Jie Zhang, PhD, is an Assistant Professor of Medicine at Boston University Chobanian & Avedisian School of Medicine and a Principal Investigator of Nephrology at Boston Medical Center. Dr. Zhang received her BS degree from Jilin University in China and her PhD degree from the University of South Florida. She joined the faculty of BU/BMC and established her independent research laboratory in 2023. Dr. Zhang’s laboratory employs a combination of classical renal physiology techniques such as micropuncture and microperfusion, as well as cutting-edge molecular biology technologies such as single-cell RNA sequencing and genetically engineered animal models to explore fundamental questions within the field of nephrology. Her research endeavors have been supported by prestigious fellowships and grants, including the American Heart Association Pre-Doctoral Fellowship, the American Society of Nephrology Ben J. Lipps Post-Doctoral Fellowship, the American Society of Nephrology Carl W. Gottschalk Research Scholar Grant, and NIH-NIDDK R01 Grant.
Diversity, Equity, Inclusion and Accessibility
Diversity, Equity, Inclusion, & Accessibility (DEIA) are essential values that I strive to uphold in my lab. To create a DEIA environment, we offer research opportunities to postdocs, graduate students, and undergraduates of all backgrounds. This approach provides a comprehensive learning experience for all members while ensuring a diverse group of individuals feel included and valued. By encouraging interaction and collaboration between all lab members, we promote inclusivity and equity.
As an Asian woman in STEM, I have faced firsthand the obstacles and challenges that come with being part of an underrepresented group. Therefore, I am committed to empowering minorities to reach their goals and strive for achievements that highlight the importance of diversity and representation. During my time as a research assistant, I mentored students from different ethnic backgrounds, including Asian, African, European, and American, with varying academic and social backgrounds, such as engineering, psychology, biomedical sciences, and more. This diversity of backgrounds brings different perspectives and skill sets to the lab and promotes inclusion and collaboration.
Going forward, I am committed to upholding the principles of DEIA. We aim to achieve and sustain a workforce that is diverse and inclusive, with lab members who represent the wide range of backgrounds and experiences that contribute to the advancement of science. We are dedicated to treating all members of our lab fairly, and ensuring that everyone has equal access to opportunities for growth and advancement. We strive to create a work environment that is respectful, inclusive, and supportive, where each lab member can contribute their unique talents and perspectives to our shared mission. Finally, we are committed to providing equitable access to technology and services, so that all individuals, including those with disabilities, can fully participate and thrive in our lab community.
In conclusion, creating a DEIA scientific environment is a critical goal that requires ongoing effort and commitment. By implementing the strategies outlined above, I aim to create an inclusive community where all lab members feel valued, supported, and encouraged to succeed.
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- Data is sorted by project end date, and updated monthly.
This tab shows grant data from BU Sponsored Research. It includes:
- Grant title
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- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
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from BU or BMC sources.
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
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- Some grants will show an agency award/project number, and may be a link.
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Significance of Tubuloglomerular Feedback in SGLT1 and SGLT2 Inhibition in Diabetic Kidney Disease04/01/2023 - 01/31/2028 (Multi-PI)
PI:
Jie Zhang, PhDNational Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
