Tyler Brown | Profiles RNS

Tyler Brown, MD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Infectious Diseases

MD, Johns Hopkins University School of Medicine
AB, Princeton University

Websites

	ResearchGate
	NCBI Bibliography

ORCID : 0000-0003-2559-2789

Tyler Brown is an infectious disease physician, epidemiologist, and Assistant Professor in the Section of Infectious Diseases. His scientific work uses phylogenomics, population genetics, and mathematical modeling to understand how microbial evolution, human host mobility, and other factors shape the transmission and geographic dispersal of tuberculosis and other infectious diseases.

Selected publications (full list available on the Publications tab of this profile):

Brown TS*, Tang L*, Omar SV, Joseph L, Meintjes G, Maartens G, Wasserman S, Shah NS, Farhat MR, Gandhi NR, Ismail N, Brust JCM, Mathema B. Genotype-Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis. Clin Infect Dis. 2023 Oct 24. PMID: 37874928; DOI: 10.1093/cid/ciad596 (*co-first authors)

Brown TS, Robinson DA, Buckee CO, Mathema B. Connecting the dots: understanding how human mobility shapes TB epidemics. Trends Microbiol. 2022 Nov; 30(11):1036-1044. PMID: 35597716; PMCID: PMC10068677; DOI: 10.1016/j.tim.2022.04.005

Brown TS, Arogbokun O, Buckee CO, Chang HH. Distinguishing gene flow between malaria parasite populations. PLoS Genet. 2021 Dec; 17(12):e1009335. PMID: 34928954; PMCID: PMC8726502; DOI: 10.1371/journal.pgen.1009335

Brown TS, Eldholm V, Brynildsrud O, Osnes M, Levy N, Stimson J, Colijn C, Alexandru S, Noroc E, Ciobanu N, Crudu V, Cohen T, Mathema B. Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova. Microb Genom. 2021 Aug; 7(8). PMID: 34431762; PMCID: PMC8549355; DOI: 10.1099/mgen.0.000620

Brown TS, Engø-Monsen K, Kiang MV, Mahmud AS, Maude RJ, Buckee CO. The impact of mobility network properties on predicted epidemic dynamics in Dhaka and Bangkok. Epidemics. 2021 Jun; 35:100441. PMID: 33667878; PMCID: PMC7899011; DOI: 10.1016/j.epidem.2021.100441

Brown TS, Challagundla L, Baugh EH, Omar SV, Mustaev A, Auld SC, Shah NS, Kreiswirth BN, Brust JCM, Nelson KN, Narechania A, Kurepina N, Mlisana K, Bonneau R, Eldholm V, Ismail N, Kolokotronis SO, Robinson DA, Gandhi NR, Mathema B. Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa. Proc Natl Acad Sci U S A. 2019 Nov 12; 116(46):23284-23291. PMID: 31659018; PMCID: PMC6859317; DOI: 10.1073/pnas.1906636116

Shah NS, Auld SC, Brust JC, Mathema B, Ismail N, Moodley P, Mlisana K, Allana S, Campbell A, Mthiyane T, Morris N, Mpangase P, van der Meulen H, Omar SV, Brown TS, Narechania A, Shaskina E, Kapwata T, Kreiswirth B, Gandhi NR. Transmission of Extensively Drug-Resistant Tuberculosis in South Africa. N Engl J Med. 2017 Jan 19; 376(3):243-253. PMID: 28099825; PMCID: PMC5330208; DOI: 10.1056/NEJMoa1604544

Diversity, Equity, Inclusion and Accessibility

2016-2017 Discussion Group Facilitator, Gold Humanism in Medicine Program, Columbia University Irving Medical Center, NY, NY

NIH RePORTER Research

Title

Yr	Title	Project-Sub Proj
2025	Geographic origins and dispersal of drug-resistant M. tuberculosis in South Africa: Advancing strategies for early detection	5K08AI166125-04
2024	Geographic origins and dispersal of drug-resistant M. tuberculosis in South Africa: Advancing strategies for early detection	5K08AI166125-03
2023	Geographic origins and dispersal of drug-resistant M. tuberculosis in South Africa: Advancing strategies for early detection	7K08AI166125-02
2022	Geographic origins and dispersal of drug-resistant M. tuberculosis in South Africa: Advancing strategies for early detection	1K08AI166125-01A1

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Website Copy PMIDs To Clipboard

