Manish Goyal | Profiles RNS

Manish Goyal, PhD

Research Assistant Professor

Boston University Henry M. Goldman School of Dental Medicine

Molecular & Cell Biology

PhD, Jadavpur University
MSc, University of Rajasthan
BVSc, University of Rajasthan

Pronouns: he/him/his

Websites

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ORCID : 0000-0003-2383-5409

Translational researcher with expertise in the areas of cell and molecular biology, protein biochemistry, pre-clinical vaccine, and drug discovery research. Broad experience with protein expression, and purification, advanced genomic (CRISPER/Cas9) and proteomic tools to develop innovative in vitro and ex vivo assays, and development and execution of genetic and biochemistry-based research methods.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Nag S, Banerjee C, Goyal M, Siddiqui AA, Saha D, Mazumder S, Debsharma S, Pramanik S, Saha SJ, De R, Bandyopadhyay U. Plasmodium falciparum Alba6 exhibits DNase activity and participates in stress response. iScience. 2024 Apr 19; 27(4):109467. PMID: 38558939; PMCID: PMC10981135; DOI: 10.1016/j.isci.2024.109467;

Banerjee C, Nag S, Goyal M, Saha D, Siddiqui AA, Mazumder S, Debsharma S, Pramanik S, Bandyopadhyay U. Nuclease activity of Plasmodium falciparum Alba family protein PfAlba3. Cell Rep. 2023 Apr 25; 42(4):112292. PMID: 36947546; DOI: 10.1016/j.celrep.2023.112292;

Goyal M, Simantov K, Dzikowski R. Beyond splicing: serine-arginine proteins as emerging multifaceted regulators of RNA metabolism in malaria parasites. Curr Opin Microbiol. 2022 Dec; 70:102201. PMID: 36087463; DOI: 10.1016/j.mib.2022.102201;

Heinberg A, Amit-Avraham I, Mitesser V, Simantov K, Goyal M, Nevo Y, Kandelis-Shalev S, Thompson E, Dzikowski R. A nuclear redox sensor modulates gene activation and var switching in Plasmodium falciparum. Proc Natl Acad Sci U S A. 2022 Aug 16; 119(33):e2201247119. PMID: 35939693; PMCID: PMC9388093; DOI: 10.1073/pnas.2201247119;

Simantov K, Goyal M, Dzikowski R. Emerging biology of noncoding RNAs in malaria parasites. PLoS Pathog. 2022 Jul; 18(7):e1010600. PMID: 35797283; PMCID: PMC9262227; DOI: 10.1371/journal.ppat.1010600;

Siddiqui AJ, Bhardwaj J, Hamadou WS, Goyal M, Jahan S, Ashraf SA, Jamal A, Sharma P, Sachidanandan M, Badraoui R, Snoussi M, Adnan M. Impact of chemoprophylaxis immunisation under halofantrine (CPS-HF) drug cover in Plasmodium yoelii Swiss mice malaria model. Folia Parasitol (Praha). 2022 Feb 03; 69. PMID: 35145048; DOI: 10.14411/fp.2022.003;

Simantov K, Goyal M. Post-transcriptional Gene Regulation in Human Disease Post-Transcriptional Gene Regulation in Human Disease 2022, Pages 309-327. Post-transcriptional regulation of gene expression in the human malaria parasite Plasmodium falciparum. Elsevier. 2022; 32:309-327. View Publication

Goyal M, Singh BK, Simantov K, Kaufman Y, Eshar S, Dzikowski R. Correction: An SR protein is essential for activating DNA repair in malaria parasites. J Cell Sci. 2021 Nov 01; 134(21). PMID: 34714333; PMCID: PMC11034871; DOI: 10.1242/jcs.259460;

Siddiqui AJ, Bhardwaj J, Hamadou WS, Goyal M, Ashraf SA, Jahan S, Jamal A, Sharma P, Sachidanandan M, Badraoui R, Adnan M. Chemoprophylaxis under sporozoites-lumefantrine (CPS-LMF) immunization induce protective immune responses against Plasmodium yoelii sporozoites infection in mice. 3 Biotech. 2021 Nov; 11(11):465. PMID: 34745816; PMCID: PMC8526652; DOI: 10.1007/s13205-021-03022-0;

Siddiqui AJ, Khan MF, Hamadou WS, Goyal M, Jahan S, Jamal A, Ashraf SA, Sharma P, Sachidanandan M, Badraoui R, Chaubey KK, Snoussi M, Adnan M. Molecular Docking and Dynamics Simulation Revealed Ivermectin as Potential Drug against Schistosoma-Associated Bladder Cancer Targeting Protein Signaling: Computational Drug Repositioning Approach. Medicina (Kaunas). 2021 Oct 03; 57(10). PMID: 34684095; PMCID: PMC8539496; DOI: 10.3390/medicina57101058;

