Keywords
Last Name

Jeffrey Boone Miller, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentNeurology
Address700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Phone(617) 638-5355
ORCID ORCID Icon0000-0001-5273-2201
Other Positions
TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics

 Awards and Honors

Start-EndDescription
1972Washington State University: Outstanding Junior in Chemistry
1973Washington State University: Phi Lambda Upsilon Scholar
1973Washington State University: Graduation with Highest Honors, Phi Beta Kappa, Phi Kappa Phi
1989-nowHarvard University: Invited member, Board of Biochemical Tutors
1993Montreal Neurological Institute: Invited Lecturer in Killam Series
2009Cure CMD: Invited Member, Animal Model Assessment Group
2009Conference on "Myogenesis: Making Muscle in the Embryo and Adult", New York, NY: Silver Medal Poster Prize (out of 262 presentations)
2013University of Maryland, School of Medicine: Robert Wade Memorial Lecturer
 NIH RePORTER Grants

Yr Title Project-Sub Proj Pubs
2016 Pathogenesis of Muscular Dystrophies 4R01AR060328-06 4
2015 Pathogenesis of Muscular Dystrophies 5R01AR060328-05 4
2014 Pathogenesis of Muscular Dystrophies 5R01AR060328-04 4
2013 Pathogenesis of Muscular Dystrophies 5R01AR060328-03 4
2012 Pathogenesis of Muscular Dystrophies 1R01AR060328-01A1 4
2012 Pathogenesis of Muscular Dystrophies 7R01AR060328-02 4
2012 Model Studies for FSHD Biomarkers 5U54HD060848-05-4 17
2011 Model Studies for FSHD Biomarkers 5U54HD060848-04-4 17
2010 Molecular physiology of respiratory muscles 5R01HL064641-11 11
2010 Model Studies for FSHD Biomarkers 5U54HD060848-03-4 17
Showing the 10 most recent of 58 results. Show All Results

 Self-Described Keywords
  • Congenital muscular dystrophy
  • Facioscapulohumeral muscular dystrophy
  • Limb-girdle muscular dystrophy
  • Motor nerve
  • Muscular dystrophy
  • Myogenesis
  • Neuromuscular disease
  • Pathogenesis
  • Skeletal muscle
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Homma S, Beermann ML, Yu B, Boyce FM, Miller JB. Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4. Skelet Muscle. 2016 Dec 01; 6(1):42. PMID: 27906075.
    View in: PubMed
  2. Jones TI, King OD, Himeda CL, Homma S, Chen JC, Beermann ML, Yan C, Emerson CP, Miller JB, Wagner KR, Jones PL. Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy. Clin Epigenetics. 2015; 7(1):37. PMID: 25904990.
    View in: PubMed
  3. Homma S, Beermann ML, Boyce FM, Miller JB. Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation. Ann Clin Transl Neurol. 2015 Feb; 2(2):151-66. PMID: 25750920.
    View in: PubMed
  4. Himeda CL, Debarnot C, Homma S, Beermann ML, Miller JB, Jones PL, Jones TI. Myogenic enhancers regulate expression of the facioscapulohumeral muscular dystrophy-associated DUX4 gene. Mol Cell Biol. 2014 Jun; 34(11):1942-55. PMID: 24636994.
    View in: PubMed
  5. Yoon S, Stadler G, Beermann ML, Schmidt EV, Windelborn JA, Schneiderat P, Wright WE, Miller JB. Immortalized myogenic cells from congenital muscular dystrophy type1A patients recapitulate aberrant caspase activation in pathogenesis: a new tool for MDC1A research. Skelet Muscle. 2013; 3(1):28. PMID: 24314268.
    View in: PubMed
  6. Jones TI, Chen JC, Rahimov F, Homma S, Arashiro P, Beermann ML, King OD, Miller JB, Kunkel LM, Emerson CP, Wagner KR, Jones PL. Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis. Hum Mol Genet. 2012 Oct 15; 21(20):4419-30. PMID: 22798623.
    View in: PubMed
  7. Homma S, Chen JC, Rahimov F, Beermann ML, Hanger K, Bibat GM, Wagner KR, Kunkel LM, Emerson CP, Miller JB. A unique library of myogenic cells from facioscapulohumeral muscular dystrophy subjects and unaffected relatives: family, disease and cell function. Eur J Hum Genet. 2012 Apr; 20(4):404-10. PMID: 22108603.
