Melisa Ruiz-Gutierrez, MD, PhD
Assistant Professor
Boston University School of Medicine
Dept of Pediatrics

MD, Mount Sinai School of Medicine
PhD, Mount Sinai School of Medicine

Melisa Ruiz-Gutierrez, MD, PhD is an Assistant Professor of Pediatrics at the Boston University School of Medicine. Before arriving at the university, Dr. Ruiz-Gutierrez was an Instructor at Harvard Medical School. Throughout her career, she has served as a research assistant and associate for organizations in the Boston and Seattle area. Dr. Ruiz-Gutierrez has lectured on the TGFb pathway, Shwachman Diamond Syndrome, and bone marrow failure.

Boston University School of Medicine
Center of Excellence in Sickle Cell Disease

2004 Outstanding Service to Mount Sinai Community

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Joyce CE, Saadatpour A, Ruiz-Gutierrez M, Bolukbasi OV, Jiang L, Thomas DD, Young S, Hofmann I, Sieff CA, Myers KC, Whangbo J, Libermann TA, Nusbaum C, Yuan GC, Shimamura A, Novina CD. TGFß signaling underlies hematopoietic dysfunction and bone marrow failure in Shwachman-Diamond Syndrome. J Clin Invest. 2019 06 18; 129(9):3821-3826. PMID: 31211692; PMCID: PMC6715362; DOI: 10.1172/JCI125375;
  2. Ruiz-Gutierrez M, Bölükbasi ÖV, Alexe G, Kotini AG, Ballotti K, Joyce CE, Russell DW, Stegmaier K, Myers K, Novina CD, Papapetrou EP, Shimamura A. Therapeutic discovery for marrow failure with MDS predisposition using pluripotent stem cells. JCI Insight. 2019 04 30; 5. PMID: 31039138; PMCID: PMC6629156; DOI: 10.1172/jci.insight.125157;
  3. Burwick N, Zhang MY, de la Puente P, Azab AK, Hyun TS, Ruiz-Gutierrez M, Sanchez-Bonilla M, Nakamura T, Delrow JJ, MacKay VL, Shimamura A. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma. Leuk Res. 2017 04; 55:23-32. PMID: 28119225; PMCID: PMC5354961; DOI: 10.1016/j.leukres.2017.01.007;
  4. Culjkovic B, Topisirovic I, Skrabanek L, Ruiz-Gutierrez M, Borden KL. eIF4E is a central node of an RNA regulon that governs cellular proliferation. J Cell Biol. 2006 Nov 06; 175(3):415-26. PMID: 17074885; PMCID: PMC2064519; DOI: 10.1083/jcb.200607020;
  5. Culjkovic B, Topisirovic I, Skrabanek L, Ruiz-Gutierrez M, Borden KL. eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR. J Cell Biol. 2005 Apr 25; 169(2):245-56. PMID: 15837800; PMCID: PMC2171863; DOI: 10.1083/jcb.200501019;
  6. Topisirovic I, Ruiz-Gutierrez M, Borden KL. Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities. Cancer Res. 2004 Dec 01; 64(23):8639-42. PMID: 15574771
  7. Hirschhorn JN, Sklar P, Lindblad-Toh K, Lim YM, Ruiz-Gutierrez M, Bolk S, Langhorst B, Schaffner S, Winchester E, Lander ES. SBE-TAGS: an array-based method for efficient single-nucleotide polymorphism genotyping. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12164-9. PMID: 11035790; PMCID: PMC17312
  8. Shapiro R, Ruiz-Gutierrez M, Chen CZ. Analysis of the interactions of human ribonuclease inhibitor with angiogenin and ribonuclease A by mutagenesis: importance of inhibitor residues inside versus outside the C-terminal "hot spot". J Mol Biol. 2000 Sep 15; 302(2):497-519. PMID: 10970748

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 8 publications over 6 distinct years, with a maximum of 2 publications in 2000 and 2019

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Boston MA 02118
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