Bei Wu, PhD
Boston University School of Medicine
Dept of Biochemistry

PhD, China Academy of Chinese Medical Sciences (CACMS)
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My research work is focused on: 1) to understand the mechanism of PrP-induced abnormal ionic activities using electrophysiological method 2) to investigate how the mutated forms of PrP or anti-prion antibodies, which induce spontaneous currents, induce neuronal toxicity 3) to investigate whether PrP-induced currents are the pathogenic mechanism underlying prion toxicity.
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Fang C, Wu B, Le NTT, Imberdis T, Mercer RCC, Harris DA. Prions activate a p38 MAPK synaptotoxic signaling pathway. PLoS Pathog. 2018 Sep; 14(9):e1007283.View Related Profiles. PMID: 30235355.
  2. McDonald AJ, Wu B, Harris DA. An inter-domain regulatory mechanism controls toxic activities of PrPC. Prion. 2017 Nov 02; 11(6):388-397.View Related Profiles. PMID: 28960140.
  3. Wu B, McDonald AJ, Markham K, Rich CB, McHugh KP, Tatzelt J, Colby DW, Millhauser GL, Harris DA. The N-terminus of the prion protein is a toxic effector regulated by the C-terminus. Elife. 2017 05 20; 6.View Related Profiles. PMID: 28527237.
  4. Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV, Moore MJ, Shaw CE, Gao FB. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013; 8(10):e76055. PMID: 24143176; PMCID: PMC3797144; DOI: 10.1371/journal.pone.0076055;.
  5. Wu B, Yamaguchi H, Lai FA, Shen J. Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons. Proc Natl Acad Sci U S A. 2013 Sep 10; 110(37):15091-6. PMID: 23918386; PMCID: PMC3773738; DOI: 10.1073/pnas.1304171110;.
  6. Kaufmann MR, Barth S, Konietzko U, Wu B, Egger S, Kunze R, Marti HH, Hick M, Müller U, Camenisch G, Wenger RH. Dysregulation of hypoxia-inducible factor by presenilin/?-secretase loss-of-function mutations. J Neurosci. 2013 Jan 30; 33(5):1915-26. PMID: 23365231; DOI: 10.1523/JNEUROSCI.3402-12.2013;.
  7. Cheng J, Dong J, Cui Y, Wang L, Wu B, Zhang C. Interacting partners of AMPA-type glutamate receptors. J Mol Neurosci. 2012 Oct; 48(2):441-7. PMID: 22361832.
  8. Yang Y, Kim AH, Yamada T, Wu B, Bilimoria PM, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science. 2009 Oct 23; 326(5952):575-8. PMID: 19900895; PMCID: PMC2846784; DOI: 10.1126/science.1177087;.
  9. Zhang C, Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Südhof TC, Shen J. Presenilins are essential for regulating neurotransmitter release. Nature. 2009 Jul 30; 460(7255):632-6. PMID: 19641596; PMCID: PMC2744588; DOI: 10.1038/nature08177;.
  10. Kitada T, Pisani A, Karouani M, Haburcak M, Martella G, Tscherter A, Platania P, Wu B, Pothos EN, Shen J. Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice. J Neurochem. 2009 Jul; 110(2):613-21. PMID: 19457102; DOI: 10.1111/j.1471-4159.2009.06152.x;.
Showing 10 of 13 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 13 publications over 8 distinct years, with a maximum of 3 publications in 2009 and 2013

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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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