Sobol R, Omar SV, Brown T, Joseph L, Lutchminarian K, Tang L, Lan Y, Willis F, Campbell A, Warren JL, Cohen T, Brust JCM, Naidoo K, Shah NS, Gandhi NR, Mathema B. Transmission of Bedaquiline-resistant Mycobacterium tuberculosis in KwaZulu-Natal, South Africa. Am J Respir Crit Care Med. 2025 Sep 30. PMID: 41026808; DOI: 10.1164/rccm.202506-1489OC;

Menzies NA, Brown TS, Imai-Eaton JW, Dodd PJ, Cohen T, Martinez L. Potential paediatric tuberculosis incidence and deaths resulting from interruption in programmes supported by international health aid, 2025-34: a mathematical modelling study. Lancet Child Adolesc Health. 2025 Nov; 9(11):787-795.View Related Profiles.

Martinez, Leonardo
Brown , Tyler

PMID: 40953585; DOI: 10.1016/S2352-4642(25)00218-4;

Begemann D, Alonso C, Bates S, Ryan ET, Walker AT, Keppard B, Kissel AM, Amaya F, Rao SR, Brown TS, Mohareb AM, Levison JH, LaRocque RC. Work-related connectivity between Boston Logan international airport and urban communities with high social vulnerability during the COVID-19 pandemic. Trop Dis Travel Med Vaccines. 2025 Jun 01; 11(1):15. PMID: 40450310; PMCID: PMC12126863; DOI: 10.1186/s40794-025-00249-0;

Lan Y, Rancu I, Chitwood MH, Sobkowiak B, Nyhan K, Lin HH, Wu CY, Mathema B, Brown TS, Colijn C, Warren JL, Cohen T. Integrating genomic and spatial analyses to describe tuberculosis transmission: a scoping review. Lancet Microbe. 2025 Aug; 6(8):101094. PMID: 40228509; PMCID: PMC12371702; DOI: 10.1016/j.lanmic.2025.101094;

Mohareb AM, Deukmejian M, Guerra Castillo C, Brown TS, LaRocque R, Taveras E, Sarin Gupta P. School-Based Mobile Clinics to Improve Vaccine Access: A Cross-sectional Study of COVID-19 Vaccination. J Pediatric Infect Dis Soc. 2024 May 30; 13(5):274-275. PMID: 38587478; PMCID: PMC11138955; DOI: 10.1093/jpids/piae032;

Brown TS, Tang L, Omar SV, Joseph L, Meintjes G, Maartens G, Wasserman S, Shah NS, Farhat MR, Gandhi NR, Ismail N, Brust JCM, Mathema B. Genotype-Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis. Clin Infect Dis. 2024 Feb 17; 78(2):269-276. PMID: 37874928; PMCID: PMC11494438; DOI: 10.1093/cid/ciad596;

Brown TS, Mohareb AM, LaRocque RC. Universal Masking in Health Care Settings. Ann Intern Med. 2023 Dec; 176(12):eL230347. PMID: 38109751; DOI: 10.7326/L23-0347;

Mohareb AM, Brown TS. Medical Student Debt and the US Infectious Diseases Workforce. Clin Infect Dis. 2023 Apr 03; 76(7):1322-1327. PMID: 36318609; PMCID: PMC10396319; DOI: 10.1093/cid/ciac862;

Brown T, de Salazar Munoz PM, Bhatia A, Bunda B, Williams EK, Bor D, Miller JS, Mohareb A, Thierauf J, Yang W, Villalba J, Naranbai V, Garcia Beltran W, Miller TE, Kress D, Stelljes K, Johnson K, Larremore D, Lennerz J, Iafrate AJ, Balsari S, Buckee C, Grad Y. Geographically skewed recruitment and COVID-19 seroprevalence estimates: a cross-sectional serosurveillance study and mathematical modelling analysis. BMJ Open. 2023 Mar 07; 13(3):e061840. PMID: 36882240; PMCID: PMC10008195; DOI: 10.1136/bmjopen-2022-061840;

Brown TS, Robinson DA, Buckee CO, Mathema B. Connecting the dots: understanding how human mobility shapes TB epidemics. Trends Microbiol. 2022 Nov; 30(11):1036-1044. PMID: 35597716; PMCID: PMC10068677; DOI: 10.1016/j.tim.2022.04.005;

Showing 10 of 38 results. Show More

Brown TS, Arogbokun O, Buckee CO, Chang HH. Distinguishing gene flow between malaria parasite populations. PLoS Genet. 2021 Dec; 17(12):e1009335. PMID: 34928954; PMCID: PMC8726502; DOI: 10.1371/journal.pgen.1009335;

