Shilpa Kuttikrishnan

Postdoctoral Associate

Boston University Chobanian & Avedisian School of Medicine

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Versatile researcher with a decade of hands on experience conducting experiments in molecular and cell biology. Worked on exploring the molecular pathways involved in cancer and investigating potential anti-cancer agents.Currently working as a postdoctoral research associate at Boston University, focusing on host-pathogen interactions, viral-molecular biology, and countermeasures.Author of numerous publications in peer- reviewed international journals.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Prabhu KS, Mariyam Z, Rahman SA, Kuttikrishnan S, Ahmad F, Habeeba U, Khan AQ, Raza A, Dermime S, Gehani SA, Junejo K, Uddin S. Targeting mTOR and Its Associated Signaling to Induce Cell Death in Breast Cancer Stem Cells. Cell Biol Int. 2025 Nov; 49(11):1493-1506. PMID: 40832706

Prabhu KS, Kuttikrishnan S, Mariyam Z, Habeeba U, Panicker AJ, Masoodi T, Junejo K, Uddin S. PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells. Naunyn Schmiedebergs Arch Pharmacol. 2025 Dec; 398(12):16779-16795. PMID: 40676293

Kuttikrishnan S, Suleman M, Ahmad F, Mariyam Z, Habeeba U, Prabhu KS, Buddenkotte J, Steinhoff M, Uddin S. Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells. Toxicol Appl Pharmacol. 2025 Aug; 501:117403. PMID: 40409732

Kuttikrishnan S, Ansari AW, Suleman M, Ahmad F, Prabhu KS, El-Elimat T, Alali FQ, Al Shabeeb Akil AS, Bhat AA, Merhi M, Dermime S, Steinhoff M, Uddin S. The apoptotic and anti-proliferative effects of Neosetophomone B in T-cell acute lymphoblastic leukaemia via PI3K/AKT/mTOR pathway inhibition. Cell Prolif. 2025 Mar; 58(3):e13773. PMID: 39542458; PMCID: PMC11882758; DOI: 10.1111/cpr.13773;

Kuttikrishnan S, Prabhu KS, Habeeba U, Mariyam Z, Fernandes Q, Maqbool M, Khan OM, Bhat AA, Uddin S. Nectin-4: A promising prognostic marker and therapeutic target in cancer. Int Rev Cell Mol Biol. 2025; 391:223-255. PMID: 39939077

Ahmad N, Moton S, Kuttikrishnan S, Prabhu KS, Masoodi T, Ahmad S, Uddin S. Fatty acid synthase: A key driver of ovarian cancer metastasis and a promising therapeutic target. Pathol Res Pract. 2024 Aug; 260:155465. PMID: 39018927

Prabhu KS, Ahmad F, Kuttikrishnan S, Leo R, Ali TA, Izadi M, Mateo JM, Alam M, Ahmad A, Al-Shabeeb Akil AS, Bhat AA, Buddenkotte J, Pourkarimi E, Steinhoff M, Uddin S. Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans. Cell Death Discov. 2024 May 09; 10(1):225. PMID: 38724504; PMCID: PMC11082213; DOI: 10.1038/s41420-024-01992-7;

Prabhu KS, Kuttikrishnan S, Ahmad N, Habeeba U, Mariyam Z, Suleman M, Bhat AA, Uddin S. H2AX: A key player in DNA damage response and a promising target for cancer therapy. Biomed Pharmacother. 2024 Jun; 175:116663. PMID: 38688170

Prabhu KS, Jessy S, Kuttikrishnan S, Mujeeb F, Mariyam Z, Habeeba U, Ahmad N, Bhat AA, Uddin S. Anticancer Potential and Molecular Targets of Pristimerin in Human Malignancies. Pharmaceuticals (Basel). 2024 Apr 30; 17(5). PMID: 38794148; PMCID: PMC11123949; DOI: 10.3390/ph17050578;

Khan A, Waheed Y, Kuttikrishnan S, Prabhu KS, El-Elimat T, Uddin S, Alali FQ, Agouni A. Network pharmacology, molecular simulation, and binding free energy calculation-based investigation of Neosetophomone B revealed key targets for the treatment of cancer. Front Pharmacol. 2024; 15:1352907. PMID: 38434705; PMCID: PMC10905267; DOI: 10.3389/fphar.2024.1352907;

Showing 10 of 47 results. Show More

Kuttikrishnan S, Prabhu KS, Khan AQ, Uddin S. Signaling networks guiding erythropoiesis. Curr Opin Hematol. 2024 May 01; 31(3):89-95. PMID: 38335037

