Randal Serafini | Profiles RNS

Randal Serafini, PhD

Postdoctoral Associate (previously held)

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

Publications
Contact Info

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Tuazon JA, Siddiqi AD, Serafini RA, Rawson CD, Guin RN, Ryva BA, Ding JL. Prioritizing mental health support for physician-scientist trainees. Commun Med (Lond). 2025 Apr 13; 5(1):113. PMID: 40223101; PMCID: PMC11994758; DOI: 10.1038/s43856-025-00843-5;

Giosan IM, Serafini RA, Ramakrishnan A, Tuffy MJ, Zimering J, Babes A, Shen L, Zachariou V. HDAC6 inhibition ameliorates sensory hypersensitivity and reduces immune cell signatures in the dorsal root ganglia in murine chronic pain models. Mol Pharmacol. 2025 May; 107(5):100034.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 40311408

Serafini RA, Frere JJ, Giosan IM, Nwaneshiudu CA. SARS-CoV-2-induced sensory perturbations: A narrative review of clinical phenotypes, molecular pathologies, and possible interventions. Brain Behav Immun Health. 2025 May; 45:100983. PMID: 40231214; PMCID: PMC11995741; DOI: 10.1016/j.bbih.2025.100983;

Serafini RA, Curtis MDE, Alimperti S. Intellectual property training should be embedded in the biomedical education process. Nat Biotechnol. 2024 Dec; 42(12):1924-1925. PMID: 39663476

Serafini RA, Farzinpour Z, Patel V, Kelley AM, Estill M, Pryce KD, Sakloth F, Teague CD, Torres-Berrio A, Nestler EJ, Shen L, Akbarian S, Karkhanis AN, Blitzer RD, Zachariou V. Nucleus accumbens myocyte enhancer factor 2C mediates the maintenance of peripheral nerve injury-induced physiological and behavioral maladaptations. Pain. 2024 Dec 01; 165(12):2733-2748.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 38985454

Serafini RA, Ramakrishnan A, Shen L, Zachariou V. Desipramine induces anti-inflammatory dorsal root ganglion transcriptional signatures in the murine spared nerve injury model. Neurobiol Pain. 2024; 15:100153.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 38549875; PMCID: PMC10973649; DOI: 10.1016/j.ynpai.2024.100153;

Mitsi V, Ruiz A, Polizu C, Farzinpour Z, Ramakrishnan A, Serafini RA, Parise EM, Floodstrand M, Sial OK, Gaspari S, Tang CY, Nestler EJ, Schmidt EF, Shen L, Zachariou V. RGS4 Actions in Mouse Prefrontal Cortex Modulate Behavioral and Transcriptomic Responses to Chronic Stress and Ketamine. Mol Pharmacol. 2024 Mar 14; 105(4):272-285.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 38351270; PMCID: PMC10949159; DOI: 10.1124/molpharm.123.000753;

Ding JL, Christophers B, Rupert DD, Tang CY, Serafini RA, Jansen CS, Curtis MDE, Chesebro AG, Waldman AD. How to diversify the dwindling physician-scientist workforce after the US affirmative action ban. Nat Med. 2024 Mar; 30(3):635-637. PMID: 38291299

Pryce KD, Serafini RA, Ramakrishnan A, Nicolais A, Giosan IM, Polizu C, Torres-Berrío A, Vuppala S, Kronman H, Ruiz A, Gaspari S, Peña CJ, Sakloth F, Mitsi V, van Duzer J, Mazitschek R, Jarpe M, Shen L, Nestler EJ, Zachariou V. Author Correction: Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury. Nat Neurosci. 2024 Feb; 27(2):384.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 38253639

Cheng CP, Serafini RA, Labkovich M, Warburton AJ, Navarro V, Shaik N, Reddy H, Chelnis JG. Clinical report: Virtual reality enables comparable contrast sensitivity measurements to in-office testing (pilot study). Optom Vis Sci. 2024 Feb 01; 101(2):124-128. PMID: 38408310; PMCID: PMC10901448; DOI: 10.1097/OPX.0000000000002107;

