Aurelie Edwards | Profiles RNS

Aurelie Edwards, PhD

Research Professor

Boston University College of Engineering

Biomedical Engineering

PhD, Massachusetts Institute of Technology
MS, Ecole Nationale Superieure De Mechanique

Websites

	BU College of Engineering
	ResearchGate

ORCID : 0000-0002-3324-2108

Aurelie Edwards is a Research Professor in Biomedical Engineering at Boston University. Her research focuses on renal transport mechanisms. After her PhD. in Chemical Engineering at MIT with Dr. William Deen, Aurélie held positions at Penn State University and Tufts University and she directed the CNRS Renal Physiology Unit at the Cordeliers Research Center (Paris, France). She co-authored the book Mathematical Modeling in Renal Physiology (Springer 2014). Current areas of interest include lifecycle adaptations in renal transporter profiles to regulate electrolyte and fluid homeostasis, and the mechanisms underlying proteinuria.

BU Research

Renal electrolyte handling in females vs. males over life cycle
08/29/2022 - 05/31/2024 (Subcontract PI)
University of Southern California NIH NIDDK
2R01DK083785-10A1

Renal sodium handling in hypertension: impact of age, sex, and dietary potassium
09/14/2020 - 08/31/2021 (Subcontract PI)
University of Southern California NIH NIDDK
1R56DK123780-01A1

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Edwards A, Kurtcuoglu V. Renal blood flow and oxygenation. Pflugers Arch. 2022 Aug; 474(8):759-770. PMID: 35438336; PMCID: PMC9338895; DOI: 10.1007/s00424-022-02690-y;

Edwards A, Long KR, Baty CJ, Shipman KE, Weisz OA. Modelling normal and nephrotic axial uptake of albumin and other filtered proteins along the proximal tubule. J Physiol. 2022 Apr; 600(8):1933-1952. PMID: 35178707; PMCID: PMC9012691; DOI: 10.1113/JP282885;

Butt L, Unnersjö-Jess D, Höhne M, Schermer B, Edwards A, Benzing T. A mathematical estimation of the physical forces driving podocyte detachment. Kidney Int. 2021 11; 100(5):1054-1062. PMID: 34332959; DOI: 10.1016/j.kint.2021.06.040;

Edwards A, Salant D, Benzing T. Insights into Glomerular Filtration and Albuminuria. Reply. N Engl J Med. 2021 07 29; 385(5):478.View Related Profiles.

Edwards, Aurelie
Salant, David

PMID: 34320302

Zajac M, Dreano E, Edwards A, Planelles G, Sermet-Gaudelus I. Airway Surface Liquid pH Regulation in Airway Epithelium Current Understandings and Gaps in Knowledge. Int J Mol Sci. 2021 Mar 25; 22(7). PMID: 33806154; PMCID: PMC8037888; DOI: 10.3390/ijms22073384;

Edwards A, Christensen EI, Unwin RJ, Norden AGW. Obesity-Related Glomerulopathy: Hyperfiltration May Contribute to Early Proteinuria. Kidney Int Rep. 2021 Mar; 6(3):867. PMID: 33733005; PMCID: PMC7938060; DOI: 10.1016/j.ekir.2021.01.019;

Edwards A, Christensen EI, Unwin RJ, Norden AGW. Predicting the protein composition of human urine in normal and pathological states: Quantitative description based on Dent1 disease (CLCN5 mutation). J Physiol. 2021 01; 599(1):323-341. PMID: 33107589; DOI: 10.1113/JP280740;

Butt L, Unnersjö-Jess D, Höhne M, Edwards A, Binz-Lotter J, Reilly D, Hahnfeldt R, Ziegler V, Fremter K, Rinschen MM, Helmstädter M, Ebert LK, Castrop H, Hackl MJ, Walz G, Brinkkoetter PT, Liebau MC, Tory K, Hoyer PF, Beck BB, Brismar H, Blom H, Schermer B, Benzing T. A molecular mechanism explaining albuminuria in kidney disease. Nat Metab. 2020 05; 2(5):461-474. PMID: 32694662; DOI: 10.1038/s42255-020-0204-y;

Marulli M, Edwards A, Milišic V, Vauchelet N. On the role of the epithelium in a model of sodium exchange in renal tubules. Math Biosci. 2020 03; 321:108308. PMID: 31978381; DOI: 10.1016/j.mbs.2020.108308;

