Samagya Banskota, PhD
Assistant Professor
Boston University College of Engineering
Biomedical Engineering

PhD, Duke University
BS, Pennsylvania State University



Precision genome editing technologies can potentially treat the root causes of several genetic diseases by making precise and targeted edits to the DNA. However, safe and effective delivery methods are needed to translate this potential into a therapeutic reality. My lab’s research interests lie in the intersection of synthetic biology, protein engineering, drug delivery, and gene editing, with a focus on using a cross-disciplinary approach to solving delivery challenges for therapeutics. Towards that goal, we are developing tools that allow us to probe and manipulate macromolecular transport to understand delivery barriers. We integrate that knowledge with synthetic biology and protein engineering to design genetically-encoded and stimuli-responsive delivery systems. By providing solutions that can overcome delivery challenges, we hope to make enabling therapeutics such as genome editors safe, accessible, and affordable.

The other interest of my lab is to develop molecular tools to elucidate the biological function of the genomic dark matter (transposable elements or TEs). TEs comprise nearly half of the human genome but we do not fully understand their roles and functions in many diseases. We are developing genome and epigenome editing technologies that act as molecular recorders to study their biological function at scale. The resulting findings will help us understand the phenotypic consequences of TEs to inspire new therapeutic strategies.


Advancing the delivery of genome editors with next-generation non-viral delivery systems
10/15/2024 - 10/30/2027 (PI)
Nvelop Therapeutics


Advancing the delivery of genome editors with next-generation non-viral delivery systems
07/01/2024 - 06/30/2027 (PI)
Massachusetts Life Sciences Center




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. An M, Raguram A, Du SW, Banskota S, Davis JR, Newby GA, Chen PZ, Palczewski K, Liu DR. Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nat Biotechnol. 2024 Oct; 42(10):1526-1537. PMID: 38191664; PMCID: PMC11228131; DOI: 10.1038/s41587-023-02078-y;
     
  2. Doman JL, Pandey S, Neugebauer ME, An M, Davis JR, Randolph PB, McElroy A, Gao XD, Raguram A, Richter MF, Everette KA, Banskota S, Tian K, Tao YA, Tolar J, Osborn MJ, Liu DR. Phage-assisted evolution and protein engineering yield compact, efficient prime editors. Cell. 2023 Aug 31; 186(18):3983-4002.e26. PMID: 37657419; PMCID: PMC10482982; DOI: 10.1016/j.cell.2023.07.039;
     
  3. Davis JR, Banskota S, Levy JM, Newby GA, Wang X, Anzalone AV, Nelson AT, Chen PJ, Hennes AD, An M, Roh H, Randolph PB, Musunuru K, Liu DR. Efficient prime editing in mouse brain, liver and heart with dual AAVs. Nat Biotechnol. 2024 Feb; 42(2):253-264. PMID: 37142705; PMCID: PMC10869272; DOI: 10.1038/s41587-023-01758-z;
     
  4. Neugebauer ME, Hsu A, Arbab M, Krasnow NA, McElroy AN, Pandey S, Doman JL, Huang TP, Raguram A, Banskota S, Newby GA, Tolar J, Osborn MJ, Liu DR. Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity. Nat Biotechnol. 2023 May; 41(5):673-685. PMID: 36357719; PMCID: PMC10188366; DOI: 10.1038/s41587-022-01533-6;
     
  5. Davis JR, Wang X, Witte IP, Huang TP, Levy JM, Raguram A, Banskota S, Seidah NG, Musunuru K, Liu DR. Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors. Nat Biomed Eng. 2022 Nov; 6(11):1317. PMID: 35931809; PMCID: PMC9652146; DOI: 10.1038/s41551-022-00934-x;
     
  6. Schaal JL, Bhattacharyya J, Brownstein J, Strickland KC, Kelly G, Saha S, Milligan J, Banskota S, Li X, Liu W, Kirsch DG, Zalutsky MR, Chilkoti A. Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours. Nat Biomed Eng. 2022 Oct; 6(10):1148-1166. PMID: 36261625; PMCID: PMC10389695; DOI: 10.1038/s41551-022-00949-4;
     
  7. Davis JR, Wang X, Witte IP, Huang TP, Levy JM, Raguram A, Banskota S, Seidah NG, Musunuru K, Liu DR. Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors. Nat Biomed Eng. 2022 Nov; 6(11):1272-1283. PMID: 35902773; PMCID: PMC9652153; DOI: 10.1038/s41551-022-00911-4;
     
  8. Saha S, Banskota S, Liu J, Zakharov N, Dzuricky M, Li X, Fan P, Deshpande S, Spasojevic I, Sharma K, Borgnia MJ, Schaal JL, Raman A, Kim S, Bhattacharyya J, Chilkoti A. Genetically Engineered Nanoparticles of Asymmetric Triblock Polypeptide with a Platinum(IV) Cargo Outperforms a Platinum(II) Analog and Free Drug in a Murine Cancer Model. Nano Lett. 2022 Jul 27; 22(14):5898-5908. PMID: 35839459; PMCID: PMC9912577; DOI: 10.1021/acs.nanolett.2c01850;
     
  9. Raguram A, Banskota S, Liu DR. Therapeutic in vivo delivery of gene editing agents. Cell. 2022 Jul 21; 185(15):2806-2827. PMID: 35798006; PMCID: PMC9454337; DOI: 10.1016/j.cell.2022.03.045;
     
  10. Choi EH, Suh S, Foik AT, Leinonen H, Newby GA, Gao XD, Banskota S, Hoang T, Du SW, Dong Z, Raguram A, Kohli S, Blackshaw S, Lyon DC, Liu DR, Palczewski K. In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nat Commun. 2022 Apr 05; 13(1):1830. PMID: 35383196; PMCID: PMC8983734; DOI: 10.1038/s41467-022-29490-3;
     
Showing 10 of 18 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 18 publications over 8 distinct years, with a maximum of 8 publications in 2022

YearPublications
20131
20161
20172
20181
20202
20228
20232
20241


2022 MIT Technological Review 35 Innovators Under 35
2019 Duke Biomaterials Symposium: Best Speaker Award
2018-2019 Duke University: BME Graduate Student Travel Award
2013-2015 Duke Graduate School: Pratt/Gardner Fellowship
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