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PhD, University of Pennsylvania
AB, Franklin & Marshall College

Websites

Research
Publications

A Vaccine Against Streptococcus Pneumoniae Based on Phylogenically Identified Highly Conserved Bacterial Surface Proteins
04/01/2010 - 03/31/2014 (PI)
The Hartwell Foundation

NTHi LPS: Virulence Factor and Vaccine Candidate
08/01/2003 - 07/31/2008 (PI)
NIH/National Institute on Deafness & Communication Disorders
5 R01 DC05855 04

Recombination-quiescent genes & phylogenic validation of encoded vaccine targets
07/01/2010 - 06/30/2013 (PI)
NIH-NIAID
5R21 AI081687-02

Role of Sialylated LPS in H. Influenza
04/25/2002 - 03/31/2004 (PI)
NIH-NIDCD
1 R21 DC 05564-02 (A)

Vaccination & The Evolutionary
02/01/2001 - 07/31/2003 (PI)
Harvard School of Public Health NIH-NIAID
1 R01 AI48935-03

Rational Strategy For Vaccine
05/01/1999 - 06/30/2003 (PI)
Cystic Fibrosis Fdtn

Microbial Population Strategy
02/01/2001 - 01/31/2003 (PI)
NIH-NIDCD
1 R01 DC04583-01A1 (A)

Virulence Genetics Of Cf Assoc
07/10/1996 - 05/31/2000 (PI)
NIH-NIDDK
5 R01 DK50838-05

Title

Yr	Title	Project-Sub Proj	Pubs
2011	Recombination-quiescent genes &phylogenic validation of encoded vaccine targets	5R21AI081687-02	1
2010	Recombination-quiescent genes &phylogenic validation of encoded vaccine targets	1R21AI081687-01A1	1
2008	THE KINETICS OF HIGH MOBILITY GROUP BOX-1 (HMGB1)	2M01RR018535-06-5485	236
2006	NTHi LPS: virulence factor and vaccine candidate	5R01DC005855-04	7
2005	NTHi LPS: virulence factor and vaccine candidate	5R01DC005855-03	7
2004	NTHi LPS: virulence factor and vaccine candidate	5R01DC005855-02	7
2003	NTHi LPS: virulence factor and vaccine candidate	1R01DC005855-01A1	7
2003	Role of sialylated LPS in H. influenzae otitis media	5R21DC005564-02	5
2002	Role of sialylated LPS in H. influenzae otitis media	1R21DC005564-01	5
2001	MICROBIAL POPULATION STRATEGY FOR VACCINE DEVELOPMENT	1R55DC004583-01A1	9

Showing 10 of 20 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Lundström SL, Li J, Månsson M, Figueira M, Leroy M, Goldstein R, Hood DW, Moxon ER, Richards JC, Schweda EK. Application of capillary electrophoresis mass spectrometry and liquid chromatography multiple-step tandem electrospray mass spectrometry to profile glycoform expression during Haemophilus influenzae pathogenesis in the chinchilla model of experimental otitis media. Infect Immun. 2008 Jul; 76(7):3255-67.View Related Profiles.

Figueira, Marisol
Goldstein, Richard

PMID: 18458064; PMCID: PMC2446737; DOI: 10.1128/IAI.01710-07;

Bouchet V, Huot H, Goldstein R. Molecular genetic basis of ribotyping. Clin Microbiol Rev. 2008 Apr; 21(2):262-73, table of contents.View Related Profiles.

Goldstein, Richard
Bouchet, Valérie

PMID: 18400796; PMCID: PMC2292578; DOI: 10.1128/CMR.00026-07;

Lipsitch M, O'Neill K, Cordy D, Bugalter B, Trzcinski K, Thompson CM, Goldstein R, Pelton S, Huot H, Bouchet V, Reid R, Santosham M, O'Brien KL. Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine. J Infect Dis. 2007 Oct 15; 196(8):1221-7.View Related Profiles.

