Keywords
Last Name

Rosina Georgiadis

TitleAssociate Professor
InstitutionBoston University College of Arts and Sciences
DepartmentChemistry
Address24 Cummington Mall
Boston MA 02215
Phone(617) 353-7218
Fax(617) 353-6466
 Research Expertise & Professional Interests
The Georgiadis Group’s research focuses on the development and use of novel label-free detection methods based on surface plasmon resonance (SPR) spectroscopy. Our current projects are focused around the development of novel label-free DNA microarray technologies. Areas of study include:

Electric field effects at interfaces: rapid mismatch discrimination by electric field induced denaturation.

DNA/protein interactions - screening methods for anti-tumor aptamers as tumor targeting reagents.

DNA/drug interactions - kinetics of binding novel platinum anti-tumor drugs with oligonucleotides.

 NIH RePORTER Grants
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Golden MS, Cote SM, Sayeg M, Zerbe BS, Villar EA, Beglov D, Sazinsky SL, Georgiadis RM, Vajda S, Kozakov D, Whitty A. Comprehensive experimental and computational analysis of binding energy hot spots at the NF-?B essential modulator/IKKß protein-protein interface. J Am Chem Soc. 2013 Apr 24; 135(16):6242-56. PMID: 23506214.
    View in: PubMed
  2. Ruemmele JA, Golden MS, Gao Y, Cornelius EM, Anderson ME, Postelnicu L, Georgiadis RM. Quantitative surface plasmon resonance imaging: a simple approach to automated angle scanning. Anal Chem. 2008 Jun 15; 80(12):4752-6. PMID: 18476718.
    View in: PubMed
  3. Wolf LK, Gao Y, Georgiadis RM. Kinetic discrimination of sequence-specific DNA-drug binding measured by surface plasmon resonance imaging and comparison to solution-phase measurements. J Am Chem Soc. 2007 Aug 29; 129(34):10503-11. PMID: 17685519.
    View in: PubMed
  4. Gao Y, Wolf LK, Georgiadis RM. Secondary structure effects on DNA hybridization kinetics: a solution versus surface comparison. Nucleic Acids Res. 2006; 34(11):3370-7. PMID: 16822858.
    View in: PubMed
  5. Wolf LK, Fullenkamp DE, Georgiadis RM. Quantitative angle-resolved SPR imaging of DNA-DNA and DNA-drug kinetics. J Am Chem Soc. 2005 Dec 14; 127(49):17453-9. PMID: 16332097.
    View in: PubMed
  6. Wolf LK, Gao Y, Georgiadis RM. Sequence-dependent DNA immobilization: specific versus nonspecific contributions. Langmuir. 2004 Apr 13; 20(8):3357-61. PMID: 15875869.
    View in: PubMed
  7. Peterson AW, Wolf LK, Georgiadis RM. Hybridization of mismatched or partially matched DNA at surfaces. J Am Chem Soc. 2002 Dec 11; 124(49):14601-7. PMID: 12465970.
    View in: PubMed
  8. Peterson AW, Heaton RJ, Georgiadis RM. The effect of surface probe density on DNA hybridization. Nucleic Acids Res. 2001 Dec 15; 29(24):5163-8. PMID: 11812850.
    View in: PubMed
  9. Heaton RJ, Peterson AW, Georgiadis RM. Electrostatic surface plasmon resonance: direct electric field-induced hybridization and denaturation in monolayer nucleic acid films and label-free discrimination of base mismatches. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3701-4. PMID: 11259682.
    View in: PubMed
  10. Grassi JH, Georgiadis RM. Temperature-Dependent Refractive Index Determination from Critical Angle Measurements:? Implications for Quantitative SPR Sensing. Anal Chem. 1999 Oct 1; 71(19):4392-6. PMID: 21662865.
    View in: PubMed
  11. Georgiadis R, Armentrout PB. Neutral and ionic metal methyl bond energies: zinc. J Am Chem Soc. 1986 Apr 1; 108(9):2119-26. PMID: 22175548.
    View in: PubMed
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