Soile Nymark | Profiles RNS

Soile Nymark, MD, PhD

Postdoctoral Fellow (previously held)

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

Publications
Contact Info

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Peussa H, Fedele C, Tran H, Marttinen M, Fadjukov J, Mäntylä E, Priimägi A, Nymark S, Ihalainen TO. Light-Induced Nanoscale Deformation in Azobenzene Thin Film Triggers Rapid Intracellular Ca2+ Increase via Mechanosensitive Cation Channels. Adv Sci (Weinh). 2023 Dec; 10(35):e2206190. PMID: 37946608; PMCID: PMC10724422; DOI: 10.1002/advs.202206190;

Tervonen A, Korpela S, Nymark S, Hyttinen J, Ihalainen TO. The Effect of Substrate Stiffness on Elastic Force Transmission in the Epithelial Monolayers over Short Timescales. Cell Mol Bioeng. 2023 Dec; 16(5-6):475-495. PMID: 38099211; PMCID: PMC10716100; DOI: 10.1007/s12195-023-00772-0;

Mäntylä E, Montonen T, Azzari L, Mattola S, Hannula M, Vihinen-Ranta M, Hyttinen J, Vippola M, Foi A, Nymark S, Ihalainen TO. Iterative immunostaining combined with expansion microscopy and image processing reveals nanoscopic network organization of nuclear lamina. Mol Biol Cell. 2023 Aug 01; 34(9):br13. PMID: 37342871; PMCID: PMC10398900; DOI: 10.1091/mbc.E22-09-0448;

Karema-Jokinen V, Koskela A, Hytti M, Hongisto H, Viheriälä T, Liukkonen M, Torsti T, Skottman H, Kauppinen A, Nymark S, Kaarniranta K. Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients. J Biol Chem. 2023 Jun; 299(6):104770. PMID: 37137441; PMCID: PMC10240424; DOI: 10.1016/j.jbc.2023.104770;

Ignatova I, Frolov R, Nymark S. The retinal pigment epithelium displays electrical excitability and lateral signal spreading. BMC Biol. 2023 Apr 17; 21(1):84. PMID: 37069561; PMCID: PMC10111697; DOI: 10.1186/s12915-023-01559-5;

Korkka I, Skottman H, Nymark S. Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Transl Med. 2022 Jul 20; 11(7):753-766. PMID: 35639962; PMCID: PMC9299513; DOI: 10.1093/stcltm/szac029;

Peussa H, Kreutzer J, Mäntylä E, Mäki AJ, Nymark S, Kallio P, Ihalainen TO. Pneumatic equiaxial compression device for mechanical manipulation of epithelial cell packing and physiology. PLoS One. 2022; 17(6):e0268570. PMID: 35657824; PMCID: PMC9165817; DOI: 10.1371/journal.pone.0268570;

Fadjukov J, Wienbar S, Hakanen S, Aho V, Vihinen-Ranta M, Ihalainen TO, Schwartz GW, Nymark S. Gap junctions and connexin hemichannels both contribute to the electrical properties of retinal pigment epithelium. J Gen Physiol. 2022 04 04; 154(4). PMID: 35275193; PMCID: PMC8922333; DOI: 10.1085/jgp.202112916;

Viheriälä T, Hongisto H, Sorvari J, Skottman H, Nymark S, Ilmarinen T. Cell maturation influences the ability of hESC-RPE to tolerate cellular stress. Stem Cell Res Ther. 2022 01 24; 13(1):30. PMID: 35073969; PMCID: PMC8785579; DOI: 10.1186/s13287-022-02712-7;

Viheriälä T, Sorvari J, Ihalainen TO, Mörö A, Grönroos P, Schlie-Wolter S, Chichkov B, Skottman H, Nymark S, Ilmarinen T. Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE. Sci Rep. 2021 01 13; 11(1):933. PMID: 33441679; PMCID: PMC7806758; DOI: 10.1038/s41598-020-79638-8;

Showing 10 of 33 results. Show More

Fedele C, Mäntylä E, Belardi B, Hamkins-Indik T, Cavalli S, Netti PA, Fletcher DA, Nymark S, Priimagi A, Ihalainen TO. Azobenzene-based sinusoidal surface topography drives focal adhesion confinement and guides collective migration of epithelial cells. Sci Rep. 2020 09 18; 10(1):15329. PMID: 32948792; PMCID: PMC7501301; DOI: 10.1038/s41598-020-71567-w;