Dizin E, Olivier V, Maire C, Komarynets O, Sassi A, Roth I, Loffing J, de Seigneux S, Maillard M, Rutkowski JM, Edwards A, Feraille E. Time-course of sodium transport along the nephron in nephrotic syndrome: The role of potassium. FASEB J. 2020 02; 34(2):2408-2424. PMID: 31908015; DOI: 10.1096/fj.201901345R;

Showing 10 of 63 results. Show More

Edwards A, Palm F, Layton AT. A model of mitochondrial O2 consumption and ATP generation in rat proximal tubule cells. Am J Physiol Renal Physiol. 2020 01 01; 318(1):F248-F259. PMID: 31790302; PMCID: PMC6985826; DOI: 10.1152/ajprenal.00330.2019;

Yu J, Chitalia VC, Akintewe OO, Edwards A, Wong JY. Determinants of Hemodialysis Performance: Modeling Fluid and Solute Transport in Hollow-Fiber Dialyzers. Regen Eng Transl Med. 2021 Sep; 7(3):291-300.View Related Profiles.

Edwards, Aurelie
Wong, Joyce
Chitalia, Vipul

PMID: 34926787; PMCID: PMC8673592; DOI: 10.1007/s40883-019-00135-0;

Simonin J, Bille E, Crambert G, Noel S, Dreano E, Edwards A, Hatton A, Pranke I, Villeret B, Cottart CH, Vrel JP, Urbach V, Baatallah N, Hinzpeter A, Golec A, Touqui L, Nassif X, Galietta LJV, Planelles G, Sallenave JM, Edelman A, Sermet-Gaudelus I. Author Correction: Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis. Sci Rep. 2019 Nov 21; 9(1):17535. PMID: 31754179; PMCID: PMC6872590; DOI: 10.1038/s41598-019-54253-4;

Edwards A, McDonough AA. Impact of angiotensin II-mediated stimulation of sodium transporters in the nephron assessed by computational modeling. Am J Physiol Renal Physiol. 2019 12 01; 317(6):F1656-F1668. PMID: 31657247; PMCID: PMC6962509; DOI: 10.1152/ajprenal.00335.2019;

Simonin J, Bille E, Crambert G, Noel S, Dreano E, Edwards A, Hatton A, Pranke I, Villeret B, Cottart CH, Vrel JP, Urbach V, Baatallah N, Hinzpeter A, Golec A, Touqui L, Nassif X, Galietta LJV, Planelles G, Sallenave JM, Edelman A, Sermet-Gaudelus I. Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis. Sci Rep. 2019 04 24; 9(1):6516. PMID: 31019198; PMCID: PMC6482305; DOI: 10.1038/s41598-019-42751-4;

Edwards A, Auberson M, Ramakrishnan SK, Bonny O. A model of uric acid transport in the rat proximal tubule. Am J Physiol Renal Physiol. 2019 05 01; 316(5):F934-F947. PMID: 30785349; DOI: 10.1152/ajprenal.00603.2018;

Edwards A, Bonny O. A model of calcium transport and regulation in the proximal tubule. Am J Physiol Renal Physiol. 2018 10 01; 315(4):F942-F953. PMID: 29846115; PMCID: PMC6230728; DOI: 10.1152/ajprenal.00129.2018;

Layton AT, Edwards A, Vallon V. Renal potassium handling in rats with subtotal nephrectomy: modeling and analysis. Am J Physiol Renal Physiol. 2018 04 01; 314(4):F643-F657. PMID: 29357444; PMCID: PMC5966763; DOI: 10.1152/ajprenal.00460.2017;

Udwan K, Abed A, Roth I, Dizin E, Maillard M, Bettoni C, Loffing J, Wagner CA, Edwards A, Feraille E. Dietary sodium induces a redistribution of the tubular metabolic workload. J Physiol. 2017 11 15; 595(22):6905-6922. PMID: 28940314; PMCID: PMC5685825; DOI: 10.1113/JP274927;

Edwards A, Layton AT. Cell Volume Regulation in the Proximal Tubule of Rat Kidney : Proximal Tubule Cell Volume Regulation. Bull Math Biol. 2017 11; 79(11):2512-2533. PMID: 28900833; PMCID: PMC5660676; DOI: 10.1007/s11538-017-0338-6;

Edwards A, Crambert G. Versatility of NaCl transport mechanisms in the cortical collecting duct. Am J Physiol Renal Physiol. 2017 Dec 01; 313(6):F1254-F1263. PMID: 28877883; DOI: 10.1152/ajprenal.00369.2017;

