Edward R Damiano, PhD
Professor
Boston University College of Engineering
Biomedical Engineering

PhD, Rensselaer Polytechnic Institute
MS, Washington University in St. Louis
BS, Rensselaer Polytechnic Institute



Dr. Ed Damiano is a Professor of Biomedical Engineering at Boston University and has held that role since 2004. He is also President and CEO of Beta Bionics. His expertise and training are in the areas of mechanical and biomedical engineering, applied mechanics, and applied mathematics. Ever since his 14-year-old son was diagnosed with type 1 diabetes at 11 months of age, he has been committed to creating and integrating closed-loop control technologies with a vision of building a bionic endocrine pancreas by the time his son heads off to college in the fall of 2017. This endeavor began with the design and development of mathematical algorithm strategies for blood glucose control, which he and his group began testing in his laboratory at Boston University in 2005 in a swine model of type 1 diabetes. In 2006, he began working with his clinical collaborators at the Massachusetts General Hospital (MGH) to design their first clinical protocol.

Between 2008 and 2012, they tested their system in the inpatient setting in one-day and two-day experiments in adults and adolescents with type 1 diabetes in the Clinical Research Center at the MGH. Near the end of 2012 they received approval from the FDA to begin testing a mobile version of their system, which integrates an iPhone with their blood-glucose control algorithm, an insulin pump, and a continuous glucose monitor. Between February and September 2013, they conducted an ambitious outpatient trial testing their bihormonal bionic pancreas in five-day experiments in 20 adult subjects with type 1 diabetes in downtown Boston. In July and August 2013, they conducted their even more ambitious Summer Camp Study testing their bihormonal bionic pancreas in five-day experiments in 32 adolescent subjects with type 1 diabetes at Camp Joslin and the Clara Barton Camp in central Massachusetts.


The Bionic Pancreas Primary Care Study
05/01/2019 - 10/31/2020 (PI)
Leona M. and Harry B. Helmsley Charitable Trust


Final clinical studies for submission of a pre-market approval application to the FDA for a bionic pancreas that automates type 1 diabetes management
09/30/2015 - 05/31/2020 (Multi-PI)
PI: Edward R Damiano, PhD
NIH/National Diabetes & Digestive & Kidney Diseases
1UC4DK108612-01

Building and autonomous glycemic control system for hyperglycemia of critical illness
03/22/2019 - 01/21/2020 (Subcontract PI)
Beta Bionics, Inc. DOD DARPA


Understanding the impact of Rapid Acting Analog Differences on Glucose Control
06/15/2018 - 12/31/2019 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital Leona&Harry Helmsley


The Monitoring Study: Evaluating the Effect of Remote Monitoring for Hypoglycemia on Bionic Pancreas Safety and Efficacy
04/01/2017 - 12/31/2018 (Subcontract PI)
Massachusetts General Hospital Leona&Harry Helmsley


The Set-Point Study: Evaluating Effects of Changing Glucose Target on Bionic Pancreas Performance
07/01/2015 - 12/31/2016 (Subcontract PI)
Massachusetts General Hospital Leona&Harry Helmsley


An Outpatient Feasibility Study of an Insulin-only Bionic Pancreas
07/01/2015 - 09/30/2016 (PI)
Leona M. and Harry B. Helmsley Charitable Trust


A Multicenter Outpatient Trial of a Bihormonal Bionic Pancreas
09/30/2013 - 08/31/2016 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
3DP3DK101084-01S1

Translational Studies of a Bionic Pancreas for Out-Patient Diabetes Management
05/01/2013 - 01/31/2016 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK097657-03

Closed-Loop, Microdose Glucagon Administration for the Automated Prevention and Treatment of Hypoglycemia
07/01/2012 - 06/30/2015 (Subcontract PI)
Massachusetts General Hospital Amer Diabetes Assoc


Showing 10 of 15 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2019 Building a commercially scalable bionic pancreas for automated diabetes management 4R44DK120234-02
2018 Building a commercially scalable bionic pancreas for automated diabetes management 1R44DK120234-01
2016 Final clinical studies for submission of a pre-market approval application to the FDA for a Bionic Pancreas that automates type 1 diabetes management 3UC4DK108612-01S1 1
2015 Final clinical studies for submission of a pre-market approval application to the FDA for a Bionic Pancreas that automates type 1 diabetes management 1UC4DK108612-01 1
2015 A multicenter outpatient trial of a bihormonal pancreas 3DP3DK101084-01S1 3
2015 Translatioanl studies of a bionic pancreas for out-patient diabetes management 5R01DK097657-03 4
2014 Translatioanl studies of a bionic pancreas for out-patient diabetes management 5R01DK097657-02 4
2013 A multicenter outpatient trial of a bihormonal bionic pancreas 1DP3DK101084-01 3
2013 Translatioanl studies of a bionic pancreas for out-patient diabetes management 1R01DK097657-01 4
2012 Clinical trials of a closed-loop control system for type 1 diabetes management 5R01DK085633-04 6
Showing 10 of 26 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Sherwood JS, Castellanos LE, O'Connor MY, Balliro CA, Hillard MA, Gaston SG, Bartholomew R, Greaux E, Sabean A, Zheng H, Marchetti P, Uluer A, Sawicki GS, Neuringer I, El-Khatib FH, Damiano ER, Russell SJ, Putman MS. Randomized Trial of the Insulin-Only iLet Bionic Pancreas for the Treatment of Cystic Fibrosis- Related Diabetes. Diabetes Care. 2024 Jan 01; 47(1):101-108. PMID: 37874987; PMCID: PMC10733649; DOI: 10.2337/dc23-1411;
     