Dugdale CM, Rubins DM, Lee H, McCluskey SM, Ryan ET, Kotton CN, Hurtado RM, Ciaranello AL, Barshak MB, McEvoy DS, Nelson SB, Basgoz N, Lazarus JE, Ivers LC, Reedy JL, Hysell KM, Lemieux JE, Heller HM, Dutta S, Albin JS, Brown TS, Miller AL, Calderwood SB, Walensky RP, Zachary KC, Hooper DC, Hyle EP, Shenoy ES. Coronavirus Disease 2019 (COVID-19) Diagnostic Clinical Decision Support: A Pre-Post Implementation Study of CORAL (COvid Risk cALculator). Clin Infect Dis. 2021 Dec 16; 73(12):2248-2256. PMID: 33564833; PMCID: PMC7929052; DOI: 10.1093/cid/ciab111;

Brown TS, de Salazar Munoz PM, Bhatia A, Bunda B, Williams EK, Bor D, Miller JS, Mohareb AM, Thierauf J, Yang W, Villalba J, Naranbai V, Beltran WG, Miller TE, Kress D, Stelljes K, Johnson K, Larremore DB, Lennerz J, Iafrate AJ, Balsari S, Buckee CO, Grad YH. Recruitment location influences bias and uncertainty in SARS-CoV-2 seroprevalence estimates. medRxiv. 2021 Oct 05. PMID: 33564784; PMCID: PMC7872379; DOI: 10.1101/2021.02.03.21251011;

Brown TS, Eldholm V, Brynildsrud O, Osnes M, Levy N, Stimson J, Colijn C, Alexandru S, Noroc E, Ciobanu N, Crudu V, Cohen T, Mathema B. Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova. Microb Genom. 2021 Aug; 7(8). PMID: 34431762; PMCID: PMC8549355; DOI: 10.1099/mgen.0.000620;

Salje H, Wesolowski A, Brown TS, Kiang MV, Berry IM, Lefrancq N, Fernandez S, Jarman RG, Ruchusatsawat K, Iamsirithaworn S, Vandepitte WP, Suntarattiwong P, Read JM, Klungthong C, Thaisomboonsuk B, Engø-Monsen K, Buckee C, Cauchemez S, Cummings DAT. Reconstructing unseen transmission events to infer dengue dynamics from viral sequences. Nat Commun. 2021 Mar 22; 12(1):1810. PMID: 33753725; PMCID: PMC7985522; DOI: 10.1038/s41467-021-21888-9;

Brown TS, Engø-Monsen K, Kiang MV, Mahmud AS, Maude RJ, Buckee CO. The impact of mobility network properties on predicted epidemic dynamics in Dhaka and Bangkok. Epidemics. 2021 Jun; 35:100441. PMID: 33667878; PMCID: PMC7899011; DOI: 10.1016/j.epidem.2021.100441;

Brown TS, Dubowski K, Plitt M, Falci L, Lee E, Huynh M, Furuya Y, Vora NM. Erroneous Reporting of Deaths Attributed to Pneumonia and Influenza at 2 New York City Teaching Hospitals, 2013-2014. Public Health Rep. 2020; 135(6):796-804. PMID: 33031711; PMCID: PMC7649996; DOI: 10.1177/0033354920953209;

Brown TS, Walensky RP. Serosurveillance and the COVID-19 Epidemic in the US: Undetected, Uncertain, and Out of Control. JAMA. 2020 Aug 25; 324(8):749-751. PMID: 32692350; DOI: 10.1001/jama.2020.14017;

Hanff TC, Harhay MO, Brown TS, Cohen JB, Mohareb AM. Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System? A Call for Epidemiologic Investigations. Clin Infect Dis. 2020 Jul 28; 71(15):870-874. PMID: 32215613; PMCID: PMC7184340; DOI: 10.1093/cid/ciaa329;

Hanff TC, Harhay MO, Brown TS, Cohen JB, Mohareb AM. Reply to Tedeschi et al. Clin Infect Dis. 2020 Jul 28; 71(15):901. PMID: 32339227; PMCID: PMC7385740; DOI: 10.1093/cid/ciaa495;

Nelson KN, Gandhi NR, Mathema B, Lopman BA, Brust JCM, Auld SC, Ismail N, Omar SV, Brown TS, Allana S, Campbell A, Moodley P, Mlisana K, Shah NS, Jenness SM. Modeling Missing Cases and Transmission Links in Networks of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa. Am J Epidemiol. 2020 Jul 01; 189(7):735-745. PMID: 32242216; PMCID: PMC7443195; DOI: 10.1093/aje/kwaa028;

