Cynthia Bradham | Profiles RNS

Cynthia A. Bradham, PhD

Associate Professor

Boston University College of Arts and Sciences

Biology

PhD, University of North Carolina at Chapel Hill
BS, University of Wisconsin–Milwaukee

Websites

	Google Scholar
	LinkedIn
	ResearchGate

ORCID : 0000-0001-8309-5807

Our research is focused on understanding secondary (dorsal-ventral) axis specification and skeletal patterning in the sea urchin. We are interested in producing a systems-level description for these processes. Sea urchin, a non-chordate deuterostome, is an ideal model organism for systems-level developmental studies. Genomic analysis has revealed that sea urchins share the diversity of signaling and transcriptional molecules with vertebrates, including humans, but lack the complexity associated with a duplicated genome. Further, sea urchin larvae are morphologically quite simple, being composed of approximately 15 cell types, and thus are accessible to detailed analysis of cell specification and cell-cell communication mechanisms. Finally, the use of gene regulatory networks to model developmental processes was pioneered in urchin, providing a strong precedent for this work. The lab is focused primarily on two projects: understanding how the dorsal-ventral axis is specified, and how the larval skeleton is patterned. We are pursuing these projects through a combination of molecular biology, biochemistry, cell biology, computational modeling, and systems biology approaches.

BU Research
NIH RePORTER Research

Spatiotemporal Regulation of Developmental Pattern Formation
12/15/2023 - 11/30/2028 (PI)
NIH/National Institute of General Medical Sciences
1R35GM152180-01

The Molecular Basis for Skeletal Patterning
01/01/2017 - 08/31/2022 (PI)
National Science Foundation
IOS-1656752

The Molecular Basis for Skeletal Patterning in Sea Urchins
12/15/2012 - 01/31/2019 (PI)
National Science Foundation
IOS-1257825

Title

Yr	Title	Project-Sub Proj	Pubs
2025	Spatiotemporal Regulation of Developmental Pattern Formation	5R35GM152180-02
2024	Spatiotemporal Regulation of Developmental Pattern Formation	1R35GM152180-01
2003	Role of p38 in the patterning of sea urchin embryos	5F32HD041802-02	3
2002	Role of p38 in the patterning of sea urchin embryos	1F32HD041802-01	3

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Thomas CF, Hawkins DY, Skidanova V, Marrujo SR, Gibson J, Ye Z, Bradham CA. Voltage-gated sodium channel activity mediates sea urchin larval skeletal patterning through spatial regulation of Wnt5 expression. Development. 2023 May 15; 150(10). PMID: 37139779

Hawkins DY, Zuch DT, Huth J, Rodriguez-Sastre N, McCutcheon KR, Glick A, Lion AT, Thomas CF, Descoteaux AE, Johnson WE, Bradham CA. ICAT: a novel algorithm to robustly identify cell states following perturbations in single-cell transcriptomes. Bioinformatics. 2023 May 04; 39(5).View Related Profiles.

Bradham, Cynthia
Johnson, William

PMID: 37086439; PMCID: PMC10172037; DOI: 10.1093/bioinformatics/btad278;

Descoteaux AE, Zuch DT, Bradham CA. Polychrome labeling reveals skeletal triradiate and elongation dynamics and abnormalities in patterning cue-perturbed embryos. Dev Biol. 2023 Jun; 498:1-13. PMID: 36948411

Rodríguez-Sastre N, Shapiro N, Hawkins DY, Lion AT, Peyreau M, Correa AE, Dionne K, Bradham CA. Ethanol exposure perturbs sea urchin development and disrupts developmental timing. Dev Biol. 2023 Jan; 493:89-102. PMID: 36368523

Hogan JD, Keenan JL, Luo L, Ibn-Salem J, Lamba A, Schatzberg D, Piacentino ML, Zuch DT, Core AB, Blumberg C, Timmermann B, Grau JH, Speranza E, Andrade-Navarro MA, Irie N, Poustka AJ, Bradham CA. The developmental transcriptome for Lytechinus variegatus exhibits temporally punctuated gene expression changes. Dev Biol. 2020 Apr 15; 460(2):139-154. PMID: 31816285

Piacentino ML, Chung O, Ramachandran J, Zuch DT, Yu J, Conaway EA, Reyna AE, Bradham CA. Zygotic LvBMP5-8 is required for skeletal patterning and for left-right but not dorsal-ventral specification in the sea urchin embryo. Dev Biol. 2016 Apr 01; 412(1):44-56. PMID: 26905309

Piacentino ML, Zuch DT, Fishman J, Rose S, Speranza EE, Li C, Yu J, Chung O, Ramachandran J, Ferrell P, Patel V, Reyna A, Hameeduddin H, Chaves J, Hewitt FB, Bardot E, Lee D, Core AB, Hogan JD, Keenan JL, Luo L, Coulombe-Huntington J, Blute TA, Oleinik E, Ibn-Salem J, Poustka AJ, Bradham CA. RNA-Seq identifies SPGs as a ventral skeletal patterning cue in sea urchins. Development. 2016 Feb 15; 143(4):703-14. PMID: 26755701

Schatzberg D, Lawton M, Hadyniak SE, Ross EJ, Carney T, Beane WS, Levin M, Bradham CA. H(+)/K(+) ATPase activity is required for biomineralization in sea urchin embryos. Dev Biol. 2015 Oct 15; 406(2):259-70. PMID: 26282894

Piacentino ML, Ramachandran J, Bradham CA. Late Alk4/5/7 signaling is required for anterior skeletal patterning in sea urchin embryos. Development. 2015 Mar 01; 142(5):943-52. PMID: 25633352

van Heijster P, Hardway H, Kaper TJ, Bradham CA. A computational model for BMP movement in sea urchin embryos. J Theor Biol. 2014 Dec 21; 363:277-89. PMID: 25167787

Showing 10 of 23 results. Show More

Wolenski FS, Bradham CA, Finnerty JR, Gilmore TD. NF-?B is required for cnidocyte development in the sea anemone Nematostella vectensis. Dev Biol. 2013 Jan 01; 373(1):205-15.View Related Profiles.

