Venetia Zachariou | Profiles RNS

Venetia (Vanna) Zachariou, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

PhD, Medical College of Georgia
BSc, University of Patras

Pronouns: she/her/hers

Websites

	Zachariou laboratory
	Department of Pharmacology, Physiology & Biophysics
	LinkedIn

ORCID : 0000-0003-3194-8569

Venetia Zachariou, PhD studies signal transduction and epigenetic mechanisms of neurological disorders and their treatment using genetic mouse models, genomic assays and brain biochemistry. Her projects have investigated transcriptional and epigenetic mechanisms of chronic pain with emphasis on the identification and validation of novel treatments for the management of peripheral neuropathy and other chronic pain conditions. Another line of research in her laboratory investigates the role of G protein signal transduction complexes in drug addiction, opioid analgesia and physical dependence. By understanding intracellular adaptations to peripheral nerve injury and/or prolonged opioid exposure she aims to develop novel therapeutics for chronic pain conditions and pain/addiction comorbidities. Her team has identified several intracellular pathways that control the perception and the maintenance of chronic pain states. They also have developed novel interventions in epigenetic pathways that allow transitioning to non-opioid analgesics while preventing the development of physical dependence.

Dr. Zachariou received her BSc in pharmacy from the University of Patras, Greece, and her PhD in pharmacology from the Medical College of Georgia, USA. Following a postdoctoral fellowship in the department of psychiatry at Yale University and a junior faculty position at UT Southwestern Medical Center in Dallas, she established her laboratory at the University of Crete School of Medicine. In 2012, she joined the departments of neuroscience and pharmacological sciences at the Icahn School of Medicine at Mount Sinai in New York as an associate professor (with tenure since 2016), and as full professor (since 2018).

Dr. Zachariou is a member of the editorial boards of Biological Psychiatry, Science Signaling, Neurobiology of Pain, British Journal of Pharmacology and Molecular Pharmacology. She is a Fellow in the American College of Neuropsychopharmacology and Chair of the ASPET Neuropharmacology Division.

Chair
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Serafini RA, Farzinpour Z, Patel V, Kelley AM, Estill M, Pryce KD, Sakloth F, Teague CD, Torres-Berrio A, Nestler EJ, Shen L, Akbarian S, Karkhanis AN, Blitzer RD, Zachariou V. Nucleus accumbens myocyte enhancer factor 2C mediates the maintenance of peripheral nerve injury-induced physiological and behavioral maladaptations. Pain. 2024 Jul 09.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 38985454

Serafini RA, Ramakrishnan A, Shen L, Zachariou V. Desipramine induces anti-inflammatory dorsal root ganglion transcriptional signatures in the murine spared nerve injury model. Neurobiol Pain. 2024; 15:100153.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 38549875; PMCID: PMC10973649; DOI: 10.1016/j.ynpai.2024.100153;

Mitsi V, Ruiz A, Polizu C, Farzinpour Z, Ramakrishnan A, Serafini RA, Parise EM, Floodstrand M, Sial OK, Gaspari S, Tang CY, Nestler EJ, Schmidt EF, Shen L, Zachariou V. RGS4 Actions in Mouse Prefrontal Cortex Modulate Behavioral and Transcriptomic Responses to Chronic Stress and Ketamine. Mol Pharmacol. 2024 Mar 14; 105(4):272-285.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 38351270; PMCID: PMC10949159; DOI: 10.1124/molpharm.123.000753;

Avila-Zozaya M, Zachariou V. Genetic mouse models in opioid research: current status and future directions. J Neural Transm (Vienna). 2024 May; 131(5):491-494. PMID: 38436758

Blaze J, Browne CJ, Futamura R, Javidfar B, Zachariou V, Nestler EJ, Akbarian S. tRNA epitranscriptomic alterations associated with opioid-induced reward-seeking and long-term opioid withdrawal in male mice. Neuropsychopharmacology. 2024 Jul; 49(8):1276-1284. PMID: 38332016; PMCID: PMC11224224; DOI: 10.1038/s41386-024-01813-6;