Granjon D, Bonny O, Edwards A. Coupling between phosphate and calcium homeostasis: a mathematical model. Am J Physiol Renal Physiol. 2017 Dec 01; 313(6):F1181-F1199. PMID: 28747359; DOI: 10.1152/ajprenal.00271.2017;

Chen Y, Sullivan JC, Edwards A, Layton AT. Sex-specific computational models of the spontaneously hypertensive rat kidneys: factors affecting nitric oxide bioavailability. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F174-F183. PMID: 28356289; PMCID: PMC5582898; DOI: 10.1152/ajprenal.00482.2016;

Layton AT, Edwards A, Vallon V. Adaptive changes in GFR, tubular morphology, and transport in subtotal nephrectomized kidneys: modeling and analysis. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F199-F209. PMID: 28331059; PMCID: PMC5582891; DOI: 10.1152/ajprenal.00018.2017;

Layton AT, Laghmani K, Vallon V, Edwards A. Solute transport and oxygen consumption along the nephrons: effects of Na+ transport inhibitors. Am J Physiol Renal Physiol. 2016 12 01; 311(6):F1217-F1229. PMID: 27707706; PMCID: PMC5210208; DOI: 10.1152/ajprenal.00294.2016;

Layton AT, Vallon V, Edwards A. A computational model for simulating solute transport and oxygen consumption along the nephrons. Am J Physiol Renal Physiol. 2016 12 01; 311(6):F1378-F1390. PMID: 27707705; PMCID: PMC5210192; DOI: 10.1152/ajprenal.00293.2016;

Pinelli L, Nissant A, Edwards A, Lourdel S, Teulon J, Paulais M. Dual regulation of the native ClC-K2 chloride channel in the distal nephron by voltage and pH. J Gen Physiol. 2016 09; 148(3):213-26. PMID: 27574292; PMCID: PMC5004338; DOI: 10.1085/jgp.201611623;

Morla L, Doucet A, Lamouroux C, Crambert G, Edwards A. The renal cortical collecting duct: a secreting epithelium? J Physiol. 2016 10 15; 594(20):5991-6008. PMID: 27412964; PMCID: PMC5063930; DOI: 10.1113/JP272877;

Granjon D, Bonny O, Edwards A. A model of calcium homeostasis in the rat. Am J Physiol Renal Physiol. 2016 11 01; 311(5):F1047-F1062. PMID: 27358053; DOI: 10.1152/ajprenal.00230.2016;

Udwan K, Brideau G, Fila M, Edwards A, Vogt B, Doucet A. Oxidative Stress and Nuclear Factor ?B (NF-?B) Increase Peritoneal Filtration and Contribute to Ascites Formation in Nephrotic Syndrome. J Biol Chem. 2016 May 20; 291(21):11105-13. PMID: 27033704; PMCID: PMC4900260; DOI: 10.1074/jbc.M116.724690;

Morla L, Edwards A, Crambert G. New insights into sodium transport regulation in the distal nephron: Role of G-protein coupled receptors. World J Biol Chem. 2016 Feb 26; 7(1):44-63. PMID: 26981195; PMCID: PMC4768124; DOI: 10.4331/wjbc.v7.i1.44;

Layton AT, Vallon V, Edwards A. Predicted consequences of diabetes and SGLT inhibition on transport and oxygen consumption along a rat nephron. Am J Physiol Renal Physiol. 2016 06 01; 310(11):F1269-83. PMID: 26764207; PMCID: PMC4935777; DOI: 10.1152/ajprenal.00543.2015;

Fry BC, Edwards A, Layton AT. Impact of nitric-oxide-mediated vasodilation and oxidative stress on renal medullary oxygenation: a modeling study. Am J Physiol Renal Physiol. 2016 Feb 01; 310(3):F237-47. PMID: 26831340; PMCID: PMC4888562; DOI: 10.1152/ajprenal.00334.2015;

Layton AT, Edwards A. Predicted effects of nitric oxide and superoxide on the vasoactivity of the afferent arteriole. Am J Physiol Renal Physiol. 2015 Oct 15; 309(8):F708-19. PMID: 26180238; PMCID: PMC4609917; DOI: 10.1152/ajprenal.00187.2015;

Layton AT, Vallon V, Edwards A. Modeling oxygen consumption in the proximal tubule: effects of NHE and SGLT2 inhibition. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1343-57. PMID: 25855513; PMCID: PMC4469883; DOI: 10.1152/ajprenal.00007.2015;

