Laura Lewis, PhD
Assistant Professor
Boston University College of Engineering
Dept of Biomedical Engineering

PhD, Massachusetts Institute of Technology




Laura Lewis is an Assistant Professor of Biomedical Engineering at Boston University. She received her Ph.D. in Neuroscience from MIT and conducted postdoctoral research as a Junior Fellow of the Harvard Society of Fellows, at the Athinoula A. Martinos Center for Biomedical Imaging. She is the recipient of the Society for Neuroscience Peter and Patricia Gruber International Research Award, the One Mind Rising Star Award, the 1907 Trailblazer Award, the Sloan Fellowship, the Searle Scholar Award, the McKnight Scholar Award, and the Pew Biomedical Scholar Award.


Subcortical circuit dynamics underlying human sleep and wakefulness
07/29/2021 - 07/31/2026 (PI)
The Pew Charitable Trusts


Neuroimaging the impact of respiration and respiratory-gated neuromodulation on human glymphatic physiology
04/01/2021 - 03/31/2026 (PI)
NIH/National Center for Complementary and Integrative Health
5R01AT011429-02

Sleep-dependent modulation of cerebrospinal fluid flow in aging and across genetic risk for Alzheimer's disease
02/01/2021 - 01/31/2026 (PI)
NIH/National Institute on Aging
5R01AG070135-02

Development of the Human Dynamic Neurochemical Connectome Scanner
09/21/2020 - 05/31/2025 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NIBIB
5U01EB029826-02

Imaging electrophysiological and fluid dynamics in the sleeping brain
07/01/2021 - 06/30/2024 (PI)
The McKnight Foundation


fMRI Technologies for Imaging at the Limit of Biological Spatiotemporal Resolution
04/01/2021 - 03/31/2024 (Subcontract PI)
Massachusetts General Hospital NIH NIBIB
5R01EB019437-06

Multimodal imaging of intersecting network dynamics underlying sleep and mood in depression
12/15/2019 - 12/31/2023 (PI)
One Mind Foundation


SPI Stevens: Glial mechanisms by which sleep preserves cognitive function and plasticity in aging
11/01/2020 - 10/31/2023 (PI)
Simons Foundation


Neural dynamics of human sleep
09/15/2021 - 09/14/2023 (PI)
Alfred P. Sloan Foundation


Neuromodulation of neural dynamics and perception across sleep and wakefulness
07/01/2020 - 06/30/2023 (PI)
Searle Scholars Program


Showing 10 of 17 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2022 Project 4: Linking neural, hemodynamic, and multiscale cerebrospinal fluid flow measures in humans 1U19NS128613-01-8811
2022 Neural circuit control of fluid and solute clearance during sleep 1U19NS128613-01
2022 Neuroimaging the impact of respiration and respiratory-gated neuromodulation on human glymphatic physiology 5R01AT011429-02
2022 Sleep-dependent modulation of cerebrospinal fluid flow in aging and across genetic risk for Alzheimers disease 5R01AG070135-02
2021 Imaging neurovascular physiology in persistent fatigue after COVID-19 1R21NS123412-01
2021 Neuroimaging the impact of respiration and respiratory-gated neuromodulation on human glymphatic physiology 1R01AT011429-01
2021 Sleep-dependent modulation of cerebrospinal fluid flow in aging and across genetic risk for Alzheimers disease 1R01AG070135-01
2021 Imaging neural dynamics at high temporal resolution in sleep and sleep deprivation 5R00MH111748-05 1
2020 Imaging neural dynamics at high temporal resolution in sleep and sleep deprivation 5R00MH111748-04 1
2019 Imaging neural dynamics at high temporal resolution in sleep and sleep deprivation 4R00MH111748-03 1
Showing 10 of 12 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. García-Gomar MG, Videnovic A, Singh K, Stauder M, Lewis LD, Wald LL, Rosen BR, Bianciardi M. Disruption of Brainstem Structural Connectivity in REM Sleep Behavior Disorder Using 7 Tesla Magnetic Resonance Imaging. Mov Disord. 2022 04; 37(4):847-853. PMID: 34964520; PMCID: PMC9018552; DOI: 10.1002/mds.28895;
     