Showing 10 of 27 results. Show More

Serafini RA, Zachariou V. The Dorsal Raphe as a Regulator of Emotion and Reward: Beyond Pain. Biol Psychiatry. 2023 Dec 01; 94(11):834-835.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 37914503

Powell SK, Serafini RA, Frere JJ, De Pins A, Saali A, Sultana SA, Ali M, Dale B, Datta D, Aaronson C, Meah Y, Katz CL, Gluhoski V. Provision of Cognitive Behavior Therapy for Depression and Anxiety Disorders by Medical Student Trainees. Acad Psychiatry. 2024 Feb; 48(1):10-17. PMID: 37770702

Serafini RA, Estill M, Pekarskaya EA, Sakloth F, Shen L, Javitch JA, Zachariou V. Tianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain. Neuropsychopharmacology. 2023 Oct; 48(11):1680-1689.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 37474762; PMCID: PMC10517169; DOI: 10.1038/s41386-023-01645-w;

Serafini RA, Frere JJ, tenOever B, Zachariou V. SARS-CoV-2 and Influenza A Virus Induce Longitudinal Transcriptomic Changes in Hamster Spinal Cord Tissue. Spine (Phila Pa 1976). 2024 Mar 01; 49(5):364-367.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 37389976; PMCID: PMC10753030; DOI: 10.1097/BRS.0000000000004765;

Pryce KD, Serafini RA, Ramakrishnan A, Nicolais A, Giosan IM, Polizu C, Torres-Berrío A, Vuppala S, Kronman H, Ruiz A, Gaspari S, Peña CJ, Sakloth F, Mitsi V, van Duzer J, Mazitschek R, Jarpe M, Shen L, Nestler EJ, Zachariou V. Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury. Nat Neurosci. 2023 Jul; 26(7):1229-1244.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 37291337; PMCID: PMC10752505; DOI: 10.1038/s41593-023-01350-3;

Serafini RA, Frere JJ, Zimering J, Giosan IM, Pryce KD, Golynker I, Panis M, Ruiz A, tenOever BR, Zachariou V. SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model. Sci Signal. 2023 May 09; 16(784):eade4984.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 37159520; PMCID: PMC10422867; DOI: 10.1126/scisignal.ade4984;

Sakloth F, Sanchez-Reyes OB, Ruiz A, Nicolais A, Serafini RA, Pryce KD, Bertherat F, Torres-Berrío A, Gomes I, Devi LA, Wacker D, Zachariou V. A Regional and Projection-Specific Role of RGSz1 in the Ventrolateral Periaqueductal Grey in the Modulation of Morphine Reward. Mol Pharmacol. 2023 Jan; 103(1):1-8.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 36310031; PMCID: PMC11033942; DOI: 10.1124/molpharm.122.000528;

Labkovich M, Warburton AJ, Ying S, Valliani AA, Kissel N, Serafini RA, Mathew R, Paul M, Hovstadius SM, Navarro VN, Patel A, Reddy H, Chelnis JG. Virtual Reality Hemifield Measurements for Corrective Surgery Eligibility in Ptosis Patients: A Pilot Clinical Trial. Transl Vis Sci Technol. 2022 Oct 03; 11(10):35. PMID: 36282119; PMCID: PMC9617504; DOI: 10.1167/tvst.11.10.35;

Frere JJ, Serafini RA, Pryce KD, Zazhytska M, Oishi K, Golynker I, Panis M, Zimering J, Horiuchi S, Hoagland DA, Møller R, Ruiz A, Kodra A, Overdevest JB, Canoll PD, Borczuk AC, Chandar V, Bram Y, Schwartz R, Lomvardas S, Zachariou V, tenOever BR. SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery. Sci Transl Med. 2022 Sep 28; 14(664):eabq3059.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 35857629; PMCID: PMC9210449; DOI: 10.1126/scitranslmed.abq3059;

Serafini RA, Frere JJ, Zimering J, Giosan IM, Pryce KD, Golynker I, Panis M, Ruiz A, tenOever B, Zachariou V. SARS-CoV-2 Airway Infection Results in Time-dependent Sensory Abnormalities in a Hamster Model. bioRxiv. 2022 Aug 19.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 36032984; PMCID: PMC9413707; DOI: 10.1101/2022.08.19.504551;

Powell SK, Saali A, Frere J, Magill E, Krystal H, Serafini RA, Sultana S, Dale B, Ali M, Kumar V, Datta D, Hernandez-Antonio J, Aronson A, Meah YS, Gluhoski V, Katz CL. Design of and outcomes in a student-run free mental health clinic serving the uninsured in East Harlem. BMC Psychiatry. 2022 Jul 26; 22(1):501. PMID: 35883038; PMCID: PMC9321276; DOI: 10.1186/s12888-022-04112-w;

Williams AV, Peña CJ, Ramos-Maciel S, Laman-Maharg A, Ordoñez-Sanchez E, Britton M, Durbin-Johnson B, Settles M, Hao R, Yokoyama S, Xu C, Luo PX, Dwyer T, Bhela S, Black AM, Labonté B, Serafini RA, Ruiz A, Neve RL, Zachariou V, Nestler EJ, Trainor BC. Comparative Transcriptional Analyses in the Nucleus Accumbens Identifies RGS2 as a Key Mediator of Depression-Related Behavior. Biol Psychiatry. 2022 Dec 15; 92(12):942-951.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 36075764; PMCID: PMC9794384; DOI: 10.1016/j.biopsych.2022.06.030;

Serafini RA, Powell SK, Frere JJ, Saali A, Krystal HL, Kumar V, Yashaswini C, Hernandez J, Moody K, Aronson A, Meah Y, Katz CL. Psychological distress in the face of a pandemic: An observational study characterizing the impact of COVID-19 on immigrant outpatient mental health. Psychiatry Res. 2021 Jan; 295:113595. PMID: 33296817; PMCID: PMC7805919; DOI: 10.1016/j.psychres.2020.113595;

Sakloth F, Manouras L, Avrampou K, Mitsi V, Serafini RA, Pryce KD, Cogliani V, Berton O, Jarpe M, Zachariou V. HDAC6-selective inhibitors decrease nerve-injury and inflammation-associated mechanical hypersensitivity in mice. Psychopharmacology (Berl). 2020 Jul; 237(7):2139-2149.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 32388618; PMCID: PMC7470631; DOI: 10.1007/s00213-020-05525-9;

Serafini RA, Pryce KD, Zachariou V. The Mesolimbic Dopamine System in Chronic Pain and Associated Affective Comorbidities. Biol Psychiatry. 2020 01 01; 87(1):64-73.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 31806085; PMCID: PMC6954000; DOI: 10.1016/j.biopsych.2019.10.018;

Avrampou K, Pryce KD, Ramakrishnan A, Sakloth F, Gaspari S, Serafini RA, Mitsi V, Polizu C, Swartz C, Ligas B, Richards A, Shen L, Carr FB, Zachariou V. RGS4 Maintains Chronic Pain Symptoms in Rodent Models. J Neurosci. 2019 10 16; 39(42):8291-8304.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 31308097; PMCID: PMC6794935; DOI: 10.1523/JNEUROSCI.3154-18.2019;

Serafini RA, Zachariou V. Opioid-galanin receptor heteromers differentiate the dopaminergic effects of morphine and methadone. J Clin Invest. 2019 05 28; 129(7):2653-2654.View Related Profiles.

Serafini, Randal
Zachariou, Venetia

PMID: 31135380; PMCID: PMC6597226; DOI: 10.1172/JCI128987;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 27 publications over 6 distinct years, with a maximum of 7 publications in 2024

Bar chart showing 27 publications over 6 distinct years, with a maximum of 7 publications in 2024

Year	Publications
2019	2
2020	3
2022	6
2023	6
2024	7
2025	3

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72 E. Concord St
Boston MA 02118
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Zachariou, Venetia

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