Jimmy Crott | Profiles RNS

Jimmy W. Crott PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Pathology & Laboratory Medicine

PhD, University of Adelaide
BSc, University of Adelaide

Websites

	LinkedIn
	Google Scholar
	NIH NLM Bibliography

ORCID : 0000-0002-3529-8826

Jimmy Crott, PhD, Pathology & Laboratory Medicine, studies the interaction between diet, gut microbiome, colon tumorigenesis and aging. His ongoing projects involve identifying the active component of a chemoprotective bacterium, understanding the role of gut barrier integrity and tight junction proteins in aging and understanding the role of the gut microbiome in colon cancer prevention by a Mediterranean diet. He came to BU/BMC in February 2022 from Tufts University, where he served in a variety of roles over 20 years, most recently as the leader of the Microbiome and Aging Program at the Jean Mayer USDA Human Nutrition Research Center on Aging and strategic initiative advisor in the Office of the Vice Provost of Research.

BU Research
NIH RePORTER Research

Strengthening gut barrier integrity with beneficial microbes to increase lifespan and healthspan
06/01/2022 - 05/31/2026 (PI)
NIH/National Institute on Aging
7R01AG069917-02

Role of ceramide and gut microbiota in fruits and vegetable induced prevention of non-alcoholic fatty liver disease
04/15/2022 - 04/14/2025 (Subcontract PI)
Trustees of Tufts College, Inc Dept of Agriculture

Identifying the active factor of an anti-inflammatory chemopreventive bacterium
04/02/2022 - 04/30/2024 (PI)
NIH/National Cancer Institute
7R21CA253392-02

Gut microbiota modulate the effect of diet on inflammation and tumorigenesis
03/01/2022 - 02/28/2024 (PI)
USDA/National Institute of Food and Agriculture

Title

Yr	Title	Project-Sub Proj	Pubs
2022	Strengthening gut barrier integrity with beneficial microbes to increase lifespan and healthspan	7R01AG069917-02
2021	Strengthening gut barrier integrity with beneficial microbes to increase lifespan and healthspan	1R01AG069917-01A1
2021	Identifying the active factor of an anti-inflammatory chemopreventive bacterium	7R21CA253392-02
2021	Identifying the active factor of an anti-inflammatory chemopreventive bacterium	1R21CA253392-01A1
2020	Role of age-associated changes in the gut microbiome in promoting colorectal carcinogenesis	5R03CA234999-02
2019	Role of age-associated changes in the gut microbiome in promoting colorectal carcinogenesis	1R03CA234999-01
2012	Effect of paternal B vitamin intake on intestinal tumorigenesis in offspring	5R03CA162505-02	1
2011	Effect of paternal B vitamin intake on intestinal tumorigenesis in offspring	1R03CA162505-01	1

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Simas AM, Crott JW, Sedore C, Rohrbach A, Monaco AP, Gabriel SB, Lennon N, Blumenstiel B, Genco CA. Pooling for SARS-CoV2 Surveillance: Validation and Strategy for Implementation in K-12 Schools. Front Public Health. 2021; 9:789402. PMID: 34976934; PMCID: PMC8718607; DOI: 10.3389/fpubh.2021.789402;

Wu X, Ueland PM, Roper J, Koh GY, Liang X, Crott JW, Yilmaz ÖH, Bronson RT, Mason JB. Combined Supplementation with Vitamin B-6 and Curcumin is Superior to Either Agent Alone in Suppressing Obesity-Promoted Colorectal Tumorigenesis in Mice. J Nutr. 2021 12 03; 151(12):3678-3688. PMID: 34590119; DOI: 10.1093/jn/nxab320;

Koh GY, Kane AV, Wu X, Crott JW. Parabacteroides distasonis attenuates tumorigenesis, modulates inflammatory markers and promotes intestinal barrier integrity in azoxymethane-treated A/J mice. Carcinogenesis. 2020 07 14; 41(7):909-917. PMID: 32115637; DOI: 10.1093/carcin/bgaa018;

Wu X, Koh GY, Huang Y, Crott JW, Bronson RT, Mason JB. The Combination of Curcumin and Salsalate is Superior to Either Agent Alone in Suppressing Pro-Cancerous Molecular Pathways and Colorectal Tumorigenesis in Obese Mice. Mol Nutr Food Res. 2019 04; 63(8):e1801097. PMID: 30680927; DOI: 10.1002/mnfr.201801097;

Pfalzer AC, Leung K, Crott JW, Kim SJ, Tai AK, Parnell LD, Kamanu FK, Liu Z, Rogers G, Shea MK, Garcia PE, Mason JB. Incremental Elevations in TNFa and IL6 in the Human Colon and Procancerous Changes in the Mucosal Transcriptome Accompany Adiposity. Cancer Epidemiol Biomarkers Prev. 2018 12; 27(12):1416-1423. PMID: 30291114; DOI: 10.1158/1055-9965.EPI-18-0121;

Koh GY, Kane A, Lee K, Xu Q, Wu X, Roper J, Mason JB, Crott JW. Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. Int J Cancer. 2018 10 01; 143(7):1797-1805. PMID: 29696632; DOI: 10.1002/ijc.31559;

Pfalzer AC, Crott JW, Koh GY, Smith DE, Garcia PE, Mason JB. Interleukin-1 Signaling Mediates Obesity-Promoted Elevations in Inflammatory Cytokines, Wnt Activation, and Epithelial Proliferation in the Mouse Colon. J Interferon Cytokine Res. 2018 10; 38(10):445-451. PMID: 30328795; DOI: 10.1089/jir.2017.0134;

Wu X, Pfalzer AC, Koh GY, Tang S, Crott JW, Thomas MJ, Meydani M, Mason JB. Curcumin and Salsalate Suppresses Colonic Inflammation and Procarcinogenic Signaling in High-Fat-Fed, Azoxymethane-Treated Mice. J Agric Food Chem. 2017 Aug 23; 65(33):7200-7209. PMID: 28745498; DOI: 10.1021/acs.jafc.7b02648;

Crott JW. Effects of altered parental folate and one-carbon nutrient status on offspring growth and metabolism. Mol Aspects Med. 2017 02; 53:28-35. PMID: 27865887; DOI: 10.1016/j.mam.2016.11.001;

Liu W, Crott JW, Lyu L, Pfalzer AC, Li J, Choi SW, Yang Y, Mason JB, Liu Z. Diet- and Genetically-induced Obesity Produces Alterations in the Microbiome, Inflammation and Wnt Pathway in the Intestine of Apc+/1638N Mice: Comparisons and Contrasts. J Cancer. 2016; 7(13):1780-1790. PMID: 27698916; PMCID: PMC5039360; DOI: 10.7150/jca.15792;

Showing 10 of 52 results. Show More

Pfalzer AC, Kamanu FK, Parnell LD, Tai AK, Liu Z, Mason JB, Crott JW. Interactions between the colonic transcriptome, metabolome, and microbiome in mouse models of obesity-induced intestinal cancer. Physiol Genomics. 2016 08 01; 48(8):545-53. PMID: 27317588; DOI: 10.1152/physiolgenomics.00034.2016;

Sabet JA, Park LK, Iyer LK, Tai AK, Koh GY, Pfalzer AC, Parnell LD, Mason JB, Liu Z, Byun AJ, Crott JW. Correction: Paternal B Vitamin Intake Is a Determinant of Growth, Hepatic Lipid Metabolism and Intestinal Tumor Volume in Female Apc1638N Mouse Offspring. PLoS One. 2016; 11(4):e0154979. PMID: 27124183; PMCID: PMC4849756; DOI: 10.1371/journal.pone.0154979;

Sabet JA, Park LK, Iyer LK, Tai AK, Koh GY, Pfalzer AC, Parnell LD, Mason JB, Liu Z, Byun AJ, Crott JW. Paternal B Vitamin Intake Is a Determinant of Growth, Hepatic Lipid Metabolism and Intestinal Tumor Volume in Female Apc1638N Mouse Offspring. PLoS One. 2016; 11(3):e0151579. PMID: 26968002; PMCID: PMC4788446; DOI: 10.1371/journal.pone.0151579;

Pfalzer AC, Nesbeth PD, Parnell LD, Iyer LK, Liu Z, Kane AV, Chen CY, Tai AK, Bowman TA, Obin MS, Mason JB, Greenberg AS, Choi SW, Selhub J, Paul L, Crott JW. Diet- and Genetically-Induced Obesity Differentially Affect the Fecal Microbiome and Metabolome in Apc1638N Mice. PLoS One. 2015; 10(8):e0135758. PMID: 26284788; PMCID: PMC4540493; DOI: 10.1371/journal.pone.0135758;

Byun AJ, Hung KE, Fleet JC, Bronson RT, Mason JB, Garcia PE, Crott JW. Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras. Cancer Lett. 2014 Jun 01; 347(2):191-5. PMID: 24632531; PMCID: PMC4418438; DOI: 10.1016/j.canlet.2014.03.004;

Sabet J, Ciappio ED, Crott JW. The Role of Nutrition and Metabolism on Epigenetic Regulation (Ho E, Domman F eds.). Parental diet and exposures, epigenetics and chronic disease. Taylor & Francis Group, CRC Press. Boca Raton, Florida. 2014.

Selhub J, Byun A, Liu Z, Mason JB, Bronson RT, Crott JW. Dietary vitamin B6 intake modulates colonic inflammation in the IL10-/- model of inflammatory bowel disease. J Nutr Biochem. 2013 Dec; 24(12):2138-43. PMID: 24183308; PMCID: PMC4199223; DOI: 10.1016/j.jnutbio.2013.08.005;

Figueiredo JC, Levine AJ, Crott JW, Baurley J, Haile RW. Folate-genetics and colorectal neoplasia: what we know and need to know next. Mol Nutr Food Res. 2013 Apr; 57(4):607-27. PMID: 23401104

Moorthy D, Peter I, Scott TM, Parnell LD, Lai CQ, Crott JW, Ordovás JM, Selhub J, Griffith J, Rosenberg IH, Tucker KL, Troen AM. Status of vitamins B-12 and B-6 but not of folate, homocysteine, and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults. J Nutr. 2012 Aug; 142(8):1554-60. PMID: 22739363; PMCID: PMC3397340; DOI: 10.3945/jn.112.161828;

Liu Z, Brooks RS, Ciappio ED, Kim SJ, Crott JW, Bennett G, Greenberg AS, Mason JB. Diet-induced obesity elevates colonic TNF-a in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer. J Nutr Biochem. 2012 Oct; 23(10):1207-13. PMID: 22209007; PMCID: PMC4142203; DOI: 10.1016/j.jnutbio.2011.07.002;

Ciappio ED, Mason JB, Crott JW. Maternal one-carbon nutrient intake and cancer risk in offspring. Nutr Rev. 2011 Oct; 69(10):561-71. PMID: 21967157; DOI: 10.1111/j.1753-4887.2011.00424.x;

Ciappio ED, Liu Z, Brooks RS, Mason JB, Bronson RT, Crott JW. Maternal B vitamin supplementation from preconception through weaning suppresses intestinal tumorigenesis in Apc1638N mouse offspring. Gut. 2011 Dec; 60(12):1695-702. PMID: 21659408; PMCID: PMC4193343; DOI: 10.1136/gut.2011.240291;

Liu Z, Ciappio ED, Crott JW, Brooks RS, Nesvet J, Smith DE, Choi SW, Mason JB. Combined inadequacies of multiple B vitamins amplify colonic Wnt signaling and promote intestinal tumorigenesis in BAT-LacZxApc1638N mice. FASEB J. 2011 Sep; 25(9):3136-45. PMID: 21646397; PMCID: PMC3157689; DOI: 10.1096/fj.11-184143;

Ye X, Lai CQ, Crott JW, Troen AM, Ordovas JM, Tucker KL. The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults. Psychosom Med. 2011 Jun; 73(5):385-92. PMID: 21597034; PMCID: PMC3110520; DOI: 10.1097/PSY.0b013e31821a1ab4;

Huang T, Tucker KL, Lee YC, Crott JW, Parnell LD, Shen J, Smith CE, Ordovas JM, Li D, Lai CQ. Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population. Public Health Nutr. 2011 Oct; 14(10):1805-12. PMID: 21338559; PMCID: PMC4357314; DOI: 10.1017/S1368980011000140;

Huang T, Tucker KL, Lee YC, Crott JW, Parnell LD, Shen J, Smith CE, Ordovas JM, Li D, Lai CQ. Methylenetetrahydrofolate reductase variants associated with hypertension and cardiovascular disease interact with dietary polyunsaturated fatty acids to modulate plasma homocysteine in puerto rican adults. J Nutr. 2011 Apr 01; 141(4):654-9. PMID: 21270364; PMCID: PMC3056580; DOI: 10.3945/jn.110.134353;

