Naotoshi Iwahara | Profiles RNS

Naotoshi Iwahara, MD

Postdoctoral Associate (previously held)

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

Publications
Contact Info

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Iwahara N, Muraoka S, Saito T, Hirano M, Yokokawa K, Tanemoto M, Oda R, Nonaka T, Suzuki S, Adachi J, Hisahara S. Elevated ITGAX/CD11c in CSF-Derived Extracellular Vesicles Reflects Disability Progression in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2025 Sep; 12(5):e200442. PMID: 40680248; PMCID: PMC12275904; DOI: 10.1212/NXI.0000000000200442;

Funakoshi T, Yamada M, Ikeda K, Yokokawa K, Saito T, Tsuda R, Iwahara N, Suzuki S, Hisahara S. Response to SARS-CoV-2 Infection in Sjögren Syndrome can be Complicated by Myelitis and Guillain-Barré Syndrome. Intern Med. 2025 Jun 05. PMID: 40467519

Funakoshi T, Yamada M, Ikeda K, Yokokawa K, Saito T, Tsuda R, Iwahara N, Suzuki S, Hisahara S. Sjögren's Syndrome with Sensory Neuronopathy and Polyradiculoneuropathy. Intern Med. 2025 Oct 15; 64(20):3033-3038. PMID: 40159161

Funakoshi T, Yamada M, Ikeda K, Yokokawa K, Saito T, Iwahara N, Suzuki S, Kimura Y, Akiyama Y, Mikuni N, Hisahara S. A Case of Multiple Intracerebral Hemorrhages Due to Early-Onset Cerebral Amyloid Angiopathy With Alzheimer's Disease: Neuropathological Changes Three Decades After Childhood Neurosurgery. Cureus. 2025 Jan; 17(1):e77700. PMID: 39974219; PMCID: PMC11837224; DOI: 10.7759/cureus.77700;

Kuno A, Hosoda R, Saga Y, Iwahara N, Tatekoshi Y, Numazawa R, Horio Y. Resveratrol promotes autophagosome elimination via SIRT1 in cardiomyocytes. J Pharmacol Sci. 2025 Jan; 157(1):25-34. PMID: 39706642

Tanemoto M, Suzuki S, Yokokawa K, Saito T, Iwahara N, Tsuda R, Watanabe O, Takahashi Y, Yoneda M, Hisahara S. [Clinical characteristics of seizure-predominant autoimmune encephalitis and utility of anti-neuronal antibody scores for early treatment]. Rinsho Shinkeigaku. 2024 Apr 24; 64(4):272-279. PMID: 38508734

Nakashima R, Hosoda R, Tatekoshi Y, Iwahara N, Saga Y, Kuno A. Transcriptional dysregulation of autophagy in the muscle of a mouse model of Duchenne muscular dystrophy. Sci Rep. 2024 Jan 16; 14(1):1365. PMID: 38228650; PMCID: PMC10791753; DOI: 10.1038/s41598-024-51746-9;

Hosoda R, Nakashima R, Yano M, Iwahara N, Asakura S, Nojima I, Saga Y, Kunimoto R, Horio Y, Kuno A. Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice. J Pharmacol Sci. 2023 Jun; 152(2):112-122. PMID: 37169475

Kuno A, Hosoda R, Tsukamoto M, Sato T, Sakuragi H, Ajima N, Saga Y, Tada K, Taniguchi Y, Iwahara N, Horio Y. SIRT1 in the cardiomyocyte counteracts doxorubicin-induced cardiotoxicity via regulating histone H2AX. Cardiovasc Res. 2023 01 18; 118(17):3360-3373. PMID: 35258628

Iwahara N, Azekami K, Hosoda R, Nojima I, Hisahara S, Kuno A. Activation of SIRT1 promotes membrane resealing via cortactin. Sci Rep. 2022 Sep 12; 12(1):15328. PMID: 36097021; PMCID: PMC9468153; DOI: 10.1038/s41598-022-19136-1;

Showing 10 of 29 results. Show More

Nojima I, Hosoda R, Toda Y, Saito Y, Ueda N, Horimoto K, Iwahara N, Horio Y, Kuno A. Downregulation of IGFBP5 contributes to replicative senescence via ERK2 activation in mouse embryonic fibroblasts. Aging (Albany NY). 2022 Apr 04; 14(7):2966-2988. PMID: 35378512; PMCID: PMC9037271; DOI: 10.18632/aging.203999;

Hayashi T, Matsushita T, Hisahara S, Iwahara N, Kuno A, Kunimoto R, Hosoda R, Tanno M, Shimohama S, Horio Y. Ubiquitin-dependent rapid degradation conceals a cell-protective function of cytoplasmic SIRT3 against oxidative stress. J Biochem. 2022 Feb 21; 171(2):201-213. PMID: 34718606

Suzuki H, Mikami T, Iwahara N, Akiyama Y, Wanibuchi M, Komatsu K, Yokoyama R, Hirano T, Hosoda R, Horio Y, Kuno A, Mikuni N. Aging-associated inflammation and fibrosis in arachnoid membrane. BMC Neurol. 2021 Apr 21; 21(1):169. PMID: 33882882; PMCID: PMC8058966; DOI: 10.1186/s12883-021-02202-y;

Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Mol Neurodegener. 2021 Apr 14; 16(1):24.View Related Profiles.

Iwahara, Naotoshi
Ikezu, Seiko
Ikezu, Tsuneya

PMID: 33853665; PMCID: PMC8048194; DOI: 10.1186/s13024-021-00447-2;

Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Mol Neurodegener. 2021 03 22; 16(1):18.View Related Profiles.

