Sachiko Homma, PhD
Research Assistant Professor
Boston University Chobanian & Avedisian School of Medicine

PhD, Otsuma Women's University
BS, University of Tsukuba
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Sachiko Homma Takayama, PhD, is a Research Assistant Professor of Neurology at the Chobanian and Avedisian School of Medicine. For her research, she has received funding from many organizations including Friends of FSH Research for researching the roles of molecular chaperones and the ubiquitin-proteasome system in skeletal muscle diseases. She has made new discoveries in the medical field including having identified a new pathway of myogenic cell death in myofibrillar myopathy.

Pathogenesis of myalgia and fatigue after SARS-CoV-2 infection
09/23/2022 - 08/31/2024 (Multi-PI)
PI: Sachiko Homma, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases

Mechanisms of DUX4-induced muscle atrophy
09/01/2019 - 02/09/2022 (PI)
FSH Society

Mechanisms of DUX4-induced muscle atrophy
05/01/2018 - 10/31/2019 (PI)
Friends of FSH Research

Inhibited protein turnover and TDP-43 aggregation in FSHD pathogenesis
08/01/2015 - 02/28/2019 (PI)
FSH Society


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Wang X, Chen J, Homma ST, Wang Y, Smith GR, Ruf-Zamojski F, Sealfon SC, Zhou L. Diverse effector and regulatory functions of fibro/adipogenic progenitors during skeletal muscle fibrosis in muscular dystrophy. iScience. 2023 Jan 20; 26(1):105775.View Related Profiles. PMID: 36594034; PMCID: PMC9804115; DOI: 10.1016/j.isci.2022.105775;
  2. Beermann ML, Homma S, Miller JB. Proximity ligation assay to detect DUX4 protein in FSHD1 muscle: a pilot study. BMC Res Notes. 2022 May 10; 15(1):163.View Related Profiles. PMID: 35538497; PMCID: PMC9092897; DOI: 10.1186/s13104-022-06054-8;
  3. Masteika IF, Sathya A, Homma S, Miller BM, Boyce FM, Miller JB. Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, ?H2AX accumulation, and Bax/Bak-dependence. Biol Open. 2022 02 15; 11(2).View Related Profiles. PMID: 35191484; PMCID: PMC8890089; DOI: 10.1242/bio.059145;
  4. Mitsuhashi H, Homma S, Beermann ML, Ishimaru S, Takeda H, Yu BK, Liu K, Duraiswamy S, Boyce FM, Miller JB. Efficient system for upstream mRNA trans-splicing to generate covalent, head-to-tail, protein multimers. Sci Rep. 2019 02 19; 9(1):2274.View Related Profiles. PMID: 30783185; PMCID: PMC6381186; DOI: 10.1038/s41598-018-36684-7;
  5. Mitsuhashi H, Ishimaru S, Homma S, Yu B, Honma Y, Beermann ML, Miller JB. Functional domains of the FSHD-associated DUX4 protein. Biol Open. 2018 Apr 26; 7(4).View Related Profiles. PMID: 29618456; PMCID: PMC5936065; DOI: 10.1242/bio.033977;
  6. Homma S, Beermann ML, Yu B, Boyce FM, Miller JB. Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4. Skelet Muscle. 2016 Dec 01; 6(1):42.View Related Profiles. PMID: 27906075; PMCID: PMC5134237; DOI: 10.1186/s13395-016-0113-7;
  7. Jones TI, King OD, Himeda CL, Homma S, Chen JC, Beermann ML, Yan C, Emerson CP, Miller JB, Wagner KR, Jones PL. Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy. Clin Epigenetics. 2015; 7(1):37.View Related Profiles. PMID: 25904990; PMCID: PMC4405830; DOI: 10.1186/s13148-015-0072-6;
  8. Homma S, Beermann ML, Boyce FM, Miller JB. Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation. Ann Clin Transl Neurol. 2015 Feb; 2(2):151-66.View Related Profiles. PMID: 25750920; PMCID: PMC4338956; DOI: 10.1002/acn3.158;
  9. Himeda CL, Debarnot C, Homma S, Beermann ML, Miller JB, Jones PL, Jones TI. Myogenic enhancers regulate expression of the facioscapulohumeral muscular dystrophy-associated DUX4 gene. Mol Cell Biol. 2014 Jun; 34(11):1942-55.View Related Profiles. PMID: 24636994; PMCID: PMC4019064; DOI: 10.1128/MCB.00149-14;
  10. Jones TI, Chen JC, Rahimov F, Homma S, Arashiro P, Beermann ML, King OD, Miller JB, Kunkel LM, Emerson CP, Wagner KR, Jones PL. Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis. Hum Mol Genet. 2012 Oct 15; 21(20):4419-30.View Related Profiles. PMID: 22798623; PMCID: PMC3459465; DOI: 10.1093/hmg/dds284;
Showing 10 of 34 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 34 publications over 23 distinct years, with a maximum of 4 publications in 1997


Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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