    View in: PubMed
  8. Homma S, Beermann ML, Miller JB. Peripheral nerve pathology, including aberrant Schwann cell differentiation, is ameliorated by doxycycline in a laminin-a2-deficient mouse model of congenital muscular dystrophy. Hum Mol Genet. 2011 Jul 1; 20(13):2662-72. PMID: 21505075.
    View in: PubMed
  9. Homma S, Beermann ML, Miller JB. Assessment of peripheral nerve pathology in laminin-alpha2-deficient mice. European Neuromuscular Network. Newcastle-upon-Tyne, United Kingdom. 2011.
    View in: External Website
  10. Beermann ML, Ardelt M, Girgenrath M, Miller JB. Prdm1 (Blimp-1) and the expression of fast and slow myosin heavy chain isoforms during avian myogenesis in vitro. PLoS One. 2010; 5(4):e9951. PMID: 20376350.
    View in: PubMed
  11. Vishnudas VK, Miller JB. Ku70 regulates Bax-mediated pathogenesis in laminin-alpha2-deficient human muscle cells and mouse models of congenital muscular dystrophy. Hum Mol Genet. 2009 Dec 1; 18(23):4467-77. PMID: 19692349.
    View in: PubMed
  12. Girgenrath M, Beermann ML, Vishnudas VK, Homma S, Miller JB. Pathology is alleviated by doxycycline in a laminin-alpha2-null model of congenital muscular dystrophy. Ann Neurol. 2009 Jan; 65(1):47-56. PMID: 19086074.
    View in: PubMed
  13. Girgenrath M, Weng S, Kostek CA, Browning B, Wang M, Brown SA, Winkles JA, Michaelson JS, Allaire N, Schneider P, Scott ML, Hsu YM, Yagita H, Flavell RA, Miller JB, Burkly LC, Zheng TS. TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration. EMBO J. 2006 Dec 13; 25(24):5826-39. PMID: 17124496.
    View in: PubMed
  14. Miller JB, Girgenrath M. The role of apoptosis in neuromuscular diseases and prospects for anti-apoptosis therapy. Trends Mol Med. 2006 Jun; 12(6):279-86. PMID: 16650805.
    View in: PubMed
  15. Girgenrath M, Kostek CA, Miller JB. Diseased muscles that lack dystrophin or laminin-alpha2 have altered compositions and proliferation of mononuclear cell populations. BMC Neurol. 2005; 5(1):7. PMID: 15817132.
    View in: PubMed
  16. Dominov JA, Kravetz AJ, Ardelt M, Kostek CA, Beermann ML, Miller JB. Muscle-specific BCL2 expression ameliorates muscle disease in laminin {alpha}2-deficient, but not in dystrophin-deficient, mice. Hum Mol Genet. 2005 Apr 15; 14(8):1029-40. PMID: 15757977.
    View in: PubMed
  17. Miller JB. Song Sparrow riding a chairlift. Bird Observer. 2005; 33:304-305.
  18. Miller JB. Spotless Robin. Bird Observer. 2005; 33:176.
  19. Girgenrath M, Dominov JA, Kostek CA, Miller JB. Inhibition of apoptosis improves outcome in a model of congenital muscular dystrophy. J Clin Invest. 2004 Dec; 114(11):1635-9. PMID: 15578095.
    View in: PubMed
  20. Nowak JA, Malowitz J, Girgenrath M, Kostek CA, Kravetz AJ, Dominov JA, Miller JB. Immortalization of mouse myogenic cells can occur without loss of p16INK4a, p19ARF, or p53 and is accelerated by inactivation of Bax. BMC Cell Biol. 2004 Jan 8; 5:1. PMID: 14711384.
    View in: PubMed
  21. Miller JB, Emerson CP. Does the road to muscle rejuvenation go through Notch? Sci Aging Knowledge Environ. 2003 Dec 3; 2003(48):pe34. PMID: 14657508.
    View in: PubMed
  22. Lykke-Andersen K, Schaefer L, Menon S, Deng XW, Miller JB, Wei N. Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Mol Cell Biol. 2003 Oct; 23(19):6790-7. PMID: 12972599.