  2. Vizioli L, Yacoub E, Lewis LD. How pushing the spatiotemporal resolution of fMRI can advance neuroscience. Prog Neurobiol. 2021 12; 207:102184. PMID: 34767874; DOI: 10.1016/j.pneurobio.2021.102184;
     
  3. Lewis LD. The interconnected causes and consequences of sleep in the brain. Science. 2021 Oct 29; 374(6567):564-568. PMID: 34709917; PMCID: PMC8815779; DOI: 10.1126/science.abi8375;
     
  4. Chen JE, Glover GH, Fultz NE, Rosen BR, Polimeni JR, Lewis LD. Investigating mechanisms of fast BOLD responses: The effects of stimulus intensity and of spatial heterogeneity of hemodynamics. Neuroimage. 2021 12 15; 245:118658. PMID: 34656783; PMCID: PMC8815416; DOI: 10.1016/j.neuroimage.2021.118658;
     
  5. Polimeni JR, Lewis LD. Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response. Prog Neurobiol. 2021 12; 207:102174. PMID: 34525404; PMCID: PMC8688322; DOI: 10.1016/j.pneurobio.2021.102174;
     
  6. Bailes SM, Lewis LD. Distinct cardiac-locked brain pulsations in Alzheimer's disease. Brain. 2021 08 17; 144(7):1941-1942. PMID: 34244731; PMCID: PMC8370395; DOI: 10.1093/brain/awab247;
     
  7. Yang Z, Lewis LD. Imaging the temporal dynamics of brain states with highly sampled fMRI. Curr Opin Behav Sci. 2021 Aug; 40:87-95. PMID: 34734109; PMCID: PMC8562679; DOI: 10.1016/j.cobeha.2021.02.005;
     
  8. Mächler P, Broggini T, Mateo C, Thunemann M, Fomin-Thunemann N, Doran PR, Sencan I, Kilic K, Desjardins M, Uhlirova H, Yaseen MA, Boas DA, Linninger AA, Vergassola M, Yu X, Lewis LD, Polimeni JR, Rosen BR, Sakadžic S, Buxton RB, Lauritzen M, Kleinfeld D, Devor A. A Suite of Neurophotonic Tools to Underpin the Contribution of Internal Brain States in fMRI. Curr Opin Biomed Eng. 2021 Jun; 18.View Related Profiles. PMID: 33959688; PMCID: PMC8095678; DOI: 10.1016/j.cobme.2021.100273;
     
  9. Polimeni, J.R., Lewis, L.D. Imaging faster neural dynamics with fast fMRI: a need for updated models of the hemodynamic response. Progress in Neurobiology. 2021.
  10. Mächler, P., Mateo, C., Thunemann, M., Fomin-Thunemann, N., Doran, P.R., Sencan, I., Kilic, K., Desjardins, M., Uhlirova, H., Yaseen, M.A., Boas, D.A., Linninger, A.A., Vergassola, M., Yu, X., Lewis, L.D., Polimeni, J.R., Rosen, B.R., Sakadžic, S., Buxton, R.B., Lauritzen, M., Kleinfeld, D., Devor, A. Neurophotonics tools for underpinning fMRI signals with respect to internal brain states. Current Opinion in Biomedical Engineering. 2021; 18:100273.
Showing 10 of 42 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 41 publications over 10 distinct years, with a maximum of 14 publications in 2021

YearPublications
20112
20122
20135
20141
20152
20162
20186
20193
20204
202114


Deep Sleep Protects Against Alzheimer's, Growing Evidence Shows

NPR 11/17/2020

Variants in Water Channel Gene Tied to More Restful Sleep

The Scientist 5/12/2020

Sleeping Brain Waves Draw a Healthy Bath for Neurons

Quanta Magazine 12/16/2019

Here’s How Sleep Removes Poisons From Your Brain, Protecting You From Alzheimer’s as Nothing Else Can

