Christopher Heaphy, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Dept of Medicine
Hematology & Medical Oncology

PhD, University of New Mexico School of Medicine



Dr. Christopher Heaphy is a cancer biologist that has been conducting basic and translational studies focused on elucidating the role of telomere alterations across a range of cancer types (e.g. prostate, breast, brain, pancreatic, ovarian). Overall, his research program uses a combination of tissue-based, cell-based, and molecular approaches to study normal and abnormal telomere biology as it relates to cancer initiation and progression, with a particular interest in the Alternative Lengthening of Telomeres (ALT) phenotype – a telomerase-independent telomere maintenance mechanism. In addition, his laboratory focuses on how these findings may be readily translated into accurately predicting cancer risk, early detection, prognosis, and potential response to targeted therapies. Dr. Heaphy received his Ph.D. from the University of New Mexico School of Medicine and did his postdoctoral training at the Johns Hopkins University School of Medicine. He is currently affiliated with Boston Medical Center and is a member of the Boston University-Boston Medical Center (BU-BMC) Cancer Center.

Diversity, Equity, Inclusion and Accessibility

Coming from both Hispanic and Irish backgrounds, and now the husband of a Vietnamese immigrant, I continually strive to promote inclusion and equality for all. In particular, I am deeply committed to promoting diversity and inclusion in academia and medicine. For example, in 2021, I served as an ally to help advocate for gender equity in medicine via the Women in NETs (WIN) initiative through the North American Neuroendocrine Tumor Society (NANETS), a society in which a serve as the Chair of the Scientific Review & Research Committee. In addition, in the summers of 2020 and 2022, I served as a faculty mentor to multiple undergraduate students in the Boston University STaRS program, which is an NIH-funded program to promote more equitable access to graduate and medical education for students historically underrepresented in science and medicine.

My research to address racial disparities in cancer outcomes is well represented in the overall mission of Boston Medical Center - “Exceptional care without exception”. For example, racial disparities in prostate cancer incidence and outcomes are well documented. Prostate cancer screening, access to care, and treatment plans are each associated with significant race-based inequities. Although biological differences have been posited to account for higher incidence rates and worse prostate cancer outcomes for Black men, recent studies have shown that, when models are adjusted for social determinants of health (e.g. education, neighborhood, healthcare access, socioeconomic status, and medical literacy), the higher prostate cancer-specific mortality risk is completely attenuated. Thus, in a collaborative research project, we are currently integrating a range of factors (racial, molecular, metabolic, and geographic) to reconsider risk of progression. We plan to determine what new clinical and social determinants of health data are needed to develop and refine a comprehensive “risk signature” that will more accurately inform the best pathway to care for an individual patient. We envision this pathway will include both clinical care and patient navigation and establish better coordination between these two activities.

Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences





Stromal senescence in lethal prostate cancer: a novel target for prognosis and therapy
01/01/2021 - 12/31/2022 (PI)
Johns Hopkins University National Cancer Inst


Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Heaphy CM, Singhi AD. The diagnostic and prognostic utility of incorporating DAXX, ATRX, and alternative lengthening of telomeres to the evaluation of pancreatic neuroendocrine tumors. Hum Pathol. 2022 Nov; 129:11-20. PMID: 35872157
     
  2. Heaphy CM, Joshu CE, Barber JR, Davis C, Lu J, Zarinshenas R, Giovannucci E, Mucci LA, Stampfer MJ, Han M, De Marzo AM, Lotan TL, Platz EA, Meeker AK. The prostate tissue-based telomere biomarker as a prognostic tool for metastasis and death from prostate cancer after prostatectomy. J Pathol Clin Res. 2022 Sep; 8(5):481-491. PMID: 35836303; PMCID: PMC9353659; DOI: 10.1002/cjp2.288;
     
  3. Yuan M, Eberhart CG, Pratilas CA, Blakeley JO, Davis C, Stojanova M, Reilly K, Meeker AK, Heaphy CM, Rodriguez FJ. Therapeutic Vulnerability to ATR Inhibition in Concurrent NF1 and ATRX-Deficient/ALT-Positive High-Grade Solid Tumors. Cancers (Basel). 2022 Jun 19; 14(12). PMID: 35740680; PMCID: PMC9221513; DOI: 10.3390/cancers14123015;
     