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Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
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Iglesias M, Wang H, Krause-Hauch M, Ren D, Zoungrana LI, Li Z, Zhang J, Wei J, Yadav N, Patel K, Fatmi MK, Liu R, Lesnefsky EJ, Li J. Sestrin2 Mediates Metformin Rescued the Age-Related Cardiac Dysfunctions of Cardiorenal Syndrome Type 3. Cells. 2023 Mar 08; 12(6).View Related Profiles. PMID: 36980186; PMCID: PMC10047033; DOI: 10.3390/cells12060845;
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Liu R, Juncos LA, Lu Y, Wei J, Zhang J, Wang L, Lai EY, Carlstrom M, Persson AEG. The Role of Macula Densa Nitric Oxide Synthase 1 Beta Splice Variant in Modulating Tubuloglomerular Feedback. Compr Physiol. 2023 Jan 30; 13(1):4215-4229.View Related Profiles. PMID: 36715280; PMCID: PMC9990375; DOI: 10.1002/cphy.c210043;
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Zhang J, Cai J, Cui Y, Jiang S, Wei J, Kim YC, Chan J, Thalakola A, Le T, Xu L, Wang L, Jiang K, Wang X, Wang H, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R. Corrigendum to Zhang J, Cai J, Cui Y, Jiang S, Wei J, Kim YC, Chan J, Thalakola A, Le T, Xu L, Wang L, Jiang K, Wang X, Wang H, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R. "Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration." Kidney Int. 2022;101:541-550. Kidney Int. 2022 Aug; 102(2):448.View Related Profiles. PMID: 35870819; PMCID: PMC9397148; DOI: 10.1016/j.kint.2022.05.011;
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Chen W, Wang L, Liang P, Mast J, Mathis C, Liu CY, Wei J, Zhang J, Fu L, Juncos LA, Buggs J, Liu R. Reducing ischemic kidney injury through application of a synchronization modulation electric field to maintain Na+/K+-ATPase functions. Sci Transl Med. 2022 Mar 09; 14(635):eabj4906.View Related Profiles. PMID: 35263146; PMCID: PMC9994383; DOI: 10.1126/scitranslmed.abj4906;
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Zhang J, Cai J, Cui Y, Jiang S, Wei J, Kim YC, Chan J, Thalakola A, Le T, Xu L, Wang L, Jiang K, Wang X, Wang H, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R. Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration. Kidney Int. 2022 Mar; 101(3):541-550.View Related Profiles. PMID: 34843754; PMCID: PMC8863629; DOI: 10.1016/j.kint.2021.10.037;
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Zhang J, Wang X, Cui Y, Jiang S, Wei J, Chan J, Thalakola A, Le T, Xu L, Zhao L, Wang L, Jiang K, Cheng F, Patel T, Buggs J, Vallon V, Liu R. Knockout of Macula Densa Neuronal Nitric Oxide Synthase Increases Blood Pressure in db/db Mice. Hypertension. 2021 Dec; 78(6):1760-1770.View Related Profiles. PMID: 34657443; PMCID: PMC8651058; DOI: 10.1161/HYPERTENSIONAHA.121.17643;
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Wei J, Zhang J, Jiang S, Xu L, Qu L, Pang B, Jiang K, Wang L, Intapad S, Buggs J, Cheng F, Mohapatra S, Juncos LA, Osborn JL, Granger JP, Liu R. Macula Densa NOS1ß Modulates Renal Hemodynamics and Blood Pressure during Pregnancy: Role in Gestational Hypertension. J Am Soc Nephrol. 2021 Oct; 32(10):2485-2500.View Related Profiles. PMID: 34127535; PMCID: PMC8722793; DOI: 10.1681/ASN.2020070969;
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Zhang J, Qu L, Wei J, Jiang S, Xu L, Wang L, Cheng F, Jiang K, Buggs J, Liu R. A new mechanism for the sex differences in angiotensin II-induced hypertension: the role of macula densa NOS1ß-mediated tubuloglomerular feedback. Am J Physiol Renal Physiol. 2020 Nov 01; 319(5):F908-F919.View Related Profiles. PMID: 33044868; PMCID: PMC7789980; DOI: 10.1152/ajprenal.00312.2020;
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Zhang J, Zhu J, Wei J, Jiang S, Xu L, Qu L, Yang K, Wang L, Buggs J, Cheng F, Tan X, Liu R. New Mechanism for the Sex Differences in Salt-Sensitive Hypertension: The Role of Macula Densa NOS1ß-Mediated Tubuloglomerular Feedback. Hypertension. 2020 Feb; 75(2):449-457.View Related Profiles. PMID: 31865794; PMCID: PMC7015450; DOI: 10.1161/HYPERTENSIONAHA.119.13822;
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Showing 10 of 31 results.
