Matthias Stangl, PhD
Assistant Professor
Boston University College of Engineering
Biomedical Engineering




Research in my lab focuses on how the human brain supports critical cognitive and behavioral functions in our everyday life, such as spatial navigation and memory, and on the neural mechanisms that underlie age-related impairments in these functions. From a methodological perspective, we employ novel neurotechnologies and advanced methodologies such as deep brain recordings in freely-moving individuals with permanently implanted neurostimulator devices, enabling us to study human brain function during natural movement and behavior in real-world settings. In addition, we conduct intracranial electrophysiological recordings in hospitalized patients, providing valuable insights into neural computations at the level of individual human neurons. To complement these invasive recordings, we also utilize non-invasive neuroimaging techniques like functional magnetic resonance imaging (fMRI) and scalp electroencephalography (EEG). Through this multimodal neuroimaging approach, we gain a comprehensive understanding of the neural mechanisms underlying spatial navigation and memory, and human behavior more generally, both within and outside of controlled laboratory environments. Together, this holistic approach enables unique insights into human brain function across multiple scales, ranging from the activity of single neurons to the dynamic interactions of whole-brain networks.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Newton C, Pope M, Rua C, Henson R, Ji Z, Burgess N, Rodgers CT, Stangl M, Dounavi ME, Castegnaro A, Koychev I, Malhotra P, Wolbers T, Ritchie K, Ritchie CW, O'Brien J, Su L, Chan D. Entorhinal-based path integration selectively predicts midlife risk of Alzheimer's disease. Alzheimers Dement. 2024 Apr; 20(4):2779-2793. PMID: 38421123; PMCID: PMC11032581; DOI: 10.1002/alz.13733;
     
  2. Maoz SLL, Stangl M, Topalovic U, Batista D, Hiller S, Aghajan ZM, Knowlton B, Stern J, Langevin JP, Fried I, Eliashiv D, Suthana N. Dynamic neural representations of memory and space during human ambulatory navigation. Nat Commun. 2023 Oct 20; 14(1):6643. PMID: 37863929; PMCID: PMC10589239; DOI: 10.1038/s41467-023-42231-4;
     
  3. Gill JL, Schneiders JA, Stangl M, Aghajan ZM, Vallejo M, Hiller S, Topalovic U, Inman CS, Villaroman D, Bari A, Adhikari A, Rao VR, Fanselow MS, Craske MG, Krahl SE, Chen JWY, Vick M, Hasulak NR, Kao JC, Koek RJ, Suthana N, Langevin JP. A pilot study of closed-loop neuromodulation for treatment-resistant post-traumatic stress disorder. Nat Commun. 2023 May 24; 14(1):2997. PMID: 37225710; PMCID: PMC10209131; DOI: 10.1038/s41467-023-38712-1;
     
  4. Stangl M, Maoz SL, Suthana N. Mobile cognition: imaging the human brain in the 'real world'. Nat Rev Neurosci. 2023 Jun; 24(6):347-362. PMID: 37046077; PMCID: PMC10642288; DOI: 10.1038/s41583-023-00692-y;
     
  5. Topalovic U, Barclay S, Ling C, Alzuhair A, Yu W, Hokhikyan V, Chandrakumar H, Rozgic D, Jiang W, Basir-Kazeruni S, Maoz SL, Inman CS, Stangl M, Gill J, Bari A, Fallah A, Eliashiv D, Pouratian N, Fried I, Suthana N, Markovic D. A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans. Nat Neurosci. 2023 Mar; 26(3):517-527. PMID: 36804647; PMCID: PMC9991917; DOI: 10.1038/s41593-023-01260-4;
     
  6. Newton C, Pope M, Rua C, Henson R, Ji Z, Burgess N, Rodgers CT, Stangl M, Dounavi ME, Castegnaro A, Koychev I, Malhotra P, Wolbers T, Ritchie K, Ritchie CW, O'Brien J, Su L, Chan D. Path integration selectively predicts midlife risk of Alzheimer's disease. bioRxiv. 2023 Feb 03. PMID: 36778428; PMCID: PMC9915680; DOI: 10.1101/2023.01.31.526473;
     
  7. Wagner IC, Graichen LP, Todorova B, Lüttig A, Omer DB, Stangl M, Lamm C. Entorhinal grid-like codes and time-locked network dynamics track others navigating through space. Nat Commun. 2023 Jan 31; 14(1):231. PMID: 36720865; PMCID: PMC9889810; DOI: 10.1038/s41467-023-35819-3;
     
  8. Stangl M, Topalovic U, Inman CS, Hiller S, Villaroman D, Aghajan ZM, Christov-Moore L, Hasulak NR, Rao VR, Halpern CH, Eliashiv D, Fried I, Suthana N. Boundary-anchored neural mechanisms of location-encoding for self and others. Nature. 2021 Jan; 589(7842):420-425. PMID: 33361808; PMCID: PMC8189322; DOI: 10.1038/s41586-020-03073-y;
     
  9. Topalovic U, Aghajan ZM, Villaroman D, Hiller S, Christov-Moore L, Wishard TJ, Stangl M, Hasulak NR, Inman CS, Fields TA, Rao VR, Eliashiv D, Fried I, Suthana N. Wireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans. Neuron. 2020 Oct 28; 108(2):322-334.e9. PMID: 32946744; PMCID: PMC7785319; DOI: 10.1016/j.neuron.2020.08.021;
     
  10. Stangl M, Kanitscheider I, Riemer M, Fiete I, Wolbers T. Sources of path integration error in young and aging humans. Nat Commun. 2020 May 26; 11(1):2626. PMID: 32457293; PMCID: PMC7250899; DOI: 10.1038/s41467-020-15805-9;
     
Showing 10 of 16 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 16 publications over 7 distinct years, with a maximum of 6 publications in 2023

YearPublications
20131
20143
20171
20181
20203
20236
20241


2022 UCLA Brain Research Institute: Arnold Scheibel Postdoctoral Lecture Award
2022 UCLA Brain Research Institute and Semel Institute: Travel Award
2021 UCLA Chancellor's Award for Postdoctoral Research
2021 Semel Institute at UCLA: ‘Spotlight Trainee’
2020 Center for Behavioral Brain Sciences (CBBS) Magdeburg: Paper of the Year Award
2019 Backyard Brains Inc: Travel Scholarship
2018 Center for Behavioral Brain Sciences (CBBS) Magdeburg: Paper of the Year Award
2018 Otto-von-Guericke University Magdeburg : PhD awarded with highest honors (‘summa cum laude’)
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44 Cummington St
Boston MA 02215
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