Lai A, Iliff D, Zaheer K, Gansau J, Laudier DM, Zachariou V, Iatridis JC. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model. Int J Mol Sci. 2024 Feb 01; 25(3). PMID: 38339040; PMCID: PMC10855200; DOI: 10.3390/ijms25031762;

Pryce KD, Serafini RA, Ramakrishnan A, Nicolais A, Giosan IM, Polizu C, Torres-Berrío A, Vuppala S, Kronman H, Ruiz A, Gaspari S, Peña CJ, Sakloth F, Mitsi V, van Duzer J, Mazitschek R, Jarpe M, Shen L, Nestler EJ, Zachariou V. Author Correction: Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury. Nat Neurosci. 2024 Feb; 27(2):384.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 38253639

Serafini RA, Zachariou V. The Dorsal Raphe as a Regulator of Emotion and Reward: Beyond Pain. Biol Psychiatry. 2023 Dec 01; 94(11):834-835.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 37914503

Serafini RA, Estill M, Pekarskaya EA, Sakloth F, Shen L, Javitch JA, Zachariou V. Tianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain. Neuropsychopharmacology. 2023 Oct; 48(11):1680-1689.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 37474762; PMCID: PMC10517169; DOI: 10.1038/s41386-023-01645-w;

Serafini RA, Frere JJ, tenOever B, Zachariou V. SARS-CoV-2 and Influenza A Virus Induce Longitudinal Transcriptomic Changes in Hamster Spinal Cord Tissue. Spine (Phila Pa 1976). 2024 Mar 01; 49(5):364-367.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 37389976; PMCID: PMC10753030; DOI: 10.1097/BRS.0000000000004765;

Showing 10 of 92 results. Show More

Pryce KD, Serafini RA, Ramakrishnan A, Nicolais A, Giosan IM, Polizu C, Torres-Berrío A, Vuppala S, Kronman H, Ruiz A, Gaspari S, Peña CJ, Sakloth F, Mitsi V, van Duzer J, Mazitschek R, Jarpe M, Shen L, Nestler EJ, Zachariou V. Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury. Nat Neurosci. 2023 Jul; 26(7):1229-1244.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 37291337; PMCID: PMC10752505; DOI: 10.1038/s41593-023-01350-3;

Serafini RA, Frere JJ, Zimering J, Giosan IM, Pryce KD, Golynker I, Panis M, Ruiz A, tenOever BR, Zachariou V. SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model. Sci Signal. 2023 May 09; 16(784):eade4984.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 37159520; PMCID: PMC10422867; DOI: 10.1126/scisignal.ade4984;

Lai A, Iliff D, Zaheer K, Wang D, Gansau J, Laudier DM, Zachariou V, Iatridis JC. Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration. Int J Mol Sci. 2023 Feb 08; 24(4). PMID: 36834838; PMCID: PMC9964286; DOI: 10.3390/ijms24043425;

Sakloth F, Sanchez-Reyes OB, Ruiz A, Nicolais A, Serafini RA, Pryce KD, Bertherat F, Torres-Berrío A, Gomes I, Devi LA, Wacker D, Zachariou V. A Regional and Projection-Specific Role of RGSz1 in the Ventrolateral Periaqueductal Grey in the Modulation of Morphine Reward. Mol Pharmacol. 2023 Jan; 103(1):1-8.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 36310031; PMCID: PMC11033942; DOI: 10.1124/molpharm.122.000528;

Frere JJ, Serafini RA, Pryce KD, Zazhytska M, Oishi K, Golynker I, Panis M, Zimering J, Horiuchi S, Hoagland DA, Møller R, Ruiz A, Kodra A, Overdevest JB, Canoll PD, Borczuk AC, Chandar V, Bram Y, Schwartz R, Lomvardas S, Zachariou V, tenOever BR. SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery. Sci Transl Med. 2022 Sep 28; 14(664):eabq3059.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 35857629; PMCID: PMC9210449; DOI: 10.1126/scitranslmed.abq3059;

