Tomoki Motegi | Profiles RNS

Tomoki Motegi, PhD

Postdoctoral Associate NRSA (previously held)

Boston University Chobanian & Avedisian School of Medicine

Computational Biomedicine

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ORCID : 0000-0002-6811-0973

Publications
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Kato T, Okauchi N, Motegi T, Sakurai M, Maeda S, Kato D, Nakagawa T, Uchida K, Mizuno T, Igase M. Lactic acid regulates antitumor immunity in canine invasive urothelial carcinoma. PLoS One. 2025; 20(9):e0332825. PMID: 40966256; PMCID: PMC12445541; DOI: 10.1371/journal.pone.0332825;

Motegi T. Comments on the Antimicrobial Use Guidelines for Canine Pyoderma by the International Society for Companion Animal Infectious Diseases. Vet Dermatol. 2025 Oct; 36(5):529-530. PMID: 40804015

Motegi T, Fukuoka R, Tsuyuki Y, Nagakubo D, Maeda S, Yonezawa T, Nishimura R, Momoi Y. Evaluating a Targeted Antimicrobial Stewardship Program and Its Temporal Association with Resistance Trends in a Veterinary Referral Hospital. Vet Sci. 2025 Aug 08; 12(8). PMID: 40872694; PMCID: PMC12390016; DOI: 10.3390/vetsci12080743;

Kurihara M, Solano M, Motegi T. Assessment of the thorax is equivalent when presented with whole body versus collimated thoracic radiographs in dogs and cats. BMC Vet Res. 2025 Apr 14; 21(1):267. PMID: 40223060; PMCID: PMC11995587; DOI: 10.1186/s12917-025-04729-5;

Takahashi Y, Kato D, Maeda S, Motegi T, Fujita A, Hashimoto Y, Nakagawa T, Nishimura R. Outcomes of total cystectomy with medical treatment in canine urothelial carcinoma of the bladder trigone. Can Vet J. 2025 Mar; 66(3):318-326. PMID: 40070938; PMCID: PMC11891803

Tanaka T, Motegi T, Sumikawa N, Mori M, Kurokawa S, Akiyoshi H. Early Enhancement in Contrast-Enhanced Computed Tomography Is an Index of DUSP9, SLPI, ALDH1L2, and SLC1A1 Expression in Canine Hepatocellular Carcinoma: A Preliminary Study. Vet Sci. 2025 Feb 07; 12(2). PMID: 40005897; PMCID: PMC11860268; DOI: 10.3390/vetsci12020137;

Matsuda N, Ito M, Nukada Y, Toyoma M, Nagai K, Motegi T, Morita T, Yamasaki M. Analysis of gene expression of Babesia gibsoni cultured with diminazene aceturate using RNA sequencing. J Vet Med Sci. 2025 Feb 04; 87(2):181-188. PMID: 39756884; PMCID: PMC11830443; DOI: 10.1292/jvms.24-0395;

Tanaka T, Motegi T, Mori M, Sumikawa N, Maeda K, Iimori Y, Akiyoshi H. Candidate genes in canine hepatocellular carcinoma for molecular targeted therapy. BMC Res Notes. 2024 Dec 02; 17(1):357. PMID: 39623442; PMCID: PMC11613665; DOI: 10.1186/s13104-024-07016-y;

Nagao I, Motegi T, Goto-Koshino Y, Tsuboi M, Takahashi N, Chambers JK, Uchida K, Baba K, Tomiyasu H, Okuda M. Comprehensive gene expression analysis in gallbladder mucosal epithelial cells of dogs with gallbladder mucocele. J Vet Intern Med. 2024; 38(6):3031-3037. PMID: 39529599; PMCID: PMC11586547; DOI: 10.1111/jvim.17157;

Yonezawa T, Takenouchi S, Motegi T, Miyazaki M, Nagata N, Kobayashi K, Yamada M, Murata T. Lipid metabolites and nitric oxide production in the cerebrospinal fluid and plasma of dogs with meningoencephalitis of unknown origin and idiopathic epilepsy: a pilot study. Front Vet Sci. 2024; 11:1397868. PMID: 38983766; PMCID: PMC11232469; DOI: 10.3389/fvets.2024.1397868;

Showing 10 of 35 results. Show More

Kusumoto M, Narita H, Motegi T, Harada K. Estimation of latamoxef (moxalactam) dosage regimens against ß-lactamase-producing Enterobacterales in dogs: a pharmacokinetic and pharmacodynamic analysis using Monte Carlo simulation. J Vet Med Sci. 2024 Aug 02; 86(8):841-846. PMID: 38897952; PMCID: PMC11300127; DOI: 10.1292/jvms.24-0197;

Kaji K, Motegi T, Yonezawa T, Momoi Y, Maeda S. Anti-tumour effects of lapatinib on HER2-positive canine prostatic carcinoma cell lines. Open Vet J. 2024 May; 14(5):1259-1268. PMID: 38938437; PMCID: PMC11199751; DOI: 10.5455/OVJ.2024.v14.i5.21;