Fry BC, Edwards A, Layton AT. Impacts of nitric oxide and superoxide on renal medullary oxygen transport and urine concentration. Am J Physiol Renal Physiol. 2015 May 01; 308(9):F967-80. PMID: 25651567; PMCID: PMC4420989; DOI: 10.1152/ajprenal.00600.2014;

Edwards A. Regulation of calcium reabsorption along the rat nephron: a modeling study. Am J Physiol Renal Physiol. 2015 Mar 15; 308(6):F553-66. PMID: 25520011; DOI: 10.1152/ajprenal.00577.2014;

Fry BC, Edwards A, Sgouralis I, Layton AT. Impact of renal medullary three-dimensional architecture on oxygen transport. Am J Physiol Renal Physiol. 2014 Aug 01; 307(3):F263-72. PMID: 24899054; PMCID: PMC4121569; DOI: 10.1152/ajprenal.00149.2014;

Edwards A, Castrop H, Laghmani K, Vallon V, Layton AT. Effects of NKCC2 isoform regulation on NaCl transport in thick ascending limb and macula densa: a modeling study. Am J Physiol Renal Physiol. 2014 Jul 15; 307(2):F137-46. PMID: 24848496; PMCID: PMC4101627; DOI: 10.1152/ajprenal.00158.2014;

Edwards A, Layton AT. Calcium dynamics underlying the myogenic response of the renal afferent arteriole. Am J Physiol Renal Physiol. 2014 Jan 01; 306(1):F34-48. PMID: 24173354; PMCID: PMC3921822; DOI: 10.1152/ajprenal.00317.2013;

Tournus M, Seguin N, Perthame B, Thomas SR, Edwards A. A model of calcium transport along the rat nephron. Am J Physiol Renal Physiol. 2013 Oct 01; 305(7):F979-94. PMID: 23761679; DOI: 10.1152/ajprenal.00696.2012;

Bonny O, Edwards A. Calcium reabsorption in the distal tubule: regulation by sodium, pH, and flow. Am J Physiol Renal Physiol. 2013 Mar 01; 304(5):F585-600. PMID: 23152295; DOI: 10.1152/ajprenal.00493.2012;

Edwards A, Layton AT. Impact of nitric oxide-mediated vasodilation on outer medullary NaCl transport and oxygenation. Am J Physiol Renal Physiol. 2012 Oct; 303(7):F907-17. PMID: 22791340; PMCID: PMC3469683; DOI: 10.1152/ajprenal.00055.2012;

Azroyan A, Morla L, Crambert G, Laghmani K, Ramakrishnan S, Edwards A, Doucet A. Regulation of pendrin by cAMP: possible involvement in ß-adrenergic-dependent NaCl retention. Am J Physiol Renal Physiol. 2012 May 01; 302(9):F1180-7. PMID: 22262479; DOI: 10.1152/ajprenal.00403.2011;

Pallone TL, Edwards A, Mattson DL. Renal medullary circulation. Compr Physiol. 2012 Jan; 2(1):97-140. PMID: 23728972; DOI: 10.1002/cphy.c100036;

Edwards A, Layton AT. Modulation of outer medullary NaCl transport and oxygenation by nitric oxide and superoxide. Am J Physiol Renal Physiol. 2011 Nov; 301(5):F979-96. PMID: 21849492; PMCID: PMC3213899; DOI: 10.1152/ajprenal.00096.2011;

Elabida B, Edwards A, Salhi A, Azroyan A, Fodstad H, Meneton P, Doucet A, Bloch-Faure M, Crambert G. Chronic potassium depletion increases adrenal progesterone production that is necessary for efficient renal retention of potassium. Kidney Int. 2011 Aug; 80(3):256-62. PMID: 21326170; DOI: 10.1038/ki.2011.15;

Azroyan A, Laghmani K, Crambert G, Mordasini D, Doucet A, Edwards A. Regulation of pendrin by pH: dependence on glycosylation. Biochem J. 2011 Feb 15; 434(1):61-72. PMID: 21073444; DOI: 10.1042/BJ20101411;

Edwards A, Cao C, Pallone TL. Cellular mechanisms underlying nitric oxide-induced vasodilation of descending vasa recta. Am J Physiol Renal Physiol. 2011 Feb; 300(2):F441-56. PMID: 21084408; PMCID: PMC3044008; DOI: 10.1152/ajprenal.00499.2010;

Cao C, Edwards A, Sendeski M, Lee-Kwon W, Cui L, Cai CY, Patzak A, Pallone TL. Intrinsic nitric oxide and superoxide production regulates descending vasa recta contraction. Am J Physiol Renal Physiol. 2010 Nov; 299(5):F1056-64. PMID: 20702600; PMCID: PMC2980406; DOI: 10.1152/ajprenal.00070.2010;