Serafini RA, Frere JJ, Zimering J, Giosan IM, Pryce KD, Golynker I, Panis M, Ruiz A, tenOever B, Zachariou V. SARS-CoV-2 Airway Infection Results in Time-dependent Sensory Abnormalities in a Hamster Model. bioRxiv. 2022 Aug 19.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 36032984; PMCID: PMC9413707; DOI: 10.1101/2022.08.19.504551;

Williams AV, Peña CJ, Ramos-Maciel S, Laman-Maharg A, Ordoñez-Sanchez E, Britton M, Durbin-Johnson B, Settles M, Hao R, Yokoyama S, Xu C, Luo PX, Dwyer T, Bhela S, Black AM, Labonté B, Serafini RA, Ruiz A, Neve RL, Zachariou V, Nestler EJ, Trainor BC. Comparative Transcriptional Analyses in the Nucleus Accumbens Identifies RGS2 as a Key Mediator of Depression-Related Behavior. Biol Psychiatry. 2022 Dec 15; 92(12):942-951.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 36075764; PMCID: PMC9794384; DOI: 10.1016/j.biopsych.2022.06.030;

Pryce KD, Kang HJ, Sakloth F, Liu Y, Khan S, Toth K, Kapoor A, Nicolais A, Che T, Qin L, Bertherat F, Kaniskan HÜ, Jin J, Cameron MD, Roth BL, Zachariou V, Filizola M. A promising chemical series of positive allosteric modulators of the µ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects. Neuropharmacology. 2021 09 01; 195:108673. PMID: 34153316; PMCID: PMC8410669; DOI: 10.1016/j.neuropharm.2021.108673;

Sakloth F, Polizu C, Bertherat F, Zachariou V. Regulators of G Protein Signaling in Analgesia and Addiction. Mol Pharmacol. 2020 12; 98(6):739-750. PMID: 32474445; PMCID: PMC7662521; DOI: 10.1124/mol.119.119206;

Sakloth F, Manouras L, Avrampou K, Mitsi V, Serafini RA, Pryce KD, Cogliani V, Berton O, Jarpe M, Zachariou V. HDAC6-selective inhibitors decrease nerve-injury and inflammation-associated mechanical hypersensitivity in mice. Psychopharmacology (Berl). 2020 Jul; 237(7):2139-2149.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 32388618; PMCID: PMC7470631; DOI: 10.1007/s00213-020-05525-9;

Zhou X, Wahane S, Friedl MS, Kluge M, Friedel CC, Avrampou K, Zachariou V, Guo L, Zhang B, He X, Friedel RH, Zou H. Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2. Nat Neurosci. 2020 03; 23(3):337-350. PMID: 32112058; PMCID: PMC7412870; DOI: 10.1038/s41593-020-0597-7;

Serafini RA, Pryce KD, Zachariou V. The Mesolimbic Dopamine System in Chronic Pain and Associated Affective Comorbidities. Biol Psychiatry. 2020 01 01; 87(1):64-73.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 31806085; PMCID: PMC6954000; DOI: 10.1016/j.biopsych.2019.10.018;

Yiannopoulou KG, Anastasiou AI, Zachariou V, Pelidou SH. Reasons for Failed Trials of Disease-Modifying Treatments for Alzheimer Disease and Their Contribution in Recent Research. Biomedicines. 2019 Dec 09; 7(4). PMID: 31835422; PMCID: PMC6966425; DOI: 10.3390/biomedicines7040097;

Avrampou K, Pryce KD, Ramakrishnan A, Sakloth F, Gaspari S, Serafini RA, Mitsi V, Polizu C, Swartz C, Ligas B, Richards A, Shen L, Carr FB, Zachariou V. RGS4 Maintains Chronic Pain Symptoms in Rodent Models. J Neurosci. 2019 10 16; 39(42):8291-8304.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 31308097; PMCID: PMC6794935; DOI: 10.1523/JNEUROSCI.3154-18.2019;

