Lynne Coluccio | Profiles RNS

Lynne Coluccio, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

PhD, Rensselaer Polytechnic Institute
MS, Rensselaer Polytechnic Institute
BS, State University of New York at Albany

Lynne Coluccio, PhD, joined the Department of Physiology & Biophysics at BUSM in 2013 as an Associate Professor after Boston Biomedical Research Institute (BBRI), where she had been a Senior Scientist, abruptly closed. While at BBRI, she played a variety of roles including chair of the Faculty Search Committee and a member of the Public Relations Committee. Throughout her career she has mentored dozens of students who have gone into academia, medicine, and teaching.

BU Research
NIH RePORTER Research

Myosin 1 in Epithelial Cell-Cell Contact and Polarity
09/16/2015 - 08/31/2020 (PI)
NIH/National Institute of General Medical Sciences
5R01GM111615-04

Role of myosin 1c in adaptation in the inner ear
02/02/2013 - 06/30/2014 (PI)
NIH/National Institute on Deafness & Communication Disorders
7R01DC008793-06

Title

Yr	Title	Project-Sub Proj	Pubs
2018	Myosin I in epithelial cell-cell contact and polarity	5R01GM111615-04	1
2017	Myosin I in epithelial cell-cell contact and polarity	5R01GM111615-03	1
2016	Myosin I in epithelial cell-cell contact and polarity	5R01GM111615-02	1
2015	Myosin I in epithelial cell-cell contact and polarity	1R01GM111615-01A1	1
2012	Role of myosin 1c in adaptation in the inner ear	5R01DC008793-05	9
2012	Role of myosin 1c in adaptation in the inner ear	7R01DC008793-06	9
2011	Role of myosin 1c in adaptation in the inner ear	5R01DC008793-04	9
2010	Role of myosin 1c in adaptation in the inner ear	5R01DC008793-03	9
2009	Role of myosin 1c in adaptation in the inner ear	3R01DC008793-01A2S1	9
2009	Role of myosin 1c in adaptation in the inner ear	5R01DC008793-02	9

Showing 10 of 31 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Tokuo H, Komaba S, Coluccio LM. In pancreatic ß-cells myosin 1b regulates glucose-stimulated insulin secretion by modulating an early step in insulin granule trafficking from the Golgi. Mol Biol Cell. 2021 06 01; 32(12):1210-1220.View Related Profiles.

Tokuo, Hiroshi
Coluccio, Lynne

PMID: 33826361; PMCID: PMC8351557; DOI: 10.1091/mbc.E21-03-0094;

Coluccio LM. Introduction. Adv Exp Med Biol. 2020; 1239:1-6. PMID: 32451852

Coluccio LM. Myosins and Disease. Adv Exp Med Biol. 2020; 1239:245-316. PMID: 32451863

Tokuo H, Bhawan J, Coluccio LM. Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. Sci Rep. 2018 Jul 11; 8(1):10449.View Related Profiles.

Tokuo, Hiroshi
Bhawan, Jag
Coluccio, Lynne

PMID: 29993000; PMCID: PMC6041326; DOI: 10.1038/s41598-018-28717-y;

Komaba S, Coluccio LM. Myosin 1b Regulates Amino Acid Transport by Associating Transporters with the Apical Plasma Membrane of Kidney Cells. PLoS One. 2015; 10(9):e0138012. PMID: 26361046; PMCID: PMC4567078; DOI: 10.1371/journal.pone.0138012;

Tokuo H, Coluccio LM. Myosin-1c regulates the dynamic stability of E-cadherin-based cell-cell contacts in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2013 Sep; 24(18):2820-33.View Related Profiles.