  2. Marak MC, Calhoun P, Damiano ER, Russell SJ, Ruedy KJ, Beck RW. Testing the Real-World Accuracy of the Dexcom G6 Pro CGM During the Insulin-Only Bionic Pancreas Pivotal Trial. Diabetes Technol Ther. 2023 Nov; 25(11):817-821. PMID: 37668666; PMCID: PMC10771867; DOI: 10.1089/dia.2023.0287;
     
  3. Weissberg-Benchell J, Vesco AT, Shapiro J, Calhoun P, Damiano ER, Russell SJ, Li Z, El-Khatib FH, Ruedy KJ, Balliro CA, Beck RW. Psychosocial Impact of the Insulin-Only iLet Bionic Pancreas for Adults, Youth, and Caregivers of Youth with Type 1 Diabetes. Diabetes Technol Ther. 2023 Oct; 25(10):705-717. PMID: 37523175; PMCID: PMC10611964; DOI: 10.1089/dia.2023.0238;
     
  4. Castellanos LE, Russell SJ, Damiano ER, Beck RW, Shah VN, Bailey R, Calhoun P, Bird K, Mauras N. The Insulin-Only Bionic Pancreas Improves Glycemic Control in Non-Hispanic White and Minority Adults and Children With Type 1 Diabetes. Diabetes Care. 2023 Jun 01; 46(6):1185-1190. PMID: 37000680; PMCID: PMC10234742; DOI: 10.2337/dc22-1478;
     
  5. Mauras N, Damiano ER, El-Khatib FH, Marak MC, Calhoun P, Ruedy KJ, Balliro C, Li Z, Beck RW, Russell SJ. Utility and Safety of Backup Insulin Regimens Generated by the Bionic Pancreas: A Randomized Study. Diabetes Technol Ther. 2023 Jun; 25(6):437-441. PMID: 36877259; PMCID: PMC10398715; DOI: 10.1089/dia.2022.0461;
     
  6. Russell SJ, Damiano ER, Calhoun P. Randomized Trial of a Bionic Pancreas in Type 1 Diabetes. Reply. N Engl J Med. 2023 Jan 26; 388(4):380-382. PMID: 36720150
     
  7. Lynch J, Kanapka LG, Russell SJ, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro C, Calhoun P, Beck RW. The Insulin-Only Bionic Pancreas Pivotal Trial Extension Study: A Multi-Center Single-Arm Evaluation of the Insulin-Only Configuration of the Bionic Pancreas in Adults and Youth with Type 1 Diabetes. Diabetes Technol Ther. 2022 Oct; 24(10):726-736. PMID: 36173238; PMCID: PMC9529297; DOI: 10.1089/dia.2022.0341;
     
  8. Messer LH, Buckingham BA, Cogen F, Daniels M, Forlenza G, Jafri RZ, Mauras N, Muir A, Wadwa RP, White PC, Russell SJ, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro CA, Li Z, Marak MC, Calhoun P, Beck RW. Positive Impact of the Bionic Pancreas on Diabetes Control in Youth 6-17 Years Old with Type 1 Diabetes: A Multicenter Randomized Trial. Diabetes Technol Ther. 2022 Oct; 24(10):712-725. PMID: 36173237; PMCID: PMC9529304; DOI: 10.1089/dia.2022.0201.pub;
     
  9. Beck RW, Russell SJ, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro C, Li Z, Calhoun P. A Multicenter Randomized Trial Evaluating Fast-Acting Insulin Aspart in the Bionic Pancreas in Adults with Type 1 Diabetes. Diabetes Technol Ther. 2022 Oct; 24(10):681-696. PMID: 36173235; PMCID: PMC9529301; DOI: 10.1089/dia.2022.0167;
     
  10. Kruger D, Kass A, Lonier J, Pettus J, Raskin P, Salam M, Trikudanathan S, Zhou K, Russell SJ, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro C, Li Z, Marak MC, Calhoun P, Beck RW. A Multicenter Randomized Trial Evaluating the Insulin-Only Configuration of the Bionic Pancreas in Adults with Type 1 Diabetes. Diabetes Technol Ther. 2022 Oct; 24(10):697-711. PMID: 36173236; PMCID: PMC9634987; DOI: 10.1089/dia.2022.0200;
     
Showing 10 of 46 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 46 publications over 22 distinct years, with a maximum of 6 publications in 2022

YearPublications
19961
19981
19991
20011
20021
20032
20041
20073
20082
20092
20102
20111
20122
20131
20143
20164
20192
20201
20213
20226
20235
20241

2016 WebMD Health Heroes Award, Recipient for the Scientist Category
2016 Boston University Office of Technology Development: Innovator of the Year
2015 American Institute for Medical and Biological Engineering College of Fellows: Elected Fellow
2014 Diabetes Technology Society: Artificial Pancreas Research Award
2001-2007 National Science Foundation: CAREER Award
1996-1998 National Institutes of Health: Individual National Research Service Award
Contact for Mentoring:

44 Cummington St
Boston MA 02215
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