Sachiko Homma | Profiles RNS

Sachiko Homma, PhD

Research Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Neurology

PhD, Otsuma Women's University
BS, University of Tsukuba

Websites

ORCID : 0000-0001-6563-8521

Sachiko Homma Takayama, PhD, is a Research Assistant Professor of Neurology at the Chobanian and Avedisian School of Medicine. For her research, she has received funding from many organizations including Friends of FSH Research for researching the roles of molecular chaperones and the ubiquitin-proteasome system in skeletal muscle diseases. She has made new discoveries in the medical field including having identified a new pathway of myogenic cell death in myofibrillar myopathy.

BU Research

Pathogenesis of myalgia and fatigue after SARS-CoV-2 infection
09/23/2022 - 08/31/2024 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R21AR081655-02

Mechanisms of DUX4-induced muscle atrophy
09/01/2019 - 02/09/2022 (PI)
FSH Society

Mechanisms of DUX4-induced muscle atrophy
05/01/2018 - 10/31/2019 (PI)
Friends of FSH Research

Inhibited protein turnover and TDP-43 aggregation in FSHD pathogenesis
08/01/2015 - 02/28/2019 (PI)
FSH Society

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Wang Y, Wang X, Alabdullatif S, Homma ST, Alekseyev YO, Zhou L. Expansion and pathogenic activation of skeletal muscle-resident macrophages in mdx5cv/Ccr2-/- mice. Proc Natl Acad Sci U S A. 2025 Mar 18; 122(11):e2410095122.View Related Profiles.

Homma, Sachiko
Alekseyev, Yuriy

PMID: 40067893; PMCID: PMC11929395; DOI: 10.1073/pnas.2410095122;

Homma ST, Wang X, Frere JJ, Gower AC, Zhou J, Lim JK, tenOever BR, Zhou L. Respiratory SARS-CoV-2 Infection Causes Skeletal Muscle Atrophy and Long-Lasting Energy Metabolism Suppression. Biomedicines. 2024 Jun 28; 12(7).View Related Profiles.

Gower, Adam
Homma, Sachiko

PMID: 39062017; PMCID: PMC11275164; DOI: 10.3390/biomedicines12071443;

Wang X, Chen J, Homma ST, Wang Y, Smith GR, Ruf-Zamojski F, Sealfon SC, Zhou L. Diverse effector and regulatory functions of fibro/adipogenic progenitors during skeletal muscle fibrosis in muscular dystrophy. iScience. 2023 Jan 20; 26(1):105775.View Related Profiles.

Zhou, Lan
Homma, Sachiko

PMID: 36594034; PMCID: PMC9804115; DOI: 10.1016/j.isci.2022.105775;

Beermann ML, Homma S, Miller JB. Proximity ligation assay to detect DUX4 protein in FSHD1 muscle: a pilot study. BMC Res Notes. 2022 May 10; 15(1):163.View Related Profiles.

Miller, Jeffrey
Homma, Sachiko

PMID: 35538497; PMCID: PMC9092897; DOI: 10.1186/s13104-022-06054-8;

Masteika IF, Sathya A, Homma S, Miller BM, Boyce FM, Miller JB. Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, ?H2AX accumulation, and Bax/Bak-dependence. Biol Open. 2022 02 15; 11(2).View Related Profiles.

Sathya, Anvitha
Miller, Jeffrey
Homma, Sachiko

PMID: 35191484; PMCID: PMC8890089; DOI: 10.1242/bio.059145;

Mitsuhashi H, Homma S, Beermann ML, Ishimaru S, Takeda H, Yu BK, Liu K, Duraiswamy S, Boyce FM, Miller JB. Efficient system for upstream mRNA trans-splicing to generate covalent, head-to-tail, protein multimers. Sci Rep. 2019 02 19; 9(1):2274.View Related Profiles.

Miller, Jeffrey
Homma, Sachiko

PMID: 30783185; PMCID: PMC6381186; DOI: 10.1038/s41598-018-36684-7;

Mitsuhashi H, Ishimaru S, Homma S, Yu B, Honma Y, Beermann ML, Miller JB. Functional domains of the FSHD-associated DUX4 protein. Biol Open. 2018 Apr 26; 7(4).View Related Profiles.

Miller, Jeffrey
Homma, Sachiko

PMID: 29618456; PMCID: PMC5936065; DOI: 10.1242/bio.033977;

Homma S, Beermann ML, Yu B, Boyce FM, Miller JB. Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4. Skelet Muscle. 2016 Dec 01; 6(1):42.View Related Profiles.

Miller, Jeffrey
Homma, Sachiko

PMID: 27906075; PMCID: PMC5134237; DOI: 10.1186/s13395-016-0113-7;

Jones TI, King OD, Himeda CL, Homma S, Chen JC, Beermann ML, Yan C, Emerson CP, Miller JB, Wagner KR, Jones PL. Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy. Clin Epigenetics. 2015; 7(1):37.View Related Profiles.

