Christopher Heaphy, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Hematology & Medical Oncology

PhD, University of New Mexico School of Medicine




Dr. Christopher Heaphy is a cancer biologist that has been conducting basic and translational studies focused on elucidating the role of telomere alterations across a range of cancer types (e.g. prostate, breast, brain, pancreatic, ovarian). Overall, his research program uses a combination of tissue-based, cell-based, and molecular approaches to study normal and abnormal telomere biology as it relates to cancer initiation and progression, with a particular interest in the Alternative Lengthening of Telomeres (ALT) phenotype – a telomerase-independent telomere maintenance mechanism. In addition, his laboratory focuses on how these findings may be readily translated into accurately predicting cancer risk, early detection, prognosis, and potential response to targeted therapies. Dr. Heaphy received his Ph.D. from the University of New Mexico School of Medicine and did his postdoctoral training at the Johns Hopkins University School of Medicine. He is currently affiliated with Boston Medical Center and is a member of the Boston University-Boston Medical Center (BU-BMC) Cancer Center.

Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research



2020 BU-BMC Cancer Center: American Cancer Society BU-BMC Cancer Center Pilot and Feasibility Program Awardee
2019 95th Annual American Association of Neuropathologists Meeting: Moore Award for the Best Clinico-Pathologic Paper in Neuropathology
2016 North American Neuroendocrine Tumor Society: Basic/Translational Science Investigator Award
2014 Patrick C. Walsh Prostate Cancer Research Fund: Dr. and Mrs. Peter S. Bing Scholar Award
2014 Prostate Cancer Foundation: Young Investigator Award
2013 Johns Hopkins Department of Pathology Young Investigator’s Day: Award for Excellence in Translational Research
2012 Johns Hopkins Fellow Research Day: 1st Place for Basic Research
2011 Johns Hopkins Department of Pathology Young Investigator’s Day: Award for Excellence in Translational Research
2011 United States and Canadian Academy of Pathology: Stowell-Orbison Award
2002 National Cancer Institute: Cancer Research Training Fellowship; Laboratory of Cellular Carcinogenesis and Tumor Promotion

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Pieterman CRC, Sadowski SM, Maxwell JE, Katz MHG, Lines KE, Heaphy CM, Tirosh A, Blau JE, Perrier ND, Lewis MA, Metzcar JP, Halperin DM, Thakker RV, Valk GD. HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: MEN1-related pancreatic NETs: identification of unmet clinical needs and future directives. Endocr Relat Cancer. 2020 Aug; 27(8):T9-T25. PMID: 32069215
     
  2. Hackeng WM, Schelhaas W, Morsink FHM, Heidsma CM, van Eeden S, Valk GD, Vriens MR, Heaphy CM, Nieveen van Dijkum EJM, Offerhaus GJA, Dreijerink KMA, Brosens LAA. Alternative Lengthening of Telomeres and Differential Expression of Endocrine Transcription Factors Distinguish Metastatic and Non-metastatic Insulinomas. Endocr Pathol. 2020 Jun; 31(2):108-118. PMID: 32103422
     
  3. Esopi D, Graham MK, Brosnan-Cashman JA, Meyers J, Vaghasia A, Gupta A, Kumar B, Haffner MC, Heaphy CM, De Marzo AM, Meeker AK, Nelson WG, Wheelan SJ, Yegnasubramanian S. Pervasive promoter hypermethylation of silenced TERT alleles in human cancers. Cell Oncol (Dordr). 2020 May 28. PMID: 32468444
     
  4. Heaphy CM, Haffner MC, Graham MK, Lim D, Davis C, Corey E, Epstein JI, Eisenberger MA, Wang H, De Marzo AM, Meeker AK, Lotan TL. Telomere lengths differ significantly between small-cell neuroendocrine prostate carcinoma and adenocarcinoma of the prostate. Hum Pathol. 2020 Jul; 101:70-79. PMID: 32389660
     
  5. Heaphy CM, Bi WL, Coy S, Davis C, Gallia GL, Santagata S, Rodriguez FJ. Telomere length alterations and ATRX/DAXX loss in pituitary adenomas. Mod Pathol. 2020 Aug; 33(8):1475-1481. PMID: 32203094
     
  6. Pea A, Yu J, Marchionni L, Noe M, Luchini C, Pulvirenti A, de Wilde RF, Brosens LA, Rezaee N, Javed A, Chianchiano P, Gobbo S, Regi P, Salvia R, Bassi C, He J, Weiss MJ, Cameron JL, Offerhaus GJA, Hruban RH, Lawlor RT, Scarpa A, Heaphy CM, Wood LD, Wolfgang CL. Genetic Analysis of Small Well-differentiated Pancreatic Neuroendocrine Tumors Identifies Subgroups With Differing Risks of Liver Metastases. Ann Surg. 2020 03; 271(3):566-573. PMID: 30339629; DOI: 10.1097/SLA.0000000000003022;
     
  7. Kim JY, Brosnan-Cashman JA, Kim J, An S, Lee KB, Kim H, Park DY, Jang KT, Oh YH, Hruban RH, Heaphy CM, Hong SM. Pancreatic acinar cell carcinomas and mixed acinar-neuroendocrine carcinomas are more clinically aggressive than grade 1 pancreatic neuroendocrine tumours. Pathology. 2020 Apr; 52(3):336-347. PMID: 32111396
     
  8. Felsenstein M, Trujillo MA, Huang B, Nanda N, Jiang Z, Jeong YJ, Pflüger M, Goggins MG, Hruban RH, Thompson ED, Heaphy CM, Roberts NJ, Wood LD. Generation and characterization of a cell line from an intraductal tubulopapillary neoplasm of the pancreas. Lab Invest. 2020 Jul; 100(7):1003-1013. PMID: 32005909
     
  9. Hempel Sullivan H, Heaphy CM, Kulac I, Cuka N, Lu J, Barber JR, De Marzo AM, Lotan TL, Joshu CE, Sfanos KS. High Extratumoral Mast Cell Counts Are Associated with a Higher Risk of Adverse Prostate Cancer Outcomes. Cancer Epidemiol Biomarkers Prev. 2020 Mar; 29(3):668-675. PMID: 31932412
     
  10. Heaphy CM, Joshu CE, Barber JR, Davis C, Zarinshenas R, De Marzo AM, Lotan TL, Sfanos KS, Meeker AK, Platz EA. Racial Difference in Prostate Cancer Cell Telomere Lengths in Men with Higher Grade Prostate Cancer: A Clue to the Racial Disparity in Prostate Cancer Outcomes. Cancer Epidemiol Biomarkers Prev. 2020 Mar; 29(3):676-680. PMID: 31915143
     
Showing 10 of 84 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 84 publications over 17 distinct years, with a maximum of 10 publications in 2018 and 2019 and 2020

YearPublications
20021
20051
20065
20073
20081
20095
20103
20116
20125
20136
20141
20157
20167
20173
201810
201910
202010

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Telomeres
Alternative lengthening of telomeres
Cancer
Tissue-based biomarkers

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