M. Carter Cornwall, PhD
Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, University of Utah



The work in our laboratory is focused on understanding the response of the vertebrate eye to and recovery from the effects of bright light. Our principal approach is to make electrophysiological measurements of rod and cone photoreceptors of cold-blooded vertebrate animals, and to correlate these physiological responses to microspectrophotomeric measurements of the visual pigments as well as microfluorometric measurements of the concentration of vitamin A and Ca2+ contained within the cells. The reduction of all–trans retinal to Vitamin A is one of the principal initial steps that must occur following exposure to bright light to allow recovery of sensitivity (dark adaptation). Experiments have also shown that Ca2+ is a principal messenger substance during bright (bleaching) adaptation.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




Spectral and Metabolic Basis of Visual Responses
09/01/2017 - 06/30/2018 (PI)
NIH/National Eye Institute
2R01EY001157-43

Phototransduction in Dark Adaptation and retinal Degeneration
02/01/2016 - 01/31/2018 (PI)
University of Southern California NIH NEI
5R01EY012155-19

Spectral and Metabolic Basis of Visual Responses
04/01/2012 - 03/31/2017 (PI)
NIH/National Eye Institute
5R01EY001157-42

Reactions of the Visual Cycle in Rods and Cones
10/01/2004 - 09/30/2006 (PI)
Russian Academy of Sciences US Civ Res & Dev Fdn

Spatial and Temporal Resolution of Retinol Fluorescence in Photoreceptors
07/01/2000 - 06/30/2002 (PI)
Foundation Fighting Blindness, The




Yr Title Project-Sub Proj Pubs
2017 Spectral & Metabolic Basis of Visual Responses 2R01EY001157-43 46
2015 Spectral and Metabolic Basis of Visual Responses 5R01EY001157-42 46
2014 Spectral and Metabolic Basis of Visual Responses 5R01EY001157-41 46
2013 Spectral and Metabolic Basis of Visual Responses 5R01EY001157-40 46
2012 Spectral and Metabolic Basis of Visual Responses 2R01EY001157-39 46
2011 Spectral and Metabolic Basis of Visual Responses 5R01EY001157-38 46
2010 Spectral and Metabolic Basis of Visual Responses 5R01EY001157-37 46
2009 Spectral and Metabolic Basis of Visual Responses 5R01EY001157-36 46
2008 Spectral and Metabolic Basis of Visual Responses 5R01EY001157-35 46
2007 Spectral and Metabolic Basis of Visual Responses 2R01EY001157-34 46
Showing 10 of 38 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Morshedian A, Toomey MB, Pollock GE, Frederiksen R, Enright JM, McCormick SD, Cornwall MC, Fain GL, Corbo JC. Cambrian origin of the CYP27C1-mediated vitamin A1-to-A2 switch, a key mechanism of vertebrate sensory plasticity. R Soc Open Sci. 2017 Jul; 4(7):170362. PMID: 28791166.
  2. Pahlberg J, Frederiksen R, Pollock GE, Miyagishima KJ, Sampath AP, Cornwall MC. Voltage-sensitive conductances increase the sensitivity of rod photoresponses following pigment bleaching. J Physiol. 2017 Jun 01; 595(11):3459-3469. PMID: 28168711; DOI: 10.1113/JP273398;.
  3. Yue WW, Frederiksen R, Ren X, Luo DG, Yamashita T, Shichida Y, Cornwall MC, Yau KW. Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket. Elife. 2017 Feb 10; 6. PMID: 28186874; DOI: 10.7554/eLife.18492;.
  4. Sato S, Frederiksen R, Cornwall MC, Kefalov VJ. The retina visual cycle is driven by cis retinol oxidation in the outer segments of cones. Vis Neurosci. 2017 Jan; 34:E004. PMID: 28359344; DOI: 10.1017/S0952523817000013;.
  5. Toomey MB, Lind O, Frederiksen R, Curley RW, Riedl KM, Wilby D, Schwartz SJ, Witt CC, Harrison EH, Roberts NW, Vorobyev M, McGraw KJ, Cornwall MC, Kelber A, Corbo JC. Complementary shifts in photoreceptor spectral tuning unlock the full adaptive potential of ultraviolet vision in birds. Elife. 2016 Jul 12; 5. PMID: 27402384; PMCID: PMC4947394; DOI: 10.7554/eLife.15675;.
  6. Frederiksen R, Nymark S, Kolesnikov AV, Berry JD, Adler L, Koutalos Y, Kefalov VJ, Cornwall MC. Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods. J Gen Physiol. 2016 Jul; 148(1):1-11.View Related Profiles. PMID: 27353443; PMCID: PMC4924931; DOI: 10.1085/jgp.201511538;.
  7. Wilby D, Toomey MB, Olsson P, Frederiksen R, Cornwall MC, Oulton R, Kelber A, Corbo JC, Roberts NW. Optics of cone photoreceptors in the chicken (Gallus gallus domesticus). J R Soc Interface. 2015 Oct 6; 12(111):20150591. PMID: 26423439; PMCID: PMC4614498; DOI: 10.1098/rsif.2015.0591;.
  8. Toomey MB, Collins AM, Frederiksen R, Cornwall MC, Timlin JA, Corbo JC. A complex carotenoid palette tunes avian colour vision. J R Soc Interface. 2015 Oct 6; 12(111):20150563. PMID: 26446559; PMCID: PMC4614492; DOI: 10.1098/rsif.2015.0563;.
  9. Wang JS, Nymark S, Frederiksen R, Estevez ME, Shen SQ, Corbo JC, Cornwall MC, Kefalov VJ. Chromophore supply rate-limits mammalian photoreceptor dark adaptation. J Neurosci. 2014 Aug 20; 34(34):11212-21.View Related Profiles. PMID: 25143602; PMCID: PMC4138333; DOI: 10.1523/JNEUROSCI.1245-14.2014;.
  10. Frederiksen R, Boyer NP, Nickle B, Chakrabarti KS, Koutalos Y, Crouch RK, Oprian D, Cornwall MC. Low aqueous solubility of 11-cis-retinal limits the rate of pigment formation and dark adaptation in salamander rods. J Gen Physiol. 2012 Jun; 139(6):493-505.View Related Profiles. PMID: 22641642; PMCID: PMC3362518; DOI: 10.1085/jgp.201110685;.
Showing 10 of 56 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 56 publications over 25 distinct years, with a maximum of 4 publications in 1996 and 2001 and 2006 and 2009 and 2017

YearPublications
19892
19903
19932
19943
19951
19964
19971
19981
19991
20002
20014
20021
20032
20042
20052
20064
20073
20081
20094
20102
20122
20141
20152
20162
20174
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

electrophysiology
fluorescence microscopy
neuroophthalmology
spectrophotometry

Available to Mentor as: (Review Mentor Role Definitions):
  • Research / Scholarly Mentor
Contact for Mentoring:


72 E. Concord St Instructional (L)
Boston MA 02118
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