Serafini RA, Zachariou V. Opioid-galanin receptor heteromers differentiate the dopaminergic effects of morphine and methadone. J Clin Invest. 2019 05 28; 129(7):2653-2654.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 31135380; PMCID: PMC6597226; DOI: 10.1172/JCI128987;

Bonsi P, Ponterio G, Vanni V, Tassone A, Sciamanna G, Migliarini S, Martella G, Meringolo M, Dehay B, Doudnikoff E, Zachariou V, Goodchild RE, Mercuri NB, D'Amelio M, Pasqualetti M, Bezard E, Pisani A. RGS9-2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models. EMBO Mol Med. 2019 01; 11(1). PMID: 30552094; PMCID: PMC6328939; DOI: 10.15252/emmm.201809283;

Michaelides M, Miller ML, Egervari G, Primeaux SD, Gomez JL, Ellis RJ, Landry JA, Szutorisz H, Hoffman AF, Lupica CR, Loos RJF, Thanos PK, Bray GA, Neumaier JF, Zachariou V, Wang GJ, Volkow ND, Hurd YL. Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity. Mol Psychiatry. 2020 09; 25(9):2058-2069. PMID: 29955167; PMCID: PMC6310669; DOI: 10.1038/s41380-018-0120-7;

Gaspari S, Purushothaman I, Cogliani V, Sakloth F, Neve RL, Howland D, Ring RH, Ross EM, Shen L, Zachariou V. Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/ß-catenin pathway. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):E2085-E2094. PMID: 29440403; PMCID: PMC5834666; DOI: 10.1073/pnas.1707887115;

Chen Y, Booth C, Wang H, Wang RX, Terzi D, Zachariou V, Jiao K, Zhang J, Wang Q. Effective Attenuation of Adenosine A1R Signaling by Neurabin Requires Oligomerization of Neurabin. Mol Pharmacol. 2017 12; 92(6):630-639. PMID: 28954816

Descalzi G, Mitsi V, Purushothaman I, Gaspari S, Avrampou K, Loh YE, Shen L, Zachariou V. Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression. Sci Signal. 2017 Mar 21; 10(471). PMID: 28325815

Zhang H, Qian YL, Li C, Liu D, Wang L, Wang XY, Liu MJ, Liu H, Zhang S, Guo XY, Yang JX, Ding HL, Koo JW, Mouzon E, Deisseroth K, Nestler EJ, Zachariou V, Han MH, Cao JL. Brain-Derived Neurotrophic Factor in the Mesolimbic Reward Circuitry Mediates Nociception in Chronic Neuropathic Pain. Biol Psychiatry. 2017 Oct 15; 82(8):608-618. PMID: 28390647

Gaspari S, Cogliani V, Manouras L, Anderson EM, Mitsi V, Avrampou K, Carr FB, Zachariou V. RGS9-2 Modulates Responses to Oxycodone in Pain-Free and Chronic Pain States. Neuropsychopharmacology. 2017 Jun; 42(7):1548-1556. PMID: 28074831

Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA, Zubieta JK. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biol Psychiatry. 2016 07 15; 80(2):84-86. PMID: 27346079

Mitsi V, Zachariou V. Modulation of pain, nociception, and analgesia by the brain reward center. Neuroscience. 2016 Dec 03; 338:81-92. PMID: 27189881

Gacias M, Gaspari S, Santos PM, Tamburini S, Andrade M, Zhang F, Shen N, Tolstikov V, Kiebish MA, Dupree JL, Zachariou V, Clemente JC, Casaccia P. Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior. Elife. 2016 04 20; 5. PMID: 27097105

Mitsi V, Terzi D, Purushothaman I, Manouras L, Gaspari S, Neve RL, Stratinaki M, Feng J, Shen L, Zachariou V. RGS9-2--controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states. Proc Natl Acad Sci U S A. 2015 Sep 08; 112(36):E5088-97. PMID: 26305935