Prabhu KS, Sadida HQ, Kuttikrishnan S, Junejo K, Bhat AA, Uddin S. Beyond genetics: Exploring the role of epigenetic alterations in breast cancer. Pathol Res Pract. 2024 Feb; 254:155174. PMID: 38306863

Patil K, Khan AQ, Ahmad F, Kuttikrishnan S, Anver R, Mateo JM, Ahmad A, Bhat AA, Buddenkotte J, Steinhoff M, Uddin S. Sanguinarine Triggers Apoptosis in Cutaneous Squamous Cell Carcinoma Cells through Reactive Oxygen Species-Dependent c-Jun N-Terminal Kinase Signaling Pathway. Front Biosci (Landmark Ed). 2024 Jan 23; 29(1):40. PMID: 38287817

Kuttikrishnan S, Hasan M, Prabhu KS, El-Elimat T, Oberlies NH, Pearce CJ, Alali FQ, Ahmad A, Pourkarimi E, Bhat AA, Yalcin HC, Uddin S. Exploring the in vivo anti-cancer potential of Neosetophomone B in leukemic cells using a zebrafish xenograft model. Exp Cell Res. 2024 Feb 01; 435(1):113907. PMID: 38184222

Fernandes Q, Sher G, Prabhu KS, Kuttikrishnan S, Merhi M, Dermime S, Junejo K, Bhat AA, Uddin S. Beyond Viral Infections: The Multifaceted Roles of Human Papillomavirus and Epstein-Barr Virus in Shaping the Tumor Microenvironment. Discov Med. 2024 Jan; 36(180):1-15. PMID: 38273742

Kuttikrishnan S, Ahmad F, Mateo JM, Prabhu KS, El-Elimat T, Oberlies NH, Pearce CJ, Akil ASA, Bhat AA, Alali FQ, Uddin S. Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway. Cell Biol Int. 2024 Feb; 48(2):190-200. PMID: 37885161; PMCID: PMC10952688; DOI: 10.1002/cbin.12101;

Kuttikrishnan S, Masoodi T, Ahmad F, Sher G, Prabhu KS, Mateo JM, Buddenkotte J, El-Elimat T, Oberlies NH, Pearce CJ, Bhat AA, Alali FQ, Steinhoff M, Uddin S. In vitro evaluation of Neosetophomone B inducing apoptosis in cutaneous T cell lymphoma by targeting the FOXM1 signaling pathway. J Dermatol Sci. 2023 Nov; 112(2):83-91. PMID: 37865581

Khan AQ, Siveen KS, Prabhu KS, Kuttikrishnan S, Akhtar S, Shaar A, Raza A, Mraiche F, Dermime S, Uddin S. Corrigendum: Curcumin-mediated degradation of S-phase kinase protein 2 induces cytotoxic effects in human papillomavirus-positive and negative squamous carcinoma cells. Front Oncol. 2023; 13:1292898. PMID: 37841444; PMCID: PMC10573288; DOI: 10.3389/fonc.2023.1292898;

Akhtar S, Zarif L, Kuttikrishnan S, Prabhu KS, Patil K, Nisar S, Abou-Saleh H, Merhi M, Dermime S, Bhat AA, Uddin S. Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway. Cancers (Basel). 2022 Nov 16; 14(22). PMID: 36428714; PMCID: PMC9688888; DOI: 10.3390/cancers14225621;

Almaghrbi H, Elkardawy R, Udhaya Kumar S, Kuttikrishnan S, Abunada T, Kashyap MK, Ahmad A, Uddin S, George Priya Doss C, Zayed H. Analysis of signaling cascades from myeloma cells treated with pristimerin. Adv Protein Chem Struct Biol. 2023; 134:147-174. PMID: 36858733

Patil K, Sher G, Kuttikrishnan S, Moton S, Alam M, Buddenkotte J, Ahmad A, Steinhoff M, Uddin S. The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities. Semin Cell Dev Biol. 2024 Feb 15; 154(Pt C):239-249. PMID: 36216715

Nisar S, Masoodi T, Prabhu KS, Kuttikrishnan S, Zarif L, Khatoon S, Ali S, Uddin S, Akil AA, Singh M, Macha MA, Bhat AA. Natural products as chemo-radiation therapy sensitizers in cancers. Biomed Pharmacother. 2022 Oct; 154:113610. PMID: 36030591