Johansson JK, Karema-Jokinen VI, Hakanen S, Jylhä A, Uusitalo H, Vihinen-Ranta M, Skottman H, Ihalainen TO, Nymark S. Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium. BMC Biol. 2019 08 15; 17(1):63. PMID: 31412898; PMCID: PMC6694495; DOI: 10.1186/s12915-019-0681-1;

Alarautalahti V, Ragauskas S, Hakkarainen JJ, Uusitalo-Järvinen H, Uusitalo H, Hyttinen J, Kalesnykas G, Nymark S. Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology. Invest Ophthalmol Vis Sci. 2019 05 01; 60(6):1914-1927. PMID: 31042799

Tervonen A, Ihalainen TO, Nymark S, Hyttinen J. Structural dynamics of tight junctions modulate the properties of the epithelial barrier. PLoS One. 2019; 14(4):e0214876. PMID: 30964903; PMCID: PMC6456171; DOI: 10.1371/journal.pone.0214876;

Sorvari J, Viheriälä T, Ilmarinen T, Ihalainen TO, Nymark S. Analysis of ATP-Induced Ca2+ Responses at Single Cell Level in Retinal Pigment Epithelium Monolayers. Adv Exp Med Biol. 2019; 1185:525-530. PMID: 31884665

Korkka I, Viheriälä T, Juuti-Uusitalo K, Uusitalo-Järvinen H, Skottman H, Hyttinen J, Nymark S. Functional Voltage-Gated Calcium Channels Are Present in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Transl Med. 2019 02; 8(2):179-193. PMID: 30394009; PMCID: PMC6344904; DOI: 10.1002/sctm.18-0026;

Alarautalahti V, Hiltunen M, Onnela N, Nymark S, Kellomäki M, Hyttinen J. Polypyrrole-coated electrodes show thickness-dependent stability in different conditions during 42-day follow-up in vitro. J Biomed Mater Res B Appl Biomater. 2018 08; 106(6):2202-2213. PMID: 29058808

Frederiksen R, Nymark S, Kolesnikov AV, Berry JD, Adler L, Koutalos Y, Kefalov VJ, Cornwall MC. Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods. J Gen Physiol. 2016 Jul; 148(1):1-11.View Related Profiles.

Berry, Justin
Cornwall, M.
Frederiksen, Rikard
Nymark, Soile

PMID: 27353443; PMCID: PMC4924931; DOI: 10.1085/jgp.201511538;

Berry J, Frederiksen R, Yao Y, Nymark S, Chen J, Cornwall C. Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods. J Neurosci. 2016 Jun 29; 36(26):6973-87.View Related Profiles.

Berry, Justin
Frederiksen, Rikard
Nymark, Soile

PMID: 27358455; PMCID: PMC4926242; DOI: 10.1523/JNEUROSCI.3544-15.2016;

Ilmarinen T, Hiidenmaa H, Kööbi P, Nymark S, Sorkio A, Wang JH, Stanzel BV, Thieltges F, Alajuuma P, Oksala O, Kataja M, Uusitalo H, Skottman H. Ultrathin Polyimide Membrane as Cell Carrier for Subretinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigment Epithelium. PLoS One. 2015; 10(11):e0143669. PMID: 26606532; PMCID: PMC4659637; DOI: 10.1371/journal.pone.0143669;

Vainio I, Abu Khamidakh A, Paci M, Skottman H, Juuti-Uusitalo K, Hyttinen J, Nymark S. Computational Model of Ca2+ Wave Propagation in Human Retinal Pigment Epithelial ARPE-19 Cells. PLoS One. 2015; 10(6):e0128434. PMID: 26070134; PMCID: PMC4466493; DOI: 10.1371/journal.pone.0128434;

Ragauskas S, Leinonen H, Puranen J, Rönkkö S, Nymark S, Gurevicius K, Lipponen A, Kontkanen O, Puoliväli J, Tanila H, Kalesnykas G. Early retinal function deficit without prominent morphological changes in the R6/2 mouse model of Huntington's disease. PLoS One. 2014; 9(12):e113317. PMID: 25469887; PMCID: PMC4254453; DOI: 10.1371/journal.pone.0113317;

Wang JS, Nymark S, Frederiksen R, Estevez ME, Shen SQ, Corbo JC, Cornwall MC, Kefalov VJ. Chromophore supply rate-limits mammalian photoreceptor dark adaptation. J Neurosci. 2014 Aug 20; 34(34):11212-21.View Related Profiles.

