Timothy O'Shea, PhD
Assistant Professor
Boston University College of Engineering
Dept of Biomedical Engineering

PhD, Massachusetts Institute of Technology
ME/MEng, Queensland University of Technology




Dr. Timothy O'Shea is an Assistant Professor in the Biomedical Engineering department at Boston University. He grew up in Brisbane, Australia and moved to the USA in 2009 for graduate study supported by a John Monash Scholarship. His research group is focused on developing new treatments for brain and spinal cord disorders by engineering glia to perform specific reparative functions. He is interested in understanding how glia respond in injury and disease using animal models and developing new bioengineering tools to regulate their functions. His labs bioengineering toolkit includes biomaterials composed of polymers with supramolecular functionality and tunable physiochemical and biological properties as well as transgenic neural cell lines that we use for transplantation studies and interrogating glia-biomaterial interactions. His current research initiatives include: (i) testing strategies to ‘re-neuralize’ stroke and spinal cord injury lesions by reinstating functional glial frameworks into non-neural lesion cores; (ii) improving the performance of neural implants by regulating the biomaterial-neural interface using glia engineering; and (iii) developing and testing drug delivery strategies to preferentially target therapies to dysfunctional glia responsible for disease.


Glia repair of chronic SCI lesion cores by a sequential enzymatic debridement and cell grafting strategy
07/01/2022 - 06/30/2024 (PI)
Wings for Life


Promoting astroglial maturation of NPC grafts in SCI lesion cores using immunomodulatory hydrogels
07/31/2021 - 07/30/2023 (PI)
Craig H. Neilsen Foundation


Promoting glia-based repair in spinal cord injury
06/01/2021 - 05/31/2022 (PI)
Bryon Riesch Paralysis Foundation




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. O’Shea, T.M., Wollenberg, A.L., Kim, J.H., Ao, Y. Deming, T.J. and Sofroniew M.V. Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions. Nature Communications. 2020; 11:6203.
  2. *Garrett, M.C., O’Shea, T.M., Wollenberg, A.L., Bernstein, A.M., Hung, D., Staarman, B., Soto, H., Deming, T.J., Sofroniew M.V., and Kornblum, H.I. Injectable diblock copolypeptide hydrogel provides platform to maintain high local concentrations of taxol and local tumor control. Plos One. 2020; 15 (7):e0219632.
  3. Anderson MA, O'Shea TM, Burda JE, Ao Y, Barlatey SL, Bernstein AM, Kim JH, James ND, Rogers A, Kato B, Wollenberg AL, Kawaguchi R, Coppola G, Wang C, Deming TJ, He Z, Courtine G, Sofroniew MV. Required growth facilitators propel axon regeneration across complete spinal cord injury. Nature. 2018 09; 561(7723):396-400. PMID: 30158698; PMCID: PMC6151128; DOI: 10.1038/s41586-018-0467-6;
     
  4. Wollenberg AL, O'Shea TM, Kim JH, Czechanski A, Reinholdt LG, Sofroniew MV, Deming TJ. Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery. Biomaterials. 2018 09; 178:527-545. PMID: 29657091; PMCID: PMC6054810; DOI: 10.1016/j.biomaterials.2018.03.057;
     
  5. *Anderson, M.A., *O’Shea, T.M., Burda, J.E., Ao, Y., Barlatey, S.L., Bernstein A.M., Kim, J.H., James, N.D., Rogers, A., Kato, B., Wollenberg, A.L., Kawaguchi, R., Coppola, G., Wang, C., Deming, T.J., He, Z., Courtine, G., and Sofroniew M.V. Required growth facilitators propel axon regeneration across complete spinal cord injury. Nature. 2018; 561:396–400.
  6. Wollenberg, A.L. *O’Shea, T.M., Kim, J., Sofroniew M.V., and Deming, T.J. Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery. Biomaterials. 2018; 178:527-545.
  7. Sun Y, Wollenberg AL, O'Shea TM, Cui Y, Zhou ZH, Sofroniew MV, Deming TJ. Conformation-Directed Formation of Self-Healing Diblock Copolypeptide Hydrogels via Polyion Complexation. J Am Chem Soc. 2017 10 25; 139(42):15114-15121. PMID: 28976744; PMCID: PMC6037417; DOI: 10.1021/jacs.7b08190;
     
  8. Martinez-Moreno M, O'Shea TM, Zepecki JP, Olaru A, Ness JK, Langer R, Tapinos N. Regulation of Peripheral Myelination through Transcriptional Buffering of Egr2 by an Antisense Long Non-coding RNA. Cell Rep. 2017 Aug 22; 20(8):1950-1963. PMID: 28834756; PMCID: PMC5800313; DOI: 10.1016/j.celrep.2017.07.068;
     
  9. O'Shea TM, Burda JE, Sofroniew MV. Cell biology of spinal cord injury and repair. J Clin Invest. 2017 Sep 01; 127(9):3259-3270. PMID: 28737515; PMCID: PMC5669582; DOI: 10.1172/JCI90608;
     
  10. Slotkin JR, Pritchard CD, Luque B, Ye J, Layer RT, Lawrence MS, O'Shea TM, Roy RR, Zhong H, Vollenweider I, Edgerton VR, Courtine G, Woodard EJ, Langer R. Biodegradable scaffolds promote tissue remodeling and functional improvement in non-human primates with acute spinal cord injury. Biomaterials. 2017 04; 123:63-76. PMID: 28167393; DOI: 10.1016/j.biomaterials.2017.01.024;
     
Showing 10 of 30 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 30 publications over 9 distinct years, with a maximum of 11 publications in 2017

YearPublications
20081
20102
20112
20142
20152
20164
201711
20184
20202


2019 Wings for Life Spinal Cord Foundation Postdoctoral Fellowship
2018 American Australian Association Keith Murdoch Scholarship
2018 Paralyzed Veterans of America (PVA) Research Foundation Fellowship
2016 Craig H Neilsen Postdoctoral Fellowship in Translational Spinal Cord Injury Research
2015 MISTI Global Seed Fund Student Award for research collaboration with Ben Gurion University, Israel
2015 HST Martha Gray Prize for Excellence in Research
2013 Langer Summit on Neurotrauma Prize
2012 HST Idea2 Fellowship for novel and inspiring ideas in medical research
2012 Society of Chemical Industry Perkins Student Scholarship
2010 Ohio State University: Spinal Cord Injury Training Program
2009 Harvard-MIT Division of Health Sciences and Technology Fellowship
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44 Cummington St, Boston MA 02215
Boston MA 02215
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