Miyanishi K, Igase M, Murakami M, Sakai Y, Sakurai M, Tani K, Motegi T, Mizuno T. Establishment of a novel canine soft tissue sarcoma cell line and comparison of its characteristics with other soft tissue sarcoma cell lines. Res Vet Sci. 2024 May; 171:105245. PMID: 38554610

Kusumoto M, Jitsuiki M, Motegi T, Harada K. Pharmacokinetic and Pharmacodynamic Analysis of the Oxacephem Antibiotic Flomoxef against Extended-Spectrum ß-Lactamase-Producing Enterobacterales from Dogs. Int J Mol Sci. 2024 Jan 16; 25(2). PMID: 38256182; PMCID: PMC10816067; DOI: 10.3390/ijms25021105;

Toyoda H, Tani A, Goto-Koshino Y, Motegi T, Sakamoto M, Mochizuki T, Harada K, Kobayashi T, Setoguchi A, Shizuta Y, Mizuno T, Irie M, Nakamichi J, Tsujimoto H, Ohmi A, Fukuoka R, Nakamura Y, Tomiyasu H. Gene expression profiles associated with early relapse during first remission induction in canine multicentric high-grade B-cell lymphoma. J Vet Med Sci. 2024 Jan 10; 86(1):18-27. PMID: 37952972; PMCID: PMC10849849; DOI: 10.1292/jvms.23-0269;

Shinada M, Kato D, Motegi T, Tsuboi M, Ikeda N, Aoki S, Iguchi T, Li T, Kodera Y, Ota R, Hashimoto Y, Takahashi Y, Chambers J, Uchida K, Kato Y, Nishimura R, Nakagawa T. Podoplanin Drives Amoeboid Invasion in Canine and Human Mucosal Melanoma. Mol Cancer Res. 2023 Nov 01; 21(11):1205-1219. PMID: 37493578

Kusumoto M, Motegi T, Uno H, Yokono M, Harada K. Pharmacokinetic-pharmacodynamic analysis of cefmetazole against extended-spectrum ß-lactamase-producing Enterobacteriaceae in dogs using Monte Carlo Simulation. Front Vet Sci. 2023; 10:1270137. PMID: 37841458; PMCID: PMC10569024; DOI: 10.3389/fvets.2023.1270137;

Yonezawa T, Marasigan CNBB, Matsumiya Y, Maeda S, Motegi T, Momoi Y. Effects of high-dose docosahexaenoic acid supplementation as an add-on therapy for canine idiopathic epilepsy: A pilot study. Open Vet J. 2023 Jul; 13(7):942-947. PMID: 37614731; PMCID: PMC10443822; DOI: 10.5455/OVJ.2023.v13.i7.14;

Yoshida S, Maeda S, Yonezawa T, Motegi T. Evaluation of antiseizure medications including zonisamide in feline idiopathic epilepsy at a referral hospital in Japan. Open Vet J. 2023 Jul; 13(7):846-853. PMID: 37614732; PMCID: PMC10443824; DOI: 10.5455/OVJ.2023.v13.i7.6;

Shitamori F, Nonogaki A, Motegi T, Matsumoto Y, Sakamoto M, Tanizawa Y, Nakamura Y, Yonezawa T, Momoi Y, Maeda S. Large-scale epidemiological study on feline autosomal dominant polycystic kidney disease and identification of novel PKD1 gene variants. J Feline Med Surg. 2023 Jul; 25(7):1098612X231185393. PMID: 37489504; PMCID: PMC10812055; DOI: 10.1177/1098612X231185393;

Uchida M, Matsumiya Y, Tsuboi M, Uchida K, Nakagawa T, Fujii W, Kobayashi T, Tsujimoto H, Ohmi A, Tomiyasu H, Motegi T, Maeda S, Momoi Y, Yonezawa T. Serum level of apoptosis inhibitor of macrophage in dogs with histiocytic sarcoma and its association with the disease. Vet Comp Oncol. 2023 Sep; 21(3):391-400. PMID: 37088561

Shinomiya Y, Takagaki S, Kawakami Y, Motegi T. Contrasting treatment responses by Burkholderia cepacia complex-related deep pyoderma: A series of two cases. Open Vet J. 2022; 12(3):308-311. PMID: 35821768; PMCID: PMC9270938; DOI: 10.5455/OVJ.2022.v12.i3.1;

Hirabayashi M, Chambers JK, Tani A, Tomiyasu H, Motegi T, Rimpo K, Nakayama H, Uchida K. mRNA sequencing analysis and growth inhibitory effects of palbociclib on cell lines from canine histiocytic proliferative disorders. Vet Comp Oncol. 2022 Sep; 20(3):587-601. PMID: 35278028