Inc. 11/22/2019

This is how a good night’s sleep cleans toxins from your brain

WIRED 11/10/2019

During deep sleep, the brain does housekeeping

Reuters 11/7/2019

Watch: Spinal Fluid Waves Flow Into Your Brain As You Sleep

Futurity 11/7/2019

To decrease risk of Alzheimer’s, quantity and quality of sleep matters, study finds

NY Daily News 11/4/2019

Brain’s Cerebrospinal Fluid Pulses During Sleep

Sleep Review 11/3/2019

Scientists Now Know How Sleep Cleans Toxins From the Brain

WIRED Science – Spoken Edition 11/3/2019

How deep sleep scrubs your brain of toxins

Mother Nature Network 11/1/2019

Brain toxins cleansed during sleep could prevent Alzheimer’s

New York Post 11/1/2019

The only detox you need is sleep—but it’s not totally clear why

Popular Science 11/1/2019

Deep Sleep Gives Your Brain a Deep Clean

Scientific American 11/1/2019

To decrease risk of Alzheimer’s, quantity and quality of sleep matters, study finds

Boston 25 News 11/1/2019

A good night’s sleep could protect against dementia because the body ‘washes’ toxic proteins out of the brain, study

Daily Mail 11/1/2019

Sleeping Washes Our Brains Clean of Unwanted Toxins, New Study Finds

Interesting Engineering 11/1/2019

Can Sleep Trigger Rhythmic Power Washing In The Brain?

Medical Daily 11/1/2019

How good night’s sleep can brainwash away dementia

The Times 11/1/2019

Researchers discover your brain has a literal “rinse cycle”

Inverse 10/31/2019

A type of brainwave may help clean your brain while you sleep

New Scientist 10/31/2019

U.S. Biotech Amgen Strikes Major Deal to Expand China Presence

Fortune 10/31/2019

How Deep Sleep May Help The Brain Clear Alzheimer’s Toxins

WBUR 10/31/2019

Sleep may trigger rhythmic power washing in the brain

Science News Magazine 10/31/2019

Scientists Now Know How Sleep Cleans Toxins From the Brain

WIRED 10/31/2019

Deep Sleep May ‘Rinse’ Day’s Toxins From Brain

Health Day 10/31/2019

Waves of Fluid Bathe the Sleeping Brain, Perhaps to Clear Waste

The Scientist 10/31/2019

2021 1907 Trailblazer Award
2021 Hariri Institute Junior Faculty Fellow
2021 Pew Scholar Award
2021 McKnight Scholar Award
2021 Sloan Research Fellow
2020 NARSAD Young Investigator Award
2020 Smith Family Award for Excellence in Biomedical Research
2020 Searle Scholar Award
2019 One Mind Rising Star Award
2018 eLife Travel Award
2017 NIMH, NIH: K99/R00 Pathway to Independence Award
2017 Winter Conference on Brain Research: Travel Fellow
2017 Organization for Human Brain Mapping: Merit Abstract Award
2017 Society for Neuroscience: Peter and Patricia Gruber International Research Award
2016 Havard: Mind Brain Behavior Small Faculty Research Award
2016 Harvard University: William F. Milton Fund Award
2015 the National Academy of Sciences: Kavli Fellow
2014 Gordon Research Conference MERIT Award
2014 Harvard University: Junior Fellowship, Society of Fellows
2014-2015 Cosyne Travel Award
2014-2015 Cosyne Travel Award
2013 American Society of Anesthesiologists: Best Abstract in Clinical Science Award
2012 Cosyne Travel Award
2011 Walle Nauta Award: Excellence in Graduate Teaching
2010 Canadian Institutes of Health Research (CIHR): Doctoral Research Award
2008 Quebec Research Council (FQRNT): Masters Research Award
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610 Commonwealth Ave
Boston MA 02215
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