullikin JC, Simek M, Burton DR, Koff WC, Shapiro L, Mascola JR, Kwong PD. Somatic Populations of PGT135-137 HIV-1-Neutralizing Antibodies Identified by 454 Pyrosequencing and Bioinformatics. Front Microbiol. 2012; 3:315. PMID: 23024643; PMCID: PMC3441199; DOI: 10.3389/fmicb.2012.00315;

Li Y, O'Dell S, Wilson R, Wu X, Schmidt SD, Hogerkorp CM, Louder MK, Longo NS, Poulsen C, Guenaga J, Chakrabarti BK, Doria-Rose N, Roederer M, Connors M, Mascola JR, Wyatt RT. HIV-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins. J Virol. 2012 Oct; 86(20):11231-41. PMID: 22875963; PMCID: PMC3457177; DOI: 10.1128/JVI.01543-12;

Kwon YD, Finzi A, Wu X, Dogo-Isonagie C, Lee LK, Moore LR, Schmidt SD, Stuckey J, Yang Y, Zhou T, Zhu J, Vicic DA, Debnath AK, Shapiro L, Bewley CA, Mascola JR, Sodroski JG, Kwong PD. Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5663-8. PMID: 22451932; PMCID: PMC3326499; DOI: 10.1073/pnas.1112391109;

Wu X, Wang C, O'Dell S, Li Y, Keele BF, Yang Z, Imamichi H, Doria-Rose N, Hoxie JA, Connors M, Shaw GM, Wyatt RT, Mascola JR. Selection pressure on HIV-1 envelope by broadly neutralizing antibodies to the conserved CD4-binding site. J Virol. 2012 May; 86(10):5844-56. PMID: 22419808; PMCID: PMC3347292; DOI: 10.1128/JVI.07139-11;

Falkowska E, Ramos A, Feng Y, Zhou T, Moquin S, Walker LM, Wu X, Seaman MS, Wrin T, Kwong PD, Wyatt RT, Mascola JR, Poignard P, Burton DR. PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4. J Virol. 2012 Apr; 86(8):4394-403. PMID: 22345481; PMCID: PMC3318667; DOI: 10.1128/JVI.06973-11;

Bonsignori M, Montefiori DC, Wu X, Chen X, Hwang KK, Tsao CY, Kozink DM, Parks RJ, Tomaras GD, Crump JA, Kapiga SH, Sam NE, Kwong PD, Kepler TB, Liao HX, Mascola JR, Haynes BF. Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design. J Virol. 2012 Apr; 86(8):4688-92.View Related Profiles.

Kepler, Thomas
Wu, Xueling

PMID: 22301150; PMCID: PMC3318651; DOI: 10.1128/JVI.07163-11;

Wu X, Zhou T, Zhu J, Zhang B, Georgiev I, Wang C, Chen X, Longo NS, Louder M, McKee K, O'Dell S, Perfetto S, Schmidt SD, Shi W, Wu L, Yang Y, Yang ZY, Yang Z, Zhang Z, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Simek M, Burton DR, Koff WC, Doria-Rose NA, Connors M, Mullikin JC, Nabel GJ, Roederer M, Shapiro L, Kwong PD, Mascola JR. Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science. 2011 Sep 16; 333(6049):1593-602. PMID: 21835983; PMCID: PMC3516815; DOI: 10.1126/science.1207532;

Li Y, O'Dell S, Walker LM, Wu X, Guenaga J, Feng Y, Schmidt SD, McKee K, Louder MK, Ledgerwood JE, Graham BS, Haynes BF, Burton DR, Wyatt RT, Mascola JR. Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01. J Virol. 2011 Sep; 85(17):8954-67. PMID: 21715490; PMCID: PMC3165784; DOI: 10.1128/JVI.00754-11;

