Zeba Wunderlich
Associate Professor
Boston University Graduate School of Arts and Sciences
Biology

PhD, Harvard University
BA, Rutgers University



Regulatory DNA encodes the gene regulatory networks that are required for virtually every process in an animal, from development to immunity. The Wunderlich lab is interested in understanding how a gene regulatory network’s tasks influence its architecture, robustness, and evolvability. To probe these questions, we use two model systems: the Drosophila early embryonic patterning system and the Drosophila innate immune response. In both systems, we pair imaging-based and genomic measurements of gene expression with statistical and physically based computational models to explore questions of gene regulatory network function. We exploit naturally occurring sequence variation between individuals and species as a tool to measure how changes in regulatory DNA affect transcriptional regulation.

Associate Professor
Boston University Graduate School of Arts and Sciences
Biomedical Engineering




Uncovering the regulatory DNA logic of the Drosophila innate immune response
03/01/2022 - 04/30/2025 (PI)
National Science Foundation
MCB-2223888

Mechanisms of shadow enhancer robustness during development
09/03/2021 - 08/31/2024 (PI)
NIH/National Institute of Child Health & Human Development
5R01HD095246-06



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Cabrera K, Hoard DS, Gibson O, Martinez DI, Wunderlich Z. Drosophila immune priming to Enterococcus faecalis relies on immune tolerance rather than resistance. PLoS Pathog. 2023 Aug; 19(8):e1011567. PMID: 37566589; PMCID: PMC10446173; DOI: 10.1371/journal.ppat.1011567;
     
  2. Fletcher A, Wunderlich Z, Enciso G. Shadow enhancers mediate trade-offs between transcriptional noise and fidelity. PLoS Comput Biol. 2023 May; 19(5):e1011071. PMID: 37205714; PMCID: PMC10234526; DOI: 10.1371/journal.pcbi.1011071;
     
  3. Ramirez-Corona BA, Love AC, Chandrasekaran S, Prescher JA, Wunderlich Z. Longitudinal monitoring of individual infection progression in Drosophila melanogaster. iScience. 2022 Nov 18; 25(11):105378. PMID: 36345341; PMCID: PMC9636044; DOI: 10.1016/j.isci.2022.105378;
     
  4. Li L, Waymack R, Gad M, Wunderlich Z. Two promoters integrate multiple enhancer inputs to drive wild-type knirps expression in the Drosophila melanogaster embryo. Genetics. 2021 Dec 10; 219(4). PMID: 34849867; PMCID: PMC8664596; DOI: 10.1093/genetics/iyab154;
     
  5. Han J, Perera S, Wunderlich Z, Periwal V. Mechanistic gene networks inferred from single-cell data with an outlier-insensitive method. Math Biosci. 2021 Dec; 342:108722. PMID: 34688607; PMCID: PMC8722367; DOI: 10.1016/j.mbs.2021.108722;
     
  6. Waymack R, Gad M, Wunderlich Z. Molecular competition can shape enhancer activity in the Drosophila embryo. iScience. 2021 Sep 24; 24(9):103034. PMID: 34568782; PMCID: PMC8449247; DOI: 10.1016/j.isci.2021.103034;
     
  7. Waymack R, Wunderlich Z. Embryonic development across space and time. Nat Comput Sci. 2021 Aug; 1(8):507-508. PMID: 38217246
     
  8. Kvon EZ, Waymack R, Gad M, Wunderlich Z. Author Correction: Enhancer redundancy in development and disease. Nat Rev Genet. 2021 May; 22(5):337. PMID: 33850330
     
  9. Ramirez-Corona BA, Fruth S, Ofoegbu O, Wunderlich Z. The mode of expression divergence in Drosophila fat body is infection-specific. Genome Res. 2021 Jun; 31(6):1024-1034. PMID: 33858842; PMCID: PMC8168590; DOI: 10.1101/gr.269597.120;
     
  10. Kvon EZ, Waymack R, Gad M, Wunderlich Z. Enhancer redundancy in development and disease. Nat Rev Genet. 2021 May; 22(5):324-336. PMID: 33442000; PMCID: PMC8068586; DOI: 10.1038/s41576-020-00311-x;
     
Showing 10 of 35 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 35 publications over 17 distinct years, with a maximum of 7 publications in 2021

YearPublications
20031
20041
20061
20071
20084
20092
20112
20121
20141
20154
20162
20171
20182
20202
20217
20221
20232


2021 Learning Experience Design and Online Teaching Award
2020 Excellence in Undergraduate Teaching: Dean’s Honoree
2019 Chancellor’s Award for Excellence in Fostering Undergraduate Research
2019 NICHD Nominee, Presidential Early Career Awards for Scientists & Engineers
2017 Hellman Fellowship
2012-2020 NIH K99/R00 Pathway to Independence Award
2009-2012 Jane Coffin Childs Memorial Fund Postdoctoral Fellow
2003-2008 Howard Hughes Medical Institute Predoctoral Fellowship
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610 Commonwealth Ave
Boston MA 02215
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