Andrea Geisz, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Surgery

PhD, University of Szeged
MSc, University of Szeged




Mechanism of Trypsin Activation in Pancreatitis
02/09/2023 - 01/31/2028 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
1R01DK132471-01A1

Cathepsin B dependent trypsin activation in a preclinical model of pancreatitis
07/01/2020 - 06/30/2023 (PI)
American Gastroenterological Association


Impact of Cathepsin B Deficiency in Pancreatitis
04/01/2022 - 03/31/2023 (PI)
University of California, Los Angeles


Impact of Sentinel Attack of Acute Pancreatitis on Severity of Subsequent Episodes in Mice
07/01/2020 - 11/30/2021 (PI)
American Pancreatic Association


Preclinical model of cathepsin B-dependent pancreatitis
02/15/2019 - 08/14/2021 (PI)
Department of Defense/Army Medical Research Acquisition Activity




Title


Yr Title Project-Sub Proj Pubs
2024 Mechanisms of Trypsin Activation in Pancreatitis 5R01DK132471-02
2023 Mechanisms of Trypsin Activation in Pancreatitis 1R01DK132471-01A1

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Németh BZ, Nagy ZA, Kiss B, Gellén G, Schlosser G, Demcsák A, Geisz A, Hegyi E, Sahin-Tóth M, Pál G. Substrate specificity of human chymotrypsin-like protease (CTRL) characterized by phage display-selected small-protein inhibitors. Pancreatology. 2023 Sep; 23(6):742-749. PMID: 37604733; PMCID: PMC10528761; DOI: 10.1016/j.pan.2023.08.004;
     
  2. Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, Ouaamari AE, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M. Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433-448. Diabetes. 2023 Aug 01; 72(8):1173. PMID: 37116182; PMCID: PMC10382644; DOI: 10.2337/db23-er08;
     
  3. Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes. 2023 Apr 01; 72(4):433-448. PMID: 36940317; PMCID: PMC10033248; DOI: 10.2337/db22-0942;
     
  4. Geisz A, Tran T, Orekhova A, Sahin-Tóth M. Trypsin Activity in Secretagogue-induced Murine Pancreatitis Is Solely Elicited by Cathepsin B and Does Not Mediate Key Pathologic Responses. Gastroenterology. 2023 Apr; 164(4):684-687.e4.View Related Profiles. PMID: 36641042; PMCID: PMC10441611; DOI: 10.1053/j.gastro.2023.01.004;
     
  5. Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Sander M, Pandol SJ. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Pancreas. 2022 Oct 01; 51(9):1061-1073. PMID: 37078927; PMCID: PMC10328394; DOI: 10.1097/MPA.0000000000002170;
     
  6. Geisz A. Aldehyde "Adduction" Explains Synergy of Smoking and Alcohol in Promoting Pancreatitis. Gastroenterology. 2022 Oct; 163(4):817-819. PMID: 35940252
     
  7. Németh BZ, Demcsák A, Micsonai A, Kiss B, Schlosser G, Geisz A, Hegyi E, Sahin-Tóth M, Pál G. Arg236 in human chymotrypsin B2 (CTRB2) is a key determinant of high enzyme activity, trypsinogen degradation capacity, and protection against pancreatitis. Biochim Biophys Acta Proteins Proteom. 2022 Sep 01; 1870(9):140831. PMID: 35934298; PMCID: PMC9426946; DOI: 10.1016/j.bbapap.2022.140831;
     
  8. Németh BC, Demcsák A, Geisz A, Sahin-Tóth M. Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3/Chop. Sci Rep. 2022 Apr 15; 12(1):6357. PMID: 35428786; PMCID: PMC9012826; DOI: 10.1038/s41598-022-09595-x;
     
  9. Orekhova A, Németh BC, Jancsó Z, Geisz A, Mosztbacher D, Demcsák A, Sahin-Tóth M. Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2021 12 01; 321(6):G719-G734. PMID: 34643096; PMCID: PMC8668397; DOI: 10.1152/ajpgi.00265.2021;
     
  10. Geisz A, Sahin-Tóth M. Sentinel Acute Pancreatitis Event Increases Severity of Subsequent Episodes in Mice. Gastroenterology. 2021 11; 161(5):1692-1694. PMID: 34139205; PMCID: PMC8545756; DOI: 10.1053/j.gastro.2021.06.013;
     
Showing 10 of 25 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 25 publications over 13 distinct years, with a maximum of 4 publications in 2022 and 2023

YearPublications
20091
20113
20132
20141
20152
20161
20171
20181
20192
20201
20212
20224
20234
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72 East Concord Street
Boston MA 02118
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