Edwards A, Layton AT. Nitric oxide and superoxide transport in a cross section of the rat outer medulla. I. Effects of low medullary oxygen tension. Am J Physiol Renal Physiol. 2010 Sep; 299(3):F616-33. PMID: 20534869; PMCID: PMC2944293; DOI: 10.1152/ajprenal.00680.2009;

Edwards A, Layton AT. Nitric oxide and superoxide transport in a cross section of the rat outer medulla. II. Reciprocal interactions and tubulovascular cross talk. Am J Physiol Renal Physiol. 2010 Sep; 299(3):F634-47. PMID: 20519375; PMCID: PMC2944298; DOI: 10.1152/ajprenal.00681.2009;

Chen J, Edwards A, Layton AT. Effects of pH and medullary blood flow on oxygen transport and sodium reabsorption in the rat outer medulla. Am J Physiol Renal Physiol. 2010 Jun; 298(6):F1369-83. PMID: 20335320; PMCID: PMC3433860; DOI: 10.1152/ajprenal.00572.2009;

Edwards A. A possible catalytic role for NH4+ in Na+ reabsorption across the thick ascending limb. Am J Physiol Renal Physiol. 2010 Mar; 298(3):F510-1. PMID: 20007343; PMCID: PMC2838586; DOI: 10.1152/ajprenal.00678.2009;

Edwards A. Modeling transport in the kidney: investigating function and dysfunction. Am J Physiol Renal Physiol. 2010 Mar; 298(3):F475-84. PMID: 19889951; PMCID: PMC2838608; DOI: 10.1152/ajprenal.00501.2009;

Lovett M, Lee K, Edwards A, Kaplan DL. Vascularization strategies for tissue engineering. Tissue Eng Part B Rev. 2009 Sep; 15(3):353-70. PMID: 19496677; PMCID: PMC2817665; DOI: 10.1089/ten.TEB.2009.0085;

Layton AT, Edwards A. Tubuloglomerular feedback signal transduction in a short loop of henle. Bull Math Biol. 2010 Jan; 72(1):34-62. PMID: 19657700; DOI: 10.1007/s11538-009-9436-4;

Eladari D, Chambrey R, Frische S, Vallet M, Edwards A. Pendrin as a regulator of ECF and blood pressure. Curr Opin Nephrol Hypertens. 2009 Jul; 18(4):356-62. PMID: 19474731; DOI: 10.1097/MNH.0b013e32832c91f4;

Chen J, Layton AT, Edwards A. A mathematical model of O2 transport in the rat outer medulla. I. Model formulation and baseline results. Am J Physiol Renal Physiol. 2009 Aug; 297(2):F517-36. PMID: 19403646; PMCID: PMC2724254; DOI: 10.1152/ajprenal.90496.2008;

Chen J, Edwards A, Layton AT. A mathematical model of O2 transport in the rat outer medulla. II. Impact of outer medullary architecture. Am J Physiol Renal Physiol. 2009 Aug; 297(2):F537-48. PMID: 19403645; PMCID: PMC2724255; DOI: 10.1152/ajprenal.90497.2008;

Edwards A, Pallone TL. Mechanisms underlying angiotensin II-induced calcium oscillations. Am J Physiol Renal Physiol. 2008 Aug; 295(2):F568-84. PMID: 18562632; PMCID: PMC2519179; DOI: 10.1152/ajprenal.00107.2008;

Zhang Q, Cao C, Zhang Z, Wier WG, Edwards A, Pallone TL. Membrane current oscillations in descending vasa recta pericytes. Am J Physiol Renal Physiol. 2008 Mar; 294(3):F656-66. PMID: 18184740; PMCID: PMC3196308; DOI: 10.1152/ajprenal.00493.2007;

Edwards A, Pallone TL. Ouabain modulation of cellular calcium stores and signaling. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1518-32. PMID: 17670901; DOI: 10.1152/ajprenal.00251.2007;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 63 publications over 16 distinct years, with a maximum of 8 publications in 2016

Bar chart showing 63 publications over 16 distinct years, with a maximum of 8 publications in 2016

Year	Publications
2007	1
2008	2
2009	7
2010	5
2011	3
2012	4
2013	2
2014	3
2015	4
2016	8
2017	7
2018	1
2019	7
2020	3
2021	4
2022	2

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