Michelle Teplensky, PhD
Assistant Professor
Boston University College of Engineering
Biomedical Engineering

PhD, University of Cambridge
BS, Massachusetts Institute of Technology



Research in Dr Teplensky's lab focuses on engineering nanotechnology to control immunological cell connectivity, processing, and communication by design. In doing so, they elucidate fundamentals about cellular events and leverage this knowledge to develop improved therapeutics and vaccines that can impact the treatment of cancer and infectious disease. Their work is highly interdisciplinary, and bridges the fields of engineering, chemistry, nanotechnology, immunology, and biomaterials. By sitting at this interface, they are able to develop and incorporate synthetic nanoscale advances to control immunological activity and elucidate design rules that have widespread impacts on therapeutic development.


Harnessing Nanoscale Presentation to Elucidate the Impact of Therapeutic Packaging on Innate Immunity
01/01/2025 - 11/30/2029 (PI)
NIH/National Institute of General Medical Sciences
1R35GM157326-01

Engineering Versatile Vaccine Responses through Nanomaterial Design
09/01/2024 - 08/31/2028 (PI)
The Arnold and Mabel Beckman Foundation


Elevating vaccine-induced protection against spretococuss pneumoniea by harnessing nanoscale structure
05/01/2024 - 04/30/2027 (PI)
The Hartwell Foundation


Equipment: MRI: Track 1 Acquisition of an Illumina NextSeq 2000 Sequencing Instrument
09/01/2023 - 08/31/2026 (Multi-PI)
PI: Michelle Teplensky, PhD
National Science Foundation
CBET-2320685



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Mirkin CA, Petrosko SH, Artzi N, Aydin K, Biaggne A, Brinker CJ, Bujold KE, Cao YC, Chan RR, Chen C, Chen PC, Chen X, Chevalier OJGL, Choi CHJ, Crooks RM, Dravid VP, Du JS, Ebrahimi SB, Fan H, Farha OK, Figg CA, Fink TD, Forsyth CM, Fuchs H, Geiger FM, Gianneschi NC, Gibson KJ, Ginger DS, Guo S, Hanes JS, Hao L, Huang J, Hunter BM, Huo F, Hwang J, Jin R, Kelley SO, Kempa TJ, Kim Y, Kudruk S, Kumari S, Landy KM, Lee KB, Leon NJ, Li J, Li Y, Li Z, Liu B, Liu G, Liu X, Liz-Marzán LM, Lorch JH, Luo T, Macfarlane RJ, Millstone JE, Mrksich M, Murphy CJ, Naik RR, Nel AE, Oetheimer C, Hedlund Orbeck JK, Park SJ, Partridge BE, Peppas NA, Personick ML, Raj A, Ramani N, Ross MB, Ross SB, Sargent EH, Sengupta T, Schatz GC, Seferos DS, Seideman T, Seo SE, Shen B, Shim W, Shin D, Simon U, Sinegra AJ, Smith PT, Spokoyny AM, Stang PJ, Stegh AH, Stoddart JF, Swearer DF, Tan W, Teplensky MH, Thaxton CS, Walt DR, Wang MX, Wang Z, Wei WD, Weiss PS, Winegar PH, Xia Y, Xie Y, Xu X, Yang P, Yang Y, Ye Z, Yoon KR, Zhang C, Zhang H, Zhang K, Zhang L, Zhang X, Zhang Y, Zheng Z, Zhou W, Zhu S, Zhu W. 33 Unresolved Questions in Nanoscience and Nanotechnology. ACS Nano. 2025 Sep 16; 19(36):31933-31968. PMID: 40905551
     
  2. Nowak JA, Cho E, Davis MA, Zheng S, Bell L, Sha F, Magdalenski JS, Farha OK, Teplensky MH. Strengthening Antisense Oligonucleotide-Mediated Anti-Tumor Immunity via Metal-Organic Framework Nanoparticles. bioRxiv. 2025 Apr 02. PMID: 40235985; DOI: 10.1101/2025.03.28.645811;
     
  3. Davis MA, Cho E, Teplensky MH. Harnessing biomaterial architecture to drive anticancer innate immunity. J Mater Chem B. 2023 Nov 29; 11(46):10982-11005. PMID: 37955201
     
  4. Dittmar JW, Teplensky MH, Evangelopoulos M, Qin L, Zhang B, Mirkin CA. Tuning DNA Dissociation from Spherical Nucleic Acids for Enhanced Immunostimulation. ACS Nano. 2023 Sep 26; 17(18):17996-18007. PMID: 37713675; DOI: 10.1021/acsnano.3c04333;
     
  5. Teplensky MH, Evangelopoulos M, Dittmar JW, Forsyth CM, Sinegra AJ, Wang S, Mirkin CA. Multi-antigen spherical nucleic acid cancer vaccines. Nat Biomed Eng. 2023 Jul; 7(7):911-927. PMID: 36717738; DOI: 10.1038/s41551-022-01000-2;
     
  6. Distler ME, Cavaliere JP, Teplensky MH, Evangelopoulos M, Mirkin CA. Molecular DNA dendron vaccines. Proc Natl Acad Sci U S A. 2023 Jan 31; 120(5):e2215091120. PMID: 36696444; DOI: 10.1073/pnas.2215091120;
     
  7. Lin M, Meckes B, Chen C, Teplensky MH, Mirkin CA. Controlling Intracellular Machinery via Polymer Pen Lithography Molecular Patterning. ACS Cent Sci. 2022 Sep 28; 8(9):1282-1289. PMID: 36188351; DOI: 10.1021/acscentsci.2c00683;
     
  8. Winegar PH, Figg CA, Teplensky MH, Ramani N, Mirkin CA. Modular Nucleic Acid Scaffolds for Synthesizing Monodisperse and Sequence-Encoded Antibody Oligomers. Chem. 2022 Nov 10; 8(11):3018-3030. PMID: 36405374; DOI: 10.1016/j.chempr.2022.07.003;
     
  9. Teplensky MH, Distler ME, Kusmierz CD, Evangelopoulos M, Gula H, Elli D, Tomatsidou A, Nicolaescu V, Gelarden I, Yeldandi A, Batlle D, Missiakas D, Mirkin CA. Spherical nucleic acids as an infectious disease vaccine platform. Proc Natl Acad Sci U S A. 2022 Apr 05; 119(14):e2119093119. PMID: 35312341; DOI: 10.1073/pnas.2119093119;
     
  10. Skakuj K, Teplensky MH, Wang S, Dittmar JW, Mirkin CA. Chemically Tuning the Antigen Release Kinetics from Spherical Nucleic Acids Maximizes Immune Stimulation. ACS Cent Sci. 2021 Nov 24; 7(11):1838-1846. PMID: 34841057; DOI: 10.1021/acscentsci.1c00779;
     
Showing 10 of 15 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 15 publications over 7 distinct years, with a maximum of 4 publications in 2023

YearPublications
20161
20171
20191
20213
20223
20234
20252

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Cancer-killing vaccines can be made even more powerful (

WalesOnline 1/31/2023

The revolutionary cancer-killing vaccine that could finally see the light of day

Study Finds 1/31/2023
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