Goldstein, Richard
Pelton, Stephen
Bouchet, Valérie

PMID: 17955441; PMCID: PMC3350793; DOI: 10.1086/521831;

Pelton SI, Huot H, Finkelstein JA, Bishop CJ, Hsu KK, Kellenberg J, Huang SS, Goldstein R, Hanage WP. Emergence of 19A as virulent and multidrug resistant Pneumococcus in Massachusetts following universal immunization of infants with pneumococcal conjugate vaccine. Pediatr Infect Dis J. 2007 Jun; 26(6):468-72.View Related Profiles.

Hsu, Katherine
Goldstein, Richard
Pelton, Stephen

PMID: 17529860

Leroy M, Cabral H, Figueira M, Bouchet V, Huot H, Ram S, Pelton SI, Goldstein R. Multiple consecutive lavage samplings reveal greater burden of disease and provide direct access to the nontypeable Haemophilus influenzae biofilm in experimental otitis media. Infect Immun. 2007 Aug; 75(8):4158-72.View Related Profiles.

Cabral, Howard
Figueira, Marisol
Goldstein, Richard
Pelton, Stephen
Bouchet, Valérie

PMID: 17517860; PMCID: PMC1952021; DOI: 10.1128/IAI.00318-07;

Hanage WP, Huang SS, Lipsitch M, Bishop CJ, Godoy D, Pelton SI, Goldstein R, Huot H, Finkelstein JA. Diversity and antibiotic resistance among nonvaccine serotypes of Streptococcus pneumoniae carriage isolates in the post-heptavalent conjugate vaccine era. J Infect Dis. 2007 Feb 1; 195(3):347-52.View Related Profiles.

Goldstein, Richard
Pelton, Stephen

PMID: 17205472

Figueira MA, Ram S, Goldstein R, Hood DW, Moxon ER, Pelton SI. Role of complement in defense of the middle ear revealed by restoring the virulence of nontypeable Haemophilus influenzae siaB mutants. Infect Immun. 2007 Jan; 75(1):325-33.View Related Profiles.

Figueira, Marisol
Goldstein, Richard
Pelton, Stephen

PMID: 17088344; PMCID: PMC1828410; DOI: 10.1128/IAI.01054-06;

Bouchet V, Hood DW, Li J, Brisson JR, Randle GA, Martin A, Li Z, Goldstein R, Schweda EK, Pelton SI, Richards JC, Moxon ER. Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8898-903.View Related Profiles.

Goldstein, Richard
Pelton, Stephen
Bouchet, Valérie

PMID: 12855765; PMCID: PMC166410

Cody AJ, Field D, Feil EJ, Stringer S, Deadman ME, Tsolaki AG, Gratz B, Bouchet V, Goldstein R, Hood DW, Moxon ER. High rates of recombination in otitis media isolates of non-typeable Haemophilus influenzae. Infect Genet Evol. 2003 May; 3(1):57-66.View Related Profiles.

Goldstein, Richard
Bouchet, Valérie

PMID: 12797973; PMCID: PMC2728426

Meats E, Feil EJ, Stringer S, Cody AJ, Goldstein R, Kroll JS, Popovic T, Spratt BG. Characterization of encapsulated and noncapsulated Haemophilus influenzae and determination of phylogenetic relationships by multilocus sequence typing. J Clin Microbiol. 2003 Apr; 41(4):1623-36. PMID: 12682154; PMCID: PMC153921

Showing 10 of 42 results. Show More

Feil EJ, Holmes EC, Bessen DE, Chan MS, Day NP, Enright MC, Goldstein R, Hood DW, Kalia A, Moore CE, Zhou J, Spratt BG. Recombination within natural populations of pathogenic bacteria: short-term empirical estimates and long-term phylogenetic consequences. Proc Natl Acad Sci U S A. 2001 Jan 2; 98(1):182-7. PMID: 11136255; PMCID: PMC14565

Bolduc GR, Bouchet V, Jiang RZ, Geisselsoder J, Truong-Bolduc QC, Rice PA, Pelton SI, Goldstein R. Variability of outer membrane protein P1 and its evaluation as a vaccine candidate against experimental otitis media due to nontypeable Haemophilus influenzae: an unambiguous, multifaceted approach. Infect Immun. 2000 Aug; 68(8):4505-17.View Related Profiles.

