S. Reza Jafarzadeh, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Rheumatology

DVM, University of Tehran
MPVM, University of California, Davis
PhD, University of California, Davis



I am interested in the application of causal inference methods in observational studies, especially in the setting of longitudinal data, where time-varying exposures, time-dependent confounding, and selection bias are often present. In particular, I am interested in the application of the variety of modern analytical techniques for estimating causal effects as well as the concepts such as direct and indirect effect decomposition (causal mediation analysis), causal interactions and sufficient causes, and causal interference and spill-over effects. These analytical techniques can be applied to broad areas of health sciences research, but I am particularly interested in the application of causal inference for comparative effectiveness research and implementation science. The methods are very useful for the development and assessment of strategies to improve population health using non-experimental data.

I am also interested in the application of Bayesian methods for evaluation of diagnostic tests and prevalence estimation in the absence of a perfect reference standard. These methods have broad applications in diagnosis and screening, and can be used to estimate true prevalence using imperfect tests.

Member
Boston University
Arthritis & Autoimmune Diseases Research Center




Patient-centered Development of a Composite Digital Endpoint of Mobility and Pain for Knee Osteoarthritis
08/01/2025 - 07/31/2027 (Multi-PI)
PI: S. Reza Jafarzadeh, DVM, MPVM, PhD
NIH/National Institute of Neurological Disorders & Stroke
1UG3NS143758-01

Innovative Research Award: Novel Bayesian approaches to identify persons with osteoarthritis in administrative data in the absence of a reference standard
07/01/2023 - 06/30/2025 (PI)
Rheumatology Research Foundation


Evaluating Routine Opioid Use during Acute Respiratory Failure
08/01/2024 - 04/30/2025 (Subcontract PI)
University of Massachusetts, Medical School NIH NHLBI
7R01HL151607-05

Drug Repurposing to Prevent Posttraumatic Osteoarthritis
01/01/2021 - 08/31/2024 (PI)
Arthritis Foundation


Bayesian approaches to identify persons with osteoarthritis in electronic health records and administrative health data in the absence of a perfect reference standard
03/15/2023 - 07/01/2023 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
1R21AR081442-01A1

Dynamic Treatment Regimens of Physical Activity for Persons with Osteoarthritis
09/01/2019 - 07/31/2022 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R21AR074578-02

Effects of NSAIDs and non-NSAID Analgesics on Osteoarthritis Outcomes
09/01/2018 - 05/31/2021 (PI)
NIH/National Institute on Aging
5R03AG060272-02

Global Awards for Advancing Chronic Pain Research (ADVANCE) 2018 _ NSAIDs, COX2 inhibitors, and opioids long-term effects on knee osteoarthritis progression and joint replacement
11/19/2018 - 12/31/2020 (PI)
Pfizer, Inc.


Personalized dynamic regimens of physical activity for persons with knee osteoarthritis
07/01/2019 - 09/30/2019 (PI)
Rheumatology Research Foundation




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Petrow E, Meade-Aguilar JA, Peloquin C, Jafarzadeh SR, Neogi T, Dubreuil M, Liew J. The Effect of Early Tumor Necrosis Factor Inhibitor Initiation on Chronic Opioid Use in Individuals with Axial Spondylarthritis. Arthritis Care Res (Hoboken). 2025 Oct 13.View Related Profiles. PMID: 41084285; DOI: 10.1002/acr.25659;
     
  2. Degirmenci HB, Peloquin CE, Westerland M, Lodi S, Machado PM, Jafarzadeh SR, Neogi T, Gensler LS, Dubreuil M, Liew JW. Trends in Opioid Prescriptions in Individuals With Axial Spondyloarthritis in the United States and United Kingdom in the Last Two Decades: Analysis of Electronic Health Records and Insurance Claims Data. Arthritis Care Res (Hoboken). 2025 Sep 22.View Related Profiles. PMID: 40977482; DOI: 10.1002/acr.25655;
     
  3. Bosch NA, Law AC, Roubinian NH, Reza Jafarzadeh S, Walkey AJ. Variation in effectiveness of blood transfusion by hospital day: A multicenter retrospective study. J Hosp Med. 2025 Jul 14.View Related Profiles. PMID: 40659365
     
