Jean-Pierre Roussarie PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Anatomy & Neurobiology

PhD, Pierre and Marie Curie University (Paris VI)
MS, Pierre and Marie Curie University (Paris VI)
BA, Ecole Poly Fed Du Lausanne

Pronouns: he/him/his



The lab is interested in deciphering the molecular events leading to neurodegeneration in Alzheimer’s disease. Like most neurodegenerative diseases, Alzheimer’s affects only very specific sets of neurons in its earliest stages. These neurons are located in the entorhinal cortex, a brain region indispensable for new memory formation. We think that understanding the particularities of these entorhinal cortex neurons will yield novel insights into the Alzheimer’s pathological processes. Eventually this will lead to the identification of new therapeutic targets to prevent neurodegeneration. In order to elucidate the properties of entorhinal neurons at single-cell resolution, we use a combination of mouse models, human postmortem tissue, novel in vitro culture protocols, and in silico modeling.

Diversity, Equity, Inclusion and Accessibility

I co-organized the first Emerging Scholars Program in Anatomy & Neurobiology (https://bostonu.qualtrics.com/jfe/form/SV_9yTbrPJSw7lA54a): we invited four senior PhD/postdocs from historically underrepresented backgrounds from outside BU to present their work as part of a university-wide symposium and to participate in networking/mentoring sessions with members of the department.


Regulation of entorhinal cortex layer II vulnerability by a cell-type specific miRNA
08/01/2024 - 04/30/2029 (PI)
NIH/National Institute on Aging
1R01AG085444-01A1

Identification of early transcriptional and pathological changes undergone by vulnerable brain regions during prodromal Alzheimer's disease
08/01/2024 - 07/31/2026 (PI)
NIH/National Institute on Aging
1R21AG085464-01A1

Multimodal characterization of the mechanisms of selective vulnerability of entorhinal cortical neurons
05/01/2024 - 04/30/2026 (Multi-PI)
PI: Jean-Pierre Roussarie PhD
NIH/National Institute on Aging
1R21AG084041-01A1

Genomics analysis of the extreme vulnerability of transentorhinal cortex
09/01/2022 - 08/31/2025 (PI)
Alzheimer's Association


APOE Consortium: Modulation of Selective Neuronal Vulnerability in Alzheimer’s disease by ApoE
12/01/2022 - 12/31/2024 (PI)
Cure Alzheimer's Fund


APOE Consortium: Regulation by APOE of selective neuronal vulnerability to Alzheimer's disease
09/01/2021 - 11/30/2022 (PI)
Cure Alzheimer's Fund


Generation of Human iPSC-derived Entorhinal Cortex Neurons for Probing Selective Neuronal Vulnerability in Alzheimer's Disease
09/01/2021 - 08/31/2022 (PI)
NIH/National Institute on Aging
7RF1AG054564-02



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Rodriguez-Rodriguez P, Arroyo-Garcia LE, Tsagkogianni C, Li L, Wang W, Végvári Á, Salas-Allende I, Plautz Z, Cedazo-Minguez A, Sinha SC, Troyanskaya O, Flajolet M, Yao V, Roussarie JP. A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons. Brain. 2024 Jul 05; 147(7):2384-2399. PMID: 38462574; PMCID: PMC11224620; DOI: 10.1093/brain/awae051;
     
  2. Lai Q, Dannenfelser R, Roussarie JP, Yao V. Disentangling associations between complex traits and cell types with seismic. bioRxiv. 2024 May 07. PMID: 38765980; PMCID: PMC11100625; DOI: 10.1101/2024.05.04.592534;
     
  3. Montalban E, Giralt A, Taing L, Nakamura Y, Pelosi A, Brown M, de Pins B, Valjent E, Martin M, Nairn AC, Greengard P, Flajolet M, Hervé D, Gambardella N, Roussarie JP, Girault JA. Operant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens D2 Neurons and Reveals a Modulatory Role of Ncdn. Biol Psychiatry. 2024 May 15; 95(10):926-937. PMID: 37579933; PMCID: PMC11059129; DOI: 10.1016/j.biopsych.2023.08.006;
     
  4. Marion-Poll L, Roussarie JP, Taing L, Dard-Dascot C, Servant N, Jaszczyszyn Y, Jordi E, Mulugeta E, Hervé D, Bourc'his D, Greengard P, Thermes C, Girault JA. DNA methylation and hydroxymethylation characterize the identity of D1 and D2 striatal projection neurons. Commun Biol. 2022 Dec 01; 5(1):1321. PMID: 36456703; PMCID: PMC9715678; DOI: 10.1038/s42003-022-04269-w;
     
  5. Montalban E, Giralt A, Taing L, Schut EHS, Supiot LF, Castell L, Nakamura Y, de Pins B, Pelosi A, Goutebroze L, Tuduri P, Wang W, Neiburga KD, Vestito L, Castel J, Luquet S, Nairn AC, Hervé D, Heintz N, Martin C, Greengard P, Valjent E, Meye FJ, Gambardella N, Roussarie JP, Girault JA. Translational profiling of mouse dopaminoceptive neurons reveals region-specific gene expression, exon usage, and striatal prostaglandin E2 modulatory effects. Mol Psychiatry. 2022 Apr; 27(4):2068-2079. PMID: 35177825; PMCID: PMC10009708; DOI: 10.1038/s41380-022-01439-4;
     
  6. Roussarie JP, Rodriguez-Rodriguez P. Deciphering cell-type specific signal transduction in the brain: Challenges and promises. Adv Pharmacol. 2021; 90:145-171. PMID: 33706931
     
  7. Roussarie JP, Yao V, Rodriguez-Rodriguez P, Oughtred R, Rust J, Plautz Z, Kasturia S, Albornoz C, Wang W, Schmidt EF, Dannenfelser R, Tadych A, Brichta L, Barnea-Cramer A, Heintz N, Hof PR, Heiman M, Dolinski K, Flajolet M, Troyanskaya OG, Greengard P. Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis. Neuron. 2020 09 09; 107(5):821-835.e12. PMID: 32603655; PMCID: PMC7580783; DOI: 10.1016/j.neuron.2020.06.010;
     
  8. Brichta L, Shin W, Jackson-Lewis V, Blesa J, Yap EL, Walker Z, Zhang J, Roussarie JP, Alvarez MJ, Califano A, Przedborski S, Greengard P. Identification of neurodegenerative factors using translatome-regulatory network analysis. Nat Neurosci. 2015 Sep; 18(9):1325-33. PMID: 26214373
     
  9. Vidalain PO, Jacob Y, Hagemeijer MC, Jones LM, Neveu G, Roussarie JP, Rottier PJ, Tangy F, de Haan CA. A field-proven yeast two-hybrid protocol used to identify coronavirus-host protein-protein interactions. Methods Mol Biol. 2015; 1282:213-29. PMID: 25720483
     
  10. Brahic M, Roussarie JP. Axon-myelin interactions during a viral infection of the central nervous system. PLoS Pathog. 2009 Sep; 5(9):e1000519. PMID: 19779566
     
Showing 10 of 13 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 13 publications over 8 distinct years, with a maximum of 2 publications in 2007 and 2015 and 2020 and 2022 and 2024

YearPublications
20041
20072
20091
20152
20202
20222
20231
20242


University Names Eight Junior Faculty to Career Development Professorships for Promising Scholars

BU Today 9/26/2022
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Selective Vulnerability
Alzheimer's disease
Neurodegeneration
Genomics
Entorhinal Cortex

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Diversity Mentor
  • Project Mentor
  • Work / Life Integration Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

72 E. Concord St
Boston MA 02118
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617.358.2200
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