Edward R Damiano, PhD
Professor
Boston University College of Engineering
Dept of Biomedical Engineering

PhD, Rensselaer Polytechnic Institute
MS, Washington University in St. Louis




Dr. Ed Damiano is a Professor of Biomedical Engineering at Boston University and has held that role since 2004. He is also President and CEO of Beta Bionics. His expertise and training are in the areas of mechanical and biomedical engineering, applied mechanics, and applied mathematics. Ever since his 14-year-old son was diagnosed with type 1 diabetes at 11 months of age, he has been committed to creating and integrating closed-loop control technologies with a vision of building a bionic endocrine pancreas by the time his son heads off to college in the fall of 2017. This endeavor began with the design and development of mathematical algorithm strategies for blood glucose control, which he and his group began testing in his laboratory at Boston University in 2005 in a swine model of type 1 diabetes. In 2006, he began working with his clinical collaborators at the Massachusetts General Hospital (MGH) to design their first clinical protocol.

Between 2008 and 2012, they tested their system in the inpatient setting in one-day and two-day experiments in adults and adolescents with type 1 diabetes in the Clinical Research Center at the MGH. Near the end of 2012 they received approval from the FDA to begin testing a mobile version of their system, which integrates an iPhone with their blood-glucose control algorithm, an insulin pump, and a continuous glucose monitor. Between February and September 2013, they conducted an ambitious outpatient trial testing their bihormonal bionic pancreas in five-day experiments in 20 adult subjects with type 1 diabetes in downtown Boston. In July and August 2013, they conducted their even more ambitious Summer Camp Study testing their bihormonal bionic pancreas in five-day experiments in 32 adolescent subjects with type 1 diabetes at Camp Joslin and the Clara Barton Camp in central Massachusetts.


The Bionic Pancreas Primary Care Study
05/01/2019 - 10/31/2020 (PI)
Leona M. and Harry B. Helmsley Charitable Trust


Final clinical studies for submission of a pre-market approval application to the FDA for a bionic pancreas that automates type 1 diabetes management
09/30/2015 - 05/31/2020 (Multi-PI)
PI: Edward R Damiano, PhD
NIH/National Diabetes & Digestive & Kidney Diseases
1UC4DK108612-01

Building and autonomous glycemic control system for hyperglycemia of critical illness
03/22/2019 - 01/21/2020 (Subcontract PI)
Beta Bionics, Inc. DOD DARPA


Understanding the impact of Rapid Acting Analog Differences on Glucose Control
06/15/2018 - 12/31/2019 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital Leona&Harry Helmsley


The Monitoring Study: Evaluating the Effect of Remote Monitoring for Hypoglycemia on Bionic Pancreas Safety and Efficacy
04/01/2017 - 12/31/2018 (Subcontract PI)
Massachusetts General Hospital Leona&Harry Helmsley


The Set-Point Study: Evaluating Effects of Changing Glucose Target on Bionic Pancreas Performance
07/01/2015 - 12/31/2016 (Subcontract PI)
Massachusetts General Hospital Leona&Harry Helmsley


An Outpatient Feasibility Study of an Insulin-only Bionic Pancreas
07/01/2015 - 09/30/2016 (PI)
Leona M. and Harry B. Helmsley Charitable Trust


A Multicenter Outpatient Trial of a Bihormonal Bionic Pancreas
09/30/2013 - 08/31/2016 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
3DP3DK101084-01S1

Translational Studies of a Bionic Pancreas for Out-Patient Diabetes Management
05/01/2013 - 01/31/2016 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK097657-03

Closed-Loop, Microdose Glucagon Administration for the Automated Prevention and Treatment of Hypoglycemia
07/01/2012 - 06/30/2015 (Subcontract PI)
Massachusetts General Hospital Amer Diabetes Assoc


Showing 10 of 15 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2019 Building a commercially scalable bionic pancreas for automated diabetes management 4R44DK120234-02
2018 Building a commercially scalable bionic pancreas for automated diabetes management 1R44DK120234-01
2016 Final clinical studies for submission of a pre-market approval application to the FDA for a Bionic Pancreas that automates type 1 diabetes management 3UC4DK108612-01S1 1
2015 Final clinical studies for submission of a pre-market approval application to the FDA for a Bionic Pancreas that automates type 1 diabetes management 1UC4DK108612-01 1
2015 A multicenter outpatient trial of a bihormonal pancreas 3DP3DK101084-01S1 3
2015 Translatioanl studies of a bionic pancreas for out-patient diabetes management 5R01DK097657-03 4
2014 Translatioanl studies of a bionic pancreas for out-patient diabetes management 5R01DK097657-02 4
2013 A multicenter outpatient trial of a bihormonal bionic pancreas 1DP3DK101084-01 3
2013 Translatioanl studies of a bionic pancreas for out-patient diabetes management 1R01DK097657-01 4
2012 Clinical trials of a closed-loop control system for type 1 diabetes management 5R01DK085633-04 6
Showing 10 of 26 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Messer LH, Buckingham BA, Cogen F, Daniels M, Forlenza GP, Jafri R, Mauras N, Muir A, Wadwa RP, White P, Russell S, Damiano ER, El-Khatib F, Ruedy KJ, Balliro C, Li Z, Marak C, Calhoun P, Beck RW. WITHDRAWN: Positive Impact of the Bionic Pancreas on Diabetes Control in Youth 6-17 Years Old with Type 1 Diabetes: A Multicenter Randomized Trial. Diabetes Technol Ther. 2022 Jun 28. PMID: 35763327
     
