Bei Wu, PhD
Boston University School of Medicine
Dept of Biochemistry

PhD, China Academy of Chinese Medical Sciences (CACMS)

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My research work is focused on: 1) to understand the mechanism of PrP-induced abnormal ionic activities using electrophysiological method 2) to investigate how the mutated forms of PrP or anti-prion antibodies, which induce spontaneous currents, induce neuronal toxicity 3) to investigate whether PrP-induced currents are the pathogenic mechanism underlying prion toxicity.
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. McDonald AJ, Leon DR, Markham KA, Wu B, Heckendorf CF, Schilling K, Showalter HD, Andrews PC, McComb ME, Pushie MJ, Costello CE, Millhauser GL, Harris DA. Altered Domain Structure of the Prion Protein Caused by Cu2+ Binding and Functionally Relevant Mutations: Analysis by Cross-Linking, MS/MS, and NMR. Structure. 2019 Jun 04; 27(6):907-922.e5.View Related Profiles. PMID: 30956132.
  2. Le NTT, Wu B, Harris DA. Prion neurotoxicity. Brain Pathol. 2019 03; 29(2):263-277.View Related Profiles. PMID: 30588688.
  3. Fang C, Wu B, Le NTT, Imberdis T, Mercer RCC, Harris DA. Prions activate a p38 MAPK synaptotoxic signaling pathway. PLoS Pathog. 2018 09; 14(9):e1007283.View Related Profiles. PMID: 30235355.
  4. McDonald AJ, Wu B, Harris DA. An inter-domain regulatory mechanism controls toxic activities of PrPC. Prion. 2017 11 02; 11(6):388-397.View Related Profiles. PMID: 28960140.
  5. Wu B, McDonald AJ, Markham K, Rich CB, McHugh KP, Tatzelt J, Colby DW, Millhauser GL, Harris DA. The N-terminus of the prion protein is a toxic effector regulated by the C-terminus. Elife. 2017 05 20; 6.View Related Profiles. PMID: 28527237.
  6. Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV, Moore MJ, Shaw CE, Gao FB. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013; 8(10):e76055. PMID: 24143176; PMCID: PMC3797144; DOI: 10.1371/journal.pone.0076055;.
  7. Wu B, Yamaguchi H, Lai FA, Shen J. Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons. Proc Natl Acad Sci U S A. 2013 Sep 10; 110(37):15091-6. PMID: 23918386; PMCID: PMC3773738; DOI: 10.1073/pnas.1304171110;.
  8. Kaufmann MR, Barth S, Konietzko U, Wu B, Egger S, Kunze R, Marti HH, Hick M, Müller U, Camenisch G, Wenger RH. Dysregulation of hypoxia-inducible factor by presenilin/?-secretase loss-of-function mutations. J Neurosci. 2013 Jan 30; 33(5):1915-26. PMID: 23365231; DOI: 10.1523/JNEUROSCI.3402-12.2013;.
  9. Cheng J, Dong J, Cui Y, Wang L, Wu B, Zhang C. Interacting partners of AMPA-type glutamate receptors. J Mol Neurosci. 2012 Oct; 48(2):441-7. PMID: 22361832.
  10. Yang Y, Kim AH, Yamada T, Wu B, Bilimoria PM, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science. 2009 Oct 23; 326(5952):575-8. PMID: 19900895; PMCID: PMC2846784; DOI: 10.1126/science.1177087;.
Showing 10 of 15 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 15 publications over 9 distinct years, with a maximum of 3 publications in 2009 and 2013

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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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