Ronald J. Killiany, PhD
Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, Northeastern University
MA, University of Hartford




The underlying theme of my research has been to explore structure – function relationships in the brain. To this end, my work has focused on uncovering the morphological changes in the brain that are responsible for the cognitive decline seen in aging and disease processes. In initial studies, I used developmental techniques to examine specific structure-function relationships in the memory system of non-human primates. I continued on to conduct studies of normal aging and cerebrovascular disease. In this work I have focused on characterize the cognitive changes taking place in non-human primate models. As my interests in studying the brain grew, I become involved in structural Magnetic Resonance Imaging (MRI) studies of normal aging and disorders such as Alzheimer’s disease. In this work I have been quantifying volumetric changes taking place in the brain in the course of the disease processes. This work continues to evolve and has changed focus somewhat in the recent years to include studies aimed at exploring the value of MRI in predicting which subjects will progress to develop cognitive decline and Alzheimer’s disease and which will remain cognitively stable.

Associate Professor
Boston University School of Public Health
Environmental Health


Professor
Boston University School of Medicine
Neurology


Associate Professor
Boston University School of Medicine
Radiology
Body Imaging

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




The A45 Study: Combination anti-amyloid therapy for preclinical Alzheimer's disease
09/30/2019 - 05/31/2024 (Subcontract PI)
University of Southern California NIH NIA
5R01AG061848-02

The A3 Study: Ante-Amyloid prevention of Alzheimer's disease
06/01/2019 - 04/30/2023 (Subcontract PI)
University of Southern California NIH NIA
1R01AG061848-01

Protocol number BAN2401-G000-303: AHEAD 3-45 Study: A Placebo-Controlled, Double-Blind, Parallel-Treatment Arm, 216 Week Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Subject
01/01/2020 - 12/31/2022 (Subcontract PI)
University of Southern California Eisai, Inc


Clarifying the Role Played by Microglia and Astrocyte Activation in Veterans with Gulf War Illness Using Positron Emission Tomography (PET)
09/30/2019 - 09/29/2022 (PI)
Department of Defense/Army Medical Research Acquisition Activity


Assessing the perivascular clearance of brain debris in familial and sporadic Alzheimer's disease
09/01/2020 - 08/31/2022 (Subcontract PI)
The Brigham and Women's Hospital, Inc. BrightFocus Fdn


Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)
09/15/2016 - 07/31/2022 (Subcontract PI)
University of Southern California NIH NIA
2U19AG024904-11

ADNI-DOD-TAU, Effects of Traumatic Brain Injury and Post-Traumatic Stress Disorder and Alzheimer's Disease on Brain Tau in Vietnam Veterans using ADNI
09/22/2016 - 09/21/2021 (Subcontract PI)
University of Southern California DOD Army Med Resrch


Vielight Neuro RX Gamma Photobiomodulation Device for Moderate to Severe Alzheimer's Disease
04/30/2019 - 04/30/2021 (PI)
Vielight Inc.


Human Neurobiology Laboratory Support Contract with Pfizer
01/01/2014 - 12/31/2018 (Co-Investigator of Sub-Project / SP)
PI: Kevin C. Thomas, PhD
Pfizer, Inc.


Alzheimer's Disease Neuroimaging Initiative 2 (ADNI2)
08/24/2015 - 03/31/2018 (Subcontract PI)
University of Southern California NIH NIA
5U01AG024904-10

Showing 10 of 14 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2013 Whole Animal Imaging Core 3UC7AI070088-05S3-6801 1
2012 Whole Animal Imaging Core 3UC7AI070088-05S2-7841 1
2011 Whole Animal Imaging Core 3UC7AI070088-05S1-7216 1
2009 3T quasar dual MRI scanner for multimodal and molecular imaging 1S10RR025035-01
2002 Primate Model of Hypertensive Cerebrovascular Disease 1R03AG021315-01
2002 MAGNETIC RESONANCE IMAGING (MRI) 2P01AG004953-19-6 107

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Morrison MS, Aparicio HJ, Blennow K, Zetterberg H, Ashton NJ, Karikari TK, Tripodis Y, Martin B, Palmisano JN, Sugarman MA, Frank B, Steinberg EG, Turk KW, Budson AE, Au R, Goldstein LE, Jun GR, Kowall NW, Killiany R, Qiu WQ, Stern RA, Mez J, McKee AC, Stein TD, Alosco ML. Antemortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy. Brain. 2022 May 13.View Related Profiles. PMID: 35554506; DOI: 10.1093/brain/awac175;
     
  2. Frank B, Ally M, Tripodis Y, Puzo C, Labriolo C, Hurley L, Martin B, Palmisano J, Chan L, Steinberg E, Turk K, Budson A, OÂ'Connor M, Au R, Qiu WQ, Goldstein L, Kukull W, Kowall N, Killiany R, Stern R, Stein T, McKee A, Mez J, Alosco M. Trajectories of Cognitive Decline in Brain Donors With Autopsy-Confirmed Alzheimer Disease and Cerebrovascular Disease. Neurology. 2022 Apr 20.View Related Profiles. PMID: 35444054; DOI: 10.1212/WNL.0000000000200304;
     