Cornwall, M.
Frederiksen, Rikard
Nymark, Soile

PMID: 25143602; PMCID: PMC4138333; DOI: 10.1523/JNEUROSCI.1245-14.2014;

Tervonen A, Vainio I, Nymark S, Hyttinen J. Prediction of passive drug permeability across the blood-retinal barrier. Pharm Res. 2014 Sep; 31(9):2297-311. PMID: 24623477; DOI: 10.1007/s11095-014-1325-3;

Juuti-Uusitalo K, Delporte C, Grégoire F, Perret J, Huhtala H, Savolainen V, Nymark S, Hyttinen J, Uusitalo H, Willermain F, Skottman H. Aquaporin expression and function in human pluripotent stem cell-derived retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci. 2013 May; 54(5):3510-9. PMID: 23687169; DOI: 10.1167/iovs.13-11800;

Subrizi A, Hiidenmaa H, Ilmarinen T, Nymark S, Dubruel P, Uusitalo H, Yliperttula M, Urtti A, Skottman H. Generation of hESC-derived retinal pigment epithelium on biopolymer coated polyimide membranes. Biomaterials. 2012 Nov; 33(32):8047-54. PMID: 22892561; DOI: 10.1016/j.biomaterials.2012.07.033;

Nymark S, Frederiksen R, Woodruff ML, Cornwall MC, Fain GL. Bleaching of mouse rods: microspectrophotometry and suction-electrode recording. J Physiol. 2012 May 1; 590(Pt 10):2353-64.View Related Profiles.

Cornwall, M.
Frederiksen, Rikard
Nymark, Soile

PMID: 22451436; PMCID: PMC3424757; DOI: 10.1113/jphysiol.2012.228627;

Heikkinen H, Vinberg F, Nymark S, Koskelainen A. Mesopic background lights enhance dark-adapted cone ERG flash responses in the intact mouse retina: a possible role for gap junctional decoupling. J Neurophysiol. 2011 May; 105(5):2309-18. PMID: 21389302; DOI: 10.1152/jn.00536.2010;

Haldin C, Nymark S, Aho AC, Koskelainen A, Donner K. Rod phototransduction determines the trade-off of temporal integration and speed of vision in dark-adapted toads. J Neurosci. 2009 May 6; 29(18):5716-25. PMID: 19420240; PMCID: PMC6665239; DOI: 10.1523/JNEUROSCI.3888-08.2009;

Heikkinen H, Nymark S, Donner K, Koskelainen A. Temperature dependence of dark-adapted sensitivity and light-adaptation in photoreceptors with A1 visual pigments: a comparison of frog L-cones and rods. Vision Res. 2009 Jul; 49(14):1717-28. PMID: 19348836; DOI: 10.1016/j.visres.2009.03.024;

Heikkinen H, Nymark S, Koskelainen A. Mouse cone photoresponses obtained with electroretinogram from the isolated retina. Vision Res. 2008 Jan; 48(2):264-72. PMID: 18166210; DOI: 10.1016/j.visres.2007.11.005;

Nymark S, Haldin C, Tenhu H, Koskelainen A. A new method for measuring free drug concentration: retinal tissue as a biosensor. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2583-8. PMID: 16723474

Nymark S, Heikkinen H, Haldin C, Donner K, Koskelainen A. Light responses and light adaptation in rat retinal rods at different temperatures. J Physiol. 2005 Sep 15; 567(Pt 3):923-38. PMID: 16037091; PMCID: PMC1474229; DOI: 10.1113/jphysiol.2005.090662;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 33 publications over 17 distinct years, with a maximum of 5 publications in 2023

Bar chart showing 33 publications over 17 distinct years, with a maximum of 5 publications in 2023

Year	Publications
2005	1
2006	1
2007	1
2009	2
2011	1
2012	2
2013	1
2014	3
2015	2
2016	2
2017	1
2018	1
2019	4
2020	1
2021	1
2022	4
2023	5

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72 E. Concord St Instructional (L)
Boston MA 02118
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