Tokuo, Hiroshi
Coluccio, Lynne

PMID: 23864705; PMCID: PMC3771945; DOI: 10.1091/mbc.E12-12-0884;

Chinthalapudi K, Taft MH, Martin R, Heissler SM, Preller M, Hartmann FK, Brandstaetter H, Kendrick-Jones J, Tsiavaliaris G, Gutzeit HO, Fedorov R, Buss F, Knölker HJ, Coluccio LM, Manstein DJ. Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. J Biol Chem. 2011 Aug 26; 286(34):29700-8. PMID: 21680745; PMCID: PMC3191011; DOI: 10.1074/jbc.M111.239210;

Adamek N, Geeves MA, Coluccio LM. Myo1c mutations associated with hearing loss cause defects in the interaction with nucleotide and actin. Cell Mol Life Sci. 2011 Jan; 68(1):139-50. PMID: 20640478; PMCID: PMC3014424; DOI: 10.1007/s00018-010-0448-x;

Komaba S, Coluccio LM. Localization of myosin 1b to actin protrusions requires phosphoinositide binding. J Biol Chem. 2010 Sep 3; 285(36):27686-93. PMID: 20610386; PMCID: PMC2934636; DOI: 10.1074/jbc.M109.087270;

Adamek N, Lieto-Trivedi A, Geeves MA, Coluccio LM. Modification of loop 1 affects the nucleotide binding properties of Myo1c, the adaptation motor in the inner ear. Biochemistry. 2010 Feb 9; 49(5):958-71. PMID: 20039646; PMCID: PMC2826812; DOI: 10.1021/bi901803j;

Showing 10 of 49 results. Show More

Wang CL, Coluccio LM. New insights into the regulation of the actin cytoskeleton by tropomyosin. Int Rev Cell Mol Biol. 2010; 281:91-128. PMID: 20460184; PMCID: PMC2923581; DOI: 10.1016/S1937-6448(10)81003-2;

Lieto-Trivedi A, Coluccio LM. Calcium, nucleotide, and actin affect the interaction of mammalian Myo1c with its light chain calmodulin. Biochemistry. 2008 Sep 23; 47(38):10218-26. PMID: 18729383; DOI: 10.1021/bi8011059;

Adamek N, Coluccio LM, Geeves MA. Calcium sensitivity of the cross-bridge cycle of Myo1c, the adaptation motor in the inner ear. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5710-5. PMID: 18391215; PMCID: PMC2299219; DOI: 10.1073/pnas.0710520105;

Coluccio LM. Myosins: A superfamily of molecular motors. Myosin I. Springer Verlag. The Netherlands. 2008; 7:95 - 124.

Lieto-Trivedi A, Dash S, Coluccio LM. Myosin surface loop 4 modulates inhibition of actomyosin 1b ATPase activity by tropomyosin. Biochemistry. 2007 Mar 13; 46(10):2779-86. PMID: 17298083

Clark R, Ansari MA, Dash S, Geeves MA, Coluccio LM. Loop 1 of transducer region in mammalian class I myosin, Myo1b, modulates actin affinity, ATPase activity, and nucleotide access. J Biol Chem. 2005 Sep 2; 280(35):30935-42. PMID: 15980431

Batters C, Wallace MI, Coluccio LM, Molloy JE. A model of stereocilia adaptation based on single molecule mechanical studies of myosin I. Philos Trans R Soc Lond B Biol Sci. 2004 Dec 29; 359(1452):1895-905. PMID: 15647165; PMCID: PMC1693475

Stafford WF, Walker ML, Trinick JA, Coluccio LM. Mammalian class I myosin, Myo1b, is monomeric and cross-links actin filaments as determined by hydrodynamic studies and electron microscopy. Biophys J. 2005 Jan; 88(1):384-91. PMID: 15475577; PMCID: PMC1305015

Batters C, Arthur CP, Lin A, Porter J, Geeves MA, Milligan RA, Molloy JE, Coluccio LM. Myo1c is designed for the adaptation response in the inner ear. EMBO J. 2004 Apr 7; 23(7):1433-40. PMID: 15014434; PMCID: PMC391074