Descalzi G, Ikegami D, Ushijima T, Nestler EJ, Zachariou V, Narita M. Epigenetic mechanisms of chronic pain. Trends Neurosci. 2015 Apr; 38(4):237-46. PMID: 25765319

Caldarone BJ, Zachariou V, King SL. Rodent models of treatment-resistant depression. Eur J Pharmacol. 2015 Apr 15; 753:51-65. PMID: 25460020

Terzi D, Gaspari S, Manouras L, Descalzi G, Mitsi V, Zachariou V. RGS9-2 modulates sensory and mood related symptoms of neuropathic pain. Neurobiol Learn Mem. 2014 Nov; 115:43-8. PMID: 25150149

Carr FB, Zachariou V. Nociception and pain: lessons from optogenetics. Front Behav Neurosci. 2014; 8:69. PMID: 24723861

Gaspari S, Papachatzaki MM, Koo JW, Carr FB, Tsimpanouli ME, Stergiou E, Bagot RC, Ferguson D, Mouzon E, Chakravarty S, Deisseroth K, Lobo MK, Zachariou V. Nucleus accumbens-specific interventions in RGS9-2 activity modulate responses to morphine. Neuropsychopharmacology. 2014 Jul; 39(8):1968-77. PMID: 24561386

Stratinaki M, Varidaki A, Mitsi V, Ghose S, Magida J, Dias C, Russo SJ, Vialou V, Caldarone BJ, Tamminga CA, Nestler EJ, Zachariou V. Regulator of G protein signaling 4 [corrected] is a crucial modulator of antidepressant drug action in depression and neuropathic pain models. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8254-9. PMID: 23630294

Sarhan M, Pawlowski SA, Barthas F, Yalcin I, Kaufling J, Dardente H, Zachariou V, Dileone RJ, Barrot M, Veinante P. BDNF parabrachio-amygdaloid pathway in morphine-induced analgesia. Int J Neuropsychopharmacol. 2013 Aug; 16(7):1649-60. PMID: 23425507

Sun H, Maze I, Dietz DM, Scobie KN, Kennedy PJ, Damez-Werno D, Neve RL, Zachariou V, Shen L, Nestler EJ. Morphine epigenomically regulates behavior through alterations in histone H3 lysine 9 dimethylation in the nucleus accumbens. J Neurosci. 2012 Nov 28; 32(48):17454-64. PMID: 23197736

Waugh JL, Celver J, Sharma M, Dufresne RL, Terzi D, Risch SC, Fairbrother WG, Neve RL, Kane JP, Malloy MJ, Pullinger CR, Gu HF, Tsatsanis C, Hamilton SP, Gold SJ, Zachariou V, Kovoor A. Association between regulator of G protein signaling 9-2 and body weight. PLoS One. 2011; 6(11):e27984. PMID: 22132185

Terzi D, Cao Y, Agrimaki I, Martemyanov KA, Zachariou V. R7BP modulates opiate analgesia and tolerance but not withdrawal. Neuropsychopharmacology. 2012 Mar; 37(4):1005-12. PMID: 22089315

Holmes FE, Armenaki A, Iismaa TP, Einstein EB, Shine J, Picciotto MR, Wynick D, Zachariou V. Galanin negatively modulates opiate withdrawal via galanin receptor 1. Psychopharmacology (Berl). 2012 Apr; 220(3):619-25. PMID: 21969124

Sim-Selley LJ, Cassidy MP, Sparta A, Zachariou V, Nestler EJ, Selley DE. Effect of ?FosB overexpression on opioid and cannabinoid receptor-mediated signaling in the nucleus accumbens. Neuropharmacology. 2011 Dec; 61(8):1470-6. PMID: 21907220

Papachatzaki MM, Antal Z, Terzi D, Szücs P, Zachariou V, Antal M. RGS9-2 modulates nociceptive behaviour and opioid-mediated synaptic transmission in the spinal dorsal horn. Neurosci Lett. 2011 Aug 21; 501(1):31-4. PMID: 21741448

