Keywords
Last Name

M. Carter Cornwall, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-4256
ORCID ORCID Icon0000-0002-0847-939X
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

 Research Expertise & Professional Interests
The work in our laboratory is focused on understanding the response of the vertebrate eye to and recovery from the effects of bright light. Our principal approach is to make electrophysiological measurements of rod and cone photoreceptors of cold-blooded vertebrate animals, and to correlate these physiological responses to microspectrophotomeric measurements of the visual pigments as well as microfluorometric measurements of the concentration of vitamin A and Ca2+ contained within the cells. The reduction of all–trans retinal to Vitamin A is one of the principal initial steps that must occur following exposure to bright light to allow recovery of sensitivity (dark adaptation). Experiments have also shown that Ca2+ is a principal messenger substance during bright (bleaching) adaptation.

 Self-Described Keywords
  • electrophysiology
  • fluorescence microscopy
  • neuroophthalmology
  • spectrophotometry
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Frederiksen R, Boyer NP, Nickle B, Chakrabarti KS, Koutalos Y, Crouch RK, Oprian D, Cornwall MC. Low aqueous solubility of 11-cis-retinal limits the rate of pigment formation and dark adaptation in salamander rods. J Gen Physiol. 2014 Nov; 144(5):487.
    View in: PubMed
  2. Wang JS, Nymark S, Frederiksen R, Estevez ME, Shen SQ, Corbo JC, Cornwall MC, Kefalov VJ. Chromophore supply rate-limits Mammalian photoreceptor dark adaptation. J Neurosci. 2014 Aug 20; 34(34):11212-21.
    View in: PubMed
  3. Frederiksen R, Boyer NP, Nickle B, Chakrabarti KS, Koutalos Y, Crouch RK, Oprian D, Cornwall MC. Low aqueous solubility of 11-cis-retinal limits the rate of pigment formation and dark adaptation in salamander rods. J Gen Physiol. 2012 Jun; 139(6):493-505.
    View in: PubMed
  4. Nymark S, Frederiksen R, Woodruff ML, Cornwall MC, Fain GL. Bleaching of mouse rods: microspectrophotometry and suction-electrode recording. J Physiol. 2012 May 1; 590(Pt 10):2353-64.
    View in: PubMed
  5. Koutalos Y, Cornwall MC. Microfluorometric measurement of the formation of all-trans-retinol in the outer segments of single isolated vertebrate photoreceptors. Methods Mol Biol. 2010; 652:129-47.
    View in: PubMed
  6. Kefalov VJ, Cornwall MC, Fain GL. Physiological studies of the interaction between opsin and chromophore in rod and cone visual pigments. Methods Mol Biol. 2010; 652:95-114.
    View in: PubMed
  7. Miyagishima KJ, Cornwall MC, Sampath AP. Metabolic constraints on the recovery of sensitivity after visual pigment bleaching in retinal rods. J Gen Physiol. 2009 Sep; 134(3):165-75.
    View in: PubMed
  8. Estevez ME, Kolesnikov AV, Ala-Laurila P, Crouch RK, Govardovskii VI, Cornwall MC. The 9-methyl group of retinal is essential for rapid Meta II decay and phototransduction quenching in red cones. J Gen Physiol. 2009 Aug; 134(2):137-50.
    View in: PubMed
  9. Ala-Laurila P, Cornwall MC, Crouch RK, Kono M. The action of 11-cis-retinol on cone opsins and intact cone photoreceptors. J Biol Chem. 2009 Jun 12; 284(24):16492-500.
    View in: PubMed
  10. Wang JS, Estevez ME, Cornwall MC, Kefalov VJ. Intra-retinal visual cycle required for rapid and complete cone dark adaptation. Nat Neurosci. 2009 Mar; 12(3):295-302.
    View in: PubMed
  11. Dizhoor AM, Woodruff ML, Olshevskaya EV, Cilluffo MC, Cornwall MC, Sieving PA, Fain GL. Night blindness and the mechanism of constitutive signaling of mutant G90D rhodopsin. J Neurosci. 2008 Nov 5; 28(45):11662-72.
    View in: PubMed
  12. Ala-Laurila P, Donner K, Crouch RK, Cornwall MC. Chromophore switch from 11-cis-dehydroretinal (A2) to 11-cis-retinal (A1) decreases dark noise in salamander red rods. J Physiol. 2007 Nov 15; 585(Pt 1):57-74.
    View in: PubMed
  13. Cornwall MC, Ala-Laurila P. A perfect marriage: molecular genetics ties the knot with electrophysiology in studies of visual transduction. J Gen Physiol. 2007 Jul; 130(1):7-10.
