| Profiles RNS

Profile

PhD, Massachusetts Institute of Technology
BS, University of Connecticut

Websites

Research
Publications

BU Research
NIH RePORTER Research

Defining programs of gene expression regulated by Ikaros in T cells
01/11/2018 - 12/31/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R03AI133228-02

Elucidation of Ikaros function in peripheral T cell responses in vivo
01/01/2016 - 04/30/2018 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI113522-02

Mechanism of Notch-induced leukemogenesis in lymphocytes
01/01/2014 - 12/31/2015 (PI)
NIH/National Cancer Institute
5R21CA176811-02

Generation of Ikaros conditional knockout mice
07/20/2011 - 06/30/2013 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R03AI094199-02

The Molecular Role of the Ikaros in Leukemogenesis
04/01/2006 - 02/28/2012 (PI)
NIH/National Cancer Institute
7R01CA104962-05

Title

Yr	Title	Project-Sub Proj	Pubs
2019	Defining programs of gene expression regulated by Ikaros in T cells	5R03AI133228-02	1
2018	Defining programs of gene expression regulated by Ikaros in T cells	1R03AI133228-01A1	1
2017	Elucidation of Ikaros function in peripheral T cell responses in vivo	5R21AI113522-02	1
2016	Elucidation of Ikaros function in peripheral T cell responses in vivo	1R21AI113522-01A1	1
2015	Mechanism of Notch-induced leukemogenesis in lymphocytes	5R21CA176811-02	2
2014	Mechanism of Notch-induced leukemogenesis in lymphocytes	1R21CA176811-01A1	2
2012	Generation of Ikaros conditional knockout mice	5R03AI094199-02
2011	Generation of Ikaros conditional knockout mice	1R03AI094199-01A1
2010	Ikaros regulates T helper cell fate decisions	1R56AI082407-01A2	1
2010	The role of Ikaros in regulation of Notch target gene expression	7R21AI078146-03	1

Showing 10 of 16 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Lyon de Ana C, Arakcheeva K, Agnihotri P, Derosia N, Winandy S. Lack of Ikaros Deregulates Inflammatory Gene Programs in T Cells. J Immunol. 2019 02 15; 202(4):1112-1123.View Related Profiles.

Agnihotri, Parul
Winandy, Susan

PMID: 30635395; PMCID: PMC6365004; DOI: 10.4049/jimmunol.1801270;

Steinbuck MP, Winandy S. A Review of Notch Processing With New Insights Into Ligand-Independent Notch Signaling in T-Cells. Front Immunol. 2018; 9:1230.View Related Profiles.

Steinbuck, Martin Peter
Winandy, Susan

PMID: 29910816; PMCID: PMC5992298; DOI: 10.3389/fimmu.2018.01230;

Steinbuck MP, Arakcheeva K, Winandy S. Novel TCR-Mediated Mechanisms of Notch Activation and Signaling. J Immunol. 2018 02 01; 200(3):997-1007.View Related Profiles.

Steinbuck, Martin Peter
Winandy, Susan

PMID: 29288204; PMCID: PMC5854196; DOI: 10.4049/jimmunol.1700070;

Agnihotri P, Robertson NM, Umetsu SE, Arakcheeva K, Winandy S. Lack of Ikaros cripples expression of Foxo1 and its targets in naive T cells. Immunology. 2017 Nov; 152(3):494-506.View Related Profiles.

Agnihotri, Parul
Winandy, Susan

PMID: 28670688; PMCID: PMC5629446; DOI: 10.1111/imm.12786;

Winandy S. Ikaros to the rescue of TCR-a chain gene rearrangement. Eur J Immunol. 2013 Feb; 43(2):314-7. PMID: 23299235; DOI: 10.1002/eji.201243272;

Malinge S, Thiollier C, Chlon TM, Doré LC, Diebold L, Bluteau O, Mabialah V, Vainchenker W, Dessen P, Winandy S, Mercher T, Crispino JD. Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling. Blood. 2013 Mar 28; 121(13):2440-51. PMID: 23335373; PMCID: PMC3612856; DOI: 10.1182/blood-2012-08-450627;

Toubai T, Sun Y, Tawara I, Friedman A, Liu C, Evers R, Nieves E, Malter C, Chockley P, Maillard I, Winandy S, Reddy P. Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease. Blood. 2011 Jul 7; 118(1):192-204. PMID: 21471527; PMCID: PMC3139384; DOI: 10.1182/blood-2010-12-324616;

Chari S, Umetsu SE, Winandy S. Notch target gene deregulation and maintenance of the leukemogenic phenotype do not require RBP-J kappa in Ikaros null mice. J Immunol. 2010 Jul 1; 185(1):410-7. PMID: 20511547; PMCID: PMC2955868; DOI: 10.4049/jimmunol.0903688;