Bull CF, Beetstra-Hill S, Benassi-Evans BJ, Crott JW, Kimura M, Teo T, Wu J, Fenech MF. Application and adaptation of the in vitro micronucleus assay for the assessment of nutritional requirements of cells for DNA damage prevention. Mutagenesis. 2011 Jan; 26(1):193-7. PMID: 21164202; DOI: 10.1093/mutage/geq065;

Fenech M, Kirsch-Volders M, Natarajan AT, Surralles J, Crott JW, Parry J, Norppa H, Eastmond DA, Tucker JD, Thomas P. Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells. Mutagenesis. 2011 Jan; 26(1):125-32. PMID: 21164193; DOI: 10.1093/mutage/geq052;

Huang T, Tucker K, Lee Y, Crott J, Parnell L, Shen J, Smith C, Ordovas J, Li D, Lai C. MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations. Nutr Metab Cardiovasc Dis. 2012 Apr; 22(4):362-8. PMID: 21185701

Lai CQ, Parnell LD, Troen AM, Shen J, Caouette H, Warodomwichit D, Lee YC, Crott JW, Qiu WQ, Rosenberg IH, Tucker KL, Ordovás JM. MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate. Am J Clin Nutr. 2010 May; 91(5):1377-86.View Related Profiles.

Crott, Jimmy
Qiu, Wendy

PMID: 20335551; PMCID: PMC2854908; DOI: 10.3945/ajcn.2009.28923;

Chen CY, Crott J, Liu Z, Smith DE. Fructose and saturated fats predispose hyperinsulinemia in lean male rat offspring. Eur J Nutr. 2010 Sep; 49(6):337-43. PMID: 20044786

Chanson A, Parnell LD, Ciappio ED, Liu Z, Crott JW, Tucker KL, Mason JB. Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population. Am J Clin Nutr. 2009 Jun; 89(6):1927-36. PMID: 19403629; PMCID: PMC2683003; DOI: 10.3945/ajcn.2009.27429;

DeVos L, Chanson A, Liu Z, Ciappio ED, Parnell LD, Mason JB, Tucker KL, Crott JW. Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. Am J Clin Nutr. 2008 Oct; 88(4):1149-58. PMID: 18842806; PMCID: PMC2728423; DOI: 10.1093/ajcn/88.4.1149;

Liu Z, Choi SW, Crott JW, Smith DE, Mason JB. Multiple B-vitamin inadequacy amplifies alterations induced by folate depletion in p53 expression and its downstream effector MDM2. Int J Cancer. 2008 Aug 01; 123(3):519-25. PMID: 18498130; PMCID: PMC2764718; DOI: 10.1002/ijc.23599;

Liu Z, Choi SW, Crott JW, Keyes MK, Jang H, Smith DE, Kim M, Laird PW, Bronson R, Mason JB. Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon. J Nutr. 2007 Dec; 137(12):2701-8.View Related Profiles.

Jang, Hyeran
Crott, Jimmy

PMID: 18029487

van den Donk M, Pellis L, Crott JW, van Engeland M, Friederich P, Nagengast FM, van Bergeijk JD, de Boer SY, Mason JB, Kok FJ, Keijer J, Kampman E. Folic acid and vitamin B-12 supplementation does not favorably influence uracil incorporation and promoter methylation in rectal mucosa DNA of subjects with previous colorectal adenomas. J Nutr. 2007 Sep; 137(9):2114-20. PMID: 17709451; DOI: 10.1093/jn/137.9.2114;

Crott JW, Liu Z, Keyes MK, Choi SW, Jang H, Moyer MP, Mason JB. Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines. J Nutr Biochem. 2008 May; 19(5):328-35. PMID: 17681772; PMCID: PMC2759072

Keyes MK, Jang H, Mason JB, Liu Z, Crott JW, Smith DE, Friso S, Choi SW. Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon. J Nutr. 2007 Jul; 137(7):1713-7. PMID: 17585020

Crott JW, Liu Z, Choi SW, Mason JB. Folate depletion in human lymphocytes up-regulates p53 expression despite marked induction of strand breaks in exons 5-8 of the gene. Mutat Res. 2007 Jan 10; 626(1-2):171-9. PMID: 17098465; DOI: 10.1016/j.mrgentox.2006.10.001;