Iwahara, Naotoshi
Ikezu, Seiko
Ikezu, Tsuneya

PMID: 33752701; PMCID: PMC7986521; DOI: 10.1186/s13024-021-00440-9;

Hisahara S, Iwahara N, Matsushita T, Suzuki S, Matsumura A, Fujikura M, Yokokawa K, Saito T, Manabe T, Kawamata J, Horio Y, Shimohama S. SIRT1 decelerates morphological processing of oligodendrocyte cell lines and regulates the expression of cytoskeleton-related oligodendrocyte proteins. Biochem Biophys Res Commun. 2021 03 26; 546:7-14. PMID: 33556638

Muraoka S, Jedrychowski MP, Iwahara N, Abdullah M, Onos KD, Keezer KJ, Hu J, Ikezu S, Howell GR, Gygi SP, Ikezu T. Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models. J Proteome Res. 2021 03 05; 20(3):1733-1743.View Related Profiles.

Iwahara, Naotoshi
Ikezu, Seiko
Ikezu, Tsuneya

PMID: 33534581; PMCID: PMC7944570; DOI: 10.1021/acs.jproteome.0c00934;

Hosoda R, Hamada H, Uesugi D, Iwahara N, Nojima I, Horio Y, Kuno A. Different Antioxidative and Antiapoptotic Effects of Piceatannol and Resveratrol. J Pharmacol Exp Ther. 2021 03; 376(3):385-396. PMID: 33335015

Saito T, Hisahara S, Iwahara N, Emoto MC, Yokokawa K, Suzuki H, Manabe T, Matsumura A, Suzuki S, Matsushita T, Kawamata J, Sato-Akaba H, Fujii HG, Shimohama S. Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease. Free Radic Biol Med. 2019 12; 145:20-32. PMID: 31536772

Fujiwara D, Iwahara N, Sebori R, Hosoda R, Shimohama S, Kuno A, Horio Y. SIRT1 deficiency interferes with membrane resealing after cell membrane injury. PLoS One. 2019; 14(6):e0218329. PMID: 31242212; PMCID: PMC6594621; DOI: 10.1371/journal.pone.0218329;

Manabe T, Matsumura A, Yokokawa K, Saito T, Fujikura M, Iwahara N, Matsushita T, Suzuki S, Hisahara S, Kawamata J, Suzuki H, Emoto MC, Fujii HG, Shimohama S. Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer's Disease by in vitro Electron Paramagnetic Resonance Spectroscopy. J Alzheimers Dis. 2019; 67(3):1079-1087. PMID: 30714961

Yokokawa K, Iwahara N, Hisahara S, Emoto MC, Saito T, Suzuki H, Manabe T, Matsumura A, Matsushita T, Suzuki S, Kawamata J, Sato-Akaba H, Fujii HG, Shimohama S. Transplantation of Mesenchymal Stem Cells Improves Amyloid-ß Pathology by Modifying Microglial Function and Suppressing Oxidative Stress. J Alzheimers Dis. 2019; 72(3):867-884. PMID: 31640102; PMCID: PMC6918908; DOI: 10.3233/JAD-190817;

Fujikura M, Iwahara N, Hisahara S, Kawamata J, Matsumura A, Yokokawa K, Saito T, Manabe T, Matsushita T, Suzuki S, Shimohama S. CD14 and Toll-Like Receptor 4 Promote Fibrillar Aß42 Uptake by Microglia Through A Clathrin-Mediated Pathway. J Alzheimers Dis. 2019; 68(1):323-337. PMID: 30775984

Iwahara N, Hisahara S, Kawamata J, Matsumura A, Yokokawa K, Saito T, Fujikura M, Manabe T, Suzuki H, Matsushita T, Suzuki S, Shimohama S. Role of Suppressor of Cytokine Signaling 3 (SOCS3) in Altering Activated Microglia Phenotype in APPswe/PS1dE9 Mice. J Alzheimers Dis. 2017; 55(3):1235-1247. PMID: 27814300

Matsumura A, Emoto MC, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H, Yamauchi A, Sato-Akaba H, Fujii HG, Shimohama S. Evaluation of oxidative stress in the brain of a transgenic mouse model of Alzheimer disease by in vivo electron paramagnetic resonance imaging. Free Radic Biol Med. 2015 Aug; 85:165-73. PMID: 25912481

Iwahara N, Hisahara S, Hayashi T, Kawamata J, Shimohama S. A novel lamin A/C gene mutation causing spinal muscular atrophy phenotype with cardiac involvement: report of one case. BMC Neurol. 2015 Feb 20; 15:13. PMID: 25886484; PMCID: PMC4342086; DOI: 10.1186/s12883-015-0269-5;

Matsumura A, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H, Yamauchi A, Takata K, Kitamura Y, Shimohama S. Temporal changes of CD68 and a7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models. J Alzheimers Dis. 2015; 44(2):409-23. PMID: 25352454

Suzuki S, Kawamata J, Iwahara N, Iwahara N, Matsumura A, Hisahara S, Matsushita T, Sasaki M, Honmou O, Shimohama S. Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats. Neurosci Lett. 2015 Jan 01; 584:276-81. PMID: 25449872

Iwahara N, Hisahara S, Hayashi T, Horio Y. Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX. Biochem Biophys Res Commun. 2009 Sep 04; 386(4):671-5. PMID: 19555662

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 29 publications over 11 distinct years, with a maximum of 5 publications in 2019 and 2021

Bar chart showing 29 publications over 11 distinct years, with a maximum of 5 publications in 2019 and 2021

Year	Publications
2009	1
2014	1
2015	3
2017	1
2019	5
2020	1
2021	5
2022	3
2023	2
2024	3
2025	4

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Ikezu, Tsuneya

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