  4. Holdhoff M, Guner G, Rodriguez FJ, Hicks JL, Zheng Q, Forman MS, Ye X, Grossman SA, Meeker AK, Heaphy CM, Eberhart CG, De Marzo AM, Arav-Boger R. Correction: Absence of Cytomegalovirus in Glioblastoma and Other High-grade Gliomas by Real-time PCR, Immunohistochemistry, and In Situ Hybridization. Clin Cancer Res. 2022 Apr 14; 28(8):1737. PMID: 35419593
     
  5. Mori JO, Shafran JS, Stojanova M, Katz MH, Gignac GA, Wisco JJ, Heaphy CM, Denis GV. Novel forms of prostate cancer chemoresistance to successful androgen deprivation therapy demand new approaches: Rationale for targeting BET proteins. Prostate. 2022 Jun; 82(10):1005-1015.View Related Profiles. PMID: 35403746
     
  6. Lally SE, Milman T, Orloff M, Dalvin LA, Eberhart CG, Heaphy CM, Rodriguez FJ, Lin CC, Dockery PW, Shields JA, Shields CL. Mutational Landscape and Outcomes of Conjunctival Melanoma in 101 Patients. Ophthalmology. 2022 Jun; 129(6):679-693. PMID: 35085662
     
  7. Dreijerink KM, Hackeng WM, Singhi AD, Heaphy CM, Brosens LA. Clinical implications of cell-of-origin epigenetic characteristics in non-functional pancreatic neuroendocrine tumors. J Pathol. 2022 02; 256(2):143-148. PMID: 34750813
     
  8. Shrestha E, Coulter JB, Guzman W, Ozbek B, Hess MM, Mummert L, Ernst SE, Maynard JP, Meeker AK, Heaphy CM, Haffner MC, De Marzo AM, Sfanos KS. Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer. Proc Natl Acad Sci U S A. 2021 08 10; 118(32). PMID: 34341114; PMCID: PMC8364155; DOI: 10.1073/pnas.2018976118;
     
  9. Heaphy CM, VandenBussche CJ. Prognostic biomarkers in pancreatic neuroendocrine tumors. Cancer Cytopathol. 2021 11; 129(11):841-843. PMID: 34242496
     
  10. Kang HJ, Oh JH, Kim YW, Kim W, An J, Sung CO, Kim J, Shim JH, Hwang S, Yu E, Heaphy CM, Hong SM. Clinicopathological and molecular characterization of chromophobe hepatocellular carcinoma. Liver Int. 2021 10; 41(10):2499-2510. PMID: 34036718
     
Showing 10 of 98 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 98 publications over 19 distinct years, with a maximum of 11 publications in 2020

YearPublications
20021
20051
20065
20073
20081
20095
20103
20116
20125
20136
20141
20157
20167
20173
201810
201910
202011
20217
20226

2022 North American Neuroendocrine Tumor Society (NANETS): Chair of the Scientific Review & Research Committee
2022 Endocrine-Related Cancer: Editorial Board Member
2021 Shipley Prostate Cancer Research Center at BU: Executive Advisory Committee Member
2021 North American Neuroendocrine Tumor Society (NANETS): Co-Chair of the Scientific Review & Research Committee
2021 Boston University: CTSI Pilot Grant Awardee
2021 Johns Hopkins University School of Medicine: Adjunct Assistant Professor in Oncology Center
2020 BU-BMC Cancer Center: American Cancer Society BU-BMC Cancer Center Pilot and Feasibility Program Awardee
2020 Boston University School of Medicine: Shipley Prostate Cancer Pilot Grant Awardee
2019 95th Annual American Association of Neuropathologists Meeting: Moore Award for the Best Clinico-Pathologic Paper in Neuropathology
2016 North American Neuroendocrine Tumor Society: Basic/Translational Science Investigator Award
2014 Patrick C. Walsh Prostate Cancer Research Fund: Dr. and Mrs. Peter S. Bing Scholar Award
2014 Prostate Cancer Foundation: Young Investigator Award
2013 Johns Hopkins Department of Pathology Young Investigator’s Day: Award for Excellence in Translational Research
2012 Johns Hopkins Fellow Research Day: 1st Place for Basic Research
2011 Johns Hopkins Department of Pathology Young Investigator’s Day: Award for Excellence in Translational Research
2011 United States and Canadian Academy of Pathology: Stowell-Orbison Award
2002 National Cancer Institute: Cancer Research Training Fellowship; Laboratory of Cellular Carcinogenesis and Tumor Promotion
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Telomeres
Alternative lengthening of telomeres
Cancer
Tissue-based biomarkers

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Co-Mentor or Peer Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')
  • Phone (see 'Contact Info')

650 Albany St
Boston MA 02118
Google Map


Heaphy's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department