Venetia (Vanna) Zachariou, PhD
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

PhD, Medical College of Georgia
BSc, University of Patras

Venetia Zachariou, PhD studies signal transduction and epigenetic mechanisms of neurological disorders and their treatment using genetic mouse models, genomic assays and brain biochemistry. Her projects have investigated transcriptional and epigenetic mechanisms of chronic pain with emphasis on the identification and validation of novel treatments for the management of peripheral neuropathy and other chronic pain conditions. Another line of research in her laboratory investigates the role of G protein signal transduction complexes in drug addiction, opioid analgesia and physical dependence. By understanding intracellular adaptations to peripheral nerve injury and/or prolonged opioid exposure she aims to develop novel therapeutics for chronic pain conditions and pain/addiction comorbidities. Her team has identified several intracellular pathways that control the perception and the maintenance of chronic pain states. They also have developed novel interventions in epigenetic pathways that allow transitioning to non-opioid analgesics while preventing the development of physical dependence.

Dr. Zachariou received her BSc in pharmacy from the University of Patras, Greece, and her PhD in pharmacology from the Medical College of Georgia. Following a postdoctoral fellowship in the department of psychiatry at Yale University and a junior faculty position at UT Southwestern Medical Center in Dallas, she established her laboratory at the University of Crete School of Medicine. In 2012, she joined the departments of neuroscience and pharmacological sciences at the Icahn School of Medicine at Mount Sinai in New York as an associate professor (with tenure since 2016), and as full professor (since 2018).

Dr. Zachariou is a member of the editorial boards of Biological Psychiatry, Molecular Pain, Science Signaling, Neurobiology of Pain, section editor for European Journal of Neuroscience, and member of the NIH MCNP study section. She is a Fellow in the American College of Neuropsychopharmacology and Chair elect for the ASPET Neuropharmacology Division.

Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics


Yr Title Project-Sub Proj Pubs
2023 Animal Models Core 5P01DA047233-05-8100
2022 Cellular mechanisms of antidepressant drug actions in neuropathic pain models 3R01NS086444-08S1
2022 A Female Specific Role of RGSz1 in Modulation of Chronic Pain 5R01NS111351-03
2022 Cellular mechanisms of antidepressant drug actions in neuropathic pain models 3R01NS086444-09S1
2022 Cellular mechanisms of antidepressant drug actions in neuropathic pain models 5R01NS086444-09
2022 Cellular mechanisms of antidepressant drug actions in neuropathic pain models 3R01NS086444-09S2
2022 Animal Models Core 5P01DA047233-04-8100
2021 Cellular mechanisms of antidepressant drug actions in neuropathic pain models 3R01NS086444-07S1 12
2021 A Female Specific Role of RGSz1 in Modulation of Chronic Pain 5R01NS111351-02
2021 Cellular mechanisms of antidepressant drug actions in neuropathic pain models 5R01NS086444-08 12
Showing 10 of 31 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Lai A, Iliff D, Zaheer K, Wang D, Gansau J, Laudier DM, Zachariou V, Iatridis JC. Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration. Int J Mol Sci. 2023 Feb 08; 24(4). PMID: 36834838; PMCID: PMC9964286; DOI: 10.3390/ijms24043425;
  2. Sakloth F, Sanchez-Reyes OB, Ruiz A, Nicolais A, Serafini RA, Pryce KD, Bertherat F, Torres-Berrío A, Gomes I, Devi LA, Wacker D, Zachariou V. A Regional and Projection-Specific Role of RGSz1 in the Ventrolateral Periaqueductal Grey in the Modulation of Morphine Reward. Mol Pharmacol. 2023 Jan; 103(1):1-8. PMID: 36310031; DOI: 10.1124/molpharm.122.000528;
  3. Frere JJ, Serafini RA, Pryce KD, Zazhytska M, Oishi K, Golynker I, Panis M, Zimering J, Horiuchi S, Hoagland DA, Møller R, Ruiz A, Kodra A, Overdevest JB, Canoll PD, Borczuk AC, Chandar V, Bram Y, Schwartz R, Lomvardas S, Zachariou V, tenOever BR. SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery. Sci Transl Med. 2022 Sep 28; 14(664):eabq3059. PMID: 35857629; PMCID: PMC9210449; DOI: 10.1126/scitranslmed.abq3059;
  4. Serafini RA, Frere JJ, Zimering J, Giosan IM, Pryce KD, Golynker I, Panis M, Ruiz A, tenOever B, Zachariou V. SARS-CoV-2 Airway Infection Results in Time-dependent Sensory Abnormalities in a Hamster Model. bioRxiv. 2022 Aug 19. PMID: 36032984; PMCID: PMC9413707; DOI: 10.1101/2022.08.19.504551;
  5. Williams AV, Peña CJ, Ramos-Maciel S, Laman-Maharg A, Ordoñez-Sanchez E, Britton M, Durbin-Johnson B, Settles M, Hao R, Yokoyama S, Xu C, Luo PX, Dwyer T, Bhela S, Black AM, Labonté B, Serafini RA, Ruiz A, Neve RL, Zachariou V, Nestler EJ, Trainor BC. Comparative Transcriptional Analyses in the Nucleus Accumbens Identifies RGS2 as a Key Mediator of Depression-Related Behavior. Biol Psychiatry. 2022 Dec 15; 92(12):942-951. PMID: 36075764; PMCID: PMC9794384; DOI: 10.1016/j.biopsych.2022.06.030;
  6. Pryce KD, Kang HJ, Sakloth F, Liu Y, Khan S, Toth K, Kapoor A, Nicolais A, Che T, Qin L, Bertherat F, Kaniskan HÜ, Jin J, Cameron MD, Roth BL, Zachariou V, Filizola M. A promising chemical series of positive allosteric modulators of the µ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects. Neuropharmacology. 2021 09 01; 195:108673. PMID: 34153316; PMCID: PMC8410669; DOI: 10.1016/j.neuropharm.2021.108673;
  7. Sakloth F, Polizu C, Bertherat F, Zachariou V. Regulators of G Protein Signaling in Analgesia and Addiction. Mol Pharmacol. 2020 12; 98(6):739-750. PMID: 32474445; PMCID: PMC7662521; DOI: 10.1124/mol.119.119206;
  8. Sakloth F, Manouras L, Avrampou K, Mitsi V, Serafini RA, Pryce KD, Cogliani V, Berton O, Jarpe M, Zachariou V. HDAC6-selective inhibitors decrease nerve-injury and inflammation-associated mechanical hypersensitivity in mice. Psychopharmacology (Berl). 2020 Jul; 237(7):2139-2149. PMID: 32388618; PMCID: PMC7470631; DOI: 10.1007/s00213-020-05525-9;
  9. Zhou X, Wahane S, Friedl MS, Kluge M, Friedel CC, Avrampou K, Zachariou V, Guo L, Zhang B, He X, Friedel RH, Zou H. Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2. Nat Neurosci. 2020 03; 23(3):337-350. PMID: 32112058; PMCID: PMC7412870; DOI: 10.1038/s41593-020-0597-7;
  10. Serafini RA, Pryce KD, Zachariou V. The Mesolimbic Dopamine System in Chronic Pain and Associated Affective Comorbidities. Biol Psychiatry. 2020 01 01; 87(1):64-73. PMID: 31806085; PMCID: PMC6954000; DOI: 10.1016/j.biopsych.2019.10.018;
Showing 10 of 80 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 80 publications over 27 distinct years, with a maximum of 7 publications in 2011


2022 ASPET-Neuropharmacology Division: Chair-elect
2021 American College of Neuropsychopharmacology: Fellow
2016 American College of Neuropsychopharmacology: Member
2009 NIDA Minisymposium: INRC Travel award
2003 Winter Conference in Brain: Research Travel Award
2002 NIDA: Travel award
1994 Medical College of Georgia: Sigma kappa Society award on Graduate Student Research
1992-1995 Department of Pharmacology, Medical College of Georgia: Fellowship for Teaching Assistantship in Pharmacology
1991 NATO meeting on Vascular Endothelium, Rhodes Greece: NATO Travel Award
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