Goldstein, Richard
Pelton, Stephen
Bouchet, Valérie

PMID: 10899849; PMCID: PMC98360

Holmes A, Nolan R, Taylor R, Finley R, Riley M, Jiang RZ, Steinbach S, Goldstein R. An epidemic of burkholderia cepacia transmitted between patients with and without cystic fibrosis. J Infect Dis. 1999 May; 179(5):1197-205. PMID: 10191223; PMCID: PMC3325287

Holmes A, Govan J, Goldstein R. Agricultural use of Burkholderia (Pseudomonas) cepacia: a threat to human health? Emerg Infect Dis. 1998 Apr-Jun; 4(2):221-7. PMID: 9621192; PMCID: PMC2640135

Sun L, Jiang RZ, Steinbach S, Holmes A, Campanelli C, Forstner J, Sajjan U, Tan Y, Riley M, Goldstein R. The emergence of a highly transmissible lineage of cbl+ Pseudomonas (Burkholderia) cepacia causing CF centre epidemics in North America and Britain. Nat Med. 1995 Jul; 1(7):661-6. PMID: 7585148

Sajjan US, Sun L, Goldstein R, Forstner JF. Cable (cbl) type II pili of cystic fibrosis-associated Burkholderia (Pseudomonas) cepacia: nucleotide sequence of the cblA major subunit pilin gene and novel morphology of the assembled appendage fibers. J Bacteriol. 1995 Feb; 177(4):1030-8. PMID: 7532166; PMCID: PMC176699

Goldstein R, Sun L, Jiang RZ, Sajjan U, Forstner JF, Campanelli C. Structurally variant classes of pilus appendage fibers coexpressed from Burkholderia (Pseudomonas) cepacia. J Bacteriol. 1995 Feb; 177(4):1039-52. PMID: 7532167; PMCID: PMC176700

Steinbach S, Sun L, Jiang RZ, Flume P, Gilligan P, Egan TM, Goldstein R. Transmissibility of Pseudomonas cepacia infection in clinic patients and lung-transplant recipients with cystic fibrosis. N Engl J Med. 1994 Oct 13; 331(15):981-7. PMID: 7521938

Agarwal M, Arthur M, Arbeit RD, Goldstein R. Regulation of icosahedral virion capsid size by the in vivo activity of a cloned gene product. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2428-32. PMID: 2181437; PMCID: PMC53702

Arbeit RD, Arthur M, Dunn R, Kim C, Selander RK, Goldstein R. Resolution of recent evolutionary divergence among Escherichia coli from related lineages: the application of pulsed field electrophoresis to molecular epidemiology. J Infect Dis. 1990 Feb; 161(2):230-5. PMID: 1967621

Arthur M, Arbeit RD, Kim C, Beltran P, Crowe H, Steinbach S, Campanelli C, Wilson RA, Selander RK, Goldstein R. Restriction fragment length polymorphisms among uropathogenic Escherichia coli isolates: pap-related sequences compared with rrn operons. Infect Immun. 1990 Feb; 58(2):471-9. PMID: 1967594; PMCID: PMC258481

Gutmann L, Agarwal M, Arthur M, Campanelli C, Goldstein R. A phasmid shuttle vector for the cloning of complex operons in Salmonella. Plasmid. 1990 Jan; 23(1):42-58. PMID: 2190245

Arthur M, Campanelli C, Arbeit RD, Kim C, Steinbach S, Johnson CE, Rubin RH, Goldstein R. Structure and copy number of gene clusters related to the pap P-adhesin operon of uropathogenic Escherichia coli. Infect Immun. 1989 Feb; 57(2):314-21. PMID: 2563255; PMCID: PMC313099

Arthur M, Johnson CE, Rubin RH, Arbeit RD, Campanelli C, Kim C, Steinbach S, Agarwal M, Wilkinson R, Goldstein R. Molecular epidemiology of adhesin and hemolysin virulence factors among uropathogenic Escherichia coli. Infect Immun. 1989 Feb; 57(2):303-13. PMID: 2563254; PMCID: PMC313098

Lagos R, Goldstein R. Evolutionary relationship between plasmids and phages: phasmid P4 as a model. Arch Biol Med Exp (Santiago). 1987; 20(3-4):325-32. PMID: 8816073