Psifogeorgou K, Psigfogeorgou K, Terzi D, Papachatzaki MM, Varidaki A, Ferguson D, Gold SJ, Zachariou V. A unique role of RGS9-2 in the striatum as a positive or negative regulator of opiate analgesia. J Neurosci. 2011 Apr 13; 31(15):5617-24. PMID: 21490202

Coogan AN, Papachatzaki MM, Clemens C, Baird A, Donev RM, Joosten J, Zachariou V, Thome J. Haloperidol alters circadian clock gene product expression in the mouse brain. World J Biol Psychiatry. 2011 Dec; 12(8):638-44. PMID: 21250933

Han MH, Renthal W, Ring RH, Rahman Z, Psifogeorgou K, Howland D, Birnbaum S, Young K, Neve R, Nestler EJ, Zachariou V. Brain region specific actions of regulator of G protein signaling 4 oppose morphine reward and dependence but promote analgesia. Biol Psychiatry. 2010 Apr 15; 67(8):761-9. PMID: 19914603

Terzi D, Stergiou E, King SL, Zachariou V. Regulators of G protein signaling in neuropsychiatric disorders. Prog Mol Biol Transl Sci. 2009; 86:299-333. PMID: 20374720

Traynor JR, Terzi D, Caldarone BJ, Zachariou V. RGS9-2: probing an intracellular modulator of behavior as a drug target. Trends Pharmacol Sci. 2009 Mar; 30(3):105-11. PMID: 19211160

Alfaras-Melainis K, Gomes I, Rozenfeld R, Zachariou V, Devi L. Modulation of opioid receptor function by protein-protein interactions. Front Biosci (Landmark Ed). 2009 01 01; 14(9):3594-607. PMID: 19273296

Terzi D, Zachariou V. Adeno-associated virus-mediated gene delivery approaches for the treatment of CNS disorders. Biotechnol J. 2008 Dec; 3(12):1555-63. PMID: 19072910

Krishnan V, Graham A, Mazei-Robison MS, Lagace DC, Kim KS, Birnbaum S, Eisch AJ, Han PL, Storm DR, Zachariou V, Nestler EJ. Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting. Biol Psychiatry. 2008 Aug 15; 64(4):336-43. PMID: 18468583

Charlton JJ, Allen PB, Psifogeorgou K, Chakravarty S, Gomes I, Neve RL, Devi LA, Greengard P, Nestler EJ, Zachariou V. Multiple actions of spinophilin regulate mu opioid receptor function. Neuron. 2008 Apr 24; 58(2):238-47. PMID: 18439408

Zachariou V, Liu R, LaPlant Q, Xiao G, Renthal W, Chan GC, Storm DR, Aghajanian G, Nestler EJ. Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies. Biol Psychiatry. 2008 Jun 01; 63(11):1013-21. PMID: 18222416

Fischer SJ, Arguello AA, Charlton JJ, Fuller DC, Zachariou V, Eisch AJ. Morphine blood levels, dependence, and regulation of hippocampal subgranular zone proliferation rely on administration paradigm. Neuroscience. 2008 Feb 19; 151(4):1217-24. PMID: 18248906

Psifogeorgou K, Papakosta P, Russo SJ, Neve RL, Kardassis D, Gold SJ, Zachariou V. RGS9-2 is a negative modulator of mu-opioid receptor function. J Neurochem. 2007 Oct; 103(2):617-25. PMID: 17725581

Hooks SB, Martemyanov K, Zachariou V. A role of RGS proteins in drug addiction. Biochem Pharmacol. 2008 Jan 01; 75(1):76-84. PMID: 17880927

Allen PB, Zachariou V, Svenningsson P, Lepore AC, Centonze D, Costa C, Rossi S, Bender G, Chen G, Feng J, Snyder GL, Bernardi G, Nestler EJ, Yan Z, Calabresi P, Greengard P. Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity. Neuroscience. 2006 Jul 07; 140(3):897-911. PMID: 16600521

