Joon Shim, PhD
Postdoctoral Associate
Boston University School of Medicine
Whitaker Cardiovascular Institute

Dr.Shim's areas of expertise are at the interface of neuroscience and vascular biology with an emphasis on neurovascular interactions. His research interest lies in roles of vascular endothelial growth factor in the brain, hydrocephalus, and neurodegeneration. Since his postdoctoral training at Boston Children’s Hospital and Boston University Medical Campus, he has experienced in translation of basic science towards the therapeutic application based on data gathered from human clinical specimens. He is dedicated to understanding hypoxia, angiogenesis, and blood-derived factors in association with human behavioral outcomes using transgenic animals, mammalian cell culture, and human postmortem tissues. His expertise in pediatric hydrocephalus and genetic rodent models of Meckel syndrome allows a systematic characterization of brain models and their utilities in neuroscience. He has a demonstrated record of successful and productive research projects in the area of basic science and clinical research, and Dr. Shim believes that his exploration to neonatal human and animal specimens will help elucidate pathogenic mechanisms and create a new platform for disease-modifying strategies. Dr. Shim has recent and previous experience in supervising undergraduate, graduate, and medical students as evidenced in recent publications. He synergizes the traditional approach of transgenic animal model with human models in vitro in comparison with human postmortem tissues to complement each other to better understand pathogenesis of neurological disorders.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Shim JW, Territo PR, Simpson S, Watson JC, Jiang L, Riley AA, McCarthy B, Persohn S, Fulkerson D, Blazer-Yost BL. Hydrocephalus in a rat model of Meckel Gruber syndrome with a TMEM67 mutation. Sci Rep. 2019 01 31; 9(1):1069. PMID: 30705305; DOI: 10.1038/s41598-018-37620-5;
  2. Shim JW, Madsen JR. VEGF Signaling in Neurological Disorders. Int J Mol Sci. 2018 Jan 17; 19(1). PMID: 29342116
  3. Shim JW, Sandlund J, Hameed MQ, Blazer-Yost B, Zhou FC, Klagsbrun M, Madsen JR. Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus. Sci Rep. 2016 05 31; 6:26794. PMID: 27243144; DOI: 10.1038/srep26794;
  4. Walsh KR, Kuwabara JT, Shim JW, Wainford RD. Norepinephrine-evoked salt-sensitive hypertension requires impaired renal sodium chloride cotransporter activity in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 15; 310(2):R115-24.View Related Profiles. PMID: 26608659; PMCID: PMC4796647; DOI: 10.1152/ajpregu.00514.2014;
  5. Shim JW, Sandlund J, Madsen JR. VEGF: a potential target for hydrocephalus. Cell Tissue Res. 2014 Dec; 358(3):667-83. PMID: 25146955; DOI: 10.1007/s00441-014-1978-6;
  6. Shim JW, Dodge TR, Hammond MA, Wallace JM, Zhou FC, Yokota H. Physical weight loading induces expression of tryptophan hydroxylase 2 in the brain stem. PLoS One. 2014; 9(1):e85095. PMID: 24416346; DOI: 10.1371/journal.pone.0085095;
  7. Hamamura K, Zhang P, Zhao L, Shim JW, Chen A, Dodge TR, Wan Q, Shih H, Na S, Lin CC, Sun HB, Yokota H. Knee loading reduces MMP13 activity in the mouse cartilage. BMC Musculoskelet Disord. 2013 Nov 01; 14:312. PMID: 24180431; DOI: 10.1186/1471-2474-14-312;
  8. Shim JW, Hamamura K, Chen A, Wan Q, Na S, Yokota H. Rac1 mediates load-driven attenuation of mRNA expression of nerve growth factor beta in cartilage and chondrocytes. J Musculoskelet Neuronal Interact. 2013 Sep; 13(3):372-9. PMID: 23989259
  9. Cho H, Park SH, Park K, Shim JW, Huang J, Smith R, Elder S, Min BH, Hasty KA. Construction of a tissue-engineered annulus fibrosus. Artif Organs. 2013 Jul; 37(7):E131-8. PMID: 23621741; DOI: 10.1111/aor.12066;
  10. Shim JW, Sandlund J, Han CH, Hameed MQ, Connors S, Klagsbrun M, Madsen JR, Irwin N. VEGF, which is elevated in the CSF of patients with hydrocephalus, causes ventriculomegaly and ependymal changes in rats. Exp Neurol. 2013 Sep; 247:703-9. PMID: 23518418; DOI: 10.1016/j.expneurol.2013.03.011;
Showing 10 of 15 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 15 publications over 8 distinct years, with a maximum of 5 publications in 2013


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