Miller, Jeffrey
Homma, Sachiko

PMID: 25904990; PMCID: PMC4405830; DOI: 10.1186/s13148-015-0072-6;

Homma S, Beermann ML, Boyce FM, Miller JB. Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation. Ann Clin Transl Neurol. 2015 Feb; 2(2):151-66.View Related Profiles.

Miller, Jeffrey
Homma, Sachiko

PMID: 25750920; PMCID: PMC4338956; DOI: 10.1002/acn3.158;

Showing 10 of 36 results. Show More

Himeda CL, Debarnot C, Homma S, Beermann ML, Miller JB, Jones PL, Jones TI. Myogenic enhancers regulate expression of the facioscapulohumeral muscular dystrophy-associated DUX4 gene. Mol Cell Biol. 2014 Jun; 34(11):1942-55.View Related Profiles.

Miller, Jeffrey
Homma, Sachiko

PMID: 24636994; PMCID: PMC4019064; DOI: 10.1128/MCB.00149-14;

Jones TI, Chen JC, Rahimov F, Homma S, Arashiro P, Beermann ML, King OD, Miller JB, Kunkel LM, Emerson CP, Wagner KR, Jones PL. Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis. Hum Mol Genet. 2012 Oct 15; 21(20):4419-30.View Related Profiles.

Miller, Jeffrey
Homma, Sachiko

PMID: 22798623; PMCID: PMC3459465; DOI: 10.1093/hmg/dds284;

Homma S, Chen JC, Rahimov F, Beermann ML, Hanger K, Bibat GM, Wagner KR, Kunkel LM, Emerson CP, Miller JB. A unique library of myogenic cells from facioscapulohumeral muscular dystrophy subjects and unaffected relatives: family, disease and cell function. Eur J Hum Genet. 2012 Apr; 20(4):404-10.View Related Profiles.

Miller, Jeffrey
Homma, Sachiko

PMID: 22108603; PMCID: PMC3306860; DOI: 10.1038/ejhg.2011.213;

Homma S, Beermann ML, Miller JB. Peripheral nerve pathology, including aberrant Schwann cell differentiation, is ameliorated by doxycycline in a laminin-a2-deficient mouse model of congenital muscular dystrophy. Hum Mol Genet. 2011 Jul 1; 20(13):2662-72.View Related Profiles.

Miller, Jeffrey
Homma, Sachiko

PMID: 21505075; PMCID: PMC3110004; DOI: 10.1093/hmg/ddr168;

Iwasaki M, Tanaka R, Hishiya A, Homma S, Reed JC, Takayama S. BAG3 directly associates with guanine nucleotide exchange factor of Rap1, PDZGEF2, and regulates cell adhesion. Biochem Biophys Res Commun. 2010 Sep 24; 400(3):413-8. PMID: 20800573; PMCID: PMC2954587; DOI: 10.1016/j.bbrc.2010.08.092;

Girgenrath M, Beermann ML, Vishnudas VK, Homma S, Miller JB. Pathology is alleviated by doxycycline in a laminin-alpha2-null model of congenital muscular dystrophy. Ann Neurol. 2009 Jan; 65(1):47-56.View Related Profiles.

Miller, Jeffrey
Homma, Sachiko

PMID: 19086074; PMCID: PMC2639627; DOI: 10.1002/ana.21523;

Iwasaki M, Homma S, Hishiya A, Dolezal SJ, Reed JC, Takayama S. BAG3 regulates motility and adhesion of epithelial cancer cells. Cancer Res. 2007 Nov 1; 67(21):10252-9. PMID: 17974966; DOI: 10.1158/0008-5472.CAN-07-0618;

Homma S, Jin X, Wang G, Tu N, Min J, Yanasak N, Mivechi NF. Demyelination, astrogliosis, and accumulation of ubiquitinated proteins, hallmarks of CNS disease in hsf1-deficient mice. J Neurosci. 2007 Jul 25; 27(30):7974-86. PMID: 17652588; PMCID: PMC6672719; DOI: 10.1523/JNEUROSCI.0006-07.2007;

Homma S, Iwasaki M, Shelton GD, Engvall E, Reed JC, Takayama S. BAG3 deficiency results in fulminant myopathy and early lethality. Am J Pathol. 2006 Sep; 169(3):761-73. PMID: 16936253; PMCID: PMC1698816; DOI: 10.2353/ajpath.2006.060250;

Shelton GD, Sammut V, Homma S, Takayama S, Mizisin AP. Myofibrillar myopathy with desmin accumulation in a young Australian Shepherd dog. Neuromuscul Disord. 2004 Jul; 14(7):399-404. PMID: 15210162; DOI: 10.1016/j.nmd.2004.03.010;

Takayama S, Reed JC, Homma S. Heat-shock proteins as regulators of apoptosis. Oncogene. 2003 Dec 8; 22(56):9041-7. PMID: 14663482; DOI: 10.1038/sj.onc.1207114;