  3. Jacobs HIL, O'Donnell A, Satizabal CL, Lois C, Kojis D, Hanseeuw BJ, Thibault E, Sanchez JS, Buckley RF, Yang Q, DeCarli C, Killiany R, Sargurupremraj M, Sperling RA, Johnson KA, Beiser AS, Seshadri S. Associations Between Brainstem Volume and Alzheimer's Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study. J Alzheimers Dis. 2022; 86(4):1603-1609.View Related Profiles. PMID: 35213372; PMCID: PMC9038711; DOI: 10.3233/JAD-215372;
     
  4. Alosco ML, Mian AZ, Buch K, Farris CW, Uretsky M, Tripodis Y, Baucom Z, Martin B, Palmisano J, Puzo C, Ang TFA, Joshi P, Goldstein LE, Au R, Katz DI, Dwyer B, Daneshvar DH, Nowinski C, Cantu RC, Kowall NW, Huber BR, Alvarez VE, Stern RA, Stein TD, Killiany RJ, McKee AC, Mez J. Structural MRI profiles and tau correlates of atrophy in autopsy-confirmed CTE. Alzheimers Res Ther. 2021 12 07; 13(1):193.View Related Profiles. PMID: 34876229; PMCID: PMC8653514; DOI: 10.1186/s13195-021-00928-y;
     
  5. Frank B, Ally M, Brekke B, Zetterberg H, Blennow K, Sugarman MA, Ashton NJ, Karikari TK, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Simkina I, Turk KW, Budson AE, O'Connor MK, Au R, Goldstein LE, Jun GR, Kowall NW, Stein TD, McKee AC, Killiany R, Qiu WQ, Stern RA, Mez J, Alosco ML. Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau. Alzheimers Dement. 2021 Dec 02.View Related Profiles. PMID: 34854549; DOI: 10.1002/alz.12508;
     
  6. Moore TL, Young DA, Killiany RJ, Fonseca KR, Volfson D, Gray DL, Balice-Gordon R, Kozak R. The Effects of a Novel Non-catechol Dopamine Partial Agonist on Working Memory in the Aged Rhesus Monkey. Front Aging Neurosci. 2021; 13:757850.View Related Profiles. PMID: 34899271; PMCID: PMC8662559; DOI: 10.3389/fnagi.2021.757850;
     
  7. Uretsky M, Bouix S, Killiany RJ, Tripodis Y, Martin B, Palmisano J, Mian AZ, Buch K, Farris C, Daneshvar DH, Dwyer B, Goldstein L, Katz D, Nowinski C, Cantu R, Kowall N, Huber BR, Stern RA, Alvarez VE, Stein TD, McKee A, Mez J, Alosco ML. Association Between Antemortem FLAIR White Matter Hyperintensities and Neuropathology in Brain Donors Exposed to Repetitive Head Impacts. Neurology. 2022 01 04; 98(1):e27-e39.View Related Profiles. PMID: 34819338; PMCID: PMC8726571; DOI: 10.1212/WNL.0000000000013012;
     
  8. Uprety A, Moss MB, Rosene DL, Killiany RJ, Moore TL. Curcumin improves reversal learning in middle-aged rhesus monkeys. Behav Neurosci. 2022 Apr; 136(2):126-138.View Related Profiles. PMID: 34780208
     
  9. Keating D, Zundel CG, Abreu M, Krengel M, Aenlle K, Nichols MD, Toomey R, Chao LL, Golier J, Abdullah L, Quinn E, Heeren T, Groh JR, Koo BB, Killiany R, Loggia ML, Younger J, Baraniuk J, Janulewicz P, Ajama J, Quay M, Baas PW, Qiang L, Conboy L, Kokkotou E, O'Callaghan JP, Steele L, Klimas N, Sullivan K. Boston biorepository, recruitment and integrative network (BBRAIN): A resource for the Gulf War Illness scientific community. Life Sci. 2021 Nov 01; 284:119903.View Related Profiles. PMID: 34453948
     
  10. Steele L, Klimas N, Krengel M, Quinn E, Toomey R, Little D, Abreu M, Aenlle K, Killiany R, Koo BB, Janulewicz P, Heeren T, Clark AN, Ajama J, Cirillo J, Buentello G, Lerma V, Coller JK, Sullivan K. Brain-Immune Interactions as the Basis of Gulf War Illness: Clinical Assessment and Deployment Profile of 1990-1991 Gulf War Veterans in the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study. Brain Sci. 2021 Aug 26; 11(9).View Related Profiles. PMID: 34573153; PMCID: PMC8467437; DOI: 10.3390/brainsci11091132;
     
Showing 10 of 127 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 127 publications over 29 distinct years, with a maximum of 13 publications in 2021

YearPublications
19931
19951
19961
19974
19981
19995
20001
20013
20024
20036
20042
20057
20066
20076
20086
20095
20107
20115
20124
20133
20144
20152
20164
201710
20184
20196
20203
202113
20223

2011 NeuroImage Award for Top-5 cited articles between 2006 & 2010
1993 Massachusetts Neuropsychological Society: Annual Award
1991 American Psychological Association: Dissertation Award
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Aging
Cerebrovascular disease
Cognition
Data analysis
Dementia
Experimental Design
Magnetic Resonance Imaging
Memory
Neuropsychology
Statistics

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Co-Mentor or Peer Mentor
  • Education Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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