S. Reza Jafarzadeh, DVM, MPVM, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine

DVM, University of Tehran
MPVM, University of California, Davis
PhD, University of California, Davis

I am interested in the application of causal inference methods in observational studies, especially in the setting of longitudinal data, where time-varying exposures, time-dependent confounding, and selection bias are often present. In particular, I am interested in the application of the variety of modern analytical techniques for estimating causal effects as well as the concepts such as direct and indirect effect decomposition (causal mediation analysis), causal interactions and sufficient causes, and causal interference and spill-over effects. These analytical techniques can be applied to broad areas of health sciences research, but I am particularly interested in the application of causal inference for comparative effectiveness research and implementation science. The methods are very useful for the development and assessment of strategies to improve population health using non-experimental data.

I am also interested in the application of Bayesian methods for evaluation of diagnostic tests and prevalence estimation in the absence of a perfect reference standard. These methods have broad applications in diagnosis and screening, and can be used to estimate true prevalence using imperfect tests.

Boston University
Arthritis & Autoimmune Diseases Research Center

Innovative Research Award: Novel Bayesian approaches to identify persons with osteoarthritis in administrative data in the absence of a reference standard
07/01/2023 - 06/30/2025 (PI)
Rheumatology Research Foundation

Drug Repurposing to Prevent Posttraumatic Osteoarthritis
01/01/2021 - 08/31/2024 (PI)
Arthritis Foundation

Bayesian approaches to identify persons with osteoarthritis in electronic health records and administrative health data in the absence of a perfect reference standard
03/15/2023 - 07/01/2023 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases

Dynamic Treatment Regimens of Physical Activity for Persons with Osteoarthritis
09/01/2019 - 07/31/2022 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases

Effects of NSAIDs and non-NSAID Analgesics on Osteoarthritis Outcomes
09/01/2018 - 05/31/2021 (PI)
NIH/National Institute on Aging

Global Awards for Advancing Chronic Pain Research (ADVANCE) 2018 _ NSAIDs, COX2 inhibitors, and opioids long-term effects on knee osteoarthritis progression and joint replacement
11/19/2018 - 12/31/2020 (PI)
Pfizer, Inc.

Personalized dynamic regimens of physical activity for persons with knee osteoarthritis
07/01/2019 - 09/30/2019 (PI)
Rheumatology Research Foundation