Zachariou V, Sgambato-Faure V, Sasaki T, Svenningsson P, Berton O, Fienberg AA, Nairn AC, Greengard P, Nestler EJ. Phosphorylation of DARPP-32 at Threonine-34 is required for cocaine action. Neuropsychopharmacology. 2006 Mar; 31(3):555-62. PMID: 16123776

Zachariou V, Bolanos CA, Selley DE, Theobald D, Cassidy MP, Kelz MB, Shaw-Lutchman T, Berton O, Sim-Selley LJ, Dileone RJ, Kumar A, Nestler EJ. An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nat Neurosci. 2006 Feb; 9(2):205-11. PMID: 16415864

McClung CA, Nestler EJ, Zachariou V. Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area. J Neurosci. 2005 Jun 22; 25(25):6005-15. PMID: 15976090

Hawes JJ, Brunzell DH, Wynick D, Zachariou V, Picciotto MR. GalR1, but not GalR2 or GalR3, levels are regulated by galanin signaling in the locus coeruleus through a cyclic AMP-dependent mechanism. J Neurochem. 2005 Jun; 93(5):1168-76. PMID: 15934937

Picciotto MR, Hawes JJ, Brunzell DH, Zachariou V. Galanin can attenuate opiate reinforcement and withdrawal. Neuropeptides. 2005 Jun; 39(3):313-5. PMID: 15944028

McClung CA, Ulery PG, Perrotti LI, Zachariou V, Berton O, Nestler EJ. DeltaFosB: a molecular switch for long-term adaptation in the brain. Brain Res Mol Brain Res. 2004 Dec 20; 132(2):146-54. PMID: 15582154

Antimisiaris SG, Klepetsanis P, Zachariou V, Giannopoulou E, Ioannou PV. In vivo distribution of arsenic after i.p. injection of arsonoliposomes in balb-c mice. Int J Pharm. 2005 Jan 31; 289(1-2):151-8. PMID: 15652207

Gold SJ, Zachariou V. In situ hybridization analysis of RGS mRNA regulation and behavioral phenotyping of RGS mutant mice. Methods Enzymol. 2004; 389:205-29. PMID: 15313568

Zachariou V, Georgescu D, Sanchez N, Rahman Z, DiLeone R, Berton O, Neve RL, Sim-Selley LJ, Selley DE, Gold SJ, Nestler EJ. Essential role for RGS9 in opiate action. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13656-61. PMID: 14595021

Zachariou V, Brunzell DH, Hawes J, Stedman DR, Bartfai T, Steiner RA, Wynick D, Langel U, Picciotto MR. The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):9028-33. PMID: 12853567

Rahman Z, Schwarz J, Gold SJ, Zachariou V, Wein MN, Choi KH, Kovoor A, Chen CK, DiLeone RJ, Schwarz SC, Selley DE, Sim-Selley LJ, Barrot M, Luedtke RR, Self D, Neve RL, Lester HA, Simon MI, Nestler EJ. RGS9 modulates dopamine signaling in the basal ganglia. Neuron. 2003 Jun 19; 38(6):941-52. PMID: 12818179

Georgescu D, Zachariou V, Barrot M, Mieda M, Willie JT, Eisch AJ, Yanagisawa M, Nestler EJ, DiLeone RJ. Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J Neurosci. 2003 Apr 15; 23(8):3106-11. PMID: 12716916

Barrot M, Olivier JD, Perrotti LI, DiLeone RJ, Berton O, Eisch AJ, Impey S, Storm DR, Neve RL, Yin JC, Zachariou V, Nestler EJ. CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):11435-40. PMID: 12165570

Shaw-Lutchman TZ, Barrot M, Wallace T, Gilden L, Zachariou V, Impey S, Duman RS, Storm D, Nestler EJ. Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawal. J Neurosci. 2002 May 01; 22(9):3663-72. PMID: 11978842

