Tova Meshulam, PhD
Research Assistant Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, Technion - Israel Institute of Technology
MSc, Technion - Israel Institute of Technology




I receive my D.Sc. from the Technion in Israel studying the antibacterial activity of human polymorphonuclear neutrophil and the effect of the bacterial product on this process. During my post doctorate in the infectious department in BU I extended these studies to include the Fungicidal activity of both human polymorphonuclear neutrophils and human platelets using candida albicans hyphae and Aspergillus fumigatus as test organisms. In both studies I concentrated mainly on reactive oxygen species.

I used these expertise when I joined Millennium Pharmaceutical as a senior scientist in the antibacterial group and developed high throughput assays to detect antibacterial in collaborations with other companies using natural products.

Coming back to BU I joined the Pilch lab and studied the effect of Caveolins/caveolae in protecting adipocytes from fatty acid-mediated lipotoxicity by sequestering fatty acids on the cytoplasmic leaflet of the plasma membrane and augmenting triglyceride formation. In Barbara Corkey’s lab I started using human adipocytes and studied the Effects of Redox Couples on ROS Production and lipid turnover and the effect of food additives such as saccharine on the production of reactive oxygen species and the function of isolated beta cells, islets and adipocytes.

In the last few years I am the Assistant Co-director of the Adipose Tissue Biology and Nutrient Metabolism (ABM) core providing human peadipocytes and adipocytes as well as banked tissues. In addition we provide consultation to new investigators in the field.

Research Assistant Professor
Boston University School of Medicine
Medicine
Endocrinology, Diabetes, Nutrition & Weight Management

Associate
Boston University
Boston Nutrition Obesity Research Center


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Thomas DD, Stockman MC, Yu L, Meshulam T, McCarthy AC, Ionson A, Burritt N, Deeney J, Cabral H, Corkey B, Istfan N, Apovian CM. Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study. PLoS One. 2019; 14(12):e0226200.View Related Profiles. PMID: 31869355
     
  2. Jones Iv AR, Meshulam T, Oliveira MF, Burritt N, Corkey BE. Extracellular Redox Regulation of Intracellular Reactive Oxygen Generation, Mitochondrial Function and Lipid Turnover in Cultured Human Adipocytes. PLoS One. 2016; 11(10):e0164011.View Related Profiles. PMID: 27741233; DOI: 10.1371/journal.pone.0164011;
     
  3. Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T, Ding SY, Wu Y, Lee MJ, Gygi SP, Fried SK, Pilch PF. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab. 2015 Nov; 4(11):758-70.View Related Profiles. PMID: 26629401; DOI: 10.1016/j.molmet.2015.09.002;
     
  4. Meshulam T, Breen MR, Liu L, Parton RG, Pilch PF. Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity. J Lipid Res. 2011 Aug; 52(8):1526-32.View Related Profiles. PMID: 21652731; PMCID: PMC3137018; DOI: 10.1194/jlr.M015628;
     
  5. Pilch PF, Meshulam T, Ding S, Liu L. Caveolae and lipid trafficking in adipocytes. Clin Lipidol. 2011; 6(1):49-58.View Related Profiles. PMID: 21625349
     
  6. Simard JR, Meshulam T, Pillai BK, Kirber MT, Brunaldi K, Xu S, Pilch PF, Hamilton JA. Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity. J Lipid Res. 2010 May; 51(5):914-22.View Related Profiles. PMID: 20388923; PMCID: PMC2853459; DOI: 10.1194/jlr.M900251;
     
  7. Meshulam T, Simard JR, Wharton J, Hamilton JA, Pilch PF. Role of caveolin-1 and cholesterol in transmembrane fatty acid movement. Biochemistry. 2006 Mar 7; 45(9):2882-93.View Related Profiles. PMID: 16503643
     
  8. Joseph-McCarthy D, Parris K, Huang A, Failli A, Quagliato D, Dushin EG, Novikova E, Severina E, Tuckman M, Petersen PJ, Dean C, Fritz CC, Meshulam T, DeCenzo M, Dick L, McFadyen IJ, Somers WS, Lovering F, Gilbert AM. Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors. J Med Chem. 2005 Dec 15; 48(25):7960-9. PMID: 16335920
     
  9. Wharton J, Meshulam T, Vallega G, Pilch P. Dissociation of insulin receptor expression and signaling from caveolin-1 expression. J Biol Chem. 2005 Apr 8; 280(14):13483-6.View Related Profiles. PMID: 15699039
     
  10. Christin L, Wysong DR, Meshulam T, Hastey R, Simons ER, Diamond RD. Human platelets damage Aspergillus fumigatus hyphae and may supplement killing by neutrophils. Infect Immun. 1998 Mar; 66(3):1181-9.View Related Profiles. PMID: 9488412; PMCID: PMC108032
     
Showing 10 of 40 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 35 publications over 20 distinct years, with a maximum of 3 publications in 1982 and 1986 and 1987 and 1988 and 1995

YearPublications
19811
19823
19831
19841
19852
19863
19873
19883
19892
19922
19953
19971
19981
20052
20061
20101
20112
20151
20161
20191

Contact for Mentoring:

72 E. Concord Street K-6
Boston MA 02118
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