Wallace MI, Batters C, Coluccio LM, Molloy JE. Nanometre resolution tracking of myosin-1b motility. IEE Proc Nanobiotechnol. 2003 Dec; 150(3):134-40. PMID: 16468942

Geeves MA, Perreault-Micale C, Coluccio LM. Kinetic analyses of a truncated mammalian myosin I suggest a novel isomerization event preceding nucleotide binding. J Biol Chem. 2000 Jul 14; 275(28):21624-30. PMID: 10781577

Perreault-Micale C, Shushan AD, Coluccio LM. Truncation of a mammalian myosin I results in loss of Ca2+-sensitive motility. J Biol Chem. 2000 Jul 14; 275(28):21618-23. PMID: 10777479

Li W, Wang J, Coluccio LM, Matsudaira P, Grand RJ. Brush border myosin I (BBMI): a basally localized transcript in human jejunal enterocytes. J Histochem Cytochem. 2000 Jan; 48(1):89-94. PMID: 10653589

Geeves MA, Coluccio LM. The XXVIII European Muscle conference. York, UK, 4-7 September 1999. J Muscle Res Cell Motil. 1999 Nov; 20(8):807-9. PMID: 10730583

Balish MF, Moeller EF, Coluccio LM. Overlapping distribution of the 130- and 110-kDa myosin I isoforms on rat liver membranes. Arch Biochem Biophys. 1999 Oct 15; 370(2):285-93. PMID: 10577358

Coluccio LM, Geeves MA. Transient kinetic analysis of the 130-kDa myosin I (MYR-1 gene product) from rat liver. A myosin I designed for maintenance of tension? J Biol Chem. 1999 Jul 30; 274(31):21575-80. PMID: 10419463

Veigel C, Coluccio LM, Jontes JD, Sparrow JC, Milligan RA, Molloy JE. The motor protein myosin-I produces its working stroke in two steps. Nature. 1999 Apr 8; 398(6727):530-3. PMID: 10206648

Coluccio LM. Myosin I. Am J Physiol. 1997 Aug; 273(2 Pt 1):C347-59. PMID: 9277333

Williams R, Coluccio LM. Phosphorylation of myosin-I from rat liver by protein kinase C reduces calmodulin binding. Biochem Biophys Res Commun. 1995 Nov 2; 216(1):90-102. PMID: 7488129

Balish MF, Coluccio LM. Identification of brush border myosin-I in liver and testis. Biochem Biophys Res Commun. 1995 Jun 6; 211(1):331-9. PMID: 7779104

Coluccio LM. An end in sight: tropomodulin. J Cell Biol. 1994 Dec; 127(6 Pt 1):1497-9. PMID: 7798305; PMCID: PMC2120316

Coluccio LM. Differential calmodulin binding to three myosin-1 isoforms from liver. J Cell Sci. 1994 Aug; 107 ( Pt 8):2279-84. PMID: 7983186

Williams R, Coluccio LM. Novel 130-kDa rat liver myosin-1 will translocate actin filaments. Cell Motil Cytoskeleton. 1994; 27(1):41-8. PMID: 8194109

Coluccio LM, Conaty C. Myosin-I in mammalian liver. Cell Motil Cytoskeleton. 1993; 24(3):189-99. PMID: 8467525

Coluccio LM. Identification of the microvillar 110-kDa calmodulin complex (myosin-1) in kidney. Eur J Cell Biol. 1991 Dec; 56(2):286-94. PMID: 1839382

Coluccio LM, Bretscher A. Mapping of the microvillar 110K-calmodulin complex (brush border myosin I). Identification of fragments containing the catalytic and F-actin-binding sites and demonstration of a calcium ion dependent conformational change. Biochemistry. 1990 Dec 18; 29(50):11089-94. PMID: 2271696

Coluccio LM, Bretscher A. Reassociation of microvillar core proteins: making a microvillar core in vitro. J Cell Biol. 1989 Feb; 108(2):495-502. PMID: 2918023; PMCID: PMC2115419

Bullitt ES, DeRosier DJ, Coluccio LM, Tilney LG. Three-dimensional reconstruction of an actin bundle. J Cell Biol. 1988 Aug; 107(2):597-611.View Related Profiles.