    View in: PubMed
  14. Wu Q, Blakeley LR, Cornwall MC, Crouch RK, Wiggert BN, Koutalos Y. Interphotoreceptor retinoid-binding protein is the physiologically relevant carrier that removes retinol from rod photoreceptor outer segments. Biochemistry. 2007 Jul 24; 46(29):8669-79.
    View in: PubMed
  15. Estevez ME, Ala-Laurila P, Crouch RK, Cornwall MC. Turning cones off: the role of the 9-methyl group of retinal in red cones. J Gen Physiol. 2006 Dec; 128(6):671-85.
    View in: PubMed
  16. Kolesnikov AV, Ala-Laurila P, Shukolyukov SA, Crouch RK, Wiggert B, Estevez ME, Govardovskii VI, Cornwall MC. Visual cycle and its metabolic support in gecko photoreceptors. Vision Res. 2007 Feb; 47(3):363-74.
    View in: PubMed
  17. He Q, Alexeev D, Estevez ME, McCabe SL, Calvert PD, Ong DE, Cornwall MC, Zimmerman AL, Makino CL. Cyclic nucleotide-gated ion channels in rod photoreceptors are protected from retinoid inhibition. J Gen Physiol. 2006 Oct; 128(4):473-85.
    View in: PubMed
  18. Ala-Laurila P, Kolesnikov AV, Crouch RK, Tsina E, Shukolyukov SA, Govardovskii VI, Koutalos Y, Wiggert B, Estevez ME, Cornwall MC. Visual cycle: Dependence of retinol production and removal on photoproduct decay and cell morphology. J Gen Physiol. 2006 Aug; 128(2):153-69.
    View in: PubMed
  19. Kolesnikov AV, Shukolyukov SA, Cornwall MC, Govardovskii VI. Recombination reaction of rhodopsin in situ studied by photoconversion of "indicator yellow". Vision Res. 2006 May; 46(10):1665-75.
    View in: PubMed
  20. Kefalov VJ, Estevez ME, Kono M, Goletz PW, Crouch RK, Cornwall MC, Yau KW. Breaking the covalent bond--a pigment property that contributes to desensitization in cones. Neuron. 2005 Jun 16; 46(6):879-90.
    View in: PubMed
  21. Chen C, Tsina E, Cornwall MC, Crouch RK, Vijayaraghavan S, Koutalos Y. Reduction of all-trans retinal to all-trans retinol in the outer segments of frog and mouse rod photoreceptors. Biophys J. 2005 Mar; 88(3):2278-87.
    View in: PubMed
  22. Tsina E, Chen C, Koutalos Y, Ala-Laurila P, Tsacopoulos M, Wiggert B, Crouch RK, Cornwall MC. Physiological and microfluorometric studies of reduction and clearance of retinal in bleached rod photoreceptors. J Gen Physiol. 2004 Oct; 124(4):429-43.
    View in: PubMed
  23. Jin S, Cornwall MC, Oprian DD. Opsin activation as a cause of congenital night blindness. Nat Neurosci. 2003 Jul; 6(7):731-5.
    View in: PubMed
  24. Cornwall MC, Tsina E, Crouch RK, Wiggert B, Chen C, Koutalos Y. Regulation of the visual cycle: retinol dehydrogenase and retinol fluorescence measurements in vertebrate retina. Adv Exp Med Biol. 2003; 533:353-60.
    View in: PubMed
  25. Crouch RK, Kefalov V, Gärtner W, Cornwall MC. Use of retinal analogues for the study of visual pigment function. Methods Enzymol. 2002; 343:29-48.
    View in: PubMed
  26. Ma J, Znoiko S, Othersen KL, Ryan JC, Das J, Isayama T, Kono M, Oprian DD, Corson DW, Cornwall MC, Cameron DA, Harosi FI, Makino CL, Crouch RK. A visual pigment expressed in both rod and cone photoreceptors. Neuron. 2001 Nov 8; 32(3):451-61.
    View in: PubMed
  27. Matthews HR, Cornwall MC, Crouch RK. Prolongation of actions of Ca2+ early in phototransduction by 9-demethylretinal. J Gen Physiol. 2001 Oct; 118(4):377-90.
    View in: PubMed
  28. Kefalov VJ, Crouch RK, Cornwall MC. Role of noncovalent binding of 11-cis-retinal to opsin in dark adaptation of rod and cone photoreceptors. Neuron. 2001 Mar; 29(3):749-55.
    View in: PubMed
  29. Fain GL, Matthews HR, Cornwall MC, Koutalos Y. Adaptation in vertebrate photoreceptors. Physiol Rev. 2001 Jan; 81(1):117-151.
    View in: PubMed
  30. Corson DW, Kefalov VJ, Cornwall MC, Crouch RK. Effect of 11-cis 13-demethylretinal on phototransduction in bleach-adapted rod and cone photoreceptors. J Gen Physiol. 2000 Aug; 116(2):283-97.