Sakai K, Motegi T, Chambers JK, Uchida K, Nishida H, Shimamura S, Tani H, Shimada T, Furuya M. Dystrophin-deficient muscular dystrophy in a Toy Poodle with a single base pair insertion in exon 45 of the Duchenne muscular dystrophy gene. J Vet Med Sci. 2022 Apr 13; 84(4):502-506. PMID: 35135937; PMCID: PMC9096033; DOI: 10.1292/jvms.21-0504;

Maeda S, Motegi T, Iio A, Kaji K, Goto-Koshino Y, Eto S, Ikeda N, Nakagawa T, Nishimura R, Yonezawa T, Momoi Y. Anti-CCR4 treatment depletes regulatory T cells and leads to clinical activity in a canine model of advanced prostate cancer. J Immunother Cancer. 2022 Feb; 10(2). PMID: 35131860; PMCID: PMC8804701; DOI: 10.1136/jitc-2021-003731;

Maeda S, Sakai K, Kaji K, Iio A, Nakazawa M, Motegi T, Yonezawa T, Momoi Y. Lapatinib as first-line treatment for muscle-invasive urothelial carcinoma in dogs. Sci Rep. 2022 Jan 13; 12(1):4. PMID: 35027594; PMCID: PMC8758709; DOI: 10.1038/s41598-021-04229-0;

Nishi R, Motegi T, Maeda S, Tamahara S, Momoi Y, Matsuki N, Yonezawa T. Clinical assessment of testosterone analogues for urethral sphincter mechanism incompetence in ten spayed female dogs. J Vet Med Sci. 2021 Mar 05; 83(2):274-279. PMID: 33441521; PMCID: PMC7972894; DOI: 10.1292/jvms.20-0515;

Takahashi J, Kanda S, Imanishi I, Hisano T, Fukamachi T, Taguchi N, Momiyama S, Nishiyama S, Motegi T, Iyori K. Efficacy and safety of 0.0584% hydrocortisone aceponate topical spray and systemic oclacitinib combination therapy in dogs with atopic dermatitis: a randomized, double-blinded, placebo-controlled trial. Vet Dermatol. 2021 Apr; 32(2):119-e25. PMID: 33185330

Iio A, Maeda S, Yonezawa T, Momoi Y, Motegi T. Isolated growth hormone deficiency in a Chihuahua with a GH1 mutation. J Vet Diagn Invest. 2020 Sep; 32(5):733-736. PMID: 32646299; PMCID: PMC7488967; DOI: 10.1177/1040638720938671;

Motegi T, Kochi Y, Matsuda K, Kubo M, Yamamoto K, Momozawa Y. Identification of rare coding variants in TYK2 protective for rheumatoid arthritis in the Japanese population and their effects on cytokine signalling. Ann Rheum Dis. 2019 Aug; 78(8):1062-1069. PMID: 31118190

Motegi T, Tomiyasu H, Goto-Koshino Y, Takahashi M, Hiyoshi-Kanemoto S, Fujino Y, Ohno K, Tsuimoto H. Prognostic value of CD44 variant isoform expression in dogs with multicentric high-grade B-cell lymphoma. Am J Vet Res. 2018 Sep; 79(9):961-969. PMID: 30153061

Suenaga M, Tomiyasu H, Watanabe M, Ogawa K, Motegi T, Goto-Koshino Y, Ohno K, Sugano S, Skorupski KA, Tsujimoto H. Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma. Vet J. 2017 Oct; 228:18-21. PMID: 29153103

Okamura Y, Heishima K, Motegi T, Sasaki J, Goryo M, Nishida H, Tsuchiya H, Katayama M, Uzuka Y. Mandibular Reconstruction by Using a Liquid Nitrogen-Treated Autograft in a Dog with an Oral Tumor. J Am Anim Hosp Assoc. 2017; 53(3):167-171. PMID: 28291396

Katayama M, Tsuchiaka S, Motegi T, Miyazaki M, Yamashita T, Shimamura S, Okamura Y, Uzuka Y. High-molecular-weight polyethylene glycol enhances hypothermic storage of feline kidney cells. J Vet Med Sci. 2014 Jun; 76(6):923-6. PMID: 24599064

Motegi T, Katayama M, Uzuka Y, Okamura Y. Evaluation of anticancer effects and enhanced doxorubicin cytotoxicity of xanthine derivatives using canine hemangiosarcoma cell lines. Res Vet Sci. 2013 Oct; 95(2):600-5. PMID: 23871419

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 35 publications over 11 distinct years, with a maximum of 8 publications in 2024

Bar chart showing 35 publications over 11 distinct years, with a maximum of 8 publications in 2024

Year	Publications
2013	1
2014	1
2017	2
2018	1
2019	1
2020	2
2021	1
2022	5
2023	7
2024	8
2025	6

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72 E. Concord St
Boston MA 02118
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