Briknarová K, Takayama S, Homma S, Baker K, Cabezas E, Hoyt DW, Li Z, Satterthwait AC, Ely KR. BAG4/SODD protein contains a short BAG domain. J Biol Chem. 2002 Aug 23; 277(34):31172-8. PMID: 12058034; DOI: 10.1074/jbc.M202792200;

Brive L, Takayama S, Briknarová K, Homma S, Ishida SK, Reed JC, Ely KR. The carboxyl-terminal lobe of Hsc70 ATPase domain is sufficient for binding to BAG1. Biochem Biophys Res Commun. 2001 Dec 21; 289(5):1099-105. PMID: 11741305; DOI: 10.1006/bbrc.2001.6087;

Quaresima V, Homma S, Azuma K, Shimizu S, Chiarotti F, Ferrari M, Kagaya A. Calf and shin muscle oxygenation patterns and femoral artery blood flow during dynamic plantar flexion exercise in humans. Eur J Appl Physiol. 2001 May; 84(5):387-94. PMID: 11417425

Briknarová K, Takayama S, Brive L, Havert ML, Knee DA, Velasco J, Homma S, Cabezas E, Stuart J, Hoyt DW, Satterthwait AC, Llinás M, Reed JC, Ely KR. Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein. Nat Struct Biol. 2001 Apr; 8(4):349-52. PMID: 11276257; DOI: 10.1038/86236;

Azuma K, Homma S, Kagaya A. Oxygen supply-consumption balance in the thigh muscles during exhausting knee-extension exercise. J Biomed Opt. 2000 Jan; 5(1):97-101. PMID: 10938772; DOI: 10.1117/1.429974;

Fujii N, Homma S, Yamazaki F, Sone R, Shibata T, Ikegami H, Murakami K, Miyazaki H. Beta-adrenergic receptor number in human lymphocytes is inversely correlated with aerobic capacity. Am J Physiol. 1998 Jun; 274(6 Pt 1):E1106-12. PMID: 9611163

Fukuoka Y, Shigematsu M, Itoh M, Fujii N, Homma S, Ikegami H. Effects of football training on ventilatory and gas exchange kinetics to sinusoidal work load. J Sports Med Phys Fitness. 1997 Sep; 37(3):161-7. PMID: 9407745

Kagaya A, Homma S. Brachial arterial blood flow during static handgrip exercise of short duration at varying intensities studied by a Doppler ultrasound method. Acta Physiol Scand. 1997 Jul; 160(3):257-65. PMID: 9246389; DOI: 10.1046/j.1365-201X.1997.00158.x;

Fujii N, Shibata T, Homma S, Ikegami H, Murakami K, Miyazaki H. Exercise-induced changes in beta-adrenergic-receptor mRNA level measured by competitive RT-PCR. J Appl Physiol (1985). 1997 Jun; 82(6):1926-31. PMID: 9173960

Homma S, Kagaya A. Detection of oxygen consumption in different forearm muscles during handgrip exercise by spatially resolved NIR spectroscopy. Adv Exp Med Biol. 1997; 428:327-32. PMID: 9500066

Homma S, Fukunaga T, Kagaya A. Influence of adipose tissue thickness on near infrared spectroscopic signal in the measurement of human muscle. J Biomed Opt. 1996 Oct; 1(4):418-24. PMID: 23014785; DOI: 10.1117/12.252417;

Homma S, Eda H, Ogasawara S, Kagaya A. Near-infrared estimation of O2 supply and consumption in forearm muscles working at varying intensity. J Appl Physiol (1985). 1996 Apr; 80(4):1279-84. PMID: 8926257

Sone R, Yamazaki F, Homma S, Fujii N, Ikegami H. Effects of sensory stimulation on respiratory cardiac cycle variability in humans. Eur J Appl Physiol Occup Physiol. 1995; 70(5):394-400. PMID: 7671873

Fujii N, Miyazaki H, Homma S, Ikegami H. Dynamic exercise induces translocation of beta-adrenergic receptors in human lymphocytes. Acta Physiol Scand. 1993 Aug; 148(4):463-4. PMID: 8105637; DOI: 10.1111/j.1748-1716.1993.tb09583.x;

Yamazaki F, Sone R, Fujii N, Homma S, Ikegami H. An improved method for measurement of sweat expulsions during profuse sweating. Jpn J Physiol. 1992; 42(6):991-6. PMID: 1297865

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 36 publications over 25 distinct years, with a maximum of 4 publications in 1997

Bar chart showing 36 publications over 25 distinct years, with a maximum of 4 publications in 1997

Year	Publications
1992	1
1993	1
1995	1
1996	2
1997	4
1998	1
2000	1
2001	3
2002	1
2003	1
2004	1
2006	1
2007	2
2009	1
2010	1
2011	2
2012	1
2014	1
2015	2
2016	1
2018	1
2019	1
2022	3
2024	1
2025	1

Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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617.358.0736

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