Sher G, Masoodi T, Patil K, Akhtar S, Kuttikrishnan S, Ahmad A, Uddin S. Dysregulated FOXM1 signaling in the regulation of cancer stem cells. Semin Cancer Biol. 2022 Nov; 86(Pt 3):107-121. PMID: 35931301

Kuttikrishnan S, Masoodi T, Sher G, Bhat AA, Patil K, El-Elimat T, Oberlies NH, Pearce CJ, Haris M, Ahmad A, Alali FQ, Uddin S. Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis. Front Oncol. 2022; 12:929996. PMID: 35847923

Kuttikrishnan S, Bhat AA, Mateo JM, Ahmad F, Alali FQ, El-Elimat T, Oberlies NH, Pearce CJ, Uddin S. Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells. Biochem Biophys Res Commun. 2022 Apr 23; 601:59-64. PMID: 35228122

Patil K, Kuttikrishnan S, Khan AQ, Ahmad F, Alam M, Buddenkotte J, Ahmad A, Steinhoff M, Uddin S. Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways. Semin Cancer Biol. 2022 Nov; 86(Pt 3):382-399. PMID: 34906723

Prabhu KS, Bhat AA, Siveen KS, Kuttikrishnan S, Raza SS, Raheed T, Jochebeth A, Khan AQ, Chawdhery MZ, Haris M, Kulinski M, Dermime S, Steinhoff M, Uddin S. Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway. Biomed Pharmacother. 2021 Dec; 144:112358. PMID: 34794241

Kuttikrishnan S, Prabhu KS, Al Sharie AH, Al Zu'bi YO, Alali FQ, Oberlies NH, Ahmad A, El-Elimat T, Uddin S. Natural resorcylic acid lactones: A chemical biology approach for anticancer activity. Drug Discov Today. 2022 Feb; 27(2):547-557. PMID: 34655796

Kuttikrishnan S, Prabhu KS, Khan AQ, Alali FQ, Ahmad A, Uddin S. Thiostrepton inhibits growth and induces apoptosis by targeting FoxM1/SKP2/MTH1 axis in B-precursor acute lymphoblastic leukemia cells. Leuk Lymphoma. 2021 Dec; 62(13):3170-3180. PMID: 34369229

Bhat AA, Younes SN, Raza SS, Zarif L, Nisar S, Ahmed I, Mir R, Kumar S, Sharawat SK, Hashem S, Elfaki I, Kulinski M, Kuttikrishnan S, Prabhu KS, Khan AQ, Yadav SK, El-Rifai W, Zargar MA, Zayed H, Haris M, Uddin S. Correction to: Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance. Mol Cancer. 2020 Dec 29; 19(1):174. PMID: 33372597

Bhat AA, Younes SN, Raza SS, Zarif L, Nisar S, Ahmed I, Mir R, Kumar S, Sharawat SK, Hashem S, Elfaki I, Kulinski M, Kuttikrishnan S, Prabhu KS, Khan AQ, Yadav SK, El-Rifai W, Zargar MA, Zayed H, Haris M, Uddin S. Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance. Mol Cancer. 2020 Mar 12; 19(1):57. PMID: 32164715

Khan AQ, Mohamed EAN, Hakeem I, Nazeer A, Kuttikrishnan S, Prabhu KS, Siveen KS, Nawaz Z, Ahmad A, Zayed H, Uddin S. Sanguinarine Induces Apoptosis in Papillary Thyroid Cancer Cells via Generation of Reactive Oxygen Species. Molecules. 2020 Mar 09; 25(5). PMID: 32182833

Prabhu KS, Raza A, Karedath T, Raza SS, Fathima H, Ahmed EI, Kuttikrishnan S, Therachiyil L, Kulinski M, Dermime S, Junejo K, Steinhoff M, Uddin S. Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells. Cancers (Basel). 2020 Feb 04; 12(2). PMID: 32033146

Kuttikrishnan S, Siveen KS, Prabhu KS, Khan AQ, Ahmed EI, Akhtar S, Ali TA, Merhi M, Dermime S, Steinhoff M, Uddin S. Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia. Front Oncol. 2019; 9:484. PMID: 31275848

Siveen KS, Raza A, Ahmed EI, Khan AQ, Prabhu KS, Kuttikrishnan S, Mateo JM, Zayed H, Rasul K, Azizi F, Dermime S, Steinhoff M, Uddin S. The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer. Cancers (Basel). 2019 May 29; 11(6). PMID: 31146452