Lagos R, Jiang RZ, Kim S, Goldstein R. Rho-dependent transcription termination of a bacterial operon is antagonized by an extrachromosomal gene product. Proc Natl Acad Sci U S A. 1986 Dec; 83(24):9561-5. PMID: 3540944; PMCID: PMC387180

Lagos R, Goldstein R. Phasmid P4: manipulation of plasmid copy number and induction from the integrated state. J Bacteriol. 1984 Apr; 158(1):208-15. PMID: 6370957; PMCID: PMC215400

Geisselsoder J, Sedivy JM, Walsh RB, Goldstein R. Capsid structure of satellite phage P4 and its P2 helper. J Ultrastruct Res. 1982 May; 79(2):165-73. PMID: 7077742

Goldstein R, Sedivy J, Ljungquist E. Propagation of satellite phage P4 as a plasmid. Proc Natl Acad Sci U S A. 1982 Jan; 79(2):515-9. PMID: 7043461; PMCID: PMC345774

Calendar R, Ljungquist E, Deho G, Usher DC, Goldstein R, Youderian P, Sironi G, Six EW. Lysogenization by satellite phage P4. Virology. 1981 Aug; 113(1):20-38. PMID: 7023020

Geisselsoder J, Youdarian P, Dehò G, Chidambaram M, Goldstein R, Ljungquist E. Mutants of satellite virus P4 that cannot derepress their bacteriophage P2 helper. J Mol Biol. 1981 May 5; 148(1):1-19. PMID: 7310867

Geisselsoder J, Chidambaram M, Goldstein R. Transcriptional control of capsid size in the P2:P4 bacteriophage system. J Mol Biol. 1978 Dec 15; 126(3):447-56. PMID: 370404

Diana C, Dehò G, Geisselsoder J, Tinelli L, Goldstein R. Viral interference at the level of capsid size determination by satellite phage P4. J Mol Biol. 1978 Dec 15; 126(3):433-45. PMID: 745236

Shore D, Dehò G, Tsipis J, Goldstein R. Determination of capsid size by satellite bacteriophage P4. Proc Natl Acad Sci U S A. 1978 Jan; 75(1):400-4. PMID: 272656; PMCID: PMC411256

Lengyel JA, Goldstein RN, Marsh M, Calendar R. Structure of the bacteriophage P2 tail. Virology. 1974 Nov; 62(1):161-74. PMID: 4607804

Pruss G, Goldstein RN, Calendar R. In vitro packaging of satellite phage P4 DNA. Proc Natl Acad Sci U S A. 1974 Jun; 71(6):2367-71. PMID: 4526304; PMCID: PMC388456

Goldstein R, Lengyel J, Pruss G, Barrett K, Calendar R, Six E. Head size determination and the morphogenesis of satellite phage P4. Curr Top Microbiol Immunol. 1974; (68):59-75. PMID: 4448101

Pruss G, Barrett K, Lengyel J, Goldstein R, Calendar R. Phage head size determination and head protein cleavage in vitro. J Supramol Struct. 1974; 2(2-4):337-48. PMID: 4612251

Lengyel JA, Goldstein RN, Marsh M, Sunshine MG, Calendar R. Bacteriophage P2 head morphogenesis: cleavage of the major capsid protein. Virology. 1973 May; 53(1):1-23. PMID: 4574872

Gibbs W, Goldstein RN, Wiener R, Lindqvist B, Calendar R. Satellite bacteriophage P4: characterization of mutants in two essential genes. Virology. 1973 May; 53(1):24-39. PMID: 4574874

Barrett K, Calendar R, Gibbs W, Goldstein RN, Lindqvist B, Six E. Helper-dependent bacteriophage P4: a model satellite virus and its implications for animal virology. Prog Med Virol. 1973; 15:309-30. PMID: 4348876

Goldstein RN, Stefanovic S, Kallenbach NR. On the conformation of transfer RNA in solution: dependence of denaturation temperature and structural parameters of mixed and formylmethionyl Escherichia coli transfer RNA on sodium ion concentration. J Mol Biol. 1972 Aug 21; 69(2):217-36. PMID: 4560948

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