  2. Rayannavar A, Mitteer LM, Balliro CA, El-Khatib FH, Lord KL, Hawkes CP, Ballester LS, Damiano ER, Russell SJ, De León DD. The Bihormonal Bionic Pancreas Improves Glycemic Control in Individuals With Hyperinsulinism and Postpancreatectomy Diabetes: A Pilot Study. Diabetes Care. 2021 11; 44(11):2582-2585. PMID: 34518377; PMCID: PMC8546273; DOI: 10.2337/dc21-0416;
     
  3. Russell SJ, Balliro C, Ekelund M, El-Khatib F, Graungaard T, Greaux E, Hillard M, Jafri RZ, Rathor N, Selagamsetty R, Sherwood J, Damiano ER. Improvements in Glycemic Control Achieved by Altering the tmax Setting in the iLet® Bionic Pancreas When Using Fast-Acting Insulin Aspart: A Randomized Trial. Diabetes Ther. 2021 Jul; 12(7):2019-2033. PMID: 34146238; PMCID: PMC8266971; DOI: 10.1007/s13300-021-01087-x;
     
  4. Castellanos LE, Balliro CA, Sherwood JS, Jafri R, Hillard MA, Greaux E, Selagamsetty R, Zheng H, El-Khatib FH, Damiano ER, Russell SJ. Performance of the Insulin-Only iLet Bionic Pancreas and the Bihormonal iLet Using Dasiglucagon in Adults With Type 1 Diabetes in a Home-Use Setting. Diabetes Care. 2021 06; 44(6):e118-e120. PMID: 33906916; PMCID: PMC8247518; DOI: 10.2337/dc20-1086;
     
  5. Jafri RZ, Balliro CA, El-Khatib F, Maheno MM, Hillard MA, O'Donovan A, Selagamsetty R, Zheng H, Damiano ER, Russell SJ. A Three-Way Accuracy Comparison of the Dexcom G5, Abbott Freestyle Libre Pro, and Senseonics Eversense Continuous Glucose Monitoring Devices in a Home-Use Study of Subjects with Type 1 Diabetes. Diabetes Technol Ther. 2020 11; 22(11):846-852. PMID: 32453604
     
  6. Ekhlaspour L, Nally LM, El-Khatib FH, Ly TT, Clinton P, Frank E, Tanenbaum ML, Hanes SJ, Selagamsetty RR, Hood K, Damiano ER, Buckingham BA. Feasibility Studies of an Insulin-Only Bionic Pancreas in a Home-Use Setting. J Diabetes Sci Technol. 2019 11; 13(6):1001-1007. PMID: 31470740; PMCID: PMC6835195; DOI: 10.1177/1932296819872225;
     
  7. Sherwood JS, Jafri RZ, Balliro CA, Zheng H, El-Khatib FH, Damiano ER, Russell SJ, Putman MS. Automated glycemic control with the bionic pancreas in cystic fibrosis-related diabetes: A pilot study. J Cyst Fibros. 2020 01; 19(1):159-161. PMID: 31420176; PMCID: PMC6995423; DOI: 10.1016/j.jcf.2019.08.002;
     
  8. El-Khatib FH, Balliro C, Hillard MA, Magyar KL, Ekhlaspour L, Sinha M, Mondesir D, Esmaeili A, Hartigan C, Thompson MJ, Malkani S, Lock JP, Harlan DM, Clinton P, Frank E, Wilson DM, DeSalvo D, Norlander L, Ly T, Buckingham BA, Diner J, Dezube M, Young LA, Goley A, Kirkman MS, Buse JB, Zheng H, Selagamsetty RR, Damiano ER, Russell SJ. Home use of a bihormonal bionic pancreas versus insulin pump therapy in adults with type 1 diabetes: a multicentre randomised crossover trial. Lancet. 2017 01 28; 389(10067):369-380. PMID: 28007348
     
  9. Maahs DM, Buckingham BA, Castle JR, Cinar A, Damiano ER, Dassau E, DeVries JH, Doyle FJ, Griffen SC, Haidar A, Heinemann L, Hovorka R, Jones TW, Kollman C, Kovatchev B, Levy BL, Nimri R, O'Neal DN, Philip M, Renard E, Russell SJ, Weinzimer SA, Zisser H, Lum JW. Outcome Measures for Artificial Pancreas Clinical Trials: A Consensus Report. Diabetes Care. 2016 Jul; 39(7):1175-9. PMID: 27330126
     
  10. Weissberg-Benchell J, Hood K, Laffel L, Heinemann L, Ball D, Kowalski A, Peters A, Damiano E, Schiller M, Davis A, Beck S, Barnard K. Toward Development of Psychosocial Measures for Automated Insulin Delivery. J Diabetes Sci Technol. 2016 05; 10(3):799-801. PMID: 26645792
     
Showing 10 of 35 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 35 publications over 20 distinct years, with a maximum of 4 publications in 2016

YearPublications
19961
19981
19991
20011
20021
20032
20041
20073
20082
20092
20102
20111
20122
20131
20143
20164
20192
20201
20213
20221

2016 WebMD Health Heroes Award, Recipient for the Scientist Category
2016 Boston University Office of Technology Development: Innovator of the Year
2015 American Institute for Medical and Biological Engineering College of Fellows: Elected Fellow
2014 Diabetes Technology Society: Artificial Pancreas Research Award
2001-2007 National Science Foundation: CAREER Award
1996-1998 National Institutes of Health: Individual National Research Service Award
Contact for Mentoring:

44 Cummington St
Boston MA 02215
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