Umetsu SE, Winandy S. Ikaros is a regulator of Il10 expression in CD4+ T cells. J Immunol. 2009 Nov 1; 183(9):5518-25. PMID: 19828627; PMCID: PMC2778601; DOI: 10.4049/jimmunol.0901284;

Urban JA, Brugmann W, Winandy S. Cutting Edge: Ikaros null thymocytes mature into the CD4 lineage with reduced TCR signal: A study using CD3{zeta} immunoreceptor tyrosine-based activation motif transgenic mice. J Immunol. 2009 Apr 1; 182(7):3955-9. PMID: 19299690; PMCID: PMC2777666; DOI: 10.4049/jimmunol.0802869;

Showing 10 of 28 results. Show More

Quirion MR, Gregory GD, Umetsu SE, Winandy S, Brown MA. Cutting edge: Ikaros is a regulator of Th2 cell differentiation. J Immunol. 2009 Jan 15; 182(2):741-5. PMID: 19124715; PMCID: PMC2718557; DOI: 10.4049/jimmunol.182.2.741;

Chari S, Winandy S. Ikaros regulates Notch target gene expression in developing thymocytes. J Immunol. 2008 Nov 1; 181(9):6265-74. PMID: 18941217; PMCID: PMC2778602; DOI: 10.4049/jimmunol.181.9.6265;

Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol. 2008 Aug; 9(8):927-36. PMID: 18568028; PMCID: PMC2699484; DOI: 10.1038/ni.1626;

Kathrein KL, Chari S, Winandy S. Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation. J Biol Chem. 2008 Apr 18; 283(16):10476-84. PMID: 18287091; PMCID: PMC2447659; DOI: 10.1074/jbc.M709643200;

Thomas RM, Chunder N, Chen C, Umetsu SE, Winandy S, Wells AD. Ikaros enforces the costimulatory requirement for IL2 gene expression and is required for anergy induction in CD4+ T lymphocytes. J Immunol. 2007 Dec 1; 179(11):7305-15. PMID: 18025173

Winandy S, Brown M. No DL1 Notch ligand? GATA be a mast cell. Nat Immunol. 2007 Aug; 8(8):796-8. PMID: 17641659

Wojcik H, Griffiths E, Staggs S, Hagman J, Winandy S. Expression of a non-DNA-binding Ikaros isoform exclusively in B cells leads to autoimmunity but not leukemogenesis. Eur J Immunol. 2007 Apr; 37(4):1022-32. PMID: 17357110

Gregory GD, Raju SS, Winandy S, Brown MA. Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE. J Clin Invest. 2006 May; 116(5):1327-36. PMID: 16628252; PMCID: PMC1440706; DOI: 10.1172/JCI27227;

Winandy S. Regulation of chromatin structure during thymic T cell development. J Cell Biochem. 2005 Jun 1; 95(3):466-77. PMID: 15832342

Kathrein KL, Lorenz R, Innes AM, Griffiths E, Winandy S. Ikaros induces quiescence and T-cell differentiation in a leukemia cell line. Mol Cell Biol. 2005 Mar; 25(5):1645-54. PMID: 15713624; PMCID: PMC549358; DOI: 10.1128/MCB.25.5.1645-1654.2005;

Urban JA, Winandy S. Ikaros null mice display defects in T cell selection and CD4 versus CD8 lineage decisions. J Immunol. 2004 Oct 1; 173(7):4470-8. PMID: 15383578

Winandy S, Wu L, Wang JH, Georgopoulos K. Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros. J Exp Med. 1999 Oct 18; 190(8):1039-48. PMID: 10523602; PMCID: PMC2195663

Avitahl N, Winandy S, Friedrich C, Jones B, Ge Y, Georgopoulos K. Ikaros sets thresholds for T cell activation and regulates chromosome propagation. Immunity. 1999 Mar; 10(3):333-43. PMID: 10204489

Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, Winandy S, Viel A, Sawyer A, Ikeda T, Kingston R, Georgopoulos K. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity. 1999 Mar; 10(3):345-55. PMID: 10204490

Koipally J, Kim J, Jones B, Jackson A, Avitahl N, Winandy S, Trevisan M, Nichogiannopoulou A, Kelley C, Georgopoulos K. Ikaros chromatin remodeling complexes in the control of differentiation of the hemo-lymphoid system. Cold Spring Harb Symp Quant Biol. 1999; 64:79-86. PMID: 11232340

Georgopoulos K, Winandy S, Avitahl N. The role of the Ikaros gene in lymphocyte development and homeostasis. Annu Rev Immunol. 1997; 15:155-76. PMID: 9143685

Winandy S, Wu P, Georgopoulos K. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell. 1995 Oct 20; 83(2):289-99. PMID: 7585946

Georgopoulos K, Bigby M, Wang JH, Molnar A, Wu P, Winandy S, Sharpe A. The Ikaros gene is required for the development of all lymphoid lineages. Cell. 1994 Oct 7; 79(1):143-56. PMID: 7923373

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Contact for Mentoring: