Laura Lewis, PhD
Assistant Professor
Boston University College of Engineering
Dept of Biomedical Engineering

PhD, Massachusetts Institute of Technology

Subcortical circuit dynamics underlying human sleep and wakefulness
07/29/2021 - 07/31/2026 (PI)
The Pew Charitable Trusts

Neuroimaging the impact of respiration and respiratory-gated neuromodulation on human glymphatic physiology
04/01/2021 - 03/31/2026 (PI)
NIH/National Center for Complementary and Integrative Health

Sleep-dependent modulation of cerebrospinal fluid flow in aging and across genetic risk for Alzheimer's disease
02/01/2021 - 01/31/2026 (PI)
NIH/National Institute on Aging

Development of the Human Dynamic Neurochemical Connectome Scanner
09/21/2020 - 05/31/2025 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NIBIB

Imaging electrophysiological and fluid dynamics in the sleeping brain
07/01/2021 - 06/30/2024 (PI)
The McKnight Foundation

fMRI Technologies for Imaging at the Limit of Biological Spatiotemporal Resolution
04/01/2021 - 03/31/2024 (Subcontract PI)
Massachusetts General Hospital NIH NIBIB

SPI Stevens: Glial mechanisms by which sleep preserves cognitive function and plasticity in aging
11/01/2020 - 10/31/2023 (PI)
Simons Foundation

Neural dynamics of human sleep
09/15/2021 - 09/14/2023 (PI)
Alfred P. Sloan Foundation

Neuromodulation of neural dynamics and perception across sleep and wakefulness
07/01/2020 - 06/30/2023 (PI)
Searle Scholars Program

Whole-brain imaging of dopamine dynamics in sleep and wakefulness
03/01/2020 - 02/28/2023 (PI)
The Smith Family Foundation

Showing 10 of 17 results. Show All Results


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Lewis, L.D. The interconnected causes and consequences of sleep in the brain. Science. 2021; 374(6567):564-568.
  2. García-Gomar, M.G., Singh, K., Stauder, M., Lewis, L.D., Wald, L.L., Rosen, B.R., Videnovic, A., Bianciardi, M. Disruption of brainstem structural connectivity in REM sleep behavior disorder using 7 Tesla MRI. Movement Disorders. 2021.
  3. Chen, J.E., Glover, G.H., Fultz, N.E., Rosen, B.R., Polimeni, J.R., Lewis, L.D. Investigating mechanisms of fast BOLD responses: the effects of stimulus intensity and of spatial heterogeneity of hemodynamics. Neuroimage. 2021; 245:118658.
  4. Polimeni, J.R., Lewis, L.D. Imaging faster neural dynamics with fast fMRI: a need for updated models of the hemodynamic response. Progress in Neurobiology. 2021.
  5. Yang, Z., Lewis, L.D. Imaging the temporal dynamics of brain states with highly sampled fMRI. Current Opinion in Behavioral Sciences. 2021; 40:87-95.
  6. Mächler, P., Mateo, C., Thunemann, M., Fomin-Thunemann, N., Doran, P.R., Sencan, I., Kilic, K., Desjardins, M., Uhlirova, H., Yaseen, M.A., Boas, D.A., Linninger, A.A., Vergassola, M., Yu, X., Lewis, L.D., Polimeni, J.R., Rosen, B.R., Sakadžic, S., Buxton, R.B., Lauritzen, M., Kleinfeld, D., Devor, A. Neurophotonics tools for underpinning fMRI signals with respect to internal brain states. Current Opinion in Biomedical Engineering. 2021; 18:100273.
  7. Chen, J.E., Lewis, L.D. , Chang, C., Tian, Q., Fultz, N.E., Ohringer, N.A., Rosen, B.R., Polimeni, J.R. Resting-state “Physiological Networks”. Neuroimage. 2020; 213:116707.
  8. Agrawal, U., Brown, E.N., Lewis, L.D. Model-based physiological noise removal for fast fMRI. Neuroimage. 2020; 205:116231.
  9. Fultz, N.E., Bonmassar, G., Setsompop, K., Stickgold, R.A., Rosen, B.R., Polimeni, J.R., Lewis, L.D. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science. 2019; 366 (6465):628-631.
  10. Lewis, L.D., Setsompop, K., Rosen, B.R., Polimeni, J.R. Stimulus-dependent hemodynamic response timing across the human subcortical-cortical visual pathway identified through high spatiotemporal resolution 7T fMRI. Neuroimage. 2018; 181:279-291.
Showing 10 of 19 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 19 publications over 10 distinct years, with a maximum of 6 publications in 2021