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Bacon KL, Felson DT, Jafarzadeh SR, Kolachalama VB, Hausdorff JM, Gazit E, Stefanik JJ, Corrigan P, Segal NA, Lewis CE, Nevitt MC, Kumar D. Gait Alterations and Association With Worsening Knee Pain and Physical Function: A Machine Learning Approach With Wearable Sensors in the Multicenter Osteoarthritis Study. Arthritis Care Res (Hoboken). 2024 Mar 24.View Related Profiles. PMID: 38523250
  2. Bosch NA, Law AC, Shi Z, Jafarzadeh SR, Walkey AJ. A novel measure to summarize blood transfusion practice during critical illness. Transfusion. 2024 May; 64(5):784-788.View Related Profiles. PMID: 38515390; PMCID: PMC11088509; DOI: 10.1111/trf.17814;
  3. Bosch NA, Myers LC, Jafarzadeh SR, Wunsch H, Stevens JP, Liu VX, Walkey AJ. Temporal Trends in Use of Opioids for Patients with Acute Respiratory Failure following "Analgesia-First" Sedation Guidelines. Ann Am Thorac Soc. 2024 Jan; 21(1):179-183.View Related Profiles. PMID: 37847821; PMCID: PMC10867903; DOI: 10.1513/AnnalsATS.202307-632RL;
  4. Aoyagi K, Jafarzadeh SR, Carlesso L, Frey Law L, Lewis CE, Nevitt M, Neogi T. Mediating Effect of Pain Sensitization on the Paradoxical Relation of Taking Opioids to Pain Severity in Knee Osteoarthritis: The Multicenter Osteoarthritis Study. Arthritis Care Res (Hoboken). 2024 Mar; 76(3):403-408.View Related Profiles. PMID: 37750238; PMCID: PMC10922135; DOI: 10.1002/acr.25244;
  5. Liew JW, Jarraya M, Guermazi A, Lynch J, Wang N, Rabasa G, Jafarzadeh SR, Nevitt M, Torner J, Lewis CE, Felson DT, Neogi T. Relation of Intra-Articular Mineralization to Knee Pain in Knee Osteoarthritis: A Longitudinal Analysis in the MOST Study. Arthritis Rheumatol. 2023 Dec; 75(12):2161-2168.View Related Profiles. PMID: 37410792; PMCID: PMC10770289; DOI: 10.1002/art.42649;
  6. Bosch NA, Teja B, Law AC, Pang B, Jafarzadeh SR, Walkey AJ. Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock. JAMA Intern Med. 2023 May 01; 183(5):451-459.View Related Profiles. PMID: 36972033; PMCID: PMC10043800; DOI: 10.1001/jamainternmed.2023.0258;
  7. Corrigan P, Neogi T, Frey-Law L, Jafarzadeh SR, Segal N, Nevitt MC, Lewis CE, Stefanik JJ. Relation of pain sensitization to self-reported and performance-based measures of physical functioning: the Multicenter Osteoarthritis (MOST) study. Osteoarthritis Cartilage. 2023 Jul; 31(7):966-975.View Related Profiles. PMID: 37003421; PMCID: PMC10330303; DOI: 10.1016/j.joca.2023.03.011;
  8. Costello KE, Felson DT, Jafarzadeh SR, Guermazi A, Roemer FW, Segal NA, Lewis CE, Nevitt MC, Lewis CL, Kolachalama VB, Kumar D. Gait, physical activity and tibiofemoral cartilage damage: a longitudinal machine learning analysis in the Multicenter Osteoarthritis Study. Br J Sports Med. 2023 Aug; 57(16):1018-1024.View Related Profiles. PMID: 36868795; PMCID: PMC10423491; DOI: 10.1136/bjsports-2022-106142;
  9. Bacon KL, Felson DT, Jafarzadeh SR, Kolachalama VB, Hausdorff JM, Gazit E, Segal NA, Lewis CE, Nevitt MC, Kumar D. Relation of gait measures with mild unilateral knee pain during walking using machine learning. Sci Rep. 2022 Dec 23; 12(1):22200.View Related Profiles. PMID: 36564397; PMCID: PMC9789148; DOI: 10.1038/s41598-022-21142-2;
  10. Riddle DL, Reza Jafarzadeh S. Effects of psychological distress on the general health to self-reported pain and function outcome relationship in knee arthroplasty: A causal mediation study. Osteoarthr Cartil Open. 2022 Dec; 4(4):100315. PMID: 36474788; PMCID: PMC9718105; DOI: 10.1016/j.ocarto.2022.100315;
Showing 10 of 58 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 58 publications over 16 distinct years, with a maximum of 9 publications in 2022


2023 Rheumatology Research Foundation (RRF): Innovative Research Award
2020 Boston University Clinical and Translational Science Institute (BU-CTSI): Mini Sabbatical Award
2019 Rheumatology Research Foundation (RRF): Innovative Research Award
2018 Arthritis & Rheumatology: Editor’s Choice Article
2014 American College of Epidemiology (ACE): Travel Award
2013 American College of Epidemiology (ACE): Travel Award
2009-2010 University of California, Davis: Graduate Student Support Program (GSSP)
2007-2008 University of California, Davis: Epidemiology Graduate Group Fellowship
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Bayesian Methods
Causal Inference
Diagnostic Tests Evaluation
Estimation of True Prevalence with Imperfect Tests
Machine Learning

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Boston MA 02118
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