Gabriel HE, Liu Z, Crott JW, Choi SW, Song BC, Mason JB, Johnson EJ. A comparison of carotenoids, retinoids, and tocopherols in the serum and buccal mucosa of chronic cigarette smokers versus nonsmokers. Cancer Epidemiol Biomarkers Prev. 2006 May; 15(5):993-9. PMID: 16702382; DOI: 10.1158/1055-9965.EPI-05-0664;

Gabriel HE, Crott JW, Ghandour H, Dallal GE, Choi SW, Keyes MK, Jang H, Liu Z, Nadeau M, Johnston A, Mager D, Mason JB. Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults. Am J Clin Nutr. 2006 Apr; 83(4):835-41. PMID: 16600936

Crott JW, Choi SW, Branda RF, Mason JB. Accumulation of mitochondrial DNA deletions is age, tissue and folate-dependent in rats. Mutat Res. 2005 Feb 15; 570(1):63-70. PMID: 15680403; DOI: 10.1016/j.mrfmmm.2004.09.009;

Mashiyama ST, Courtemanche C, Elson-Schwab I, Crott J, Lee BL, Ong CN, Fenech M, Ames BN. Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes. Anal Biochem. 2004 Jul 01; 330(1):58-69. PMID: 15183762

Crott JW, Mason JB. MTHFR Polymorphisms and Disease (Ueland PM, Rozen R eds.). MTHFR Polymorphisms and Colorectal Neoplasia. Landes Bioscience/Eurekah.com. Georgetown, Texas. 2004.

Crott JW, Choi SW, Ordovas JM, Ditelberg JS, Mason JB. Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis. Carcinogenesis. 2004 Jan; 25(1):69-76. PMID: 12970065; DOI: 10.1093/carcin/bgg150;

Fenech M, Crott JW. Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay. Mutat Res. 2002 Jul 25; 504(1-2):131-6. PMID: 12106653; DOI: 10.1016/s0027-5107(02)00086-6;

Crott JW, Mashiyama ST, Ames BN, Fenech M. The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. Cancer Epidemiol Biomarkers Prev. 2001 Oct; 10(10):1089-96. PMID: 11588136

Crott JW, Mashiyama ST, Ames BN, Fenech MF. Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro. Carcinogenesis. 2001 Jul; 22(7):1019-25. PMID: 11408344; DOI: 10.1093/carcin/22.7.1019;

Crott J, Thomas P, Fenech M. Normal human lymphocytes exhibit a wide range of methionine-dependency which is related to altered cell division but not micronucleus frequency. Mutagenesis. 2001 Jul; 16(4):317-22. PMID: 11420399

Crott J, Fenech M. Preliminary study of the genotoxic potential of homocysteine in human lymphocytes in vitro. Mutagenesis. 2001 May; 16(3):213-7. PMID: 11320146

Fenech M, Crott J, Turner J, Brown S. Necrosis, apoptosis, cytostasis and DNA damage in human lymphocytes measured simultaneously within the cytokinesis-block micronucleus assay: description of the method and results for hydrogen peroxide. Mutagenesis. 1999 Nov; 14(6):605-12. PMID: 10567036

Crott JW, Fenech M. Effect of vitamin C supplementation on chromosome damage, apoptosis and necrosis ex vivo. Carcinogenesis. 1999 Jun; 20(6):1035-41. PMID: 10357785; DOI: 10.1093/carcin/20.6.1035;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 52 publications over 22 distinct years, with a maximum of 9 publications in 2011

Bar chart showing 52 publications over 22 distinct years, with a maximum of 9 publications in 2011

Year	Publications
1999	2
2001	4
2002	1
2003	1
2004	2
2005	1
2006	3
2007	4
2008	2
2009	1
2010	3
2011	9
2012	1
2013	2
2014	2
2015	1
2016	5
2017	1
2018	3
2019	1
2020	1
2021	2

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

microbiome
inflammation
colorectal cancer
aging
healthspan
diet

Contact for Mentoring:

670 Albany St
Boston MA 02118
Google Map

617.358.2812

Download vCard

Crott's Networks

Click the "See All" links for more information and interactive visualizations

Concepts

See all (265) concept(s)

Co-Authors

See all (2) people

Similar People

See all (60) people

Same Department

Search Department