Zachariou V, Benoit-Marand M, Allen PB, Ingrassia P, Fienberg AA, Gonon F, Greengard P, Picciotto MR. Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1. Biol Psychiatry. 2002 Apr 15; 51(8):612-20. PMID: 11955461

Picciotto MR, Caldarone BJ, Brunzell DH, Zachariou V, Stevens TR, King SL. Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacol Ther. 2001 Nov-Dec; 92(2-3):89-108. PMID: 11916531

Zachariou V, Caldarone BJ, Weathers-Lowin A, George TP, Elsworth JD, Roth RH, Changeux JP, Picciotto MR. Nicotine receptor inactivation decreases sensitivity to cocaine. Neuropsychopharmacology. 2001 May; 24(5):576-89. PMID: 11282258

Zachariou V, Georgescu D, Kansal L, Merriam P, Picciotto MR. Galanin receptor 1 gene expression is regulated by cyclic AMP through a CREB-dependent mechanism. J Neurochem. 2001 Jan; 76(1):191-200. PMID: 11145992

Zachariou V, Thome J, Parikh K, Picciotto MR. Upregulation of galanin binding sites and GalR1 mRNA levels in the mouse locus coeruleus following chronic morphine treatments and precipitated morphine withdrawal. Neuropsychopharmacology. 2000 Aug; 23(2):127-37. PMID: 10882839

Caldarone BJ, George TP, Zachariou V, Picciotto MR. Gender differences in learned helplessness behavior are influenced by genetic background. Pharmacol Biochem Behav. 2000 Aug; 66(4):811-7. PMID: 10973520

Picciotto MR, Caldarone BJ, King SL, Zachariou V. Nicotinic receptors in the brain. Links between molecular biology and behavior. Neuropsychopharmacology. 2000 May; 22(5):451-65. PMID: 10731620

Thome J, Gewirtz JC, Sakai N, Zachariou V, Retz-Junginger P, Retz W, Duman RS, Rösler M. Polymorphisms of the human apolipoprotein E promoter and bleomycin hydrolase gene: risk factors for Alzheimer's dementia? Neurosci Lett. 1999 Oct 15; 274(1):37-40. PMID: 10530514

Zachariou V, Parikh K, Picciotto MR. Centrally administered galanin blocks morphine place preference in the mouse. Brain Res. 1999 Jun 12; 831(1-2):33-42. PMID: 10411981

Papapetropoulos A, Piccardoni P, Cirino G, Bucci M, Sorrentino R, Cicala C, Johnson K, Zachariou V, Sessa WC, Altieri DC. Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling. Proc Natl Acad Sci U S A. 1998 Apr 14; 95(8):4738-42. PMID: 9539808

Picciotto MR, Zoli M, Zachariou V, Changeux JP. Contribution of nicotinic acetylcholine receptors containing the beta 2-subunit to the behavioural effects of nicotine. Biochem Soc Trans. 1997 Aug; 25(3):824-9. PMID: 9388554

Zachariou V, Goldstein BD. Dynorphin-(1-8) inhibits the release of substance P-like immunoreactivity in the spinal cord of rats following a noxious mechanical stimulus. Eur J Pharmacol. 1997 Apr 04; 323(2-3):159-65. PMID: 9128834

Zachariou V, Goldstein BD, Yeomans DC. Low but not high rate noxious radiant skin heating evokes a capsaicin-sensitive increase in spinal cord dorsal horn release of substance P. Brain Res. 1997 Mar 28; 752(1-2):143-50. PMID: 9106450

Zachariou V, Goldstein BD. Delta-Opioid receptor modulation of the release of substance P-like immunoreactivity in the dorsal horn of the rat following mechanical or thermal noxious stimulation. Brain Res. 1996 Oct 14; 736(1-2):305-14. PMID: 8930337

Zachariou V, Goldstein BD. Kappa-opioid receptor modulation of the release of substance P in the dorsal horn. Brain Res. 1996 Jan 08; 706(1):80-8. PMID: 8720494

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 92 publications over 28 distinct years, with a maximum of 7 publications in 2011 and 2024