Ronald J. Killiany, PhD
Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, Northeastern University
MA, University of Hartford




The underlying theme of my research has been to explore structure – function relationships in the brain. To this end, my work has focused on uncovering the morphological changes in the brain that are responsible for the cognitive decline seen in aging and disease processes. In initial studies, I used developmental techniques to examine specific structure-function relationships in the memory system of non-human primates. I continued on to conduct studies of normal aging and cerebrovascular disease. In this work I have focused on characterize the cognitive changes taking place in non-human primate models. As my interests in studying the brain grew, I become involved in structural Magnetic Resonance Imaging (MRI) studies of normal aging and disorders such as Alzheimer’s disease. In this work I have been quantifying volumetric changes taking place in the brain in the course of the disease processes. This work continues to evolve and has changed focus somewhat in the recent years to include studies aimed at exploring the value of MRI in predicting which subjects will progress to develop cognitive decline and Alzheimer’s disease and which will remain cognitively stable.

Associate Professor
Boston University School of Public Health
Environmental Health


Professor
Boston University School of Medicine
Neurology


Associate Professor
Boston University School of Medicine
Radiology
Body Imaging

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2011 NeuroImage Award for Top-5 cited articles between 2006 & 2010
1993 Massachusetts Neuropsychological Society: Annual Award
1991 American Psychological Association: Dissertation Award


Clarifying the Role Played by Microglia and Astrocyte Activation in Veterans with Gulf War Illness Using Positron Emission Tomography (PET)
09/30/2019 - 09/29/2021 (PI)
Department of Defense/Army Medical Research Acquisition Activity


ADNI-DOD-TAU, Effects of Traumatic Brain Injury and Post-Traumatic Stress Disorder and Alzheimer's Disease on Brain Tau in Vietnam Veterans using ADNI
09/22/2016 - 09/21/2021 (Subcontract PI)
University of Southern California DOD Army Med Resrch


Assessing the perivascular clearance of brain debris in familial and sporadic Alzheimer's disease
09/01/2020 - 08/31/2021 (Subcontract PI)
The Brigham and Women's Hospital, Inc. BrightFocus Fdn


Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)
09/15/2016 - 07/31/2021 (Subcontract PI)
University of Southern California NIH NIA
2U19AG024904-11

Vielight Neuro RX Gamma Photobiomodulation Device for Moderate to Severe Alzheimer's Disease
04/30/2019 - 04/30/2021 (PI)
Vielight Inc.


Human Neurobiology Laboratory Support Contract with Pfizer
01/01/2014 - 12/31/2018 (Co-Investigator of Sub-Project / SP)
PI: Kevin C. Thomas, PhD
Pfizer, Inc.


Alzheimer's Disease Neuroimaging Initiative 2 (ADNI2)
08/24/2015 - 03/31/2018 (Subcontract PI)
University of Southern California NIH NIA
5U01AG024904-10

Neurobiological Consequences of Hypertension and Age
03/01/2000 - 02/28/2010 (Co-PI)
NIH/National Institute on Aging
5 R37 AG17609 10

Age-Related Changes of Cognition in Health and Disease
08/01/2002 - 07/31/2007 (PI)
Massachusetts General Hospital NIH NIA

A Primate Model of Hypertensive Cerebrovascular
09/30/2002 - 08/31/2004 (PI)
NIH/National Institute on Aging
1 R03 AG21315 01



Title


Yr Title Project-Sub Proj Pubs
2013 Whole Animal Imaging Core 3UC7AI070088-05S3-6801 1
2012 Whole Animal Imaging Core 3UC7AI070088-05S2-7841 1
2011 Whole Animal Imaging Core 3UC7AI070088-05S1-7216 1
2009 3T quasar dual MRI scanner for multimodal and molecular imaging 1S10RR025035-01
2002 Primate Model of Hypertensive Cerebrovascular Disease 1R03AG021315-01
2002 MAGNETIC RESONANCE IMAGING (MRI) 2P01AG004953-19-6 107

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Keating D, Zundel CG, Abreu M, Krengel M, Aenlle K, Nichols MD, Toomey R, Chao LL, Golier J, Abdullah L, Quinn E, Heeren T, Groh JR, Koo BB, Killiany R, Loggia ML, Younger J, Baraniuk J, Janulewicz P, Ajama J, Quay M, Baas PW, Qiang L, Conboy L, Kokkotou E, O'Callaghan JP, Steele L, Klimas N, Sullivan K. Boston biorepository, recruitment and integrative network (BBRAIN): A resource for the Gulf War Illness scientific community. Life Sci. 2021 Nov 01; 284:119903.View Related Profiles. PMID: 34453948
     