Akhtar S, Achkar IW, Siveen KS, Kuttikrishnan S, Prabhu KS, Khan AQ, Ahmed EI, Sahir F, Jerobin J, Raza A, Merhi M, Elsabah HM, Taha R, Omri HE, Zayed H, Dermime S, Steinhoff M, Uddin S. Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling. Front Oncol. 2019; 9:285. PMID: 31058086

Prabhu KS, Siveen KS, Kuttikrishnan S, Jochebeth A, Ali TA, Elareer NR, Iskandarani A, Quaiyoom Khan A, Merhi M, Dermime S, El-Elimat T, Oberlies NH, Alali FQ, Steinhoff M, Uddin S. Greensporone A, a Fungal Secondary Metabolite Suppressed Constitutively Activated AKT via ROS Generation and Induced Apoptosis in Leukemic Cell Lines. Biomolecules. 2019 Mar 29; 9(4). PMID: 30934922

Khan AQ, Siveen KS, Prabhu KS, Kuttikrishnan S, Akhtar S, Shaar A, Raza A, Mraiche F, Dermime S, Uddin S. Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells. Front Oncol. 2018; 8:399. PMID: 30333956

Kuttikrishnan S, Siveen KS, Prabhu KS, Khan AQ, Akhtar S, Mateo JM, Merhi M, Taha R, Omri HE, Mraiche F, Dermime S, Uddin S. Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia. Leuk Lymphoma. 2019 Mar; 60(3):782-794. PMID: 30187808

Prabhu KS, Siveen KS, Kuttikrishnan S, Iskandarani AN, Khan AQ, Merhi M, Omri HE, Dermime S, El-Elimat T, Oberlies NH, Alali FQ, Uddin S. Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines. Front Pharmacol. 2018; 9:720. PMID: 30061828

Prabhu KS, Achkar IW, Kuttikrishnan S, Akhtar S, Khan AQ, Siveen KS, Uddin S. Embelin: a benzoquinone possesses therapeutic potential for the treatment of human cancer. Future Med Chem. 2018 Apr 01; 10(8):961-976. PMID: 29620447

Khan AQ, Kuttikrishnan S, Siveen KS, Prabhu KS, Shanmugakonar M, Al-Naemi HA, Haris M, Dermime S, Uddin S. RAS-mediated oncogenic signaling pathways in human malignancies. Semin Cancer Biol. 2019 Feb; 54:1-13. PMID: 29524560

Siveen KS, Prabhu KS, Achkar IW, Kuttikrishnan S, Shyam S, Khan AQ, Merhi M, Dermime S, Uddin S. Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products. Mol Cancer. 2018 Feb 19; 17(1):31. PMID: 29455667

Prabhu KS, Siveen KS, Kuttikrishnan S, Iskandarani A, Tsakou M, Achkar IW, Therachiyil L, Krishnankutty R, Parray A, Kulinski M, Merhi M, Dermime S, Mohammad RM, Uddin S. Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells. PLoS One. 2017; 12(7):e0180895. PMID: 28704451

Bhat AA, Prabhu KS, Kuttikrishnan S, Krishnankutty R, Babu J, Mohammad RM, Uddin S. Potential therapeutic targets of Guggulsterone in cancer. Nutr Metab (Lond). 2017; 14:23. PMID: 28261317

Siveen KS, Prabhu K, Krishnankutty R, Kuttikrishnan S, Tsakou M, Alali FQ, Dermime S, Mohammad RM, Uddin S. Vascular Endothelial Growth Factor (VEGF) Signaling in Tumour Vascularization: Potential and Challenges. Curr Vasc Pharmacol. 2017; 15(4):339-351. PMID: 28056756

Iskandarani A, Bhat AA, Siveen KS, Prabhu KS, Kuttikrishnan S, Khan MA, Krishnankutty R, Kulinski M, Nasr RR, Mohammad RM, Uddin S. Bortezomib-mediated downregulation of S-phase kinase protein-2 (SKP2) causes apoptotic cell death in chronic myelogenous leukemia cells. J Transl Med. 2016 Mar 09; 14:69. PMID: 26956626

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 47 publications over 10 distinct years, with a maximum of 12 publications in 2024

Bar chart showing 47 publications over 10 distinct years, with a maximum of 12 publications in 2024

Year	Publications
2016	1
2017	3
2018	6
2019	4
2020	4
2021	4
2022	7
2023	3
2024	12
2025	3

2023 Qatar University: Distinguished student award

2023 Qatar University: Best Dissertation Award

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