Zeba Wunderlich

Associate Professor

Boston University Graduate School of Arts and Sciences

Biology

PhD, Harvard University
BA, Rutgers University

Websites

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ORCID : 0000-0003-4491-5715

Regulatory DNA encodes the gene regulatory networks that are required for virtually every process in an animal, from development to immunity. The Wunderlich lab is interested in understanding how a gene regulatory network’s tasks influence its architecture, robustness, and evolvability. To probe these questions, we use two model systems: the Drosophila early embryonic patterning system and the Drosophila innate immune response. In both systems, we pair imaging-based and genomic measurements of gene expression with statistical and physically based computational models to explore questions of gene regulatory network function. We exploit naturally occurring sequence variation between individuals and species as a tool to measure how changes in regulatory DNA affect transcriptional regulation.

Associate Professor
Boston University Graduate School of Arts and Sciences
Biomedical Engineering

BU Research

Mechanisms of shadow enhancer robustness during development
09/03/2021 - 08/31/2025 (PI)
NIH/National Institute of Child Health & Human Development
5R01HD095246-06

Uncovering the regulatory DNA logic of the Drosophila innate immune response
03/01/2022 - 04/30/2025 (PI)
National Science Foundation
MCB-2223888

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Zhu Y, Wunderlich Z, Lander AD. Epithelial cell competition is promoted by signaling from immune cells. Nat Commun. 2025 Apr 19; 16(1):3710. PMID: 40251197; PMCID: PMC12008283; DOI: 10.1038/s41467-025-59130-5;

Gibbs JR, Mei C, Wunderlich Z. Beyond the heat shock pathway: Heat stress responses in Drosophila development. Dev Biol. 2025 Feb; 518:53-60. PMID: 39557149; PMCID: PMC11703687; DOI: 10.1016/j.ydbio.2024.11.003;

Cabrera K, Hoard DS, Gibson O, Martinez DI, Wunderlich Z. Drosophila immune priming to Enterococcus faecalis relies on immune tolerance rather than resistance. PLoS Pathog. 2023 Aug; 19(8):e1011567. PMID: 37566589; PMCID: PMC10446173; DOI: 10.1371/journal.ppat.1011567;

Fletcher A, Wunderlich Z, Enciso G. Shadow enhancers mediate trade-offs between transcriptional noise and fidelity. PLoS Comput Biol. 2023 May; 19(5):e1011071. PMID: 37205714; PMCID: PMC10234526; DOI: 10.1371/journal.pcbi.1011071;

Ramirez-Corona BA, Love AC, Chandrasekaran S, Prescher JA, Wunderlich Z. Longitudinal monitoring of individual infection progression in Drosophila melanogaster. iScience. 2022 Nov 18; 25(11):105378. PMID: 36345341; PMCID: PMC9636044; DOI: 10.1016/j.isci.2022.105378;

Li L, Waymack R, Gad M, Wunderlich Z. Two promoters integrate multiple enhancer inputs to drive wild-type knirps expression in the Drosophila melanogaster embryo. Genetics. 2021 Dec 10; 219(4). PMID: 34849867; PMCID: PMC8664596; DOI: 10.1093/genetics/iyab154;

Han J, Perera S, Wunderlich Z, Periwal V. Mechanistic gene networks inferred from single-cell data with an outlier-insensitive method. Math Biosci. 2021 Dec; 342:108722. PMID: 34688607; PMCID: PMC8722367; DOI: 10.1016/j.mbs.2021.108722;

Waymack R, Gad M, Wunderlich Z. Molecular competition can shape enhancer activity in the Drosophila embryo. iScience. 2021 Sep 24; 24(9):103034. PMID: 34568782; PMCID: PMC8449247; DOI: 10.1016/j.isci.2021.103034;

Waymack R, Wunderlich Z. Embryonic development across space and time. Nat Comput Sci. 2021 Aug; 1(8):507-508. PMID: 38217246

Kvon EZ, Waymack R, Gad M, Wunderlich Z. Author Correction: Enhancer redundancy in development and disease. Nat Rev Genet. 2021 May; 22(5):337. PMID: 33850330

Showing 10 of 42 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 42 publications over 20 distinct years, with a maximum of 7 publications in 2021