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Jiang S, Wang X, Wei J, Zhang G, Zhang J, Xie P, Xu L, Wang L, Zhao L, Li L, Wilcox CS, Chen J, Lai EY, Liu R. NaHCO3 Dilates Mouse Afferent Arteriole Via Na+/HCO3- Cotransporters NBCs. Hypertension. 2019 Nov; 74(5):1104-1112.View Related Profiles. PMID: 31522618; PMCID: PMC6785401; DOI: 10.1161/HYPERTENSIONAHA.119.13235;
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Zhang J, Wei J, Jiang S, Xu L, Wang L, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R. Macula Densa SGLT1-NOS1-Tubuloglomerular Feedback Pathway, a New Mechanism for Glomerular Hyperfiltration during Hyperglycemia. J Am Soc Nephrol. 2019 Apr; 30(4):578-593.View Related Profiles. PMID: 30867247; PMCID: PMC6442354; DOI: 10.1681/ASN.2018080844;
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Zhang J, Qu HY, Song J, Wei J, Jiang S, Wang L, Wang L, Buggs J, Liu R. Enhanced hemodynamic responses to angiotensin II in diabetes are associated with increased expression and activity of AT1 receptors in the afferent arteriole. Physiol Genomics. 2017 Oct 01; 49(10):531-540.View Related Profiles. PMID: 28842434; PMCID: PMC5668650; DOI: 10.1152/physiolgenomics.00025.2017;
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Wang L, Song J, Wang S, Buggs J, Chen R, Zhang J, Wang L, Rong S, Li W, Wei J, Liu R. Cross-sex transplantation alters gene expression and enhances inflammatory response in the transplanted kidneys. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F326-F338.View Related Profiles. PMID: 28515172; PMCID: PMC5582902; DOI: 10.1152/ajprenal.00039.2017;
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Wang S, Wang X, Boone J, Wie J, Yip KP, Zhang J, Wang L, Liu R. Application of Hanging Drop Technique for Kidney Tissue Culture. Kidney Blood Press Res. 2017; 42(2):220-231. PMID: 28478441; PMCID: PMC6050513; DOI: 10.1159/000476018;
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Wei J, Song J, Jiang S, Zhang G, Wheeler D, Zhang J, Wang S, Lai EY, Wang L, Buggs J, Liu R. Role of intratubular pressure during the ischemic phase in acute kidney injury. Am J Physiol Renal Physiol. 2017 Jun 01; 312(6):F1158-F1165.View Related Profiles. PMID: 28579560; PMCID: PMC6148315; DOI: 10.1152/ajprenal.00527.2016;
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Lu Y, Wei J, Stec DE, Roman RJ, Ge Y, Cheng L, Liu EY, Zhang J, Hansen PB, Fan F, Juncos LA, Wang L, Pollock J, Huang PL, Fu Y, Wang S, Liu R. Macula Densa Nitric Oxide Synthase 1ß Protects against Salt-Sensitive Hypertension. J Am Soc Nephrol. 2016 Aug; 27(8):2346-56.View Related Profiles. PMID: 26647426; PMCID: PMC4978040; DOI: 10.1681/ASN.2015050515;
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Wang L, Shen C, Liu H, Wang S, Chen X, Roman RJ, Juncos LA, Lu Y, Wei J, Zhang J, Yip KP, Liu R. Shear stress blunts tubuloglomerular feedback partially mediated by primary cilia and nitric oxide at the macula densa. Am J Physiol Regul Integr Comp Physiol. 2015 Oct; 309(7):R757-66.View Related Profiles. PMID: 26269519; PMCID: PMC4666931; DOI: 10.1152/ajpregu.00173.2015;
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Wang X, Johnson AC, Williams JM, White T, Chade AR, Zhang J, Liu R, Roman RJ, Lee JW, Kyle PB, Solberg-Woods L, Garrett MR. Nephron Deficiency and Predisposition to Renal Injury in a Novel One-Kidney Genetic Model. J Am Soc Nephrol. 2015 Jul; 26(7):1634-46. PMID: 25349207; PMCID: PMC4483580; DOI: 10.1681/ASN.2014040328;
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This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
| Year | Publications |
|---|
| 2013 | 1 |
| 2014 | 1 |
| 2015 | 2 |
| 2016 | 3 |
| 2017 | 6 |
| 2018 | 3 |
| 2019 | 7 |
| 2020 | 1 |
| 2021 | 3 |
| 2022 | 2 |
| 2023 | 2 |
2022 American Physiological Society / American Society of Nephrology Conference: Control of Renal Functio:
Oral Abstract Award
2020-2022 American Society of Nephrology:
Carl W. Gottschalk Research Transition to Independence Grant
2018 American Heart Association Council of Hypertension:
New Investigator Travel Award
2018-2020 American Society of Nephrology:
Ben J. Lipps Research Post-Doctoral Fellowship
2017 American Heart Association Council of Hypertension:
Early Career Oral Presentation Award
2015-2017 American Heart Association:
Pre-Doctoral Fellowship