Showing 10 of 41 results. Show More

Goyal M, Singh BK, Simantov K, Kaufman Y, Eshar S, Dzikowski R. An SR protein is essential for activating DNA repair in malaria parasites. J Cell Sci. 2021 Aug 15; 134(16). PMID: 34291805; PMCID: PMC8435287; DOI: 10.1242/jcs.258572;

Gangwar M, Jha R, Goyal M, Srivastava M. Biochemical characterization of Recombinase A from Wolbachia endosymbiont of filarial nematode Brugia malayi (wBmRecA). Int J Parasitol. 2021 Sep; 51(10):841-853. PMID: 34273392; DOI: 10.1016/j.ijpara.2021.02.007;

Goyal M, Heinberg A, Mitesser V, Kandelis-Shalev S, Singh BK, Dzikowski R. Phosphorylation of the Canonical Histone H2A Marks Foci of Damaged DNA in Malaria Parasites. mSphere. 2021 Jan 13; 6(1). PMID: 33441412; PMCID: PMC7845613; DOI: 10.1128/mSphere.01131-20;

Siddiqui AJ, Bhardwaj J, Goyal M, Prakash K, Adnan M, Alreshidi MM, Patel M, Soni A, Redman W. Immune responses in liver and spleen against Plasmodium yoelii pre-erythrocytic stages in Swiss mice model. J Adv Res. 2020 Jul; 24:29-41. PMID: 32181014; PMCID: PMC7063113; DOI: 10.1016/j.jare.2020.02.016;

Gangwar M, Jha R, Goyal M, Srivastava M. Immunogenicity and protective efficacy of Recombinase A from Wolbachia endosymbiont of filarial nematode Brugia malayi (wBmRecA). Vaccine. 2019 Jan 21; 37(4):571-580. PMID: 30595344; DOI: 10.1016/j.vaccine.2018.12.015;

Chaubey KK, Gupta RD, Gupta S, Singh SV, Bhatia AK, Jayaraman S, Kumar N, Goel A, Rathore AS, Sahzad, Sohal JS, Stephen BJ, Singh M, Goyal M, Dhama K, Derakhshandeh A. Trends and advances in the diagnosis and control of paratuberculosis in domestic livestock. Vet Q. 2016 Dec; 36(4):203-227. PMID: 27356470; DOI: 10.1080/01652176.2016.1196508;

Bhardwaj J, Siddiqui AJ, Goyal M, Prakash K, Soni A, Puri SK. Repetitive live sporozoites inoculation under arteether chemoprophylaxis confers protection against subsequent sporozoite challenge in rodent malaria model. Acta Trop. 2016 Jun; 158:130-138. PMID: 26925772; DOI: 10.1016/j.actatropica.2016.02.016;

Goyal M, Banerjee C, Nag S, Bandyopadhyay U. The Alba protein family: Structure and function. Biochim Biophys Acta. 2016 May; 1864(5):570-83. PMID: 26900088; DOI: 10.1016/j.bbapap.2016.02.015;

Iqbal MS, Siddiqui AA, Alam A, Goyal M, Banerjee C, Sarkar S, Mazumder S, De R, Nag S, Saha SJ, Bandyopadhyay U. Expression, purification and characterization of Plasmodium falciparum vacuolar protein sorting 29. Protein Expr Purif. 2016 Apr; 120:7-15. PMID: 26690372; DOI: 10.1016/j.pep.2015.12.004;

Siddiqui AJ, Bhardwaj J, Goyal M, Prakash K, Soni A, Tiwari V, Puri SK. Assessment of real-time method to detect liver parasite burden under different experimental conditions in mice infected with Plasmodium yoelii sporozoites. Microb Pathog. 2015 Dec; 89:35-42. PMID: 26341953; DOI: 10.1016/j.micpath.2015.08.015;

Bhardwaj J, Siddiqui AJ, Goyal M, Prakash K, Soni A, Puri SK, Srivastava M. Host immune response is severely compromised during lethal Plasmodium vinckei infection. Parasitol Res. 2015 Sep; 114(9):3445-57. PMID: 26077756; DOI: 10.1007/s00436-015-4570-4;