    View in: PubMed
  23. Pavlath GK, Dominov JA, Kegley KM, Miller JB. Regeneration of transgenic skeletal muscles with altered timing of expression of the basic helix-loop-helix muscle regulatory factor MRF4. Am J Pathol. 2003 May; 162(5):1685-91. PMID: 12707053.
    View in: PubMed
  24. Kostek CA, Dominov JA, Miller JB. Up-regulation of MHC class I expression accompanies but is not required for spontaneous myopathy in dysferlin-deficient SJL/J mice. Am J Pathol. 2002 Mar; 160(3):833-9. PMID: 11891182.
    View in: PubMed
  25. Miller JB. Impact factors & publishing research. The Scientist. 2002; 16:11.
  26. Miller JB. Molecular marker of muscle stem cells (US patent #6,337,184). 2002.
  27. Dominov JA, Houlihan-Kawamoto CA, Swap CJ, Miller JB. Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis. Dev Dyn. 2001 Jan; 220(1):18-26. PMID: 11146504.
    View in: PubMed
  28. Miller JB. Developmental biology of skeletal muscle. in “Disorders of Voluntary Muscle” (eds. D. Hilton-Jones, R. C. Griggs, and G. Karpati). Cambridge University Press. Cambridge. 2001; 26-41.
  29. Schaefer L, Engman H, Miller JB. Coding sequence, chromosomal localization, and expression pattern of Nrf1: the mouse homolog of Drosophila erect wing. Mamm Genome. 2000 Feb; 11(2):104-10. PMID: 10656923.
    View in: PubMed
  30. Schaefer L, Beermann ML, Miller JB. Coding sequence, genomic organization, chromosomal localization, and expression pattern of the signalosome component Cops2: the mouse homologue of Drosophila alien. Genomics. 1999 Mar 15; 56(3):310-6. PMID: 10087198.
    View in: PubMed
  31. Miller JB, Schaefer L, Dominov JA. Seeking muscle stem cells. Curr Top Dev Biol. 1999; 43:191-219. PMID: 9891887.
    View in: PubMed
  32. Dominov JA, Dunn JJ, Miller JB. Bcl-2 expression identifies an early stage of myogenesis and promotes clonal expansion of muscle cells. J Cell Biol. 1998 Jul 27; 142(2):537-44. PMID: 9679150.
    View in: PubMed
  33. Zhu Z, Miller JB. MRF4 can substitute for myogenin during early stages of myogenesis. Dev Dyn. 1997 Jun; 209(2):233-41. PMID: 9186058.
    View in: PubMed
  34. Miller JB. Unitary construction. Nature. 1997 Jan 30; 385(6615):384. PMID: 9009178.
    View in: PubMed
  35. Block NE, Zhu Z, Kachinsky AM, Dominov JA, Miller JB. Acceleration of somitic myogenesis in embryos of myogenin promoter-MRF4 transgenic mice. Dev Dyn. 1996 Dec; 207(4):382-94. PMID: 8950513.
    View in: PubMed
  36. Brown RH, Miller JB. Progress, problems, and prospects for gene therapy in muscle. Curr Opin Rheumatol. 1996 Nov; 8(6):539-43. PMID: 9018457.
    View in: PubMed
  37. Nikovits W, Wang GF, Feldman JL, Miller JB, Wade R, Nelson L, Stockdale FE. Isolation and characterization of an avian slow myosin heavy chain gene expressed during embryonic skeletal muscle fiber formation. J Biol Chem. 1996 Jul 19; 271(29):17047-56. PMID: 8663323.
    View in: PubMed
  38. Mei L, Kachinsky AM, Seiden JE, Kuncl RW, Miller JB, Huganir RL. Differential expression of PTP1D, a protein tyrosine phosphatase with two SH2 domains, in a slow and fast skeletal muscle fibers. Exp Cell Res. 1996 May 1; 224(2):379-90. PMID: 8612715.
    View in: PubMed
  39. Miller JB. Red-breasted Mergansers in an urban winter habitat. J Field Ornithol. 1996; 67:477-483.
  40. Dominov JA, Miller JB. POU homeodomain genes and myogenesis. Dev Genet. 1996; 19(2):108-18. PMID: 8900043.
    View in: PubMed
  41. Miller JB. Developmental biology. Making one cell from two. Nature. 1995 Oct 19; 377(6550):575-6. PMID: 7566164.
    View in: PubMed
  42. Kachinsky AM, Dominov JA, Miller JB. Intermediate filaments in cardiac myogenesis: nestin in the developing mouse heart. J Histochem Cytochem. 1995 Aug; 43(8):843-7. PMID: 7542682.
