Philipp Mews | Profiles RNS

Philipp Mews, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Physiology & Biophysics

PhD, University of Pennsylvania School of Medicine
BS, Freie Universität Berlin

Websites

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ORCID : 0000-0003-2052-1578

The Mews Lab is pioneering research at the intersection of neuroepigenetics, metabolism, and neural plasticity in the adult brain, with an emphasis on substance use disorders. Our research builds on the concept that metabolic processes and the epigenome are deeply interconnected, influencing gene expression and behavior in profound ways. At the heart of our work are two critical questions that drive our investigations:

Interplay of Metabolism and Epigenetics: How do metabolic processes intertwine with epigenetic factors to orchestrate gene responses in the brain? This question delves into the heart of cellular function, exploring the dynamic and reciprocal relationship between the metabolic state of a cell and its epigenetic landscape. We are committed to deciphering how these interactions dictate gene expression patterns, influence neural plasticity, and ultimately shape cognitive and behavioral outcomes.

Influence of Diet and Substance Use on Chromatin Dynamics: How do external factors like nutrients and drugs of abuse alter chromatin states, thereby impacting brain function? Here, we probe the profound effects of environmental inputs on the brain’s epigenetic makeup. We seek to understand how these factors induce changes in chromatin structure and function, leading to lasting modifications in neural circuits and behavior. This line of investigation is particularly crucial in understanding the pathogenesis of substance use disorders and in identifying potential epigenetic targets for therapeutic intervention.

The lab combines innovative molecular and behavioral methodologies to explore how metabolism-to-epigenome signaling governs brain function. Our work not only bridges diverse scientific disciplines but also holds the promise of unlocking new therapeutic avenues for neuropsychiatric disorders. Join our team and explore opportunities to contribute, learn, and thrive in our dynamic research environment.

NIH RePORTER Research

Title

Yr	Title	Project-Sub Proj
2023	Defining the metabolic-epigenetic regulation of neuronal chromatin by alcohol	4R00AA027839-03
2021	Defining the metabolic-epigenetic regulation of neuronal chromatin by alcohol	5K99AA027839-02
2020	Defining the metabolic-epigenetic regulation of neuronal chromatin by alcohol	1K99AA027839-01A1

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Martínez-Rivera FJ, Holt LM, Minier-Toribio A, Estill M, Yeh SY, Tofani S, Futamura R, Browne CJ, Mews P, Shen L, Nestler EJ. Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens. bioRxiv. 2024 Mar 14. PMID: 38559084; PMCID: PMC10980003; DOI: 10.1101/2024.03.12.584637;

Browne CJ, Mews P, Zhou X, Holt LM, Estill M, Futamura R, Schaefer A, Kenny PJ, Hurd YL, Shen L, Zhang B, Nestler EJ. Shared and divergent transcriptomic regulation in nucleus accumbens D1 and D2 medium spiny neurons by cocaine and morphine. bioRxiv. 2023 Sep 19. PMID: 37781621; PMCID: PMC10541108; DOI: 10.1101/2023.09.19.558477;

Godino A, Salery M, Durand-de Cuttoli R, Estill MS, Holt LM, Futamura R, Browne CJ, Mews P, Hamilton PJ, Neve RL, Shen L, Russo SJ, Nestler EJ. Transcriptional control of nucleus accumbens neuronal excitability by retinoid X receptor alpha tunes sensitivity to drug rewards. Neuron. 2023 May 03; 111(9):1453-1467.e7. PMID: 36889314; PMCID: PMC10164098; DOI: 10.1016/j.neuron.2023.02.013;

Emerson SD, Chevée M, Mews P, Calipari ES. The transcriptional response to acute cocaine is inverted in male mice with a history of cocaine self-administration and withdrawal throughout the mesocorticolimbic system. Mol Cell Neurosci. 2023 Jun; 125:103823. PMID: 36868542; PMCID: PMC10247534; DOI: 10.1016/j.mcn.2023.103823;

Mews P, Cunningham AM, Scarpa J, Ramakrishnan A, Hicks EM, Bolnick S, Garamszegi S, Shen L, Mash DC, Nestler EJ. Convergent abnormalities in striatal gene networks in human cocaine use disorder and mouse cocaine administration models. Sci Adv. 2023 Feb 10; 9(6):eadd8946. PMID: 36763659; PMCID: PMC9916993; DOI: 10.1126/sciadv.add8946;

Alexander DC, Corman T, Mendoza M, Glass A, Belity T, Wu R, Campbell RR, Han J, Keiser AA, Winkler J, Wood MA, Kim T, Garcia BA, Cohen H, Mews P, Egervari G, Berger SL. Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation. Proc Natl Acad Sci U S A. 2022 Aug 09; 119(32):e2114758119. PMID: 35921439; PMCID: PMC9371679; DOI: 10.1073/pnas.2114758119;

van der Zee YY, Eijssen LMT, Mews P, Ramakrishnan A, Alvarez K, Lardner CK, Cates HM, Walker DM, Torres-Berrío A, Browne CJ, Cunningham A, Cathomas F, Kronman H, Parise EM, de Nijs L, Shen L, Murrough JW, Rutten BPF, Nestler EJ, Issler O. Blood miR-144-3p: a novel diagnostic and therapeutic tool for depression. Mol Psychiatry. 2022 Nov; 27(11):4536-4549. PMID: 35902629; PMCID: PMC9832789; DOI: 10.1038/s41380-022-01712-6;

