Robert C. Mercer, PhD
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology

PhD, University of Alberta
MSc, Memorial University of Newfoundland
BSc, Memorial University of Newfoundland

Microenvironment mapping of the PrPSc Interactome
01/16/2023 - 01/15/2025 (PI)
Creutzfeldt-Jakob Diseases Foundation, Inc.

Identification of Receptors for TDP-43 That Mediate Cellular Uptake and Neurotoxicity
02/15/2021 - 08/14/2023 (PI)
Department of Defense/Army Medical Research Acquisition Activity


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Mercer RCC, Le NTT, Houser MCQ, Beeler AB, Harris DA. Sigma receptor ligands are potent anti-prion compounds that act independently of sigma receptor binding. bioRxiv. 2023 Nov 29.View Related Profiles. PMID: 38077011; PMCID: PMC10705434; DOI: 10.1101/2023.11.28.569035;
  2. Mercer RCC, Harris DA. Mechanisms of prion-induced toxicity. Cell Tissue Res. 2023 Apr; 392(1):81-96.View Related Profiles. PMID: 36070155
  3. Mercer RC, Harris DA. Identification of anti-prion drugs and targets using toxicity-based assays. Curr Opin Pharmacol. 2019 02; 44:20-27.View Related Profiles. PMID: 30684854; PMCID: PMC6561806; DOI: 10.1016/j.coph.2018.12.005;
  4. Fang C, Wu B, Le NTT, Imberdis T, Mercer RCC, Harris DA. Prions activate a p38 MAPK synaptotoxic signaling pathway. PLoS Pathog. 2018 09; 14(9):e1007283.View Related Profiles. PMID: 30235355; PMCID: PMC6147624; DOI: 10.1371/journal.ppat.1007283;
  5. Mercer RCC, Daude N, Dorosh L, Fu ZL, Mays CE, Gapeshina H, Wohlgemuth SL, Acevedo-Morantes CY, Yang J, Cashman NR, Coulthart MB, Pearson DM, Joseph JT, Wille H, Safar JG, Jansen GH, Stepanova M, Sykes BD, Westaway D. A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles. PLoS Pathog. 2018 01; 14(1):e1006826. PMID: 29338055; PMCID: PMC5786331; DOI: 10.1371/journal.ppat.1006826;
  6. Lau A, McDonald A, Daude N, Mays CE, Walter ED, Aglietti R, Mercer RC, Wohlgemuth S, van der Merwe J, Yang J, Gapeshina H, Kim C, Grams J, Shi B, Wille H, Balachandran A, Schmitt-Ulms G, Safar JG, Millhauser GL, Westaway D. Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation. EMBO Mol Med. 2015 Mar; 7(3):339-56. PMID: 25661904; PMCID: PMC4364950; DOI: 10.15252/emmm.201404588;
  7. Mays CE, Coomaraswamy J, Watts JC, Yang J, Ko KW, Strome B, Mercer RC, Wohlgemuth SL, Schmitt-Ulms G, Westaway D. Endoproteolytic processing of the mammalian prion glycoprotein family. FEBS J. 2014 Feb; 281(3):862-76. PMID: 24286250
  8. Mercer RC, Ma L, Watts JC, Strome R, Wohlgemuth S, Yang J, Cashman NR, Coulthart MB, Schmitt-Ulms G, Jhamandas JH, Westaway D. The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. J Biol Chem. 2013 Dec 27; 288(52):37241-55. PMID: 24225951; PMCID: PMC3873577; DOI: 10.1074/jbc.M113.488650;
  9. Mercer RC, Mudalige WA, Ige TO, Heeley DH. Vertebrate slow skeletal muscle actin - conservation, distribution and conformational flexibility. Biochim Biophys Acta. 2011 Oct; 1814(10):1253-60. PMID: 21722757

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 9 publications over 7 distinct years, with a maximum of 2 publications in 2013 and 2018


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