Nelson KN, Jenness SM, Mathema B, Lopman BA, Auld SC, Shah NS, Brust JCM, Ismail N, Omar SV, Brown TS, Allana S, Campbell A, Moodley P, Mlisana K, Gandhi NR. Social Mixing and Clinical Features Linked With Transmission in a Network of Extensively Drug-resistant Tuberculosis Cases in KwaZulu-Natal, South Africa. Clin Infect Dis. 2020 May 23; 70(11):2396-2402. PMID: 31342067; PMCID: PMC7245156; DOI: 10.1093/cid/ciz636;

Driggin E, Madhavan MV, Bikdeli B, Chuich T, Laracy J, Biondi-Zoccai G, Brown TS, Der Nigoghossian C, Zidar DA, Haythe J, Brodie D, Beckman JA, Kirtane AJ, Stone GW, Krumholz HM, Parikh SA. Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic. J Am Coll Cardiol. 2020 May 12; 75(18):2352-2371. PMID: 32201335; PMCID: PMC7198856; DOI: 10.1016/j.jacc.2020.03.031;

Brown TS, Challagundla L, Baugh EH, Omar SV, Mustaev A, Auld SC, Shah NS, Kreiswirth BN, Brust JCM, Nelson KN, Narechania A, Kurepina N, Mlisana K, Bonneau R, Eldholm V, Ismail N, Kolokotronis SO, Robinson DA, Gandhi NR, Mathema B. Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa. Proc Natl Acad Sci U S A. 2019 Nov 12; 116(46):23284-23291. PMID: 31659018; PMCID: PMC6859317; DOI: 10.1073/pnas.1906636116;

O'Donnell MR, Larsen MH, Brown TS, Jain P, Munsamy V, Wolf A, Uccellini L, Karim F, de Oliveira T, Mathema B, Jacobs WR, Pym A. Erratum for O'Donnell et al., "Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing". Antimicrob Agents Chemother. 2019 Jun; 63(6). PMID: 31126923; PMCID: PMC6535552; DOI: 10.1128/AAC.00764-19;

O'Donnell MR, Larsen MH, Brown TS, Jain P, Munsamy V, Wolf A, Uccellini L, Karim F, de Oliveira T, Mathema B, Jacobs WR, Pym A. Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing. Antimicrob Agents Chemother. 2019 Apr; 63(4). PMID: 30670422; PMCID: PMC6437479; DOI: 10.1128/AAC.01834-18;

Yuengling KA, Padayatchi N, Wolf A, Mathema B, Brown T, Horsburgh CR, O'Donnell MR. Effect of Antiretroviral Therapy on Treatment Outcomes in a Prospective Study of Extensively Drug-Resistant Tuberculosis (XDR-TB) HIV Coinfection Treatment in KwaZulu-Natal, South Africa. J Acquir Immune Defic Syndr. 2018 12 01; 79(4):474-480.View Related Profiles.

Horsburgh, C.
Brown , Tyler

PMID: 30212394; PMCID: PMC6203657; DOI: 10.1097/QAI.0000000000001833;

Nelson KN, Shah NS, Mathema B, Ismail N, Brust JCM, Brown TS, Auld SC, Omar SV, Morris N, Campbell A, Allana S, Moodley P, Mlisana K, Gandhi NR. Spatial Patterns of Extensively Drug-Resistant Tuberculosis Transmission in KwaZulu-Natal, South Africa. J Infect Dis. 2018 Nov 05; 218(12):1964-1973. PMID: 29961879; PMCID: PMC6217717; DOI: 10.1093/infdis/jiy394;

Auld SC, Shah NS, Mathema B, Brown TS, Ismail N, Omar SV, Brust JCM, Nelson KN, Allana S, Campbell A, Mlisana K, Moodley P, Gandhi NR. Extensively drug-resistant tuberculosis in South Africa: genomic evidence supporting transmission in communities. Eur Respir J. 2018 Oct; 52(4). PMID: 30115614; PMCID: PMC6195447; DOI: 10.1183/13993003.00246-2018;