Soni A, Goyal M, Prakash K, Bhardwaj J, Siddiqui AJ, Puri SK. Cloning, expression and functional characterization of heme detoxification protein (HDP) from the rodent malaria parasite Plasmodium vinckei. Gene. 2015 Jul 15; 566(1):109-19. PMID: 25891072; DOI: 10.1016/j.gene.2015.04.037;

Singh CP, Chaudhary NS, Goyal M, Wallace S, Karan RZ. Arabidopsis Thaliana: Cultivation, Life Cycle and Functional Genomics. Nova Science Publishers, Inc. New York, USA. Role of miRNA in Abiotic Stress Responses in Arabidopsis thaliana. Nova Science Publisher. 2015. View Publication
Goyal M, Chauhan P, Singh CP, Wallace S, Karan RZ. Arabidopsis Thaliana: Cultivation, Life Cycle and Functional Genomics. Redox regulation in arabidopsis: an introduction to antioxidant and redox defense systems. Nova Science Publishers, Inc. New York, USA. 2015.

Prakash K, Goyal M, Soni A, Siddiqui AJ, Bhardwaj J, Puri SK. Molecular cloning and biochemical characterization of iron superoxide dismutase from the rodent malaria parasite Plasmodium vinckei. Parasitol Int. 2014 Dec; 63(6):817-25. PMID: 25091832; DOI: 10.1016/j.parint.2014.07.004;

Dey S, Mazumder S, Siddiqui AA, Iqbal MS, Banerjee C, Sarkar S, De R, Goyal M, Bindu S, Bandyopadhyay U. Association of heme oxygenase 1 with the restoration of liver function after damage in murine malaria by Plasmodium yoelii. Infect Immun. 2014 Aug; 82(8):3113-26. PMID: 24818663; PMCID: PMC4136231; DOI: 10.1128/IAI.01598-14;

Manna, S.K., Singh, P., Mondal, S., Goyal. M., Bandyopadhyay, U., and , Panda, G. . Trisubstituted Methanes (TRSMs): Synthesis and Bioevaluation as Anti-malarials. SOP Trans Org Chem. 2014; 1:8-20.. View Publication

Bindu S, Mazumder S, Dey S, Pal C, Goyal M, Alam A, Iqbal MS, Sarkar S, Azhar Siddiqui A, Banerjee C, Bandyopadhyay U. Nonsteroidal anti-inflammatory drug induces proinflammatory damage in gastric mucosa through NF-?B activation and neutrophil infiltration: anti-inflammatory role of heme oxygenase-1 against nonsteroidal anti-inflammatory drug. Free Radic Biol Med. 2013 Dec; 65:456-467. PMID: 23892052; DOI: 10.1016/j.freeradbiomed.2013.07.027;

Dey S, Bindu S, Goyal M, Pal C, Alam A, Iqbal MS, Kumar R, Sarkar S, Bandyopadhyay U. Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-?B activation, and neutrophil infiltration. J Biol Chem. 2012 Aug 03; 287(32):26630-46. PMID: 22696214; PMCID: PMC3411003; DOI: 10.1074/jbc.M112.341255;

Alam A, Haldar S, Thulasiram HV, Kumar R, Goyal M, Iqbal MS, Pal C, Dey S, Bindu S, Sarkar S, Pal U, Maiti NC, Bandyopadhyay U. Novel anti-inflammatory activity of epoxyazadiradione against macrophage migration inhibitory factor: inhibition of tautomerase and proinflammatory activities of macrophage migration inhibitory factor. J Biol Chem. 2012 Jul 13; 287(29):24844-61. PMID: 22645149; PMCID: PMC3397911; DOI: 10.1074/jbc.M112.341321;

Goyal M, Singh P, Alam A, Das SK, Iqbal MS, Dey S, Bindu S, Pal C, Das SK, Panda G, Bandyopadhyay U. Aryl aryl methyl thio arenes prevent multidrug-resistant malaria in mouse by promoting oxidative stress in parasites. Free Radic Biol Med. 2012 Jul 01; 53(1):129-42. PMID: 22588006; DOI: 10.1016/j.freeradbiomed.2012.04.028;

Goyal M, Alam A, Bandyopadhyay U. Redox regulation in malaria: current concepts and pharmacotherapeutic implications. Curr Med Chem. 2012; 19(10):1475-503. PMID: 22360482; DOI: 10.2174/092986712799828328;

Alam A, Pal C, Goyal M, Kundu MK, Kumar R, Iqbal MS, Dey S, Bindu S, Sarkar S, Pal U, Maiti NC, Adhikari S, Bandyopadhyay U. Synthesis and bio-evaluation of human macrophage migration inhibitory factor inhibitor to develop anti-inflammatory agent. Bioorg Med Chem. 2011 Dec 15; 19(24):7365-73. PMID: 22088307; DOI: 10.1016/j.bmc.2011.10.056;

