Andrea Geisz | Profiles RNS

Andrea Geisz, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Surgery

PhD, University of Szeged
MS, University of Szeged

Websites

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	ResearchGate

ORCID : 0000-0003-0971-6876

BU Research
NIH RePORTER Research

Mechanism of Trypsin Activation in Pancreatitis
02/09/2023 - 01/31/2028 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK132471-02

Cathepsin B dependent trypsin activation in a preclinical model of pancreatitis
07/01/2020 - 06/30/2023 (PI)
American Gastroenterological Association

Impact of Cathepsin B Deficiency in Pancreatitis
04/01/2022 - 03/31/2023 (PI)
University of California, Los Angeles

Impact of Sentinel Attack of Acute Pancreatitis on Severity of Subsequent Episodes in Mice
07/01/2020 - 11/30/2021 (PI)
American Pancreatic Association

Preclinical model of cathepsin B-dependent pancreatitis
02/15/2019 - 08/14/2021 (PI)
Department of Defense/Army Medical Research Acquisition Activity

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Mechanisms of Trypsin Activation in Pancreatitis	5R01DK132471-02
2023	Mechanisms of Trypsin Activation in Pancreatitis	1R01DK132471-01A1

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Németh BZ, Nagy ZA, Kiss B, Gellén G, Schlosser G, Demcsák A, Geisz A, Hegyi E, Sahin-Tóth M, Pál G. Substrate specificity of human chymotrypsin-like protease (CTRL) characterized by phage display-selected small-protein inhibitors. Pancreatology. 2023 Sep; 23(6):742-749. PMID: 37604733; PMCID: PMC10528761; DOI: 10.1016/j.pan.2023.08.004;

Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, Ouaamari AE, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M. Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433-448. Diabetes. 2023 Aug 01; 72(8):1173. PMID: 37116182; PMCID: PMC10382644; DOI: 10.2337/db23-er08;

Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes. 2023 Apr 01; 72(4):433-448. PMID: 36940317; PMCID: PMC10033248; DOI: 10.2337/db22-0942;

Geisz A, Tran T, Orekhova A, Sahin-Tóth M. Trypsin Activity in Secretagogue-induced Murine Pancreatitis Is Solely Elicited by Cathepsin B and Does Not Mediate Key Pathologic Responses. Gastroenterology. 2023 Apr; 164(4):684-687.e4.View Related Profiles.

Geisz, Andrea
Tran, Thanh

PMID: 36641042; PMCID: PMC10441611; DOI: 10.1053/j.gastro.2023.01.004;

Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Sander M, Pandol SJ. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Pancreas. 2022 Oct 01; 51(9):1061-1073. PMID: 37078927; PMCID: PMC10328394; DOI: 10.1097/MPA.0000000000002170;

Németh BZ, Demcsák A, Micsonai A, Kiss B, Schlosser G, Geisz A, Hegyi E, Sahin-Tóth M, Pál G. Arg236 in human chymotrypsin B2 (CTRB2) is a key determinant of high enzyme activity, trypsinogen degradation capacity, and protection against pancreatitis. Biochim Biophys Acta Proteins Proteom. 2022 Sep 01; 1870(9):140831. PMID: 35934298; PMCID: PMC9426946; DOI: 10.1016/j.bbapap.2022.140831;

Geisz A. Aldehyde "Adduction" Explains Synergy of Smoking and Alcohol in Promoting Pancreatitis. Gastroenterology. 2022 Oct; 163(4):817-819. PMID: 35940252

Németh BC, Demcsák A, Geisz A, Sahin-Tóth M. Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3/Chop. Sci Rep. 2022 Apr 15; 12(1):6357. PMID: 35428786; PMCID: PMC9012826; DOI: 10.1038/s41598-022-09595-x;

Orekhova A, Németh BC, Jancsó Z, Geisz A, Mosztbacher D, Demcsák A, Sahin-Tóth M. Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2021 12 01; 321(6):G719-G734. PMID: 34643096; PMCID: PMC8668397; DOI: 10.1152/ajpgi.00265.2021;

Geisz A, Sahin-Tóth M. Sentinel Acute Pancreatitis Event Increases Severity of Subsequent Episodes in Mice. Gastroenterology. 2021 11; 161(5):1692-1694. PMID: 34139205; PMCID: PMC8545756; DOI: 10.1053/j.gastro.2021.06.013;

Showing 10 of 25 results. Show More

Orekhova A, Geisz A, Sahin-Tóth M. Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice. Am J Physiol Gastrointest Liver Physiol. 2020 04 01; 318(4):G694-G704. PMID: 32116022; PMCID: PMC7191466; DOI: 10.1152/ajpgi.00007.2020;

Demcsák A, Geisz A, Sahin-Tóth M. Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B. Sci Rep. 2019 06 24; 9(1):9188. PMID: 31235832; PMCID: PMC6591424; DOI: 10.1038/s41598-019-45631-z;

Geisz A, Jancsó Z, Németh BC, Hegyi E, Sahin-Tóth M. Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice. JCI Insight. 2019 07 25; 4(14):e129717. PMID: 31211695; PMCID: PMC6675558; DOI: 10.1172/jci.insight.129717;

Geisz A, Sahin-Tóth M. A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation. Nat Commun. 2018 11 28; 9(1):5033. PMID: 30487519; PMCID: PMC6261995; DOI: 10.1038/s41467-018-07347-y;

Wu H, Zhou DZ, Berki D, Geisz A, Zou WB, Sun XT, Hu LH, Zhao ZH, Zhao AJ, He L, Cooper DN, Férec C, Chen JM, Li ZS, Sahin-Tóth M, Liao Z. No significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort. Hum Mutat. 2017 Aug; 38(8):959-963.View Related Profiles.

