Tuan Leng Tay | Profiles RNS

Tuan Leng Tay, PhD

Assistant Professor

Boston University College of Arts and Sciences

Biology

PhD, Albert-Ludwigs-Universität Freiburg
MS, National University of Singapore (NUS)
BA, National University of Singapore (NUS)

Websites

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ORCID : 0000-0002-3507-6502

Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Anatomy & Neurobiology

BU Research

Dynamics of glial reactivity to neuromodulatory devices
01/15/2023 - 01/14/2025 (PI)
Brain & Behavior Research Foundation

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Kikhia M, Schilling S, Herzog ML, Livne M, Semtner M, Tay TL, Prinz M, Kettenmann H, Endres M, Kronenberg G, Göttert R, Gertz K. Multicolor fate mapping of microglia reveals polyclonal proliferation, heterogeneity, and cell-cell interactions after ischemic stroke in mice. Nat Commun. 2025 Sep 16; 16(1):8294. PMID: 40957877; PMCID: PMC12441135; DOI: 10.1038/s41467-025-63949-3;

Bouadi O, Tay TL. Automated Cell Counting of Macrophages In Situ. Methods Mol Biol. 2024; 2713:505-518. PMID: 37639144

Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brône B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, González B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T. Microglia states and nomenclature: A field at its crossroads. Neuron. 2022 Nov 02; 110(21):3458-3483. PMID: 36327895; PMCID: PMC9999291; DOI: 10.1016/j.neuron.2022.10.020;

Mehl LC, Manjally AV, Bouadi O, Gibson EM, Leng Tay T. Microglia in brain development and regeneration. Development. 2022 Apr 15; 149(8). PMID: 35502782; PMCID: PMC9124570; DOI: 10.1242/dev.200425;

Manjally AV, Tay TL. Attack of the Clones: Microglia in Health and Disease. Front Cell Neurosci. 2022; 16:831747. PMID: 35173585; PMCID: PMC8841846; DOI: 10.3389/fncel.2022.831747;

Bouadi O, Tay TL. More Than Cell Markers: Understanding Heterogeneous Glial Responses to Implantable Neural Devices. Front Cell Neurosci. 2021; 15:658992. PMID: 33912015; PMCID: PMC8071943; DOI: 10.3389/fncel.2021.658992;

Falk T, Mai D, Bensch R, Çiçek Ö, Abdulkadir A, Marrakchi Y, Böhm A, Deubner J, Jäckel Z, Seiwald K, Dovzhenko A, Tietz O, Bosco CD, Walsh S, Saltukoglu D, Tay TL, Prinz M, Palme K, Simons M, Diester I, Brox T, Ronneberger O. Author Correction: U-Net: deep learning for cell counting, detection, and morphometry. Nat Methods. 2019 Apr; 16(4):351. PMID: 30804552

Jordão MJC, Sankowski R, Brendecke SM, Sagar, Locatelli G, Tai YH, Tay TL, Schramm E, Armbruster S, Hagemeyer N, Groß O, Mai D, Çiçek Ö, Falk T, Kerschensteiner M, Grün D, Prinz M. Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation. Science. 2019 01 25; 363(6425). PMID: 30679343

Tay TL, Carrier M, Tremblay MÈ. Physiology of Microglia. Adv Exp Med Biol. 2019; 1175:129-148. PMID: 31583587

Falk T, Mai D, Bensch R, Çiçek Ö, Abdulkadir A, Marrakchi Y, Böhm A, Deubner J, Jäckel Z, Seiwald K, Dovzhenko A, Tietz O, Dal Bosco C, Walsh S, Saltukoglu D, Tay TL, Prinz M, Palme K, Simons M, Diester I, Brox T, Ronneberger O. U-Net: deep learning for cell counting, detection, and morphometry. Nat Methods. 2019 01; 16(1):67-70. PMID: 30559429

Showing 10 of 23 results. Show More

Shemer A, Grozovski J, Tay TL, Tao J, Volaski A, Süß P, Ardura-Fabregat A, Gross-Vered M, Kim JS, David E, Chappell-Maor L, Thielecke L, Glass CK, Cornils K, Prinz M, Jung S. Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge. Nat Commun. 2018 12 06; 9(1):5206. PMID: 30523248; PMCID: PMC6284018; DOI: 10.1038/s41467-018-07548-5;

Tay TL, Sagar, Dautzenberg J, Grün D, Prinz M. Unique microglia recovery population revealed by single-cell RNAseq following neurodegeneration. Acta Neuropathol Commun. 2018 09 05; 6(1):87. PMID: 30185219; PMCID: PMC6123921; DOI: 10.1186/s40478-018-0584-3;

