Jimmy W. Crott PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

PhD, University of Adelaide
BSc, University of Adelaide

Jimmy Crott, PhD, Pathology & Laboratory Medicine, studies the interaction between diet, gut microbiome, colon tumorigenesis and aging. His ongoing projects involve identifying the active component of a chemoprotective bacterium, understanding the role of gut barrier integrity and tight junction proteins in aging and understanding the role of the gut microbiome in colon cancer prevention by a Mediterranean diet. He came to BU/BMC in February 2022 from Tufts University, where he served in a variety of roles over 20 years, most recently as the leader of the Microbiome and Aging Program at the Jean Mayer USDA Human Nutrition Research Center on Aging and strategic initiative advisor in the Office of the Vice Provost of Research.

Strengthening gut barrier integrity with beneficial microbes to increase lifespan and healthspan
06/01/2022 - 05/31/2026 (PI)
NIH/National Institute on Aging

Role of ceramide and gut microbiota in fruits and vegetable induced prevention of non-alcoholic fatty liver disease
04/15/2022 - 04/14/2025 (Subcontract PI)
Trustees of Tufts College, Inc Dept of Agriculture

Identifying the active factor of an anti-inflammatory chemopreventive bacterium
04/02/2022 - 04/30/2024 (PI)
NIH/National Cancer Institute

Gut microbiota modulate the effect of diet on inflammation and tumorigenesis
03/01/2022 - 02/28/2024 (PI)
USDA/National Institute of Food and Agriculture


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Crossland NA, Beck S, Tan WY, Lo M, Mason JB, Zhang C, Guo W, Crott JW. Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice. Gut Microbes. 2023 Dec; 15(2):2288187.View Related Profiles. PMID: 38031252; PMCID: PMC10730208; DOI: 10.1080/19490976.2023.2288187;
  2. Shaikh SR, Crott JW, Comstock SS, Yeruva L, Davis TA. Nutritional Immunology Across the Lifespan: A Call for Papers. J Nutr. 2023 Aug; 153(8):2135-2136. PMID: 37349203
  3. Simas AM, Crott JW, Sedore C, Rohrbach A, Monaco AP, Gabriel SB, Lennon N, Blumenstiel B, Genco CA. Pooling for SARS-CoV2 Surveillance: Validation and Strategy for Implementation in K-12 Schools. Front Public Health. 2021; 9:789402. PMID: 34976934; PMCID: PMC8718607; DOI: 10.3389/fpubh.2021.789402;
  4. Wu X, Ueland PM, Roper J, Koh GY, Liang X, Crott JW, Yilmaz ÖH, Bronson RT, Mason JB. Combined Supplementation with Vitamin B-6 and Curcumin is Superior to Either Agent Alone in Suppressing Obesity-Promoted Colorectal Tumorigenesis in Mice. J Nutr. 2021 12 03; 151(12):3678-3688. PMID: 34590119; DOI: 10.1093/jn/nxab320;
  5. Koh GY, Kane AV, Wu X, Crott JW. Parabacteroides distasonis attenuates tumorigenesis, modulates inflammatory markers and promotes intestinal barrier integrity in azoxymethane-treated A/J mice. Carcinogenesis. 2020 07 14; 41(7):909-917. PMID: 32115637; DOI: 10.1093/carcin/bgaa018;
  6. Wu X, Koh GY, Huang Y, Crott JW, Bronson RT, Mason JB. The Combination of Curcumin and Salsalate is Superior to Either Agent Alone in Suppressing Pro-Cancerous Molecular Pathways and Colorectal Tumorigenesis in Obese Mice. Mol Nutr Food Res. 2019 04; 63(8):e1801097. PMID: 30680927; DOI: 10.1002/mnfr.201801097;
  7. Pfalzer AC, Leung K, Crott JW, Kim SJ, Tai AK, Parnell LD, Kamanu FK, Liu Z, Rogers G, Shea MK, Garcia PE, Mason JB. Incremental Elevations in TNFa and IL6 in the Human Colon and Procancerous Changes in the Mucosal Transcriptome Accompany Adiposity. Cancer Epidemiol Biomarkers Prev. 2018 12; 27(12):1416-1423. PMID: 30291114; DOI: 10.1158/1055-9965.EPI-18-0121;
  8. Pfalzer AC, Crott JW, Koh GY, Smith DE, Garcia PE, Mason JB. Interleukin-1 Signaling Mediates Obesity-Promoted Elevations in Inflammatory Cytokines, Wnt Activation, and Epithelial Proliferation in the Mouse Colon. J Interferon Cytokine Res. 2018 10; 38(10):445-451. PMID: 30328795; DOI: 10.1089/jir.2017.0134;
  9. Koh GY, Kane A, Lee K, Xu Q, Wu X, Roper J, Mason JB, Crott JW. Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. Int J Cancer. 2018 10 01; 143(7):1797-1805. PMID: 29696632; DOI: 10.1002/ijc.31559;
  10. Wu X, Pfalzer AC, Koh GY, Tang S, Crott JW, Thomas MJ, Meydani M, Mason JB. Curcumin and Salsalate Suppresses Colonic Inflammation and Procarcinogenic Signaling in High-Fat-Fed, Azoxymethane-Treated Mice. J Agric Food Chem. 2017 Aug 23; 65(33):7200-7209. PMID: 28745498; DOI: 10.1021/acs.jafc.7b02648;
Showing 10 of 54 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 54 publications over 23 distinct years, with a maximum of 9 publications in 2011


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

colorectal cancer
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670 Albany St
Boston MA 02118
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