  2. Steele L, Klimas N, Krengel M, Quinn E, Toomey R, Little D, Abreu M, Aenlle K, Killiany R, Koo BB, Janulewicz P, Heeren T, Clark AN, Ajama J, Cirillo J, Buentello G, Lerma V, Coller JK, Sullivan K. Brain-Immune Interactions as the Basis of Gulf War Illness: Clinical Assessment and Deployment Profile of 1990-1991 Gulf War Veterans in the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study. Brain Sci. 2021 Aug 26; 11(9).View Related Profiles. PMID: 34573153; PMCID: PMC8467437; DOI: 10.3390/brainsci11091132;
     
  3. Tao Q, Alvin Ang TF, Akhter-Khan SC, Itchapurapu IS, Killiany R, Zhang X, Budson AE, Turk KW, Goldstein L, Mez J, Alosco ML, Qiu WQ. Impact of C-Reactive Protein on Cognition and Alzheimer Disease Biomarkers in Homozygous Apolipoprotein E ?4 Carriers. Neurology. 2021 Jul 15.View Related Profiles. PMID: 34266923
     
  4. Farris CW, Killiany RJ, O'Donoghue E, Koo BB, Wainford RD, Moss MB, Rosene DL, Moore TL. The relationship of age and hypertension with cognition and gray matter cerebral blood volume in a rhesus monkey model of human aging. Behav Neurosci. 2021 Oct; 135(5):680-692.View Related Profiles. PMID: 34197136
     
  5. Zhou X, Qiu S, Joshi PS, Xue C, Killiany RJ, Mian AZ, Chin SP, Au R, Kolachalama VB. Enhancing magnetic resonance imaging-driven Alzheimer's disease classification performance using generative adversarial learning. Alzheimers Res Ther. 2021 03 14; 13(1):60.View Related Profiles. PMID: 33715635; PMCID: PMC7958452; DOI: 10.1186/s13195-021-00797-5;
     
  6. Zajac L, Killiany R. Activity Strength within Optic Flow-Sensitive Cortical Regions Is Associated with Visual Path Integration Accuracy in Aged Adults. Brain Sci. 2021 Feb 16; 11(2). PMID: 33669177; PMCID: PMC7919670; DOI: 10.3390/brainsci11020245;
     
  7. Sanchez JS, Becker JA, Jacobs HIL, Hanseeuw BJ, Jiang S, Schultz AP, Properzi MJ, Katz SR, Beiser A, Satizabal CL, O'Donnell A, DeCarli C, Killiany R, El Fakhri G, Normandin MD, Gómez-Isla T, Quiroz YT, Rentz DM, Sperling RA, Seshadri S, Augustinack J, Price JC, Johnson KA. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography. Sci Transl Med. 2021 01 20; 13(577).View Related Profiles. PMID: 33472953; PMCID: PMC7978042; DOI: 10.1126/scitranslmed.abc0655;
     
  8. Gonzales MM, Samra J, O'Donnell A, Mackin RS, Salinas J, Jacob ME, Satizabal CL, Aparicio HJ, Thibault EG, Sanchez JS, Finney R, Rubinstein ZB, Mayblyum DV, Killiany RJ, Decarli CS, Johnson KA, Beiser AS, Seshadri S. Association of Midlife Depressive Symptoms with Regional Amyloid-ß and Tau in the Framingham Heart Study. J Alzheimers Dis. 2021; 82(1):249-260.View Related Profiles. PMID: 34024836
     
  9. Sugarman MA, Zetterberg H, Blennow K, Tripodis Y, McKee AC, Stein TD, Martin B, Palmisano JN, Steinberg EG, Simkin I, Budson AE, Killiany R, O'Connor MK, Au R, Qiu WWQ, Goldstein LE, Kowall NW, Mez J, Stern RA, Alosco ML. A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer's disease. Neurobiol Aging. 2020 10; 94:60-70.View Related Profiles. PMID: 32585491; PMCID: PMC7484086; DOI: 10.1016/j.neurobiolaging.2020.05.011;
     
  10. Zajac L, Koo BB, Tripodis Y, Mian A, Steinberg E, Mez J, Alosco ML, Cervantes-Arslanian A, Stern R, Killiany R. Hippocampal Resting-State Functional Connectivity Patterns are More Closely Associated with Severity of Subjective Memory Decline than Whole Hippocampal and Subfield Volumes. Cereb Cortex Commun. 2020; 1(1):tgaa019.View Related Profiles. PMID: 32905008; PMCID: PMC7463163; DOI: 10.1093/texcom/tgaa019;
     
Showing 10 of 119 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 119 publications over 28 distinct years, with a maximum of 10 publications in 2017

YearPublications
19931
19951
19961
19974
19981
19995
20001
20013
20024
20036
20042
20057
20066
20076
20086
20095
20107
20115
20124
20133
20144
20152
20164
201710
20184
20196
20203
20218
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Aging
Cerebrovascular disease
Cognition
Data analysis
Dementia
Experimental Design
Magnetic Resonance Imaging
Memory
Neuropsychology
Statistics

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Co-Mentor or Peer Mentor
  • Education Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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