    View in: PubMed
  31. Cornwall MC, Jones GJ, Kefalov VJ, Fain GL, Matthews HR. Electrophysiological methods for measurement of activation of phototransduction by bleached visual pigment in salamander photoreceptors. Methods Enzymol. 2000; 316:224-52.
    View in: PubMed
  32. Sampath AP, Matthews HR, Cornwall MC, Bandarchi J, Fain GL. Light-dependent changes in outer segment free-Ca2+ concentration in salamander cone photoreceptors. J Gen Physiol. 1999 Feb; 113(2):267-77.
    View in: PubMed
  33. Sampath AP, Matthews HR, Cornwall MC, Fain GL. Bleached pigment produces a maintained decrease in outer segment Ca2+ in salamander rods. J Gen Physiol. 1998 Jan; 111(1):53-64.
    View in: PubMed
  34. Cameron DA, Cornwall MC, MacNichol EF. Visual pigment assignments in regenerated retina. J Neurosci. 1997 Feb 1; 17(3):917-23.
    View in: PubMed
  35. Matthews HR, Cornwall MC, Fain GL. Persistent activation of transducin by bleached rhodopsin in salamander rods. J Gen Physiol. 1996 Dec; 108(6):557-63.
    View in: PubMed
  36. Fain GL, Matthews HR, Cornwall MC. Dark adaptation in vertebrate photoreceptors. Trends Neurosci. 1996 Nov; 19(11):502-7.
    View in: PubMed
  37. Jones GJ, Cornwall MC, Fain GL. Equivalence of background and bleaching desensitization in isolated rod photoreceptors of the larval tiger salamander. J Gen Physiol. 1996 Oct; 108(4):333-40.
    View in: PubMed
  38. Matthews HR, Fain GL, Cornwall MC. Role of cytoplasmic calcium concentration in the bleaching adaptation of salamander cone photoreceptors. J Physiol. 1996 Jan 15; 490 ( Pt 2):293-303.
    View in: PubMed
  39. Cornwall MC, Matthews HR, Crouch RK, Fain GL. Bleached pigment activates transduction in salamander cones. J Gen Physiol. 1995 Sep; 106(3):543-57.
    View in: PubMed
  40. Cornwall MC, Fain GL. Bleached pigment activates transduction in isolated rods of the salamander retina. J Physiol. 1994 Oct 15; 480 ( Pt 2):261-79.
    View in: PubMed
  41. Corson DW, Cornwall MC, MacNichol EF, Tsang S, Derguini F, Crouch RK, Nakanishi K. Relief of opsin desensitization and prolonged excitation of rod photoreceptors by 9-desmethylretinal. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):6958-62.
    View in: PubMed
  42. Jin J, Jones GJ, Cornwall MC. Movement of retinal along cone and rod photoreceptors. Vis Neurosci. 1994 Mar-Apr; 11(2):389-99.
    View in: PubMed
  43. Jones GJ, Fein A, MacNichol EF, Cornwall MC. Visual pigment bleaching in isolated salamander retinal cones. Microspectrophotometry and light adaptation. J Gen Physiol. 1993 Sep; 102(3):483-502.
    View in: PubMed
  44. Jin J, Crouch RK, Corson DW, Katz BM, MacNichol EF, Cornwall MC. Noncovalent occupancy of the retinal-binding pocket of opsin diminishes bleaching adaptation of retinal cones. Neuron. 1993 Sep; 11(3):513-22.
    View in: PubMed
  45. Corson DW, Cornwall MC, MacNichol EF, Jin J, Johnson R, Derguini F, Crouch RK, Nakanishi K. Sensitization of bleached rod photoreceptors by 11-cis-locked analogues of retinal. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6823-7.
    View in: PubMed
  46. Cornwall MC, Fein A, MacNichol EF. Cellular mechanisms that underlie bleaching and background adaptation. J Gen Physiol. 1990 Aug; 96(2):345-72.
    View in: PubMed
  47. Corson DW, Cornwall MC, MacNichol EF, Mani V, Crouch RK. Transduction noise induced by 4-hydroxy retinals in rod photoreceptors. Biophys J. 1990 Jan; 57(1):109-15.
    View in: PubMed
  48. Jones GJ, Crouch RK, Wiggert B, Cornwall MC, Chader GJ. Retinoid requirements for recovery of sensitivity after visual-pigment bleaching in isolated photoreceptors. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9606-10.
    View in: PubMed
  49. Cornwall MC, Ripps H, Chappell RL, Jones GJ. Membrane current responses of skate photoreceptors. J Gen Physiol. 1989 Oct; 94(4):633-47.
    View in: PubMed
M.'s Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
BU Co-Authors
_
Similar BU People
_
Same Department