Dr. Shim's areas of expertise are at the interface of neuroscience and vascular biology with an emphasis on neurovascular interactions. His research interest lies in roles of vascular endothelial growth factor in the brain, hydrocephalus, and neurodegeneration. Since his postdoctoral training at Boston Children’s Hospital and Boston University Medical Campus, he has experienced in translation of basic science towards the therapeutic application based on data gathered from human clinical specimens. He is dedicated to understanding hypoxia, angiogenesis, and blood-derived factors in association with human behavioral outcomes using transgenic animals, mammalian cell culture, and human postmortem tissues. His expertise in pediatric hydrocephalus and genetic rodent models of Meckel syndrome allows a systematic characterization of brain models and their utilities in neuroscience. He has a demonstrated record of successful and productive research projects in the area of basic science and clinical research, and Dr. Shim believes that his exploration to neonatal human and animal specimens will help elucidate pathogenic mechanisms and create a new platform for disease-modifying strategies. Dr. Shim has recent and previous experience in supervising undergraduate, graduate, and medical students as evidenced in recent publications. He synergizes the traditional approach of transgenic animal model with human models in vitro in comparison with human postmortem tissues to complement each other to better understand pathogenesis of neurological disorders.