Rosina Georgiadis
Associate Professor
Boston University College of Arts and Sciences
Chemistry

PhD, University of California, Berkeley
BS, Indiana University Bloomington



The Georgiadis Group’s research focuses on the development and use of novel label-free detection methods based on surface plasmon resonance (SPR) spectroscopy. Our current projects are focused around the development of novel label-free DNA microarray technologies. Areas of study include:

Electric field effects at interfaces: rapid mismatch discrimination by electric field induced denaturation.

DNA/protein interactions - screening methods for anti-tumor aptamers as tumor targeting reagents.

DNA/drug interactions - kinetics of binding novel platinum anti-tumor drugs with oligonucleotides.




Title


Yr Title Project-Sub Proj Pubs
2004 Accurate SPR methods for DNA/drug interactions 5R01CA089562-04 5
2003 Accurate SPR methods for DNA/drug interactions 5R01CA089562-03 5
2002 Accurate SPR methods for DNA/drug interactions 5R01CA089562-02 5
2001 Accurate SPR methods for DNA/drug interactions 1R01CA089562-01A1 5

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Georgiadis RM, Streu K, Lee NC. Cutting the cord: virtual machines for real instrumental analysis not just at the instrument. Anal Bioanal Chem. 2018 Apr; 410(11):2657-2662. PMID: 29536152
     
  2. Golden MS, Cote SM, Sayeg M, Zerbe BS, Villar EA, Beglov D, Sazinsky SL, Georgiadis RM, Vajda S, Kozakov D, Whitty A. Comprehensive experimental and computational analysis of binding energy hot spots at the NF-?B essential modulator/IKKß protein-protein interface. J Am Chem Soc. 2013 Apr 24; 135(16):6242-56.View Related Profiles. PMID: 23506214; PMCID: PMC3680600; DOI: 10.1021/ja400914z;
     
  3. Ruemmele JA, Golden MS, Gao Y, Cornelius EM, Anderson ME, Postelnicu L, Georgiadis RM. Quantitative surface plasmon resonance imaging: a simple approach to automated angle scanning. Anal Chem. 2008 Jun 15; 80(12):4752-6. PMID: 18476718; DOI: 10.1021/ac702544q;
     
  4. Wolf LK, Gao Y, Georgiadis RM. Kinetic discrimination of sequence-specific DNA-drug binding measured by surface plasmon resonance imaging and comparison to solution-phase measurements. J Am Chem Soc. 2007 Aug 29; 129(34):10503-11. PMID: 17685519
     
  5. Gao Y, Wolf LK, Georgiadis RM. Secondary structure effects on DNA hybridization kinetics: a solution versus surface comparison. Nucleic Acids Res. 2006; 34(11):3370-7. PMID: 16822858; PMCID: PMC1488884; DOI: 10.1093/nar/gkl422;
     
  6. Wolf LK, Fullenkamp DE, Georgiadis RM. Quantitative angle-resolved SPR imaging of DNA-DNA and DNA-drug kinetics. J Am Chem Soc. 2005 Dec 14; 127(49):17453-9. PMID: 16332097
     
  7. Wolf LK, Gao Y, Georgiadis RM. Sequence-dependent DNA immobilization: specific versus nonspecific contributions. Langmuir. 2004 Apr 13; 20(8):3357-61. PMID: 15875869
     
  8. Peterson AW, Wolf LK, Georgiadis RM. Hybridization of mismatched or partially matched DNA at surfaces. J Am Chem Soc. 2002 Dec 11; 124(49):14601-7. PMID: 12465970
     
  9. Peterson AW, Heaton RJ, Georgiadis RM. The effect of surface probe density on DNA hybridization. Nucleic Acids Res. 2001 Dec 15; 29(24):5163-8. PMID: 11812850; PMCID: PMC97561
     
  10. Heaton RJ, Peterson AW, Georgiadis RM. Electrostatic surface plasmon resonance: direct electric field-induced hybridization and denaturation in monolayer nucleic acid films and label-free discrimination of base mismatches. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3701-4. PMID: 11259682; PMCID: PMC31115
     
Showing 10 of 12 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 12 publications over 11 distinct years, with a maximum of 2 publications in 2001

YearPublications
19861
19991
20012
20021
20041
20051
20061
20071
20081
20131
20181

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24 Cummington St
Boston MA 02215
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617.353.7218
(617) 353-6466 (fax)
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