Bullitt, Esther
Coluccio, Lynne

PMID: 3417764; PMCID: PMC2115194

Coluccio LM, Bretscher A. Mapping of the microvillar 110K-calmodulin complex: calmodulin-associated or -free fragments of the 110-kD polypeptide bind F-actin and retain ATPase activity. J Cell Biol. 1988 Feb; 106(2):367-73. PMID: 2963011; PMCID: PMC2114968

Krizek J, Coluccio LM, Bretscher A. ATPase activity of the microvillar 110 kDa polypeptide-calmodulin complex is activated in Mg2+ and inhibited in K+-EDTA by F-actin. FEBS Lett. 1987 Dec 10; 225(1-2):269-72. PMID: 2961614

Coluccio LM, Bretscher A. Calcium-regulated cooperative binding of the microvillar 110K-calmodulin complex to F-actin: formation of decorated filaments. J Cell Biol. 1987 Jul; 105(1):325-33. PMID: 2956267; PMCID: PMC2114924

Coluccio LM, Sedlar PA, Bryan J. The effects of a 45 000 molecular weight protein from unfertilized sea urchin eggs and its 1:1 actin complex on actin filaments. J Muscle Res Cell Motil. 1986 Apr; 7(2):133-41. PMID: 3086378

Bryan J, Coluccio LM. Kinetic analysis of F-actin depolymerization in the presence of platelet gelsolin and gelsolin-actin complexes. J Cell Biol. 1985 Oct; 101(4):1236-44. PMID: 2995403; PMCID: PMC2113914

Coluccio LM, Tilney LG. Phalloidin enhances actin assembly by preventing monomer dissociation. J Cell Biol. 1984 Aug; 99(2):529-35. PMID: 6746738; PMCID: PMC2113271

Coluccio LM, Tilney LG. Under physiological conditions actin disassembles slowly from the nonpreferred end of an actin filament. J Cell Biol. 1983 Nov; 97(5 Pt 1):1629-34. PMID: 6630295; PMCID: PMC2112688

Tilney LG, Bonder EM, Coluccio LM, Mooseker MS. Actin from Thyone sperm assembles on only one end of an actin filament: a behavior regulated by profilin. J Cell Biol. 1983 Jul; 97(1):112-24. PMID: 6863386; PMCID: PMC2112487

Coluccio LM, Brady RJ, Parsons RH. Pressure effects on the ADH-induced initiation of water flow in toad bladder. Am J Physiol. 1983 May; 244(5):F547-53. PMID: 6303132

Koretz JF, Coluccio LM, Bertasso AM. The aggregation characteristics of column-purified rabbit skeletal myosin in the presence and absence of C-protein at pH 7.0. Biophys J. 1982 Feb; 37(2):433-40. PMID: 6895856; PMCID: PMC1328825

Brady RJ, Parsons RH, Coluccio LM. Nocodazole inhibition of the vasopressin-induced water permeability increase in toad urinary bladder. Biochim Biophys Acta. 1981 Sep 7; 646(3):399-401. PMID: 7284368

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 49 publications over 29 distinct years, with a maximum of 4 publications in 1999 and 2010

Bar chart showing 49 publications over 29 distinct years, with a maximum of 4 publications in 1999 and 2010

Year	Publications
1981	1
1982	1
1983	3
1984	1
1985	1
1986	1
1987	2
1988	2
1989	1
1990	1
1991	1
1993	1
1994	3
1995	2
1997	1
1999	4
2000	3
2003	1
2004	3
2005	1
2007	1
2008	3
2010	4
2011	1
2013	1
2015	1
2018	1
2020	2
2021	1

Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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617.358.8447

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