    View in: PubMed
  43. Miller JB, Boyce FM. Gene therapy by and for muscle cells. Trends Genet. 1995 May; 11(5):163-5. PMID: 7785070.
    View in: PubMed
  44. Miller JB. Mind, brain, behavior. Harvard Magazine. 1995; 97:6.
  45. Miller, J.B. . Somite subdomains and muscle cell origins. J. NIH Res. 1995; 7:42-43.
  46. Smith TH, Kachinsky AM, Miller JB. Somite subdomains, muscle cell origins, and the four muscle regulatory factor proteins. J Cell Biol. 1994 Oct; 127(1):95-105. PMID: 7929574.
    View in: PubMed
  47. Kachinsky AM, Dominov JA, Miller JB. Myogenesis and the intermediate filament protein, nestin. Dev Biol. 1994 Sep; 165(1):216-28. PMID: 8088440.
    View in: PubMed
  48. Miller JB. Don't call us... Nature. 1994 Mar 10; 368(6467):93. PMID: 8139669.
    View in: PubMed
  49. Smith TH, Block NE, Rhodes SJ, Konieczny SF, Miller JB. A unique pattern of expression of the four muscle regulatory factor proteins distinguishes somitic from embryonic, fetal and newborn mouse myogenic cells. Development. 1993 Mar; 117(3):1125-33. PMID: 8391976.
    View in: PubMed
  50. Miller JB, Everitt EA, Smith TH, Block NE, Dominov JA. Cellular and molecular diversity in skeletal muscle development: news from in vitro and in vivo. Bioessays. 1993 Mar; 15(3):191-6. PMID: 8387785.
    View in: PubMed
  51. Page S, Miller JB, DiMario JX, Hager EJ, Moser A, Stockdale FE. Developmentally regulated expression of three slow isoforms of myosin heavy chain: diversity among the first fibers to form in avian muscle. Dev Biol. 1992 Nov; 154(1):118-28. PMID: 1426621.
    View in: PubMed
  52. Block NE, Miller JB. Expression of MRF4, a myogenic helix-loop-helix protein, produces multiple changes in the myogenic program of BC3H-1 cells. Mol Cell Biol. 1992 Jun; 12(6):2484-92. PMID: 1588952.
    View in: PubMed
  53. Miller JB. Myoblast diversity in skeletal myogenesis: how much and to what end? Cell. 1992 Apr 3; 69(1):1-3. PMID: 1555234.
    View in: PubMed
  54. Miner JH, Miller JB, Wold BJ. Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart. Development. 1992 Apr; 114(4):853-60. PMID: 1618148.
    View in: PubMed
  55. Smith TH, Miller JB. Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro. Dev Biol. 1992 Jan; 149(1):16-26. PMID: 1728586.
    View in: PubMed
  56. Miller JB. Myoblasts, myosins, MyoDs, and the diversification of muscle fibers. Neuromuscul Disord. 1991; 1(1):7-17. PMID: 1822778.
    View in: PubMed
  57. Miller JB. Myogenic programs of mouse muscle cell lines: expression of myosin heavy chain isoforms, MyoD1, and myogenin. J Cell Biol. 1990 Sep; 111(3):1149-59. PMID: 2167895.
    View in: PubMed
  58. Miller JB, Stockdale FE. Multiple cellular processes regulate expression of slow myosin heavy chain isoforms during avian myogenesis in vitro. Dev Biol. 1989 Dec; 136(2):393-404. PMID: 2684708.
    View in: PubMed
  59. Miller JB, Teal SB, Stockdale FE. Evolutionarily conserved sequences of striated muscle myosin heavy chain isoforms. Epitope mapping by cDNA expression. J Biol Chem. 1989 Aug 5; 264(22):13122-30. PMID: 2473986.
    View in: PubMed
  60. Miller JB. Dealing with job applicants. Nature. 1989; 334:98.
  61. Evans D, Miller JB, Stockdale FE. Developmental patterns of expression and coexpression of myosin heavy chains in atria and ventricles of the avian heart. Dev Biol. 1988 Jun; 127(2):376-83. PMID: 3378670.