Brynildsrud OB, Pepperell CS, Suffys P, Grandjean L, Monteserin J, Debech N, Bohlin J, Alfsnes K, Pettersson JO, Kirkeleite I, Fandinho F, da Silva MA, Perdigao J, Portugal I, Viveiros M, Clark T, Caws M, Dunstan S, Thai PVK, Lopez B, Ritacco V, Kitchen A, Brown TS, van Soolingen D, O'Neill MB, Holt KE, Feil EJ, Mathema B, Balloux F, Eldholm V. Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation. Sci Adv. 2018 Oct; 4(10):eaat5869. PMID: 30345355; PMCID: PMC6192687; DOI: 10.1126/sciadv.aat5869;

Shah NS, Auld SC, Brust JC, Mathema B, Ismail N, Moodley P, Mlisana K, Allana S, Campbell A, Mthiyane T, Morris N, Mpangase P, van der Meulen H, Omar SV, Brown TS, Narechania A, Shaskina E, Kapwata T, Kreiswirth B, Gandhi NR. Transmission of Extensively Drug-Resistant Tuberculosis in South Africa. N Engl J Med. 2017 Jan 19; 376(3):243-253. PMID: 28099825; PMCID: PMC5330208; DOI: 10.1056/NEJMoa1604544;

Brown TS, Narechania A, Walker JR, Planet PJ, Bifani PJ, Kolokotronis SO, Kreiswirth BN, Mathema B. Genomic epidemiology of Lineage 4 Mycobacterium tuberculosis subpopulations in New York City and New Jersey, 1999-2009. BMC Genomics. 2016 Nov 21; 17(1):947. PMID: 27871225; PMCID: PMC5117616; DOI: 10.1186/s12864-016-3298-6;

Brown TS, Jacob CG, Silva JC, Takala-Harrison S, Djimdé A, Dondorp AM, Fukuda M, Noedl H, Nyunt MM, Kyaw MP, Mayxay M, Hien TT, Plowe CV, Cummings MP. Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype. Infect Genet Evol. 2015 Mar; 30:318-322. PMID: 25514047; PMCID: PMC4316729; DOI: 10.1016/j.meegid.2014.12.010;

Takala-Harrison S, Jacob CG, Arze C, Cummings MP, Silva JC, Dondorp AM, Fukuda MM, Hien TT, Mayxay M, Noedl H, Nosten F, Kyaw MP, Nhien NT, Imwong M, Bethell D, Se Y, Lon C, Tyner SD, Saunders DL, Ariey F, Mercereau-Puijalon O, Menard D, Newton PN, Khanthavong M, Hongvanthong B, Starzengruber P, Fuehrer HP, Swoboda P, Khan WA, Phyo AP, Nyunt MM, Nyunt MH, Brown TS, Adams M, Pepin CS, Bailey J, Tan JC, Ferdig MT, Clark TG, Miotto O, MacInnis B, Kwiatkowski DP, White NJ, Ringwald P, Plowe CV. Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia. J Infect Dis. 2015 Mar 01; 211(5):670-9.View Related Profiles.

Newton, Paul
Brown , Tyler

PMID: 25180241; PMCID: PMC4334802; DOI: 10.1093/infdis/jiu491;

Brown T, Shah N, Brown L. Aiding and abetting: Aggregatibacter aphrophilus coinciding with Mycobacterium avium. Am J Med. 2014 Jun; 127(6):494-7. PMID: 24632057; DOI: 10.1016/j.amjmed.2014.03.001;

Brown T, Smith LS, Oo EK, Shawng K, Lee TJ, Sullivan D, Beyrer C, Richards AK. Molecular surveillance for drug-resistant Plasmodium falciparum in clinical and subclinical populations from three border regions of Burma/Myanmar: cross-sectional data and a systematic review of resistance studies. Malar J. 2012 Sep 19; 11:333. PMID: 22992214; PMCID: PMC3518194; DOI: 10.1186/1475-2875-11-333;

Kolling DR, Brown TS, Ananyev G, Dismukes GC. Photosynthetic oxygen evolution is not reversed at high oxygen pressures: mechanistic consequences for the water-oxidizing complex. Biochemistry. 2009 Feb 17; 48(6):1381-9. PMID: 19166323; PMCID: PMC2701480; DOI: 10.1021/bi801774f;

Carrieri D, Ananyev G, Brown T, Dismukes GC. In vivo bicarbonate requirement for water oxidation by Photosystem II in the hypercarbonate-requiring cyanobacterium Arthrospira maxima. J Inorg Biochem. 2007 Nov; 101(11-12):1865-74. PMID: 17707911; DOI: 10.1016/j.jinorgbio.2007.06.039;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 38 publications over 14 distinct years, with a maximum of 7 publications in 2020