Mews P. Targeting memories to treat trauma. Science. 2022 Apr 08; 376(6589):147. PMID: 35389804

Kronman H, Torres-Berrío A, Sidoli S, Issler O, Godino A, Ramakrishnan A, Mews P, Lardner CK, Parise EM, Walker DM, van der Zee YY, Browne CJ, Boyce BF, Neve R, Garcia BA, Shen L, Peña CJ, Nestler EJ. Author Correction: Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons. Nat Neurosci. 2021 May; 24(5):753-754. PMID: 33833436; DOI: 10.1038/s41593-021-00848-y;

Kronman H, Torres-Berrío A, Sidoli S, Issler O, Godino A, Ramakrishnan A, Mews P, Lardner CK, Parise EM, Walker DM, van der Zee YY, Browne CJ, Boyce BF, Neve R, Garcia BA, Shen L, Peña CJ, Nestler EJ. Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons. Nat Neurosci. 2021 May; 24(5):667-676. PMID: 33723435; PMCID: PMC8216773; DOI: 10.1038/s41593-021-00814-8;

Showing 10 of 19 results. Show More

van der Zee YY, Lardner CK, Parise EM, Mews P, Ramakrishnan A, Patel V, Teague CD, Salery M, Walker DM, Browne CJ, Labonté B, Parise LF, Kronman H, Penã CJ, Torres-Berrío A, Duffy JE, de Nijs L, Eijssen LMT, Shen L, Rutten B, Issler O, Nestler EJ. Sex-Specific Role for SLIT1 in Regulating Stress Susceptibility. Biol Psychiatry. 2022 Jan 01; 91(1):81-91. PMID: 33896623; PMCID: PMC8390577; DOI: 10.1016/j.biopsych.2021.01.019;

Mews P, Calipari ES, Day J, Lobo MK, Bredy T, Abel T. From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health. J Neurosci. 2021 Feb 03; 41(5):873-882. PMID: 33446519; PMCID: PMC7880276; DOI: 10.1523/JNEUROSCI.1649-20.2020;

Mews P, Egervari G, Nativio R, Sidoli S, Donahue G, Lombroso SI, Alexander DC, Riesche SL, Heller EA, Nestler EJ, Garcia BA, Berger SL. Alcohol metabolism contributes to brain histone acetylation. Nature. 2019 Oct; 574(7780):717-721. PMID: 31645761; PMCID: PMC6907081; DOI: 10.1038/s41586-019-1700-7;

Lorsch ZS, Hamilton PJ, Ramakrishnan A, Parise EM, Salery M, Wright WJ, Lepack AE, Mews P, Issler O, McKenzie A, Zhou X, Parise LF, Pirpinias ST, Ortiz Torres I, Kronman HG, Montgomery SE, Loh YE, Labonté B, Conkey A, Symonds AE, Neve RL, Turecki G, Maze I, Dong Y, Zhang B, Shen L, Bagot RC, Nestler EJ. Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex. Nat Neurosci. 2019 Sep; 22(9):1413-1423. PMID: 31427770; PMCID: PMC6713580; DOI: 10.1038/s41593-019-0462-8;

Mews P, Walker DM, Nestler EJ. Epigenetic Priming in Drug Addiction. Cold Spring Harb Symp Quant Biol. 2018; 83:131-139. PMID: 30936392; PMCID: PMC6764605; DOI: 10.1101/sqb.2018.83.037663;

Walker DM, Cates HM, Loh YE, Purushothaman I, Ramakrishnan A, Cahill KM, Lardner CK, Godino A, Kronman HG, Rabkin J, Lorsch ZS, Mews P, Doyle MA, Feng J, Labonté B, Koo JW, Bagot RC, Logan RW, Seney ML, Calipari ES, Shen L, Nestler EJ. Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain's Reward Circuitry. Biol Psychiatry. 2018 12 15; 84(12):867-880.View Related Profiles.

Mews, Philipp
Logan, Ryan

PMID: 29861096; PMCID: PMC6202276; DOI: 10.1016/j.biopsych.2018.04.009;

Mews P, Calipari ES. Cross-talk between the epigenome and neural circuits in drug addiction. Prog Brain Res. 2017; 235:19-63. PMID: 29054289; PMCID: PMC6339819; DOI: 10.1016/bs.pbr.2017.08.012;

Mews P, Donahue G, Drake AM, Luczak V, Abel T, Berger SL. Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory. Nature. 2017 Jun 15; 546(7658):381-386. PMID: 28562591

Mews P, Zee BM, Liu S, Donahue G, Garcia BA, Berger SL. Histone methylation has dynamics distinct from those of histone acetylation in cell cycle reentry from quiescence. Mol Cell Biol. 2014 Nov; 34(21):3968-80. PMID: 25154414

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 19 publications over 8 distinct years, with a maximum of 4 publications in 2021 and 2023