Datta M, Staszewski O, Raschi E, Frosch M, Hagemeyer N, Tay TL, Blank T, Kreutzfeldt M, Merkler D, Ziegler-Waldkirch S, Matthias P, Meyer-Luehmann M, Prinz M. Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner. Immunity. 2018 03 20; 48(3):514-529.e6. PMID: 29548672

Tay TL, Béchade C, D'Andrea I, St-Pierre MK, Henry MS, Roumier A, Tremblay ME. Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan. Front Mol Neurosci. 2017; 10:421. PMID: 29354029; PMCID: PMC5758507; DOI: 10.3389/fnmol.2017.00421;

Tay TL, Mai D, Dautzenberg J, Fernández-Klett F, Lin G, Sagar, Datta M, Drougard A, Stempfl T, Ardura-Fabregat A, Staszewski O, Margineanu A, Sporbert A, Steinmetz LM, Pospisilik JA, Jung S, Priller J, Grün D, Ronneberger O, Prinz M. A new fate mapping system reveals context-dependent random or clonal expansion of microglia. Nat Neurosci. 2017 Jun; 20(6):793-803. PMID: 28414331

Tay TL, Savage JC, Hui CW, Bisht K, Tremblay MÈ. Microglia across the lifespan: from origin to function in brain development, plasticity and cognition. J Physiol. 2017 03 15; 595(6):1929-1945. PMID: 27104646

Tay TL, Hagemeyer N, Prinz M. The force awakens: insights into the origin and formation of microglia. Curr Opin Neurobiol. 2016 08; 39:30-7. PMID: 27107946

Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, Basters A, Staszewski O, Brendecke SM, Spiess A, Tay TL, Kreutz C, Timmer J, Mancini GM, Blank T, Fritz G, Biber K, Lang R, Malo D, Merkler D, Heikenwälder M, Knobeloch KP, Prinz M. USP18 lack in microglia causes destructive interferonopathy of the mouse brain. EMBO J. 2015 Jun 12; 34(12):1612-29. PMID: 25896511

Prinz M, Tay TL, Wolf Y, Jung S. Microglia: unique and common features with other tissue macrophages. Acta Neuropathol. 2014 Sep; 128(3):319-31. PMID: 24652058

Goldmann T, Tay TL, Prinz M. Love and death: microglia, NLRP3 and the Alzheimer's brain. Cell Res. 2013 May; 23(5):595-6. PMID: 23399597

Tay TL, Ronneberger O, Ryu S, Nitschke R, Driever W. Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems. Nat Commun. 2011 Jan 25; 2:171. PMID: 21266970

Tay TL, Lin Q, Seow TK, Tan KH, Hew CL, Gong Z. Proteomic analysis of protein profiles during early development of the zebrafish, Danio rerio. Proteomics. 2006 May; 6(10):3176-88. PMID: 16622891

Gong Z, Wan H, Tay TL, Wang H, Chen M, Yan T. Development of transgenic fish for ornamental and bioreactor by strong expression of fluorescent proteins in the skeletal muscle. Biochem Biophys Res Commun. 2003 Aug 15; 308(1):58-63. PMID: 12890479

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 23 publications over 14 distinct years, with a maximum of 5 publications in 2018

Bar chart showing 23 publications over 14 distinct years, with a maximum of 5 publications in 2018

Year	Publications
2003	1
2006	1
2011	1
2013	1
2014	1
2015	1
2016	2
2017	1
2018	5
2019	3
2021	1
2022	3
2024	1
2025	1

2019 6th Venusberg Neuroinflammation Meeting: 1st Prize for Poster Presentation

2019-2020 Freiburg Institute for Advanced Studies, University of Freiburg: FRIAS Junior Fellow

2019-2021 German Scholars Organisation e. V. / Klaus Tschira Stiftung: Klaus Tschira Boost Fund Fellow

2018 Wissenschaftliche Gesellschaft Freiburg: Helmut Holzer Research Prize

2017 Faculty of Medicine, University of Freiburg: Faculty of Medicine Research Day: Poster Prize

2016-2017 University of Freiburg & Ministry for Science, Research and Arts, Baden-Württemberg, Germany: MWK Baden-Württemberg Research Seed Capital

2014-2016 German Research Foundation: Individual Research Grant

2013 Faculty of Medicine, University of Freiburg: Research Commission Grant

2005-2008 Research Training Program GRK 1104, German Research Foundation: Ph.D. Fellowship

2004 Human Genome Organization: Pacific Fellowship Award

2004 Society of Chinese Bioscientists in America: Scholarship

2003-2005 National University of Singapore Research: Scholarship

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