Wu X, Changela A, O'Dell S, Schmidt SD, Pancera M, Yang Y, Zhang B, Gorny MK, Phogat S, Robinson JE, Stamatatos L, Zolla-Pazner S, Kwong PD, Mascola JR. Immunotypes of a quaternary site of HIV-1 vulnerability and their recognition by antibodies. J Virol. 2011 May; 85(9):4578-85. PMID: 21325411; PMCID: PMC3126226; DOI: 10.1128/JVI.02585-10;

Changela A, Wu X, Yang Y, Zhang B, Zhu J, Nardone GA, O'Dell S, Pancera M, Gorny MK, Phogat S, Robinson JE, Stamatatos L, Zolla-Pazner S, Mascola JR, Kwong PD. Crystal structure of human antibody 2909 reveals conserved features of quaternary structure-specific antibodies that potently neutralize HIV-1. J Virol. 2011 Mar; 85(6):2524-35. PMID: 21191009; PMCID: PMC3067962; DOI: 10.1128/JVI.02335-10;

Wu X, Yang ZY, Li Y, Hogerkorp CM, Schief WR, Seaman MS, Zhou T, Schmidt SD, Wu L, Xu L, Longo NS, McKee K, O'Dell S, Louder MK, Wycuff DL, Feng Y, Nason M, Doria-Rose N, Connors M, Kwong PD, Roederer M, Wyatt RT, Nabel GJ, Mascola JR. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science. 2010 Aug 13; 329(5993):856-61. PMID: 20616233; PMCID: PMC2965066; DOI: 10.1126/science.1187659;

Zhou T, Georgiev I, Wu X, Yang ZY, Dai K, Finzi A, Kwon YD, Scheid JF, Shi W, Xu L, Yang Y, Zhu J, Nussenzweig MC, Sodroski J, Shapiro L, Nabel GJ, Mascola JR, Kwong PD. Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science. 2010 Aug 13; 329(5993):811-7. PMID: 20616231; PMCID: PMC2981354; DOI: 10.1126/science.1192819;

Pancera M, McLellan JS, Wu X, Zhu J, Changela A, Schmidt SD, Yang Y, Zhou T, Phogat S, Mascola JR, Kwong PD. Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1. J Virol. 2010 Aug; 84(16):8098-110. PMID: 20538861; PMCID: PMC2916520; DOI: 10.1128/JVI.00966-10;

Chen L, Kwon YD, Zhou T, Wu X, O'Dell S, Cavacini L, Hessell AJ, Pancera M, Tang M, Xu L, Yang ZY, Zhang MY, Arthos J, Burton DR, Dimitrov DS, Nabel GJ, Posner MR, Sodroski J, Wyatt R, Mascola JR, Kwong PD. Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120. Science. 2009 Nov 20; 326(5956):1123-7. PMID: 19965434; PMCID: PMC2862588; DOI: 10.1126/science.1175868;

Wu X, Zhou T, O'Dell S, Wyatt RT, Kwong PD, Mascola JR. Mechanism of human immunodeficiency virus type 1 resistance to monoclonal antibody B12 that effectively targets the site of CD4 attachment. J Virol. 2009 Nov; 83(21):10892-907. PMID: 19692465; PMCID: PMC2772753; DOI: 10.1128/JVI.01142-09;

Provine NM, Puryear WB, Wu X, Overbaugh J, Haigwood NL. The infectious molecular clone and pseudotyped virus models of human immunodeficiency virus type 1 exhibit significant differences in virion composition with only moderate differences in infectivity and inhibition sensitivity. J Virol. 2009 Sep; 83(17):9002-7.View Related Profiles.

Puryear, Wendy
Wu, Xueling

PMID: 19535443; PMCID: PMC2738156; DOI: 10.1128/JVI.00423-09;

Li Y, Svehla K, Louder MK, Wycuff D, Phogat S, Tang M, Migueles SA, Wu X, Phogat A, Shaw GM, Connors M, Hoxie J, Mascola JR, Wyatt R. Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals. J Virol. 2009 Jan; 83(2):1045-59. PMID: 19004942; PMCID: PMC2612402; DOI: 10.1128/JVI.01992-08;