Goyal M, Alam A, Iqbal MS, Dey S, Bindu S, Pal C, Banerjee A, Chakrabarti S, Bandyopadhyay U. Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum. Nucleic Acids Res. 2012 Feb; 40(3):1174-90. PMID: 22006844; PMCID: PMC3273813; DOI: 10.1093/nar/gkr821;

Bindu S, Pal C, Dey S, Goyal M, Alam A, Iqbal MS, Dutta S, Sarkar S, Kumar R, Maity P, Bandyopadhyay U. Translocation of heme oxygenase-1 to mitochondria is a novel cytoprotective mechanism against non-steroidal anti-inflammatory drug-induced mitochondrial oxidative stress, apoptosis, and gastric mucosal injury. J Biol Chem. 2011 Nov 11; 286(45):39387-402. PMID: 21908612; PMCID: PMC3234763; DOI: 10.1074/jbc.M111.279893;

Alam A, Goyal M, Iqbal MS, Bindu S, Dey S, Pal C, Maity P, Mascarenhas NM, Ghoshal N, Bandyopadhyay U. Cysteine-3 and cysteine-4 are essential for the thioredoxin-like oxidoreductase and antioxidant activities of Plasmodium falciparum macrophage migration inhibitory factor. Free Radic Biol Med. 2011 Jun 01; 50(11):1659-68. PMID: 21406224; DOI: 10.1016/j.freeradbiomed.2011.03.012;

Pal C, Bindu S, Dey S, Alam A, Goyal M, Iqbal MS, Maity P, Adhikari SS, Bandyopadhyay U. Gallic acid prevents nonsteroidal anti-inflammatory drug-induced gastropathy in rat by blocking oxidative stress and apoptosis. Free Radic Biol Med. 2010 Jul 15; 49(2):258-67. PMID: 20406680; DOI: 10.1016/j.freeradbiomed.2010.04.013;

Alam A, Goyal M, Iqbal MS, Pal C, Dey S, Bindu S, Maity P, Bandyopadhyay U. Novel antimalarial drug targets: hope for new antimalarial drugs. Expert Rev Clin Pharmacol. 2009 Sep; 2(5):469-89. PMID: 22112223; DOI: 10.1586/ecp.09.28;

Maity P, Bindu S, Dey S, Goyal M, Alam A, Pal C, Reiter R, Bandyopadhyay U. Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis. J Pineal Res. 2009 Apr; 46(3):314-23. PMID: 19220725; DOI: 10.1111/j.1600-079X.2009.00663.x;

Maity P, Bindu S, Dey S, Goyal M, Alam A, Pal C, Mitra K, Bandyopadhyay U. Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel role of mitochondrial aconitase oxidation. J Biol Chem. 2009 Jan 30; 284(5):3058-3068. PMID: 19049974; DOI: 10.1074/jbc.M805329200;

Dey S, Guha M, Alam A, Goyal M, Bindu S, Pal C, Maity P, Mitra K, Bandyopadhyay U. Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis. Free Radic Biol Med. 2009 Jan 15; 46(2):271-81. PMID: 19015023; DOI: 10.1016/j.freeradbiomed.2008.10.032;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 41 publications over 15 distinct years, with a maximum of 6 publications in 2015 and 2021

Bar chart showing 41 publications over 15 distinct years, with a maximum of 6 publications in 2015 and 2021

Year	Publications
2008	2
2009	2
2010	1
2011	4
2012	4
2013	1
2014	3
2015	6
2016	3
2018	1
2020	1
2021	6
2022	5
2023	1
2024	1

2017 PBC Fellowship

2012 Ranbaxy Science Foundation (Now Sun Pharma): Young research scholar award

2012 81st Annual meeting of Society of Biological Chemist: D. P. Burma Best Poster Awards

2012 Department of Science and Technology, Govt. of India: INSPIRE young faculty award

2009 Selected among top 20% awardees in CSIR-NET

2009 Council for Scientific and Industrial Research (CSIR) New Delhi, India: Senior research fellowship

2006 Qualified CSIR-NET/JRF

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Molecular Parasitology
Genomics
Proteomics
Drug Discovery
Nuclear biology
Cell Wall proteins
Glycobiology
Epigenetic
Giardia
Plasmodium falciparum
Cryptosporidium parvums
Acanthamoeba castellanii

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617.358.3833

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