Bradham, Cynthia
Gilmore, Thomas

PMID: 23063796

Core AB, Reyna AE, Conaway EA, Bradham CA. Pantropic retroviruses as a transduction tool for sea urchin embryos. Proc Natl Acad Sci U S A. 2012 Apr 03; 109(14):5334-9. PMID: 22431628

Modell JW, Bradham CA. Mitochondrial gradients and p38 activity in early sea urchin embryos. Mol Reprod Dev. 2011 Apr; 78(4):225. PMID: 21387455

Bradham CA, Oikonomou C, Kühn A, Core AB, Modell JW, McClay DR, Poustka AJ. Chordin is required for neural but not axial development in sea urchin embryos. Dev Biol. 2009 Apr 15; 328(2):221-33. PMID: 19389361

Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Bellé R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Genevière AM, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallböök F, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C, Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Röttinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R. The genome of the sea urchin Strongylocentrotus purpuratus. Science. 2006 Nov 10; 314(5801):941-52. PMID: 17095691

Fernandez-Guerra A, Aze A, Morales J, Mulner-Lorillon O, Cosson B, Cormier P, Bradham C, Adams N, Robertson AJ, Marzluff WF, Coffman JA, Genevière AM. The genomic repertoire for cell cycle control and DNA metabolism in S. purpuratus. Dev Biol. 2006 Dec 01; 300(1):238-51. PMID: 17078944

Roux MM, Townley IK, Raisch M, Reade A, Bradham C, Humphreys G, Gunaratne HJ, Killian CE, Moy G, Su YH, Ettensohn CA, Wilt F, Vacquier VD, Burke RD, Wessel G, Foltz KR. A functional genomic and proteomic perspective of sea urchin calcium signaling and egg activation. Dev Biol. 2006 Dec 01; 300(1):416-33. PMID: 17054939

Bradham CA, Foltz KR, Beane WS, Arnone MI, Rizzo F, Coffman JA, Mushegian A, Goel M, Morales J, Geneviere AM, Lapraz F, Robertson AJ, Kelkar H, Loza-Coll M, Townley IK, Raisch M, Roux MM, Lepage T, Gache C, McClay DR, Manning G. The sea urchin kinome: a first look. Dev Biol. 2006 Dec 01; 300(1):180-93. PMID: 17027740

Lapraz F, Röttinger E, Duboc V, Range R, Duloquin L, Walton K, Wu SY, Bradham C, Loza MA, Hibino T, Wilson K, Poustka A, McClay D, Angerer L, Gache C, Lepage T. RTK and TGF-beta signaling pathways genes in the sea urchin genome. Dev Biol. 2006 Dec 01; 300(1):132-52. PMID: 17084834

Morales J, Mulner-Lorillon O, Cosson B, Morin E, Bellé R, Bradham CA, Beane WS, Cormier P. Translational control genes in the sea urchin genome. Dev Biol. 2006 Dec 01; 300(1):293-307. PMID: 16959243

Bradham C, McClay DR. p38 MAPK in development and cancer. Cell Cycle. 2006 Apr; 5(8):824-8. PMID: 16627995

Bradham CA, McClay DR. p38 MAPK is essential for secondary axis specification and patterning in sea urchin embryos. Development. 2006 Jan; 133(1):21-32. PMID: 16319119

Bradham CA, Miranda EL, McClay DR. PI3K inhibitors block skeletogenesis but not patterning in sea urchin embryos. Dev Dyn. 2004 Apr; 229(4):713-21. PMID: 15042695

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 23 publications over 12 distinct years, with a maximum of 7 publications in 2006

Bar chart showing 23 publications over 12 distinct years, with a maximum of 7 publications in 2006

Year	Publications
2004	1
2005	1
2006	7
2009	1
2011	1
2012	2
2014	1
2015	2
2016	2
2019	1
2022	1
2023	3

Featured Videos

Bricks of Life: How LEGO Inspires a Sea Urchin Researcher

2018 Sea Urchin Embryo XXV: Organizer, International Conference for the Development of the Sea Urchin Embryo XXV

2017-2024 MBL, Woods Hole MA: Lecturer- Embryology Course Echinoderm Module

2011 Sea Urchin Embryo XX: Organizer, International Conference for the Development of the Sea Urchin Embryo XX

Contact for Mentoring:

5 Cummington St
Boston MA 02215
Google Map

617.353.2432

Download vCard

Bradham's Networks

Click the "See All" links for more information and interactive visualizations

Concepts

See all (133) concept(s)

Co-Authors

See all (2) people

Similar People

See all (60) people

Same Department

Search Department