Wu X, Sambor A, Nason MC, Yang ZY, Wu L, Zolla-Pazner S, Nabel GJ, Mascola JR. Soluble CD4 broadens neutralization of V3-directed monoclonal antibodies and guinea pig vaccine sera against HIV-1 subtype B and C reference viruses. Virology. 2008 Oct 25; 380(2):285-95. PMID: 18804254; PMCID: PMC3739291; DOI: 10.1016/j.virol.2008.07.007;

Eastman D, Piantadosi A, Wu X, Forthal DN, Landucci G, Kimata JT, Overbaugh J. Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses. Virol J. 2008 Aug 04; 5:90. PMID: 18680596; PMCID: PMC2518139; DOI: 10.1186/1743-422X-5-90;

Li Y, Migueles SA, Welcher B, Svehla K, Phogat A, Louder MK, Wu X, Shaw GM, Connors M, Wyatt RT, Mascola JR. Broad HIV-1 neutralization mediated by CD4-binding site antibodies. Nat Med. 2007 Sep; 13(9):1032-4. PMID: 17721546; PMCID: PMC2584972; DOI: 10.1038/nm1624;

Rainwater SM, Wu X, Nduati R, Nedellec R, Mosier D, John-Stewart G, Mbori-Ngacha D, Overbaugh J. Cloning and characterization of functional subtype A HIV-1 envelope variants transmitted through breastfeeding. Curr HIV Res. 2007 Mar; 5(2):189-97. PMID: 17346133; DOI: 10.2174/157016207780076986;

Sagar M, Wu X, Lee S, Overbaugh J. Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity. J Virol. 2006 Oct; 80(19):9586-98.View Related Profiles.

Sagar, Manish
Wu, Xueling

PMID: 16973562; PMCID: PMC1617272; DOI: 10.1128/JVI.00141-06;

Wu X, Parast AB, Richardson BA, Nduati R, John-Stewart G, Mbori-Ngacha D, Rainwater SM, Overbaugh J. Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant. J Virol. 2006 Jan; 80(2):835-44. PMID: 16378985; PMCID: PMC1346878; DOI: 10.1128/JVI.80.2.835-844.2006;

Moore JS, Wu X, Kulhavy R, Tomana M, Novak J, Moldoveanu Z, Brown R, Goepfert PA, Mestecky J. Increased levels of galactose-deficient IgG in sera of HIV-1-infected individuals. AIDS. 2005 Mar 04; 19(4):381-9. PMID: 15750391; DOI: 10.1097/01.aids.0000161767.21405.68;

Wu X, Hall S, Jackson S. Tropism-restricted neutralization by secretory IgA from parotid saliva of HIV type 1-infected individuals. AIDS Res Hum Retroviruses. 2003 Apr; 19(4):275-81. PMID: 12804003; DOI: 10.1089/088922203764969474;

Wu X, Jackson S. Plasma and salivary IgA subclasses and IgM in HIV-1-infected individuals. J Clin Immunol. 2002 Mar; 22(2):106-15. PMID: 11998891; DOI: 10.1023/a:1014435920321;

Wu X, Jackson S. A longitudinal study of plasma and salivary antibodies in HIV-1 infection. Viral Immunol. 2002; 15(2):325-35. PMID: 12081015; DOI: 10.1089/08828240260066251;

Wu X, Jackson S. Plasma and salivary IgG subclasses in HIV type 1 infection: evidence of both transudation and local synthesis of IgG in parotid saliva. AIDS Res Hum Retroviruses. 2000 Sep 20; 16(14):1423-31. PMID: 11018862; DOI: 10.1089/08892220050140973;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 58 publications over 22 distinct years, with a maximum of 8 publications in 2012

Bar chart showing 58 publications over 22 distinct years, with a maximum of 8 publications in 2012

Year	Publications
2000	1
2002	2
2003	1
2005	1
2006	2
2007	2
2008	3
2009	3
2010	4
2011	3
2012	8
2013	3
2014	2
2015	3
2016	5
2018	3
2019	2
2020	1
2021	2
2022	3
2024	3
2025	1

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