Philipp Mews, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Physiology & Biophysics

PhD, University of Pennsylvania School of Medicine
BS, Freie Universität Berlin



The Mews Lab is pioneering research at the intersection of neuroepigenetics, metabolism, and neural plasticity in the adult brain, with an emphasis on substance use disorders. Our research builds on the concept that metabolic processes and the epigenome are deeply interconnected, influencing gene expression and behavior in profound ways. At the heart of our work are two critical questions that drive our investigations:

Interplay of Metabolism and Epigenetics: How do metabolic processes intertwine with epigenetic factors to orchestrate gene responses in the brain? This question delves into the heart of cellular function, exploring the dynamic and reciprocal relationship between the metabolic state of a cell and its epigenetic landscape. We are committed to deciphering how these interactions dictate gene expression patterns, influence neural plasticity, and ultimately shape cognitive and behavioral outcomes.

Influence of Diet and Substance Use on Chromatin Dynamics: How do external factors like nutrients and drugs of abuse alter chromatin states, thereby impacting brain function? Here, we probe the profound effects of environmental inputs on the brain’s epigenetic makeup. We seek to understand how these factors induce changes in chromatin structure and function, leading to lasting modifications in neural circuits and behavior. This line of investigation is particularly crucial in understanding the pathogenesis of substance use disorders and in identifying potential epigenetic targets for therapeutic intervention.

The lab combines innovative molecular and behavioral methodologies to explore how metabolism-to-epigenome signaling governs brain function. Our work not only bridges diverse scientific disciplines but also holds the promise of unlocking new therapeutic avenues for neuropsychiatric disorders. Join our team and explore opportunities to contribute, learn, and thrive in our dynamic research environment.


Defining the metabolic-epigenetic regulation of neuronal chromatin by alcohol
09/20/2023 - 08/31/2026 (PI)
NIH/National Institute on Alcohol Abuse and Alcoholism
4R00AA027839-03



Title

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Mews P, Sosnick L, Gurung A, Sidoli S, Nestler EJ. Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens. Sci Signal. 2024 Apr 16; 17(832):eadl4738. PMID: 38626009; PMCID: PMC11170322; DOI: 10.1126/scisignal.adl4738;
     
  2. Martínez-Rivera FJ, Holt LM, Minier-Toribio A, Estill M, Yeh SY, Tofani S, Futamura R, Browne CJ, Mews P, Shen L, Nestler EJ. Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens. bioRxiv. 2024 Mar 14. PMID: 38559084; PMCID: PMC10980003; DOI: 10.1101/2024.03.12.584637;
     
  3. Browne CJ, Mews P, Zhou X, Holt LM, Estill M, Futamura R, Schaefer A, Kenny PJ, Hurd YL, Shen L, Zhang B, Nestler EJ. Shared and divergent transcriptomic regulation in nucleus accumbens D1 and D2 medium spiny neurons by cocaine and morphine. bioRxiv. 2023 Sep 19. PMID: 37781621; PMCID: PMC10541108; DOI: 10.1101/2023.09.19.558477;
     
  4. Godino A, Salery M, Durand-de Cuttoli R, Estill MS, Holt LM, Futamura R, Browne CJ, Mews P, Hamilton PJ, Neve RL, Shen L, Russo SJ, Nestler EJ. Transcriptional control of nucleus accumbens neuronal excitability by retinoid X receptor alpha tunes sensitivity to drug rewards. Neuron. 2023 May 03; 111(9):1453-1467.e7. PMID: 36889314; PMCID: PMC10164098; DOI: 10.1016/j.neuron.2023.02.013;
     
  5. Emerson SD, Chevée M, Mews P, Calipari ES. The transcriptional response to acute cocaine is inverted in male mice with a history of cocaine self-administration and withdrawal throughout the mesocorticolimbic system. Mol Cell Neurosci. 2023 Jun; 125:103823. PMID: 36868542; PMCID: PMC10247534; DOI: 10.1016/j.mcn.2023.103823;
     
