Thilina Alawathugoda
Postdoctoral Associate
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics




At Boston University School of Medicine, my dedication is directed toward elucidating genetic mechanisms responsible for the onset of Alzheimer's disease. With a robust background in protein isolation and cell biology, my previous focus has been on the impact of maternal obesity on embryonic neurogenesis.

My research, harnessing small animal models and human induced pluripotent stem cells, has illuminated pathways in biomedical sciences. This work not only furthers our understanding of complex diseases but also paves the way for innovative preventative strategies, reflecting my commitment to improving global health outcomes.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Alawathugoda TT, Sheikh MA, Challagandla AK, Dheen ST, Emerald BS, Ansari SA. Maternal obesity alters histone modifications mediated by the interaction between EZH2 and AMPK, impairing neural differentiation in the developing embryonic brain cortex. J Biol Chem. 2025 Jan 10; 301(2):108173. PMID: 39798880; PMCID: PMC11847741; DOI: 10.1016/j.jbc.2025.108173;
     
  2. Sheikh MA, Alawathugoda TT, Vyas G, Emerald BS, Ansari SA. O-GlcNAc transferase promotes glioblastoma by modulating genes responsible for cell survival, invasion, and inflammation. J Biol Chem. 2023 Oct; 299(10):105235. PMID: 37689115; PMCID: PMC10570119; DOI: 10.1016/j.jbc.2023.105235;
     
  3. Varghese DS, Alawathugoda TT, Sheikh MA, Challagandla AK, Emerald BS, Ansari SA. Developmental modeling of hepatogenesis using obese iPSCs-hepatocyte differentiation uncovers pathological features. Cell Death Dis. 2022 Aug 01; 13(8):670. PMID: 35915082; PMCID: PMC9343434; DOI: 10.1038/s41419-022-05125-9;
     
  4. Parween S, Alawathugoda TT, Prabakaran AD, Dheen ST, Morse RH, Emerald BS, Ansari SA. Nutrient sensitive protein O-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis. Life Sci Alliance. 2022 Aug; 5(8). PMID: 35470239; PMCID: PMC9039347; DOI: 10.26508/lsa.202201385;
     
  5. Varghese DS, Alawathugoda TT, Ansari SA. Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches. Stem Cells Int. 2019; 2019:5968236. PMID: 30805010
     

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 5 publications over 4 distinct years, with a maximum of 2 publications in 2022

YearPublications
20191
20222
20231
20251

Contact for Mentoring:

72 E Concord St
Boston MA 02118
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