Deep Sleep Protects Against Alzheimer's, Growing Evidence Shows

NPR 11/17/2020

Variants in Water Channel Gene Tied to More Restful Sleep

The Scientist 5/12/2020

Sleeping Brain Waves Draw a Healthy Bath for Neurons

Quanta Magazine 12/16/2019

Here’s How Sleep Removes Poisons From Your Brain, Protecting You From Alzheimer’s as Nothing Else Can

Inc. 11/22/2019

This is how a good night’s sleep cleans toxins from your brain

WIRED 11/10/2019

During deep sleep, the brain does housekeeping

Reuters 11/7/2019

Watch: Spinal Fluid Waves Flow Into Your Brain As You Sleep

Futurity 11/7/2019

To decrease risk of Alzheimer’s, quantity and quality of sleep matters, study finds

NY Daily News 11/4/2019

Brain’s Cerebrospinal Fluid Pulses During Sleep

Sleep Review 11/3/2019

Scientists Now Know How Sleep Cleans Toxins From the Brain

WIRED Science – Spoken Edition 11/3/2019

How deep sleep scrubs your brain of toxins

Mother Nature Network 11/1/2019

Brain toxins cleansed during sleep could prevent Alzheimer’s

New York Post 11/1/2019

The only detox you need is sleep—but it’s not totally clear why

Popular Science 11/1/2019

Deep Sleep Gives Your Brain a Deep Clean

Scientific American 11/1/2019

To decrease risk of Alzheimer’s, quantity and quality of sleep matters, study finds

Boston 25 News 11/1/2019

A good night’s sleep could protect against dementia because the body ‘washes’ toxic proteins out of the brain, study

Daily Mail 11/1/2019

Sleeping Washes Our Brains Clean of Unwanted Toxins, New Study Finds

Interesting Engineering 11/1/2019

Can Sleep Trigger Rhythmic Power Washing In The Brain?

Medical Daily 11/1/2019

How good night’s sleep can brainwash away dementia

The Times 11/1/2019

Researchers discover your brain has a literal “rinse cycle”

Inverse 10/31/2019

A type of brainwave may help clean your brain while you sleep

New Scientist 10/31/2019

U.S. Biotech Amgen Strikes Major Deal to Expand China Presence

Fortune 10/31/2019

How Deep Sleep May Help The Brain Clear Alzheimer’s Toxins

WBUR 10/31/2019

Sleep may trigger rhythmic power washing in the brain

Science News Magazine 10/31/2019

Scientists Now Know How Sleep Cleans Toxins From the Brain

WIRED 10/31/2019

Deep Sleep May ‘Rinse’ Day’s Toxins From Brain

Health Day 10/31/2019

Waves of Fluid Bathe the Sleeping Brain, Perhaps to Clear Waste

The Scientist 10/31/2019

2021 1907 Trailblazer Award
2021 Hariri Institute Junior Faculty Fellow
2021 Pew Scholar Award
2021 McKnight Scholar Award
2021 Sloan Research Fellow
2020 NARSAD Young Investigator Award
2020 Smith Family Award for Excellence in Biomedical Research
2020 Searle Scholar Award
2019 One Mind Rising Star Award
2018 eLife Travel Award
2017 NIMH, NIH: K99/R00 Pathway to Independence Award
2017 Winter Conference on Brain Research: Travel Fellow
2017 Organization for Human Brain Mapping: Merit Abstract Award
2017 Society for Neuroscience: Peter and Patricia Gruber International Research Award
2016 Havard: Mind Brain Behavior Small Faculty Research Award
2016 Harvard University: William F. Milton Fund Award
2015 the National Academy of Sciences: Kavli Fellow
2014 Gordon Research Conference MERIT Award
2014 Harvard University: Junior Fellowship, Society of Fellows
2014-2015 Cosyne Travel Award
2014-2015 Cosyne Travel Award
2013 American Society of Anesthesiologists: Best Abstract in Clinical Science Award
2012 Cosyne Travel Award
2011 Walle Nauta Award: Excellence in Graduate Teaching
2010 Canadian Institutes of Health Research (CIHR): Doctoral Research Award
2008 Quebec Research Council (FQRNT): Masters Research Award
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