  6. Mews P, Cunningham AM, Scarpa J, Ramakrishnan A, Hicks EM, Bolnick S, Garamszegi S, Shen L, Mash DC, Nestler EJ. Convergent abnormalities in striatal gene networks in human cocaine use disorder and mouse cocaine administration models. Sci Adv. 2023 Feb 10; 9(6):eadd8946. PMID: 36763659; PMCID: PMC9916993; DOI: 10.1126/sciadv.add8946;
     
  7. Alexander DC, Corman T, Mendoza M, Glass A, Belity T, Wu R, Campbell RR, Han J, Keiser AA, Winkler J, Wood MA, Kim T, Garcia BA, Cohen H, Mews P, Egervari G, Berger SL. Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation. Proc Natl Acad Sci U S A. 2022 Aug 09; 119(32):e2114758119. PMID: 35921439; PMCID: PMC9371679; DOI: 10.1073/pnas.2114758119;
     
  8. van der Zee YY, Eijssen LMT, Mews P, Ramakrishnan A, Alvarez K, Lardner CK, Cates HM, Walker DM, Torres-Berrío A, Browne CJ, Cunningham A, Cathomas F, Kronman H, Parise EM, de Nijs L, Shen L, Murrough JW, Rutten BPF, Nestler EJ, Issler O. Blood miR-144-3p: a novel diagnostic and therapeutic tool for depression. Mol Psychiatry. 2022 Nov; 27(11):4536-4549. PMID: 35902629; PMCID: PMC9832789; DOI: 10.1038/s41380-022-01712-6;
     
  9. Mews P. Targeting memories to treat trauma. Science. 2022 Apr 08; 376(6589):147. PMID: 35389804
     
  10. Kronman H, Torres-Berrío A, Sidoli S, Issler O, Godino A, Ramakrishnan A, Mews P, Lardner CK, Parise EM, Walker DM, van der Zee YY, Browne CJ, Boyce BF, Neve R, Garcia BA, Shen L, Peña CJ, Nestler EJ. Author Correction: Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons. Nat Neurosci. 2021 May; 24(5):753-754. PMID: 33833436; DOI: 10.1038/s41593-021-00848-y;
     
Showing 10 of 20 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 20 publications over 8 distinct years, with a maximum of 4 publications in 2021 and 2023

YearPublications
20141
20172
20181
20193
20214
20223
20234
20242


2023 International Society for Neurochemistry: Emerging Group Leader Award
2022 Science and AAAS: BII & Science Prize
2022 The Friedman Brain Institute: FBI Research Scholar
2021 Keystone for Incubating Innovation in Life Sciences Network: Postdoctoral Entrepreneurship Award
2021 NIAAA: NIH K99 Pathway to Independence Award
2020 Winter Conference on Brain Research: WCBR Travel Fellow Awardee
2020 Nature Research Award: The Spinoff Prize – Finalist
2019 Brain & Behavior Research Foundation: NARSAD Young Investigator Award
2019 College on Problems of Drug Dependence: CPDD Award for Early Career Investigators
2018 Molecular and Cellular Cognition Society: MCCS Scholar
2018 Society for Neuroscience: Trainee Professional Development Award
2018 Research Society on Alcoholism: Gordis Award Finalist
2017 University of Pennsylvania: Kadesh Prize, Penn Award of Excellence in Research
2017 EMBO Conference on Neural Fate Decisions: Travel Award
2015 Abcam Epigenetics, Obesity and Metabolism: Travel Grant Recipient
2014 National Academy of Sciences, Epigenetic Changes in the Brain: Travel Award
2013 Abcam Chromatin: Structure and Function: Travel Grant Recipient
2012 University of Pennsylvania : President Gutmann Leadership Award
2012 Chemistry-Biology Interface Training Program: CBI Scholar
2011 University of Pennsylvania: Travel Grant Recipient
2009 United States Department of State: Fulbright Scholar
2009 Freie Universität Berlin: University Honors, summa cum laude
Contact for Mentoring:

700 Albany St
Boston MA 02118
Google Map


Mews's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Similar People
_
Same Department