Zhen (Jane) Ding, PhD
Postdoctoral Associate
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology

I am currently a Postdoctoral Associate in the laboratory of Dr. Mohsan Saeed at the Department of Biochemistry and the National Emerging Infectious Diseases Laboratories (NEIDL) of Boston University.

For my Ph.D. degree in Preventive Veterinary Medicine at Huazhong Agricultural University, I studied the molecular details of how animal coronaviruses, such as porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV) evade host innate immune responses. In addition, I employed proteomics, RNA sequencing, and advanced molecular biology approaches to probe the mechanisms through which gastrointestinal coronaviruses caused severe inflammation.

I joined the Saeed lab in September 2022. My current focus is on dissecting the ways in which 2A protease of enteroviruses, such as poliovirus and coxsackieviruses, blunt the interferon response pathway in virus-infected cells. To answer this question, my research is utilizing systems-level strategies, including degradomics and proximity-based protein labeling. These studies are expected to provide unparalleled insights into the enterovirus biology and open up avenues for the development of better disease management strategies.

In the future, I will also be involved in a project exploring the mechanisms that underlie SARS-CoV-2-mediated immune dysregulation. To this end, we will utilize advanced multiplex imaging technologies and suitable animal models. An in-depth understanding of how SARS-CoV-2 impairs immune signaling will pave the way for the development of better treatment regimens.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Wang YF, Li X, Luo SS, Huang ZC, Ding ZZ, Zhou N, Zhao YG. Effects of temperature and initial pH on the growth of four dominant cyanobacteria species in biological soil crusts. Ying Yong Sheng Tai Xue Bao. 2024 Feb; 35(2):516-522. PMID: 38523110
  2. Hu X, Chen Z, Wu X, Ding Z, Huang Y, Fu Q, Chen Z, Wu H. Phosphorylation of VP1 Mediated by CDK1-Cyclin B1 Facilitates Infectious Bursal Disease Virus Replication. J Virol. 2023 Jan 31; 97(1):e0194122. PMID: 36602364; PMCID: PMC9888224; DOI: 10.1128/jvi.01941-22;
  3. Liang W, Wu X, Ding Z, Zhong S, Qian X, Ye P, Liu H, Chen Z, Zhang J, Cao H, Hu G, Luo J, Li Z, Ding N, Hu R. Identification of a novel porcine Teschovirus 2 strain as causative agent of encephalomyelitis in suckling piglets with high mortality in China. BMC Vet Res. 2023 Jan 04; 19(1):2. PMID: 36597091; PMCID: PMC9810521; DOI: 10.1186/s12917-022-03549-1;
  4. Hu X, Ding Z, Li Y, Chen Z, Wu H. Serum investigation of antibodies against porcine circovirus 4 Rep and Cap protein in Jiangxi Province, China. Front Microbiol. 2022; 13:944679. PMID: 36338086; PMCID: PMC9634748; DOI: 10.3389/fmicb.2022.944679;
  5. Hu X, Chen Z, Song D, Li Y, Ding Z, Wu X, You H, Wu H. Frequency detection of porcine circovirus-like viruses in pigs with porcine respiratory disease. Vet Microbiol. 2022 Dec; 275:109581. PMID: 36279656; DOI: 10.1016/j.vetmic.2022.109581;
  6. Hu X, Wu X, Ding Z, Chen Z, Wu H. Characterization and functional analysis of chicken dsRNA binding protein hnRNPU. Dev Comp Immunol. 2023 Jan; 138:104521. PMID: 36044969; DOI: 10.1016/j.dci.2022.104521;
  7. Hu X, Chen Z, Li Y, Ding Z, Zeng Q, Wan T, Wu H. Detection of Porcine Circovirus 1/2/3 and Genetic Analysis of Porcine Circovirus 2 in Wild Boar from Jiangxi Province of China. Animals (Basel). 2022 Aug 10; 12(16). PMID: 36009613; PMCID: PMC9404430; DOI: 10.3390/ani12162021;
  8. Chen Z, Hu X, Wu X, Li Y, Ding Z, Zeng Q, Wan T, Yin J, Wu H. Development and Primary Application of an Indirect ELISA Based on Rep Protein to Analyze Antibodies against Porcine Cocirvirus-like Virus (PCLV). Viruses. 2022 Jun 27; 14(7). PMID: 35891379; PMCID: PMC9317306; DOI: 10.3390/v14071398;
  9. Hu X, Chen Z, Wu X, Ding Z, Zeng Q, Wu H. An Improved, Dual-Direction, Promoter-Driven, Reverse Genetics System for the Infectious Bursal Disease Virus (IBDV). Viruses. 2022 Jun 27; 14(7). PMID: 35891377; PMCID: PMC9324645; DOI: 10.3390/v14071396;
  10. Zhang J, Yuan S, Peng Q, Ding Z, Hao W, Peng G, Xiao S, Fang L. Porcine Epidemic Diarrhea Virus nsp7 Inhibits Interferon-Induced JAK-STAT Signaling through Sequestering the Interaction between KPNA1 and STAT1. J Virol. 2022 May 11; 96(9):e0040022. PMID: 35442061; PMCID: PMC9093119; DOI: 10.1128/jvi.00400-22;
Showing 10 of 22 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 22 publications over 5 distinct years, with a maximum of 7 publications in 2022


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