Geisz, Andrea
Sahin-Toth, Miklos

PMID: 28497564; PMCID: PMC5542845; DOI: 10.1002/humu.23254;

Hegyi E, Geisz A, Sahin-Tóth M, Derikx MH, Németh BC, Balázs A, Hritz I, Izbéki F, Halász A, Párniczky A, Takács T, Kelemen D, Sarlós P, Hegyi P, Czakó L. SPINK1 Promoter Variants in Chronic Pancreatitis. Pancreas. 2016 Jan; 45(1):148-53.View Related Profiles.

Geisz, Andrea
Sahin-Toth, Miklos

PMID: 26348468; DOI: 10.1097/MPA.0000000000000412;

Nakano E, Geisz A, Masamune A, Niihori T, Hamada S, Kume K, Kakuta Y, Aoki Y, Matsubara Y, Ebert K, Ludwig M, Braun M, Groneberg DA, Shimosegawa T, Sahin-Tóth M, Witt H. Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2015 Oct 15; 309(8):G688-94.View Related Profiles.

Geisz, Andrea
Sahin-Toth, Miklos

PMID: 26316592; PMCID: PMC4609930; DOI: 10.1152/ajpgi.00241.2015;

Derikx MH, Geisz A, Kereszturi É, Sahin-Tóth M. Functional significance of SPINK1 promoter variants in chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2015 May 01; 308(9):G779-84.View Related Profiles.

Geisz, Andrea
Sahin-Toth, Miklos

PMID: 25792561; PMCID: PMC4421017; DOI: 10.1152/ajpgi.00022.2015;

Derikx MH, Kovacs P, Scholz M, Masson E, Chen JM, Ruffert C, Lichtner P, Te Morsche RH, Cavestro GM, Férec C, Drenth JP, Witt H, Rosendahl J. Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study. Gut. 2015 Sep; 64(9):1426-33. PMID: 25253127; DOI: 10.1136/gutjnl-2014-307453;

Kemény LV, Schnúr A, Czepán M, Rakonczay Z, Gál E, Lonovics J, Lázár G, Simonka Z, Venglovecz V, Maléth J, Judák L, Németh IB, Szabó K, Almássy J, Virág L, Geisz A, Tiszlavicz L, Yule DI, Wittmann T, Varró A, Hegyi P. Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15; 305(8):G552-63.View Related Profiles.

Geisz, Andrea
Schnur, Andrea

PMID: 23907822; DOI: 10.1152/ajpgi.00394.2012;

Geisz A, Hegyi P, Sahin-Tóth M. Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants. FEBS J. 2013 Jun; 280(12):2888-99.View Related Profiles.

Geisz, Andrea
Sahin-Toth, Miklos

PMID: 23601753; PMCID: PMC3676443; DOI: 10.1111/febs.12292;

Czepán M, Rakonczay Z, Varró A, Steele I, Dimaline R, Lertkowit N, Lonovics J, Schnúr A, Biczó G, Geisz A, Lázár G, Simonka Z, Venglovecz V, Wittmann T, Hegyi P. NHE1 activity contributes to migration and is necessary for proliferation of human gastric myofibroblasts. Pflugers Arch. 2012 Mar; 463(3):459-75.View Related Profiles.

Geisz, Andrea
Schnur, Andrea

PMID: 22138972; DOI: 10.1007/s00424-011-1059-6;

Pallagi P, Venglovecz V, Rakonczay Z, Borka K, Korompay A, Ozsvári B, Judák L, Sahin-Tóth M, Geisz A, Schnúr A, Maléth J, Takács T, Gray MA, Argent BE, Mayerle J, Lerch MM, Wittmann T, Hegyi P. Trypsin reduces pancreatic ductal bicarbonate secretion by inhibiting CFTR Cl? channels and luminal anion exchangers. Gastroenterology. 2011 Dec; 141(6):2228-2239.e6.View Related Profiles.

Geisz, Andrea
Schnur, Andrea
Sahin-Toth, Miklos

PMID: 21893120; PMCID: PMC3273991; DOI: 10.1053/j.gastro.2011.08.039;

Joergensen MT, Geisz A, Brusgaard K, Schaffalitzky de Muckadell OB, Hegyi P, Gerdes AM, Sahin-Tóth M. Intragenic duplication: a novel mutational mechanism in hereditary pancreatitis. Pancreas. 2011 May; 40(4):540-6.View Related Profiles.

Geisz, Andrea
Sahin-Toth, Miklos

PMID: 21499207; PMCID: PMC3088488; DOI: 10.1097/MPA.0b013e3182152fdf;

Zádori D, Geisz A, Vámos E, Vécsei L, Klivényi P. Valproate ameliorates the survival and the motor performance in a transgenic mouse model of Huntington's disease. Pharmacol Biochem Behav. 2009 Nov; 94(1):148-53. PMID: 19698736

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 25 publications over 13 distinct years, with a maximum of 4 publications in 2022 and 2023