    View in: PubMed
  62. Stockdale FE, Miller JB. The cellular basis of myosin heavy chain isoform expression during development of avian skeletal muscles. Dev Biol. 1987 Sep; 123(1):1-9. PMID: 3305110.
    View in: PubMed
  63. Miller JB, Scott DJ, Amy NK. Molybdenum-sensitive transcriptional regulation of the chlD locus of Escherichia coli. J Bacteriol. 1987 May; 169(5):1853-60. PMID: 3106322.
    View in: PubMed
  64. Schafer DA, Miller JB, Stockdale FE. Cell diversification within the myogenic lineage: in vitro generation of two types of myoblasts from a single myogenic progenitor cell. Cell. 1987 Feb 27; 48(4):659-70. PMID: 3545495.
    View in: PubMed
  65. Miller JB, Stockdale FE. What muscle cells know that nerves don't tell them. Trends in Neurosciences. 1987; 10:325-329.
  66. Miller JB, Stockdale FE. Developmental regulation of the multiple myogenic cell lineages of the avian embryo. J Cell Biol. 1986 Dec; 103(6 Pt 1):2197-208. PMID: 3782296.
    View in: PubMed
  67. Miller JB, Stockdale FE. Developmental origins of skeletal muscle fibers: clonal analysis of myogenic cell lineages based on expression of fast and slow myosin heavy chains. Proc Natl Acad Sci U S A. 1986 Jun; 83(11):3860-4. PMID: 3520558.
    View in: PubMed
  68. Miller JB, Crow MT, Stockdale FE. Slow and fast myosin heavy chain content defines three types of myotubes in early muscle cell cultures. J Cell Biol. 1985 Nov; 101(5 Pt 1):1643-50. PMID: 3902852.
    View in: PubMed
  69. Miller JB. Regulation of acetylcholine receptors in the mouse muscle cell line, C2. Exp Cell Res. 1984 Sep; 154(1):256-69. PMID: 6468527.
    View in: PubMed
  70. Miller JB, Hall ZW. Acetylcholine receptors from Torpedo californica membrane vesicles are metabolized after fusion with cultured mammalian muscle cells. Brain Res. 1984 Mar 19; 295(2):227-31. PMID: 6713185.
    View in: PubMed
  71. Inestrosa NC, Miller JB, Silberstein L, Ziskind-Conhaim L, Hall ZW. Developmental regulation of 16S acetylcholinesterase and acetylcholine receptors in a mouse muscle cell line. Exp Cell Res. 1983 Sep; 147(2):393-405. PMID: 6617773.
    View in: PubMed
  72. Miller JB, Amy NK. Molybdenum cofactor in chlorate-resistant and nitrate reductase-deficient insertion mutants of Escherichia coli. J Bacteriol. 1983 Aug; 155(2):793-801. PMID: 6307982.
    View in: PubMed
  73. Miller JB, Koshland DE. Protonmotive force and bacterial sensing. J Bacteriol. 1980 Jan; 141(1):26-32. PMID: 6766440.
    View in: PubMed
  74. Taylor BL, Miller JB, Warrick HM, Koshland DE. Electron acceptor taxis and blue light effect on bacterial chemotaxis. J Bacteriol. 1979 Nov; 140(2):567-73. PMID: 387740.
    View in: PubMed
  75. Miller JB, Koshland DE. Effects of cyanine dye membrane probes on cellular properties. Nature. 1978 Mar 2; 272(5648):83-4. PMID: 415251.
    View in: PubMed
  76. Miller JB. Role of the membrane in bacterial chemotaxis. (PhD thesis in biochemistry, University of California at Berkeley). Berkeley. 1977.
  77. Miller JB, Koshland DE. Sensory electrophysiology of bacteria: relationship of the membrane potential to motility and chemotaxis in Bacillus subtilis. Proc Natl Acad Sci U S A. 1977 Nov; 74(11):4752-6. PMID: 412194.
    View in: PubMed
  78. Miller JB, Koshland DE. Membrane fluidity and chemotaxis: effects of temperature and membrane lipid composition on the swimming behavior of Salmonella typhimurium and Escherichia coli. J Mol Biol. 1977 Apr; 111(2):183-201. PMID: 323503.
    View in: PubMed
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