Lynne Coluccio, PhD
Associate Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Rensselaer Polytechnic Institute
MS, Rensselaer Polytechnic Institute



Lynne Coluccio, PhD, began her career at Boston University as a Principal Scientist at the Boston Biomedical Research Institute (BBRI) in 1996. After the institute was closed in 2013, she became a Research Associate in the Department of Physiology & Biophysics at the Boston University School of Medicine and has remained since then. While at the BBRI, she played a variety of roles on the committee including as a chair of the Faculty Search Committee and as a member of the Public Relations Committee. Throughout her she career she has mentored dozens of students who have gone into academia, medicine, teaching, and music.


Myosin 1 in Epithelial Cell-Cell Contact and Polarity
09/16/2015 - 08/31/2019 (PI)
NIH/National Institute of General Medical Sciences
5R01GM111615-03

Role of myosin 1c in adaptation in the inner ear
02/02/2013 - 06/30/2014 (PI)
NIH/National Institute on Deafness & Communication Disorders
7R01DC008793-06




Yr Title Project-Sub Proj Pubs
2017 Myosin I in epithelial cell-cell contact and polarity 5R01GM111615-03
2016 Myosin I in epithelial cell-cell contact and polarity 5R01GM111615-02
2015 Myosin I in epithelial cell-cell contact and polarity 1R01GM111615-01A1
2012 Role of myosin 1c in adaptation in the inner ear 5R01DC008793-05 2
2012 Role of myosin 1c in adaptation in the inner ear 7R01DC008793-06 2
2011 Role of myosin 1c in adaptation in the inner ear 5R01DC008793-04 2
2010 Role of myosin 1c in adaptation in the inner ear 5R01DC008793-03 2
2009 Role of myosin 1c in adaptation in the inner ear 3R01DC008793-01A2S1 2
2009 Role of myosin 1c in adaptation in the inner ear 5R01DC008793-02 2
2008 Role of myosin 1c in adaptation in the inner ear 1R01DC008793-01A2 2
Showing 10 of 30 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Tokuo H, Bhawan J, Coluccio LM. Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. Sci Rep. 2018 Jul 11; 8(1):10449.View Related Profiles. PMID: 29993000.
     
  2. Komaba S, Coluccio LM. Myosin 1b Regulates Amino Acid Transport by Associating Transporters with the Apical Plasma Membrane of Kidney Cells. PLoS One. 2015; 10(9):e0138012. PMID: 26361046; PMCID: PMC4567078; DOI: 10.1371/journal.pone.0138012;.
     
  3. Tokuo H, Coluccio LM. Myosin-1c regulates the dynamic stability of E-cadherin-based cell-cell contacts in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2013 Sep; 24(18):2820-33.View Related Profiles. PMID: 23864705; PMCID: PMC3771945; DOI: 10.1091/mbc.E12-12-0884;.
     
  4. Chinthalapudi K, Taft MH, Martin R, Heissler SM, Preller M, Hartmann FK, Brandstaetter H, Kendrick-Jones J, Tsiavaliaris G, Gutzeit HO, Fedorov R, Buss F, Knölker HJ, Coluccio LM, Manstein DJ. Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. J Biol Chem. 2011 Aug 26; 286(34):29700-8. PMID: 21680745; PMCID: PMC3191011; DOI: 10.1074/jbc.M111.239210;.
     
  5. Adamek N, Geeves MA, Coluccio LM. Myo1c mutations associated with hearing loss cause defects in the interaction with nucleotide and actin. Cell Mol Life Sci. 2011 Jan; 68(1):139-50. PMID: 20640478; PMCID: PMC3014424; DOI: 10.1007/s00018-010-0448-x;.
     
  6. Komaba S, Coluccio LM. Localization of myosin 1b to actin protrusions requires phosphoinositide binding. J Biol Chem. 2010 Sep 3; 285(36):27686-93. PMID: 20610386; PMCID: PMC2934636; DOI: 10.1074/jbc.M109.087270;.
     
  7. Adamek N, Lieto-Trivedi A, Geeves MA, Coluccio LM. Modification of loop 1 affects the nucleotide binding properties of Myo1c, the adaptation motor in the inner ear. Biochemistry. 2010 Feb 9; 49(5):958-71. PMID: 20039646; PMCID: PMC2826812; DOI: 10.1021/bi901803j;.
     
  8. Wang CL, Coluccio LM. New insights into the regulation of the actin cytoskeleton by tropomyosin. Int Rev Cell Mol Biol. 2010; 281:91-128. PMID: 20460184; PMCID: PMC2923581; DOI: 10.1016/S1937-6448(10)81003-2;.
     
  9. Lieto-Trivedi A, Coluccio LM. Calcium, nucleotide, and actin affect the interaction of mammalian Myo1c with its light chain calmodulin. Biochemistry. 2008 Sep 23; 47(38):10218-26. PMID: 18729383; DOI: 10.1021/bi8011059;.
     
  10. Adamek N, Coluccio LM, Geeves MA. Calcium sensitivity of the cross-bridge cycle of Myo1c, the adaptation motor in the inner ear. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5710-5. PMID: 18391215; PMCID: PMC2299219; DOI: 10.1073/pnas.0710520105;.
     
Showing 10 of 46 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 46 publications over 27 distinct years, with a maximum of 4 publications in 1999 and 2010

YearPublications
19811
19821
19833
19841
19851
19861
19872
19882
19891
19901
19911
19931
19943
19952
19971
19994
20003
20031
20043
20051
20071
20083
20104
20111
20131
20151
20181
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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