  4. Reshadmanesh T, Mohebi R, Behnoush AH, Reshadmanesh A, Khalaji A, Norouzi M, Javanmardi E, Pishdad R, Jafarzadeh SR, Ghondaghsaz E, Chaparro S. The effects of sodium-glucose cotransporter-2 inhibitors in chemotherapy-induced cardiotoxicity and mortality in patients with cancer: a systematic review and meta-analysis. Cardiooncology. 2025 May 27; 11(1):50.View Related Profiles. PMID: 40426171; PMCID: PMC12107967; DOI: 10.1186/s40959-025-00343-4;
     
  5. Lee S, Neogi T, Senderling BM, Jafarzadeh SR, Gheller M, Tuttle PG, Demanuele C, Viktrup L, Wacnik P, Kumar D. Association of Pain During Exercise With Exercise-Induced Hypoalgesia in People With Knee Osteoarthritis. Arthritis Care Res (Hoboken). 2025 Jul; 77(7):900-905.View Related Profiles. PMID: 40099368; PMCID: PMC12213136; DOI: 10.1002/acr.25524;
     
  6. Ferrandiz-Espadin R, Rabasa G, Gasman S, McGinley B, Stovall R, Jafarzadeh SR, Liew JW, Dubreuil M. Disparities in Time to Diagnosis of Radiographic Axial Spondyloarthritis. J Rheumatol. 2025 Apr 01; 52(4):344-351.View Related Profiles. PMID: 39486857; PMCID: PMC11961325; DOI: 10.3899/jrheum.2024-0574;
     
  7. Driscoll D, George N, Peloquin C, Jafarzadeh SR, Liew JW, Dubreuil M. Association of Therapies for Axial Spondyloarthritis on the Risk of Hip and Spine Fractures. Arthritis Rheumatol. 2025 Jun; 77(6):677-685.View Related Profiles. PMID: 39679763; PMCID: PMC12124969; DOI: 10.1002/art.43082;
     
  8. Myers LC, Bosch NA, Soltesz L, Daly KA, Campbell CI, Schwager E, Salvati E, Stevens JP, Wunsch H, Rucci JM, Jafarzadeh SR, Liu VX, Walkey AJ. Opioid Administration Practice Patterns in Patients With Acute Respiratory Failure Who Undergo Invasive Mechanical Ventilation. Crit Care Explor. 2024 Jul 01; 6(7):e1123.View Related Profiles. PMID: 39018285; PMCID: PMC11257673; DOI: 10.1097/CCE.0000000000001123;
     
  9. Myers LC, Soltesz L, Bosch N, Daly KA, Devis Y, Rucci J, Stevens J, Wunsch H, Jafarzadeh SR, Campbell CI, Liu VX, Walkey AJ. Intravenous Opioid Administration During Mechanical Ventilation and Use After Hospital Discharge. JAMA Netw Open. 2024 Jun 03; 7(6):e2417292.View Related Profiles. PMID: 38874921; PMCID: PMC11179130; DOI: 10.1001/jamanetworkopen.2024.17292;
     
  10. Bacon KL, Felson DT, Jafarzadeh SR, Kolachalama VB, Hausdorff JM, Gazit E, Stefanik JJ, Corrigan P, Segal NA, Lewis CE, Nevitt MC, Kumar D. Gait Alterations and Association With Worsening Knee Pain and Physical Function: A Machine Learning Approach With Wearable Sensors in the Multicenter Osteoarthritis Study. Arthritis Care Res (Hoboken). 2024 Jul; 76(7):984-992.View Related Profiles. PMID: 38523250; PMCID: PMC11209802; DOI: 10.1002/acr.25327;
     
Showing 10 of 67 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 67 publications over 17 distinct years, with a maximum of 9 publications in 2022

YearPublications
20041
20051
20092
20101
20121
20141
20154
20164
20173
20188
20192
20206
20217
20229
20235
20245
20257

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2023 Rheumatology Research Foundation (RRF): Innovative Research Award
2020 Boston University Clinical and Translational Science Institute (BU-CTSI): Mini Sabbatical Award
2019 Rheumatology Research Foundation (RRF): Innovative Research Award
2018 Arthritis & Rheumatology: Editor’s Choice Article
2014 American College of Epidemiology (ACE): Travel Award
2013 American College of Epidemiology (ACE): Travel Award
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Bayesian Methods
Causal Inference
Diagnostic Tests Evaluation
Epidemiology
Estimation of True Prevalence with Imperfect Tests
Machine Learning

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