Pawel F Przytycki
Assistant Professor
Boston University
Computing & Data Sciences

PhD, Princeton University
MA, Princeton University
BA, Columbia University



Pawel Przytycki is an assistant professor in the Faculty of Computing & Data Sciences (CDS) and a core faculty member in the Bioinformatics Program. Prior to joining BU, Pawel was a Bioinformatics Fellow at the Gladstone Institutes at the University of California, San Francisco. His research is focused on the development of novel computational methods to understand the regulatory effects of noncoding variants in neurological development and diseases. While high-throughput genetic sequencing makes it possible to unravel the genetics of these diseases, sequencing data is often sparse, high-dimensional, and heterogeneous across individuals and cells. Pawel’s work addresses these challenges through development of algorithms for integrating and interpreting large-scale multi-modal genomics data.

Member
Boston University
Genome Science Institute


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Przytycki PF, Pollard KS. Hierarchical annotation of eQTLs by H-eQTL enables identification of genes with cell type-divergent regulation. Genome Biol. 2024 Nov 25; 25(1):299. PMID: 39587678; PMCID: PMC11587609; DOI: 10.1186/s13059-024-03440-2;
     
  2. Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Pelonero A, Lee CY, Sadagopan N, Huang Y, Auclair K, Zhu A, An Y, Ekstrand CA, Martinez C, Teran BG, Flanigan WR, Kim CK, Lumbao-Conradson K, Gardner Z, Li L, Costa MW, Jain R, Charo I, Combes AJ, Haldar SM, Pollard KS, Vagnozzi RJ, McKinsey TA, Przytycki PF, Srivastava D. Chromatin remodelling drives immune cell-fibroblast communication in heart failure. Nature. 2024 Nov; 635(8038):434-443. PMID: 39443808; PMCID: PMC11698514; DOI: 10.1038/s41586-024-08085-6;
     
  3. Deng C, Whalen S, Steyert M, Ziffra R, Przytycki PF, Inoue F, Pereira DA, Capauto D, Norton S, Vaccarino FM, Pollen AA, Nowakowski TJ, Ahituv N, Pollard KS. Massively parallel characterization of regulatory elements in the developing human cortex. Science. 2024 May 24; 384(6698):eadh0559. PMID: 38781390; DOI: 10.1126/science.adh0559;
     
  4. Wen C, Margolis M, Dai R, Zhang P, Przytycki PF, Vo DD, Bhattacharya A, Matoba N, Tang M, Jiao C, Kim M, Tsai E, Hoh C, Aygün N, Walker RL, Chatzinakos C, Clarke D, Pratt H, Peters MA, Gerstein M, Daskalakis NP, Weng Z, Jaffe AE, Kleinman JE, Hyde TM, Weinberger DR, Bray NJ, Sestan N, Geschwind DH, Roeder K, Gusev A, Pasaniuc B, Stein JL, Love MI, Pollard KS, Liu C, Gandal MJ. Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain. Science. 2024 May 24; 384(6698):eadh0829. PMID: 38781368; DOI: 10.1126/science.adh0829;
     
  5. Hu Z, Przytycki PF, Pollard KS. CellWalker2: multi-omic discovery of hierarchical cell type relationships and their associations with genomic annotations. bioRxiv. 2024 May 17. PMID: 38798605; PMCID: PMC11118555; DOI: 10.1101/2024.05.17.594770;
     
  6. Przytycki PF. Uncovering the genetic circuits that drive diseases. Nat Comput Sci. 2023 Jul; 3(7):584-585. PMID: 38177750
     
  7. Keough KC, Whalen S, Inoue F, Przytycki PF, Fair T, Deng C, Steyert M, Ryu H, Lindblad-Toh K, Karlsson E, Nowakowski T, Ahituv N, Pollen A, Pollard KS. Three-dimensional genome rewiring in loci with human accelerated regions. Science. 2023 Apr 28; 380(6643):eabm1696. PMID: 37104607; PMCID: PMC10999243; DOI: 10.1126/science.abm1696;
     
  8. Blair AP, Hu RK, Farah EN, Chi NC, Pollard KS, Przytycki PF, Kathiriya IS, Bruneau BG. Cell Layers: uncovering clustering structure in unsupervised single-cell transcriptomic analysis. Bioinform Adv. 2022; 2(1):vbac051. PMID: 35967929; PMCID: PMC9362878; DOI: 10.1093/bioadv/vbac051;
     
  9. Przytycki PF, Pollard KS. CellWalkR: an R package for integrating and visualizing single-cell and bulk data to resolve regulatory elements. Bioinformatics. 2022 Apr 28; 38(9):2621-2623. PMID: 35274675; PMCID: PMC9048661; DOI: 10.1093/bioinformatics/btac150;
     
  10. Ziffra RS, Kim CN, Ross JM, Wilfert A, Turner TN, Haeussler M, Casella AM, Przytycki PF, Keough KC, Shin D, Bogdanoff D, Kreimer A, Pollard KS, Ament SA, Eichler EE, Ahituv N, Nowakowski TJ. Single-cell epigenomics reveals mechanisms of human cortical development. Nature. 2021 Oct; 598(7879):205-213. PMID: 34616060; PMCID: PMC8494642; DOI: 10.1038/s41586-021-03209-8;
     
Showing 10 of 17 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 17 publications over 7 distinct years, with a maximum of 5 publications in 2024

YearPublications
20092
20171
20202
20213
20222
20232
20245


2021 Gladstone Institutes: Distinguished Achievement in Science Award
2020 Gladstone Institutes: Robert and Linda Mahley Career Advancement Award
2013-2018 NSF: NSF Graduate Research Fellowship Program
2007-2011 Columbia University: I.I. Rabi Science Scholar
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