I receive my D.Sc. from the Technion in Israel studying the antibacterial activity of human polymorphonuclear neutrophil and the effect of the bacterial product on this process. During my post doctorate in the infectious department in BU I extended these studies to include the Fungicidal activity of both human polymorphonuclear neutrophils and human platelets using candida albicans hyphae and Aspergillus fumigatus as test organisms. In both studies I concentrated mainly on reactive oxygen species.
I used these expertise when I joined Millennium Pharmaceutical as a senior scientist in the antibacterial group and developed high throughput assays to detect antibacterial in collaborations with other companies using natural products.
Coming back to BU I joined the Pilch lab and studied the effect of Caveolins/caveolae in protecting adipocytes from fatty acid-mediated lipotoxicity by sequestering fatty acids on the cytoplasmic leaflet of the plasma membrane and augmenting triglyceride formation. In Barbara Corkey’s lab I started using human adipocytes and studied the Effects of Redox Couples on ROS Production and lipid turnover and the effect of food additives such as saccharine on the production of reactive oxygen species and the function of isolated beta cells, islets and adipocytes.
In the last few years I am the Assistant Co-director of the Adipose Tissue Biology and Nutrient Metabolism (ABM) core providing human peadipocytes and adipocytes as well as banked tissues. In addition we provide consultation to new investigators in the field.
Research Assistant Professor
Boston University School of Medicine
Endocrinology, Diabetes, Nutrition & Weight Management
Boston Nutrition Obesity Research Center
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
to make corrections and additions.
Showing 10 of 42 results.
Istfan N, Hasson B, Apovian C, Meshulam T, Yu L, Anderson W, Corkey BE. Acute Carbohydrate Overfeeding: A Redox Model of Insulin Action and Its Impact on Metabolic Dysfunction in Humans. Am J Physiol Endocrinol Metab. 2021 Sep 27.View Related Profiles. PMID: 34569273
Batista ML, Meshulam T, Desevin K, Rabhi N, Farmer SR. Three-Dimensional Adipocyte Culture as a Model to Study Cachexia-Induced White Adipose Tissue Remodeling. J Vis Exp. 2021 01 18; (167).View Related Profiles. PMID: 33522508
Thomas DD, Stockman MC, Yu L, Meshulam T, McCarthy AC, Ionson A, Burritt N, Deeney J, Cabral H, Corkey B, Istfan N, Apovian CM. Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study. PLoS One. 2019; 14(12):e0226200.View Related Profiles. PMID: 31869355; PMCID: PMC6927614; DOI: 10.1371/journal.pone.0226200;
Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T, Ding SY, Wu Y, Lee MJ, Gygi SP, Fried SK, Pilch PF. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab. 2015 Nov; 4(11):758-70.View Related Profiles. PMID: 26629401; PMCID: PMC4632174; DOI: 10.1016/j.molmet.2015.09.002;
Simard JR, Meshulam T, Pillai BK, Kirber MT, Brunaldi K, Xu S, Pilch PF, Hamilton JA. Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity. J Lipid Res. 2010 May; 51(5):914-22.View Related Profiles. PMID: 20388923; PMCID: PMC2853459; DOI: 10.1194/jlr.M900251;
Meshulam T, Simard JR, Wharton J, Hamilton JA, Pilch PF. Role of caveolin-1 and cholesterol in transmembrane fatty acid movement. Biochemistry. 2006 Mar 7; 45(9):2882-93.View Related Profiles. PMID: 16503643
Joseph-McCarthy D, Parris K, Huang A, Failli A, Quagliato D, Dushin EG, Novikova E, Severina E, Tuckman M, Petersen PJ, Dean C, Fritz CC, Meshulam T, DeCenzo M, Dick L, McFadyen IJ, Somers WS, Lovering F, Gilbert AM. Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors. J Med Chem. 2005 Dec 15; 48(25):7960-9. PMID: 16335920
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