Lynne Coluccio, PhD
Associate Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Rensselaer Polytechnic Institute
MS, Rensselaer Polytechnic Institute

Lynne Coluccio, PhD, began her career at Boston University as a Principal Scientist at the Boston Biomedical Research Institute (BBRI) in 1996. After the institute was closed in 2013, she became a Research Associate in the Department of Physiology & Biophysics at the Boston University School of Medicine and has remained since then. While at the BBRI, she played a variety of roles on the committee including as a chair of the Faculty Search Committee and as a member of the Public Relations Committee. Throughout her she career she has mentored dozens of students who have gone into academia, medicine, teaching, and music.

Myosin 1 in Epithelial Cell-Cell Contact and Polarity
09/16/2015 - 08/31/2020 (PI)
NIH/National Institute of General Medical Sciences

Role of myosin 1c in adaptation in the inner ear
02/02/2013 - 06/30/2014 (PI)
NIH/National Institute on Deafness & Communication Disorders


Yr Title Project-Sub Proj Pubs
2018 Myosin I in epithelial cell-cell contact and polarity 5R01GM111615-04 1
2017 Myosin I in epithelial cell-cell contact and polarity 5R01GM111615-03 1
2016 Myosin I in epithelial cell-cell contact and polarity 5R01GM111615-02 1
2015 Myosin I in epithelial cell-cell contact and polarity 1R01GM111615-01A1 1
2012 Role of myosin 1c in adaptation in the inner ear 5R01DC008793-05 9
2012 Role of myosin 1c in adaptation in the inner ear 7R01DC008793-06 9
2011 Role of myosin 1c in adaptation in the inner ear 5R01DC008793-04 9
2010 Role of myosin 1c in adaptation in the inner ear 5R01DC008793-03 9
2009 Role of myosin 1c in adaptation in the inner ear 3R01DC008793-01A2S1 9
2009 Role of myosin 1c in adaptation in the inner ear 5R01DC008793-02 9
Showing 10 of 31 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Tokuo H, Komaba S, Coluccio LM. In pancreatic ß-cells myosin 1b regulates glucose-stimulated insulin secretion by modulating an early step in insulin granule trafficking from the Golgi. Mol Biol Cell. 2021 Jun 01; 32(12):1210-1220.View Related Profiles. PMID: 33826361
  2. Coluccio LM. Introduction. Adv Exp Med Biol. 2020; 1239:1-6. PMID: 32451852
  3. Coluccio LM. Myosins and Disease. Adv Exp Med Biol. 2020; 1239:245-316. PMID: 32451863
  4. Tokuo H, Bhawan J, Coluccio LM. Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. Sci Rep. 2018 Jul 11; 8(1):10449.View Related Profiles. PMID: 29993000; PMCID: PMC6041326; DOI: 10.1038/s41598-018-28717-y;
  5. Komaba S, Coluccio LM. Myosin 1b Regulates Amino Acid Transport by Associating Transporters with the Apical Plasma Membrane of Kidney Cells. PLoS One. 2015; 10(9):e0138012. PMID: 26361046; PMCID: PMC4567078; DOI: 10.1371/journal.pone.0138012;
  6. Tokuo H, Coluccio LM. Myosin-1c regulates the dynamic stability of E-cadherin-based cell-cell contacts in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2013 Sep; 24(18):2820-33.View Related Profiles. PMID: 23864705; PMCID: PMC3771945; DOI: 10.1091/mbc.E12-12-0884;
  7. Chinthalapudi K, Taft MH, Martin R, Heissler SM, Preller M, Hartmann FK, Brandstaetter H, Kendrick-Jones J, Tsiavaliaris G, Gutzeit HO, Fedorov R, Buss F, Knölker HJ, Coluccio LM, Manstein DJ. Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. J Biol Chem. 2011 Aug 26; 286(34):29700-8. PMID: 21680745; PMCID: PMC3191011; DOI: 10.1074/jbc.M111.239210;
  8. Adamek N, Geeves MA, Coluccio LM. Myo1c mutations associated with hearing loss cause defects in the interaction with nucleotide and actin. Cell Mol Life Sci. 2011 Jan; 68(1):139-50. PMID: 20640478; PMCID: PMC3014424; DOI: 10.1007/s00018-010-0448-x;
  9. Komaba S, Coluccio LM. Localization of myosin 1b to actin protrusions requires phosphoinositide binding. J Biol Chem. 2010 Sep 3; 285(36):27686-93. PMID: 20610386; PMCID: PMC2934636; DOI: 10.1074/jbc.M109.087270;
  10. Adamek N, Lieto-Trivedi A, Geeves MA, Coluccio LM. Modification of loop 1 affects the nucleotide binding properties of Myo1c, the adaptation motor in the inner ear. Biochemistry. 2010 Feb 9; 49(5):958-71. PMID: 20039646; PMCID: PMC2826812; DOI: 10.1021/bi901803j;
Showing 10 of 49 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 49 publications over 29 distinct years, with a maximum of 4 publications in 1999 and 2010


Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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